Prognostic impact of tumor deposits in colorectal cancer

doi:10.3748/wjg.v31.i47.114506

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Dec 21, 2025 (publication date) through Dec 19, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastroenterol. Dec 21, 2025; 31(47): 114506
Published online Dec 21, 2025. doi: 10.3748/wjg.v31.i47.114506

Prognostic impact of tumor deposits in colorectal cancer

Bilal Turan

Bilal Turan, Department of General Surgery, Faculty of Medicine, Suleyman Demirel University, Isparta 32260, Türkiye

Author contributions: Turan B designed the overall concept and outline of the manuscript, contributed to the design of the manuscript, the writing and editing of the manuscript, and review of the literature.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Bilal Turan, MD, Assistant Professor, Researcher, Department of General Surgery, Faculty of Medicine, Suleyman Demirel University, Suleyman Demirel Universitesi Arastirma ve Uygulama Hastanesi, Isparta 32260, Türkiye bturan117@gmail.com

Received: September 22, 2025
Revised: October 18, 2025
Accepted: October 29, 2025
Published online: December 21, 2025
Processing time: 89 Days and 4.2 Hours

Core Tip

Core Tip: Tumor deposits (TDs) are an independent adverse prognostic factor in colorectal cancer across all stages. Evidence from both single-center analyses introducing the NLNTD index and large-scale population-based cohorts consistently shows that TDs should be recognized as high-risk features and incorporated into adjuvant treatment algorithms and follow-up strategies, rather than regarded as incidental findings.