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Contents Volume 16 Issue 4 December 22, 2025

Review

Pathophysiology of depression and anxiety in metabolic dysfunction-associated steatotic liver disease

Sampada, Mohammad Naseem, Mehul Solanki, Ragini Sharma, Carol Singh, Aalam Sohal

World J Gastrointest Pathophysiol 16(4):111029. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111029

Abstract (74) | Core Tip (60) | Full Article (HTML) (539) | Figures (1-3) (63) | Tables (1-1) (51) | Full Article (PDF)-1726K (61) | Full Article with Cover (PDF)-2003K (32) | Full Article (XML)-341K (29) | Audio-2835K (9) | Peer-Review Report-278K (32) | Answering Reviewers-187K (38) | Received: 06/21/2025 | Revised: 07/31/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (1482) | Similar Articles (415) | Timeline of Article Publication (1) | Cite |

(0) | (0) | (0) | (0) | Open

Guardians within: Cross-talk between the gut microbiome and host immune system

Nabanita Ghosh, Krishnendu Sinha

World J Gastrointest Pathophysiol 16(4):111245. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111245

Abstract (71) | Core Tip (55) | Full Article (HTML) (652) | Figures (1-2) (73) | Tables (1-1) (66) | Full Article (PDF)-3017K (267) | Full Article with Cover (PDF)-3294K (30) | Full Article (XML)-302K (39) | Audio-152K (9) | Peer-Review Report-447K (31) | Answering Reviewers-72K (29) | Received: 06/25/2025 | Revised: 07/28/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2072) | Similar Articles (40) | Timeline of Article Publication (1) | Cite |

(0) | (0) | (0) | (0) | Open

Update on the pathogenesis and clinical management of Helicobacter pylori gastric infection and associated diseases

Juan Marcos Caram Costa, Carlos Eduardo Oliveira Aguiar, Marina Maria Gomes Leite Oliveira, Victoria Cenci Dietrich, Pedro Henrique Melo Lima, João Pedro Camargo Freire, Fabian Fellipe Bueno Lemos, Dulciene Maria de Magalhães Queiroz, Fabrício Freire de Melo

World J Gastrointest Pathophysiol 16(4):111432. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111432

Abstract (92) | Core Tip (65) | Full Article (HTML) (560) | Figures (1-2) (59) | Tables (1-2) (244) | Full Article (PDF)-1153K (85) | Full Article with Cover (PDF)-1429K (34) | Full Article (XML)-448K (40) | Audio-274K (5) | Peer-Review Report-209K (35) | Answering Reviewers-90K (45) | Received: 06/28/2025 | Revised: 07/26/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1899) | Similar Articles (333) | Timeline of Article Publication (2) | Cite |

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Roles of chemokines in pancreatitis: A review

Wei-Fang Ni, Chao-Chao Qin

World J Gastrointest Pathophysiol 16(4):111550. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111550

Abstract (79) | Core Tip (57) | Full Article (HTML) (215) | Figures (1-5) (73) | Tables (1-1) (49) | Full Article (PDF)-4791K (48) | Full Article with Cover (PDF)-5071K (25) | Full Article (XML)-235K (28) | Audio-1761K (12) | Peer-Review Report-306K (25) | Answering Reviewers-224K (31) | Received: 07/03/2025 | Revised: 09/01/2025 | Accepted: 10/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1707) | Similar Articles (170) | Timeline of Article Publication (1) | Authors Evaluation (1) | Cite |

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Constipation in critically ill adults

Yuri Kim, Kay C See

World J Gastrointest Pathophysiol 16(4):112019. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112019

Abstract (86) | Core Tip (56) | Full Article (HTML) (810) | Tables (1-5) (66) | Full Article (PDF)-600K (357) | Full Article with Cover (PDF)-876K (39) | Full Article (XML)-287K (32) | Audio-350K (16) | Peer-Review Report-306K (30) | Answering Reviewers-246K (90) | Received: 07/15/2025 | Revised: 08/25/2025 | Accepted: 12/01/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (2055) | Similar Articles (53) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

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Minireviews

Gluten’s silent strike: Unmasking its impact on liver health

Shivam Kalra, Simran Joshi, Manjeet K Goyal, Kartikay Goyal, Bhupender Singh, Ashita R Vuthaluru, Omesh Goyal

World J Gastrointest Pathophysiol 16(4):111957. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111957

Abstract (71) | Core Tip (51) | Full Article (HTML) (633) | Figures (1-1) (58) | Tables (1-1) (49) | Full Article (PDF)-1092K (82) | Full Article with Cover (PDF)-1371K (28) | Full Article (XML)-124K (31) | Audio-779K (6) | Peer-Review Report-259K (32) | Answering Reviewers-81K (27) | Received: 07/16/2025 | Revised: 08/18/2025 | Accepted: 11/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1625) | Similar Articles (8) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Imaging of appendicitis: Computed tomography, magnetic resonance imaging, and ultrasound in diagnosis and management

Arosh S Perera Molligoda Arachchige, Ana Claudia Teixeira de Castro Gonçalves Ortega, Gabriel Amorim Moreira Alves

World J Gastrointest Pathophysiol 16(4):112695. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112695

Abstract (84) | Core Tip (63) | Full Article (HTML) (336) | Figures (1-2) (54) | Full Article (PDF)-2895K (61) | Full Article with Cover (PDF)-3175K (35) | Full Article (XML)-59K (28) | Audio-2416K (8) | Peer-Review Report-313K (34) | Answering Reviewers-64K (28) | Received: 08/02/2025 | Revised: 08/18/2025 | Accepted: 12/01/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1692) | Similar Articles (620) | Timeline of Article Publication (0) | Cite |

(0) | (0) | (0) | (0) | Open

Case Control Study

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test

Niranga Manjuri Devanarayana, Shaman Rajindrajith, Delpechitracharige Gajabahu Harendra de Silva, Hithanadura Janaka de Silva

World J Gastrointest Pathophysiol 16(4):110421. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.110421

Abstract (75) | Core Tip (54) | Full Article (HTML) (172) | Figures (1-1) (56) | Tables (1-2) (52) | Full Article (PDF)-587K (47) | Full Article with Cover (PDF)-866K (128) | Full Article (XML)-141K (35) | Audio-1227K (7) | Peer-Review Report-254K (35) | Answering Reviewers-164K (24) | Received: 06/05/2025 | Revised: 07/04/2025 | Accepted: 11/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1398) | Similar Articles (1) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Observational Study

Gastric motility and its association with adiposity and metabolic health in a cohort of Sri Lankan office workers

Pradeepa Isurumali Basnayake, Dulani Kottahachchi, Dinu Santha Chandran, Kushan Medagoda, Niranga Manjuri Devanarayana

World J Gastrointest Pathophysiol 16(4):112536. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112536

Abstract (81) | Core Tip (61) | Full Article (HTML) (227) | Figures (1-1) (51) | Tables (1-4) (48) | Full Article (PDF)-1262K (55) | Full Article with Cover (PDF)-1540K (61) | Full Article (XML)-116K (40) | Audio-842K (10) | Peer-Review Report-222K (36) | Answering Reviewers-696K (38) | Supplementary Material-286K (33) | Received: 07/29/2025 | Revised: 08/13/2025 | Accepted: 10/29/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1382) | Similar Articles (14) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Prospective Study

Gender, racial, and stage-specific trends in esophageal cancer: Insights from longitudinal population data

Silpa Choday, Anthony Yeung, Paul Kang, Tina Younger, Wael Youssef

World J Gastrointest Pathophysiol 16(4):110243. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.110243

Abstract (73) | Core Tip (51) | Full Article (HTML) (215) | Figures (1-1) (52) | Tables (1-4) (57) | Full Article (PDF)-2680K (71) | Full Article with Cover (PDF)-2961K (83) | Full Article (XML)-101K (26) | Audio-113K (8) | Peer-Review Report-460K (24) | Answering Reviewers-463K (31) | Received: 06/02/2025 | Revised: 07/17/2025 | Accepted: 11/26/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1946) | Similar Articles (162) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Systematic Reviews

Metabolic changes after hepatectomy: Implications for perioperative management and long-term outcomes

Joshua Zhuo Lee, Sandra Joanne Kar Kwan Ng, Vishal G Shelat

World J Gastrointest Pathophysiol 16(4):109860. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.109860

Abstract (101) | Core Tip (53) | Full Article (HTML) (290) | Figures (1-2) (47) | Full Article (PDF)-2638K (126) | Full Article with Cover (PDF)-2917K (98) | Full Article (XML)-208K (28) | Audio-2303K (5) | Peer-Review Report-223K (21) | Answering Reviewers-44K (28) | Received: 05/23/2025 | Revised: 07/12/2025 | Accepted: 10/30/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1843) | Similar Articles (95) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Colorectal cancer metastasis to the brain: A scoping review of incidence, treatment, and outcomes

Hunter J Hutchinson, Melanie Gonzalez, Diana Feier, Colin E Welch, Brandon Lucke-Wold

World J Gastrointest Pathophysiol 16(4):110961. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.110961

Abstract (96) | Core Tip (59) | Full Article (HTML) (377) | Figures (1-3) (52) | Tables (1-3) (53) | Full Article (PDF)-805K (53) | Full Article with Cover (PDF)-1085K (111) | Full Article (XML)-374K (35) | Audio-198K (11) | Peer-Review Report-346K (31) | Answering Reviewers-354K (37) | Received: 06/19/2025 | Revised: 07/13/2025 | Accepted: 10/22/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1593) | Similar Articles (1286) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review

Amit Kumar Dutta, Subitha Vishruth, Sai Lakshmi Kovi, Piyush Dadhich, Jagadish Polavarapu, Dilip Abraham

World J Gastrointest Pathophysiol 16(4):112961. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112961

Abstract (93) | Core Tip (56) | Full Article (HTML) (308) | Figures (1-2) (50) | Tables (1-5) (49) | Full Article (PDF)-739K (51) | Full Article with Cover (PDF)-1018K (103) | Full Article (XML)-229K (34) | Audio-414K (8) | Peer-Review Report-236K (36) | Answering Reviewers-208K (34) | Supplementary Material-102K (34) | Received: 08/10/2025 | Revised: 09/13/2025 | Accepted: 11/20/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1594) | Similar Articles (349) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Role of gut microbiomes in different ocular pathologies: A systematic review

Priyanka Priyanka, Srishti Khullar, Mamta Singh, Arvind Kumar Morya, Bhavana Sharma, Brindha Periasamy, Bruttendu Moharana, Rannusha Morya

World J Gastrointest Pathophysiol 16(4):113488. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.113488

Abstract (69) | Core Tip (57) | Full Article (HTML) (439) | Figures (1-2) (53) | Tables (1-3) (43) | Full Article (PDF)-3892K (56) | Full Article with Cover (PDF)-4170K (117) | Full Article (XML)-259K (22) | Audio-366K (7) | Peer-Review Report-219K (30) | Answering Reviewers-115K (35) | Supplementary Material-4654K (25) | Received: 08/26/2025 | Revised: 09/21/2025 | Accepted: 12/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1538) | Similar Articles (33) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

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Case Report

Isolated hilar mass mimicking cholangiocarcinoma as a rare metastatic manifestation of recurrent colorectal cancer: A case report

Nisar Amin, Ebubekir Daglilar, Harleen Kaur Chela

World J Gastrointest Pathophysiol 16(4):111865. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111865

Abstract (61) | Core Tip (53) | Full Article (HTML) (205) | Figures (1-4) (50) | Full Article (PDF)-5833K (53) | Full Article with Cover (PDF)-6113K (27) | Full Article (XML)-47K (34) | Audio-809K (7) | Peer-Review Report-308K (24) | Answering Reviewers-186K (30) | Received: 07/11/2025 | Revised: 08/30/2025 | Accepted: 11/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1115) | Similar Articles (4556) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Chronic mesenteric ischemia diagnosed via incidental CT findings with gastroenterologist perspective: Two case reports

Mohammed Abdulrasak, Isak Wernehov, Johanna Holmgren

World J Gastrointest Pathophysiol 16(4):112822. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112822

Abstract (65) | Core Tip (54) | Full Article (HTML) (234) | Figures (1-4) (55) | Full Article (PDF)-5668K (211) | Full Article with Cover (PDF)-5948K (493) | Full Article (XML)-51K (41) | Audio-149K (8) | Peer-Review Report-236K (35) | Answering Reviewers-155K (30) | Received: 08/06/2025 | Revised: 09/09/2025 | Accepted: 10/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (2231) | Similar Articles (4558) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

Letter to the Editor

Drug-induced liver injury from high-dose intravenous methylprednisolone: A rare but known adverse effect

Kevan English

World J Gastrointest Pathophysiol 16(4):111306. Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.111306

Abstract (86) | Core Tip (64) | Full Article (HTML) (491) | Tables (1-2) (46) | Full Article (PDF)-386K (45) | Full Article with Cover (PDF)-667K (105) | Full Article (XML)-44K (30) | Audio-335K (4) | Peer-Review Report-353K (29) | Answering Reviewers-119K (34) | Received: 06/26/2025 | Revised: 07/30/2025 | Accepted: 09/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (1489) | Similar Articles (22) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

(0) | (0) | (0) | (0) | Open

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