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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2025; 31(48): 112683
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112683
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112683
Artificial intelligence-assisted diagnosis of rectal neuroendocrine tumors during white-light endoscopy
Ke Liu, Li-Zhi Yi, Xian-Fei Zhong, Department of Gastroenterology, The People’s Hospital of Leshan, Southwest Medical University, Leshan 614000, Sichuan Province, China
Zhen-Yu Wang, Su-Zuan Chen, Department of Digestive Endoscope, The First Affiliated Hospital of Shantou University Medical College, Shantou 515000, Guangdong Province, China
Feng Li, Lin Qiu, Yang Bai, Fang Xie, Meng-Nan Zhang, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Shun-Hui He, Zhi-Jian Li, Department of Gastroenterology, The Eighth Affiliated Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China
Xi-Gang Zhang, Department of Gastroenterology, Shenzhen Second People’s Hospital, Shenzhen 518020, Guangdong Province, China
Chun-Xiao Lai, Gastrointestinal Cancer Center, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Rui-Ya Zhang, Department of Gastroenterology, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, Shanxi Province, China
Wen Wu, Department of Gastroenterology, Shanxi Academy of Traditional Chinese Medicine, Taiyuan 030024, Shanxi Province, China
Yu Lin, Department of Gastroenterology, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Hui Yang, Department of Spleen and Stomach, Rizhao Hospital of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Rizhao 276800, Shandong Province, China
Gui-Ming Liu, Quan-Sheng Guan, Department of Gastroenterology, Shayang Hospital of Traditional Chinese Medicine, Jingmen 448200, Hubei Province, China
Zhi-Fang Zhao, Department of Gastroenterology, National Institution of Drug Clinical Trial, Guizhou Provincial People’s Hospital, Medical College of Guizhou University, Guiyang 550000, Guizhou Province, China
Li-Ming Cheng, Department of Internal Medicine, Taihe People’s Hospital Baiyun District, Guangzhou 510515, Guangdong Province, China
Jie Dai, Suzhou Wellomen Information Technology Co. Ltd., Suzhou 215000, Jiangsu Province, China
Author contributions: Liu K and Wang ZY were responsible for data collection, analysis, and drafting of the manuscript, they contributed equally to this work and are co-first authors. Liu K, Wang ZY, Yi LZ, Li F, He SH, Zhang XG, Lai CX, Li ZJ, Qiu L, Zhang RY, Wu W, Lin Y, Yang H, Liu GM, Guan QS, Zhao ZF, Cheng LM, Dai J, Bai Y, Xie F, and Zhang MN performed the research; Chen SZ and Zhong XF designed the study and revised the manuscript, they serve as co-corresponding authors.
Supported by the Municipal Key Science and Technology Program of Leshan, No. 23SZD039; and National Natural Science Foundation of China, No. 82470539.
Institutional review board statement: The study was approved by the Ethics Committee of the People’s Hospital of Leshan (approval No. LYLL2023ky066) and Nanfang Hospital of Southern Medical University (approval No. NFEC-2024-333).
Informed consent statement: The informed consent was waived by the Ethics Committee of the People’s Hospital of Leshan.
Conflict-of-interest statement: Zhong XF reports grants from the Municipal Key Science and Technology Program of Leshan, No. 23SZD039; and National Natural Science Foundation of China, No. 82470539, during the conduct of the study.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Fei Zhong, Department of Gastroenterology, The People’s Hospital of Leshan, Southwest Medical University, No. 238 White Tower Road, Leshan 614000, Sichuan Province, China. 13981302161@163.com
Received: August 4, 2025
Revised: September 17, 2025
Accepted: November 12, 2025
Published online: December 28, 2025
Processing time: 146 Days and 10.1 Hours
Revised: September 17, 2025
Accepted: November 12, 2025
Published online: December 28, 2025
Processing time: 146 Days and 10.1 Hours
Core Tip
Core Tip: Due to significantly lower incidence compared to colorectal polyps and macroscopic features resembling hyper