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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2025; 31(48): 113243
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113243
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113243
Exploring exercise modalities and their impact on inflammatory bowel disease: A systematic review of rodent colitis models
Shao-Peng Sun, Yu-Qing Mao, Yi-Hong Fan, Bin Lv, Department of Gastroenterology, Zhejiang Hospital of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China
Co-first authors: Shao-Peng Sun and Yu-Qing Mao.
Author contributions: Sun SP and Mao YQ contributed to conceive the study design and wrote the manuscript; Sun SP contributed to made data analysis and prepared the figures; Lv B and Fan YH contributed to supervise the scientific work and revised the manuscript; all authors have read and agreed to the published version of the manuscript.
Supported by the 2024 General Scientific Research Project of Zhejiang Provincial Department of Education-Special Project for Reform of Professional Degree Graduate Training Mode, No. Y202456174; and “Pioneer” and “Leading Goose” R and D Program of Zhejiang, No. 2023C03050.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Lv, MD, Doctor, Department of Gastroenterology, Zhejiang Hospital of Traditional Chinese Medicine, No. 54 Youdian Road, Shangcheng District, Hangzhou 310000, Zhejiang Province, China. lvbin@medmail.com.cn
Received: August 20, 2025
Revised: September 28, 2025
Accepted: November 14, 2025
Published online: December 28, 2025
Processing time: 129 Days and 16.5 Hours
Revised: September 28, 2025
Accepted: November 14, 2025
Published online: December 28, 2025
Processing time: 129 Days and 16.5 Hours
Core Tip
Core Tip: In rodent models of colitis, the impact of exercise on inflammatory bowel disease (IBD) is highly modality-dependent. Voluntary wheel running, swimming, and strength training consistently ameliorate colitis by reducing inflammation, oxidative stress, and improving gut barrier integrity. In contrast, forced treadmill running yields inconsistent or detri