Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer

doi:10.3748/wjg.v31.i48.113550

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Dec 28, 2025 (publication date) through Dec 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2025; 31(48): 113550
Published online Dec 28, 2025. doi: 10.3748/wjg.v31.i48.113550

Capecitabine maintenance after radiofrequency ablation: A preventive strategy for lung oligometastases from colorectal cancer

Francesco Giangregorio

Francesco Giangregorio, Department of Internal Medicine, Castel San Giovanni Hospital, Piacenza 29015, Emilia-Romagna, Italy

Author contributions: Giangregorio F was responsible for the conception and design of the study, and the drafting of the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Francesco Giangregorio, MD, PhD, Associate Professor, Chief Physician, Director, Department of Internal Medicine, Castel San Giovanni Hospital, Viale II Giugno 1, Castel San Giovanni, Piacenza 29015, Emilia-Romagna, Italy. f.giangregorio67@gmail.com

Received: August 28, 2025
Revised: October 11, 2025
Accepted: November 6, 2025
Published online: December 28, 2025
Processing time: 121 Days and 7.4 Hours

Core Tip

Core Tip: Preventing the recurrence of lung oligometastases from colorectal cancer after local therapy is crucial. Recent evidence demonstrated that capecitabine maintenance after radiofrequency ablation significantly increased 5-year overall survival and reduced 5-year local tumor progression rates compared with radiofrequency ablation alone. This synergistic approach proactively targets micrometastatic disease. Despite the retrospective nature of the study, its robust results support the confirmation of systemic maintenance with local ablation in prospective randomized controlled trials.