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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Dec 22, 2025; 16(4): 110421
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.110421
Published online Dec 22, 2025. doi: 10.4291/wjgp.v16.i4.110421
Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test
Niranga Manjuri Devanarayana, Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka
Shaman Rajindrajith, Delpechitracharige Gajabahu Harendra de Silva, Department of Pediatrics, Faculty of Medicine, University of Colombo, Colombo 00800, Western Province, Sri Lanka
Hithanadura Janaka de Silva, Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka
Author contributions: Devanarayana NM conceptualized and designed the study, collected and analyzed the data, and wrote the initial manuscript; Rajindrajith S and de Silva DGH revised the manuscript; de Silva HJ contributed to the study concept and design and revised the manuscript.
Supported by The University of Kelaniya, No. RP/03/04/13/01/01.
Institutional review board statement: Ethical approval for the study was granted by the Ethics Review Committee of the Faculty of Medicine, University of Kelaniya, Sri Lanka.
Informed consent statement: Written informed consent was obtained from a parent or a guardian of each participant.
Conflict-of-interest statement: The authors report having no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE statement checklist of items, and the manuscript was prepared and revised according to the STROBE statement checklist of items.
Data sharing statement: The dataset used in the current study is available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Niranga Manjuri Devanarayana, MD, PhD, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 11010, Western Province, Sri Lanka. niranga@kln.ac.lk
Received: June 7, 2025
Revised: July 4, 2025
Accepted: November 4, 2025
Published online: December 22, 2025
Processing time: 199 Days and 16.7 Hours
Revised: July 4, 2025
Accepted: November 4, 2025
Published online: December 22, 2025
Processing time: 199 Days and 16.7 Hours
Core Tip
Core Tip: This study evaluated orocecal transit time (OCTT) in children with functional abdominal pain disorders (FAPDs) using the breath hydrogen test. Results showed significantly longer OCTT in patients compared to healthy controls, suggesting that impaired small intestinal transit may be a feature of FAPDs. However, the lack of correlation between OCTT and symptom severity indicates that delayed transit is unlikely to be a major contributor to symptom generation. These findings highlight the complexity of FAPD pathophysiology and suggest that while small intestinal motility disturbances are present, other mechanisms likely play a key role in symptom expression.