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Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review
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World Journal of Gastrointestinal Pathophysiology is an international, peer-reviewed, open-access academic journal dedicated to publishing original, high-quality research findings in the field of gastrointestinal pathophysiology and liver physiology, including clinical, translational, and basic studies, as well as research involving artificial intelligence. The journal focuses on, but is not limited to, the following areas: Gastrointestinal pathophysiology (motility disorders, secretion and absorption, mucosal barrier and inflammation, neoplastic pathophysiology), liver physiology (metabolism, bile production, detoxification and drug metabolism, and liver regeneration), gut-liver axis, microbiome sciences, and neurogastroenterology. Types of articles published by the journal include clinical study, basic study, case report, editorial, review, minireview, systematic review, meta-analysis, guidelines, and correspondence. All submissions undergo a rigorous and transparent peer-review process by at least two independent reviewers. Manuscripts are evaluated based on scientific rigor, originality, clinical relevance, and reproducibility, with particular attention to methodological robustness and data integrity. Constructive and timely feedback is provided to ensure the highest standards of scholarly communication. The journal adheres to the highest standards of publication ethics and editorial integrity, in accordance with the guidelines of the Committee on Publication Ethics, the International Committee of Medical Journal Editors, and the World Association of Medical Editors. To advance scientific discovery, promote evidence-based clinical practice, and foster innovation in gastrointestinal pathophysiology, ultimately improving global health outcomes. We invite researchers, clinicians, and multidisciplinary experts worldwide to submit high-quality manuscripts and contribute to shaping the future of gastrointestinal pathophysiological science. Submit an Article >>

2026 Published Issues
2 1
Editors-in-Chief
  • Kusum K Kharbanda, PhD, Professor, (Email: kkharbanda@unmc.edu) Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, United States
  • Tsutomu Nishida, MD, PhD, (Email: tnishida@gh.med.osaka-u.ac.jp) Department of Gastroenterology, Toyonaka Municipal Hospital, Toyonaka, Osaka 560-8565, Japan
Indexing/Abstracting
The WJGP is now abstracted and indexed in PubMed, PubMed Central, Reference Citation Analysis, China Science and Technology Journal Database, and Superstar Journals Database.
Journal Metrics
There is currently no impact factor.
ISSN
2150-5330 (online)
Latest Manuscript Statistics
Received (506), Duration of Peer Review (24 days/Mean), Days from Submission to First Decision (41 days/Mean), Second Decision Time (40 days/Mean), Accepted (56.1%/Mean), Production Time (55 days/Mean), Time to Publication (194 days/Mean), and Rejected (31.2%/Mean).
Current Issue
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Contents Volume 17 Issue 2 June 22, 2026
Minireviews
Body mass index and gastrointestinal inflammation: Bio-molecular pathophysiology
Roberto Anaya-Prado, Andrea M Murrieta-Verduzco, Ivanna R Peña-Mascorro, Anna C Portillo-Valles, Alejandro Calderon-Velazquez, Hector Lopez-Hernandez, Dalia G Monge-Rosales, Jose L Montes de Oca-Martinez, Christopher E Castellanos-Garcia, Gustavo Servin-Romero, Roberto Anaya-Fernández, Ana P Cardenas-Fregoso, Michelle M Anaya-Fernández, Consuelo C Azcona-Ramirez, Cynthia N Heredia-Garcia 
World J Gastrointest Pathophysiol 17(2):120474. Published online Jun 22, 2026. doi: 10.4291/wjgp.120474
Appendix in ulcerative colitis pathogenesis and therapy: An updated narrative review
Omar AbdelGhani, Sherreen Elhariri, Payal Bhatnagar, Htar Htar Aung, Mohamed Abdel Wahab, Nabil Eid 
World J Gastrointest Pathophysiol 17(2):122072. Published online Jun 22, 2026. doi: 10.4291/wjgp.v17.i2.122072
Case Control Study
Liver stiffness at baseline as a marker of hepatocellular carcinoma in cirrhosis: A matched analysis
Varun Mehta, Manjeet Kumar Goyal, Yogesh Kumar Gupta, Abhinav Gupta, Manisha Khubber, Tanisha Sehgal, Prabhav Mehta, Omesh Goyal 
World J Gastrointest Pathophysiol 17(2):120603. Published online Jun 22, 2026. doi: 10.4291/wjgp.v17.i2.120603
Observational Study
Occult constipation masking as irritable bowel syndrome with predominant diarrhea in Bangladeshi children
Md Benzamin, Md Ziaur Rahman Chowdhury, Pranto Chakroborty, Akhlaq Ahmed, Tuhin Barua Tamal, Aparajita Chowdhury, Abu Sayed Mohammad Bazlul Karim 
World J Gastrointest Pathophysiol 17(2):121705. Published online Jun 22, 2026. doi: 10.4291/wjgp.v17.i2.121705
Systematic Reviews
Gut barrier dysfunction and multidrug-resistant bacterial translocation in adult critical illness: Mechanistic insights from a systematic review
Shree V Dhotre, Pradnya S Dhotre, Sachin S Mumbre, Basavraj S Nagoba 
World J Gastrointest Pathophysiol 17(2):122029. Published online Jun 22, 2026. doi: 10.4291/wjgp.v17.i2.122029
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