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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2025; 31(47): 112705
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.112705
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.112705
Indolent T-cell lymphoma of the gastrointestinal tract coexisting with gastric signet-ring cell carcinoma: A case report and review of literature
Xue Chen, Jia-Qi Bo, Su-Xia Zhang, Jie Li, Hui Wang, Mu-Ye Yang, Qian-Qian Guo, Yu Zeng, Department of Pathology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai 200065, China
Xiao-Xiang Gao, Department of Orthopedics, Chinese People's Liberation Army Naval Medical Center, Shanghai 200052, China
Bing Xiu, Department of Hematology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai 200065, China
Co-first authors: Xue Chen and Jia-Qi Bo.
Co-corresponding authors: Bing Xiu and Yu Zeng.
Author contributions: Chen X and Bo JQ were primarily involved in literature retrieval, consultation, paper writing, in charge of T-cell receptor rearrangement detection and result interpretation as the co-first authors of the paper; Gao XX looked through books and other sources for information; Zhang SX interpreted the data of the immunohistochemical results; LI J, Wang H, Yang MY and Guo QQ consulted the literature, providing retrieval, corresponding clinical data and follow-up information; Xiu B and Zeng Y revised it critically for important intellectual content as the co-corresponding authors; Zeng Y gave financial assistance for this study; all authors have read and approved the final manuscript.
Supported by Key Disciplines of The Sixth Cycle of Tongji Hospital, No. ZDTS24-BL; Shanghai Municipal Science and Technology Commission 2021 "Science and Technology Innovation Action Plan" Medical Innovation Research Project, No. 21Y11908800; and Clinical Research Project of Tongji Hospital of Tongji University, No. ITJ(ZD) 2206.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Zeng, MD, PhD, Chief Physician, Department of Pathology, Tongji Hospital Affiliated to Tongji University School of Medicine, No. 389 Xincun Road, Putuo District, Shanghai 200065, China. yuzeng2013@163.com
Received: August 19, 2025
Revised: September 28, 2025
Accepted: November 4, 2025
Published online: December 21, 2025
Processing time: 123 Days and 2.5 Hours
Revised: September 28, 2025
Accepted: November 4, 2025
Published online: December 21, 2025
Processing time: 123 Days and 2.5 Hours
Core Tip
Core Tip: This article is the first to present a rare case of indolent T-cell lymphoma of the gastrointestinal tract coexisting with gastric signet-ring cell carcinoma. The immunohistochemistry results revealed that CD3, CD8, and TIA-1 expression was positive, whereas the Ki-67 score was low. Clonal T-cell receptor rearrangement was detected. The main differential diagnoses were aggressive T-cell lymphomas and inflammatory issues. This rare case emphasizes that clinicians and patho