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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Dec 22, 2025; 16(4): 112961
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112961
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.112961
Gut microbiota as a potential predictor of therapeutic response in adults with Crohn’s disease: A systematic review
Amit Kumar Dutta, Subitha Vishruth, Sai Lakshmi Kovi, Piyush Dadhich, Jagadish Polavarapu, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India
Dilip Abraham, Wellcome Trust Research Laboratory, Christian Medical College Vellore, Vellore 632004, Tamil Nādu, India
Author contributions: Dutta AK conceived the review and wrote the manuscript; Vishruth S, Kovi SL, Dadhich P, and Polavarapu J did the data extraction and critically reviewed the manuscript; Abraham D wrote the manuscript and critically reviewed the manuscript.
Conflict-of-interest statement: None of the authors have any financial disclosure or conflict of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amit Kumar Dutta, FRCPE, Professor, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Ground Floor, Williams Building, Vellore 632004, Tamil Nadu, India. akdutta1995@yahoo.co.in
Received: August 11, 2025
Revised: September 13, 2025
Accepted: November 20, 2025
Published online: December 22, 2025
Processing time: 133 Days and 11.7 Hours
Revised: September 13, 2025
Accepted: November 20, 2025
Published online: December 22, 2025
Processing time: 133 Days and 11.7 Hours
Core Tip
Core Tip: Crohn’s disease is a chronic inflammatory bowel condition requiring lifelong therapy. However, about one-third of patients do not respond to any particular treatment, and a change of therapy is needed. There is a need for identifying predictors of therapy before treatment to avoid non-response, but such markers are uncommon. Accumulating evidence suggests that the gut bacterial population can serve as a potentially useful prediction tool. In this review, we have presented the current status of the role of gut microbial community as a biomarker of response. The results are encouraging but further work is needed before they can be used in clinical practice.