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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2025; 31(47): 111599
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.111599
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.111599
Postoperative depression and anxiety in patients undergoing intestinal tumor surgery: Incidence, predictors, and impact on quality of life
Zhi-Jian Wei, A-Man Xu, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Pei-Pei Liang, Department of Emergency Intensive Care Unit, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Co-first authors: Zhi-Jian Wei and Pei-Pei Liang.
Author contributions: Wei ZJ and Liang PP, as co-first authors, were responsible for the overall study design, data analysis, experimental implementation, and manuscript drafting; Xu AM the corresponding author, guided the overall direction of the study and contributed to data analysis and revisions of the manuscript; Wei ZJ, Xu AM and Liang PP was involved in data collection and experiment implementation, assisting with data analysis and discussion of results; Xu AM provided support in experimental design and data analysis, offering technical assistance; Wei ZJ, Liang PP, Xu AM, contributed to data collection and experiment implementation, as well as assisting with parts of the manuscript writing.
Supported by Key Project of the Education Department of Anhui Province, No. 2023AH053330.
Institutional review board statement: This study has been reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Anhui Medical University, with approval number PJ2024-07-63.
Informed consent statement: All study participants, or their legal guardians, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: There is no additional data available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: A-Man Xu, MD, Chief Pharmacist, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 210 Jixi Road, Shu
Received: August 1, 2025
Revised: September 8, 2025
Accepted: November 7, 2025
Published online: December 21, 2025
Processing time: 140 Days and 3.3 Hours
Revised: September 8, 2025
Accepted: November 7, 2025
Published online: December 21, 2025
Processing time: 140 Days and 3.3 Hours
Core Tip
Core Tip: Postoperative depression and anxiety are frequent but often overlooked in patients undergoing intestinal tumor surgery. This prospective observational study systematically evaluated the incidence, predictors, and impact on quality of life. Dynamic monitoring showed that psychological symptoms improved over time but were closely linked with inflammatory activation and nutritional imbalance. Intraoperative hypotension, high neutrophil-to-lymphocyte ratio, and low albumin-to-fibrinogen ratio emerged as strong predictors of adverse outcomes. These findings highlight the importance of early monitoring and integrated physical-psychological rehabilitation strategies to optimize recovery and long-term prognosis in intestinal tumor surgery patients.