Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(48): 112972 [DOI: 10.3748/wjg.v31.i48.112972]
Corresponding Author of This Article
Qi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, No. 390 Xincheng Road, Taihu Sub-district, Binhu District, Wuxi 214121, Jiangsu Province, China. 810204666@qq.com
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Endocrinology & Metabolism
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Retrospective Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 28, 2025 (publication date) through Dec 27, 2025
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Wang Y, Ma GH, Qu MY, Xu QS, Huang HX. Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2025; 31(48): 112972 [DOI: 10.3748/wjg.v31.i48.112972]
World J Gastroenterol. Dec 28, 2025; 31(48): 112972 Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.112972
Serum uric acid-to-high-density lipoprotein cholesterol ratio and cardiovascular risk in Asian patients with metabolic dysfunction-associated steatotic liver disease
Yang Wang, Guang-Hui Ma, Ming-Yue Qu, Qi-Shui Xu, Hai-Xia Huang
Yang Wang, Department of Radiology, Affiliated Hospital of Jiangnan University, Wuxi 214100, Jiangsu Province, China
Guang-Hui Ma, Ming-Yue Qu, Hai-Xia Huang, Department of Radiology, Shanghai Health and Medical Center, Wuxi 214065, Jiangsu Province, China
Qi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, Wuxi 214121, Jiangsu Province, China
Co-first authors: Yang Wang and Guang-Hui Ma.
Co-corresponding authors: Qi-Shui Xu and Hai-Xia Huang.
Author contributions: Wang Y and Ma GH made equal contributions as co-first authors; Wang Y, Xu QS, Ma GH, and Qu MY designed the study; Wang Y, Xu QS, and Ma GH contributed to data analysis; Ma GH and Qu MY contributed to data collection; Ma GH wrote the draft; Xu QS and Huang HX made equal contributions as co-corresponding authors. All authors approved the final version to publish.
Supported by Shanghai Health and Medical Center Star Talent Program, No. 2023QMX01 and No. 2023QMX11.
Institutional review board statement: The study protocol was approved by the Ethics Committee of Shanghai Health and Medical Center, No. LLSC202535.
Informed consent statement: Written informed consent was waived because of the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data supporting the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Shui Xu, Department of Anesthesiology, Wuxi No. 2 Chinese Medicine Hospital, No. 390 Xincheng Road, Taihu Sub-district, Binhu District, Wuxi 214121, Jiangsu Province, China. 810204666@qq.com
Received: August 12, 2025 Revised: September 16, 2025 Accepted: November 12, 2025 Published online: December 28, 2025 Processing time: 137 Days and 20 Hours
Core Tip
Core Tip: This study demonstrated that an elevated uric acid-to-high-density lipoprotein cholesterol ratio (UHR) was independently associated with a higher predicted 10-year CVD risk, as estimated by the Framingham risk score, in a large cohort of Asian patients with metabolic dysfunction-associated steatotic liver disease. A distinct linear dose-response association between increasing UHR levels and CVD risk was observed. Notably, UHR exhibited superior predictive performance compared with conventional biomarkers (area under the curve = 0.655), with an optimal cutoff value of 292. Readily obtainable from routine biochemical testing, UHR thus represents a simple and cost-effective indicator for early CVD risk stratification in patients with metabolic dysfunction-associated steatotic liver disease.
