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Contents Volume 18 Issue 4 April 27, 2026

Editorial

Retroperitoneal laparoscopic partial hepatectomy: A novel approach to posterosuperior right-lobe tumors

Raed Hamzah Ogaili, Ismail Abdul Sattar Burud, Nabil Eid

World J Hepatol 18(4):117129. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.117129

Abstract (48) | Core Tip (40) | Full Article (HTML) (148) | Figures (1-1) (42) | Full Article (PDF)-559K (37) | Full Article with Cover (PDF)-815K (65) | Full Article (XML)-63K (11) | Audio-614K (7) | Peer-Review Report-225K (15) | Answering Reviewers-113K (20) | Received: 11/28/2025 | Revised: 12/11/2025 | Accepted: 01/06/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (587) | Similar Articles (342) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Review

Time sensitive managements in hepato-gastroenterology

Mohammad A Sakr, Samy Zaky, Mahmoud Anees, Amgad Elzahaby, Yasser Fouad, Mohamed H Emara, Hoda Mohamed Rabie Gabal, Hanan Hamed Soliman, Ebada M Said

World J Hepatol 18(4):114793. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114793

Abstract (43) | Core Tip (39) | Full Article (HTML) (142) | Figures (1-6) (37) | Tables (1-7) (46) | Full Article (PDF)-1906K (209) | Full Article with Cover (PDF)-2131K (224) | Full Article (XML)-400K (14) | Audio-1076K (3) | Peer-Review Report-281K (16) | Answering Reviewers-342K (13) | Supplementary Material-64K (9) | Received: 09/27/2025 | Revised: 11/25/2025 | Accepted: 02/10/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (922) | Similar Articles (50) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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High-fat diet, gut dysbiosis, and oxidative stress: A synergistic triangle in metabolic dysfunction-associated steatotic liver disease pathogenesis

Zi-Rui Zhang, Ling She, Yi-Rong Cao, Yuan-Wen Chen

World J Hepatol 18(4):116074. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116074

Abstract (43) | Core Tip (36) | Full Article (HTML) (89) | Figures (1-2) (45) | Full Article (PDF)-1041K (118) | Full Article with Cover (PDF)-1269K (160) | Full Article (XML)-354K (11) | Audio-1167K (5) | Peer-Review Report-152K (10) | Answering Reviewers-167K (14) | Received: 11/01/2025 | Revised: 12/29/2025 | Accepted: 01/27/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (690) | Similar Articles (202) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Minireviews

Acute mesenteric ischemia in cirrhosis: Diagnostic and management challenges

Amine Benmassaoud, Boaz Laor, Adam Sahl Hassan

World J Hepatol 18(4):114916. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114916

Abstract (39) | Core Tip (43) | Full Article (HTML) (102) | Figures (1-1) (43) | Tables (1-1) (41) | Full Article (PDF)-585K (101) | Full Article with Cover (PDF)-818K (128) | Full Article (XML)-148K (12) | Audio-636K (5) | Peer-Review Report-243K (12) | Answering Reviewers-231K (10) | Received: 10/01/2025 | Revised: 11/27/2025 | Accepted: 02/09/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (658) | Similar Articles (273) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Precision targeting of pathological angiogenesis in liver cirrhosis: Molecular mechanisms and therapeutic translation challenges

Biao Wen, Qiong-Ya Wang, Lan Li, Jian-Guo Zhang

World J Hepatol 18(4):114955. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114955

Abstract (45) | Core Tip (44) | Full Article (HTML) (115) | Tables (1-1) (39) | Full Article (PDF)-480K (55) | Full Article with Cover (PDF)-713K (71) | Full Article (XML)-140K (12) | Audio-920K (5) | Peer-Review Report-215K (8) | Answering Reviewers-186K (14) | Received: 10/02/2025 | Revised: 12/29/2025 | Accepted: 02/13/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (551) | Similar Articles (150) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Cell-free DNA in hepatocellular carcinoma: Biology to treatment response

Gayatri Ramakrishna, Garima Bhatia, Satender Pal Singh, Rishabh Sharma

World J Hepatol 18(4):115582. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115582

Abstract (36) | Core Tip (36) | Full Article (HTML) (88) | Figures (1-1) (41) | Tables (1-2) (42) | Full Article (PDF)-1999K (71) | Full Article with Cover (PDF)-2254K (87) | Full Article (XML)-171K (10) | Audio-396K (3) | Peer-Review Report-287K (10) | Answering Reviewers-146K (13) | Received: 10/22/2025 | Revised: 11/11/2025 | Accepted: 01/20/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (621) | Similar Articles (1886) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Monocyte reprogramming and trained immunity: Linking metabolism to inflammation in non-alcoholic fatty liver disease

Stanislav Kotlyarov

World J Hepatol 18(4):116689. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116689

Abstract (41) | Core Tip (39) | Full Article (HTML) (89) | Figures (1-1) (40) | Full Article (PDF)-556K (16) | Full Article with Cover (PDF)-788K (68) | Full Article (XML)-124K (10) | Audio-738K (6) | Peer-Review Report-200K (14) | Answering Reviewers-129K (12) | Received: 11/17/2025 | Revised: 12/09/2025 | Accepted: 02/05/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (636) | Similar Articles (227) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Glucocorticoid therapy in acute liver failure: Survival outcomes, predictors, and a response prediction model

Qing-Hua Meng, Juan Li, Xiao-Tong Xu, Xue-Hong Yin, Yu-Lan He

World J Hepatol 18(4):117905. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.117905

Abstract (53) | Core Tip (53) | Full Article (HTML) (102) | Figures (1-5) (39) | Tables (1-2) (43) | Full Article (PDF)-2235K (42) | Full Article with Cover (PDF)-2481K (40) | Full Article (XML)-83K (13) | Audio-657K (10) | Peer-Review Report-231K (11) | Answering Reviewers-233K (15) | Supplementary Material-339K (10) | Received: 12/19/2025 | Revised: 01/27/2026 | Accepted: 03/23/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (652) | Similar Articles (208) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk

Qian-Qian Chen, Hui Shi, Sheng-Shu Wang, Pan-Yang Shi, Bin-Bin Su, Zhao-Bei Cai

World J Hepatol 18(4):115475. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115475

Abstract (43) | Core Tip (44) | Full Article (HTML) (76) | Tables (1-5) (44) | Full Article (PDF)-468K (38) | Full Article with Cover (PDF)-700K (60) | Full Article (XML)-106K (11) | Audio-1765K (3) | Peer-Review Report-215K (11) | Answering Reviewers-244K (15) | Received: 10/31/2025 | Revised: 12/15/2025 | Accepted: 01/20/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (871) | Similar Articles (95) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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In-hospital mortality and dynamic modified end-stage liver disease score after emergency general surgery in patients with cirrhosis

Ashling L Zhang, Nathnael Tessema, Jaclyn Clark, Roumen Vesselinov, Lindsay O’Meara, David T Efron, Mira H Ghneim

World J Hepatol 18(4):116176. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116176

Abstract (40) | Core Tip (42) | Full Article (HTML) (111) | Figures (1-4) (46) | Tables (1-4) (42) | Full Article (PDF)-780K (42) | Full Article with Cover (PDF)-1039K (68) | Full Article (XML)-151K (15) | Audio-470K (6) | Peer-Review Report-243K (15) | Answering Reviewers-161K (34) | Supplementary Material-93K (15) | Received: 11/04/2025 | Revised: 12/09/2025 | Accepted: 01/20/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (832) | Similar Articles (413) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Novel nomogram for differential diagnosis of UGT1A1 gene mutation-associated unconjugated hyperbilirubinemia with hemolytic diseases

Hai-Tian Yu, Mei-Han Li, Shan Tang, Chen Liang, Da-Cheng Sheng, Hui Jiang, Jian-Xia Dong, Wei Hou, Su-Jun Zheng

World J Hepatol 18(4):117456. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.117456

Abstract (43) | Core Tip (44) | Full Article (HTML) (94) | Figures (1-5) (46) | Tables (1-3) (40) | Full Article (PDF)-1467K (66) | Full Article with Cover (PDF)-1724K (108) | Full Article (XML)-95K (12) | Audio-598K (7) | Peer-Review Report-263K (12) | Answering Reviewers-496K (14) | Supplementary Material-387K (13) | Received: 12/07/2025 | Revised: 01/20/2026 | Accepted: 03/03/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1042) | Similar Articles (374) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Observational Study

Poor performance of strength, assistance with walking, rising from a chair, climbing stairs and falls for sarcopenia screening in cirrhosis: A pilot study

Sabrina Alves Fernandes, Claudio A Marroni, Lilian Kethelyn Teixeira Pinheiro, Luis F Ferreira, Bruna Goularth Lacerda

World J Hepatol 18(4):113458. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.113458

Abstract (41) | Core Tip (40) | Full Article (HTML) (85) | Tables (1-3) (42) | Full Article (PDF)-405K (42) | Full Article with Cover (PDF)-662K (37) | Full Article (XML)-60K (8) | Audio-1080K (4) | Peer-Review Report-226K (11) | Answering Reviewers-253K (9) | Received: 08/25/2025 | Revised: 12/17/2025 | Accepted: 02/10/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (488) | Similar Articles (54) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Shifting cirrhosis phenotype with changes in liver disease etiology in an Australian tertiary hospital

Ryma Terbah, Chris Zhao, Tessa Greeve, Elise Cannan, Darren Wong, Adam Testro, Avik Majumdar, Marie Sinclair

World J Hepatol 18(4):115060. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115060

Abstract (40) | Core Tip (43) | Full Article (HTML) (87) | Figures (1-2) (41) | Tables (1-5) (44) | Full Article (PDF)-756K (23) | Full Article with Cover (PDF)-988K (40) | Full Article (XML)-98K (11) | Audio-713K (4) | Peer-Review Report-192K (11) | Answering Reviewers-94K (14) | Supplementary Material-70K (10) | Received: 10/06/2025 | Revised: 11/20/2025 | Accepted: 02/02/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (779) | Similar Articles (299) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Randomized Controlled Trial

Impact of two-session fecal microbiota transplantation on minimal hepatic encephalopathy in cirrhosis

Ankit Agarwal, Samagra Agrawal, Daizee Talukdar, Manjeet Kaur, Sagnik Biswas, Shekhar Swaroop, Rithvik Golla, Bharti Kandiyal, Pradipta Jana, Subhash Tanwar, Arnav Aggarwal, Hem C Singh, Ayush Agarwal, Mridul Mahajan, Bipin Tiwari, Baibaswata Nayak, Amit Goel, Bhabatosh Das, Shalimar

World J Hepatol 18(4):116153. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116153

Abstract (49) | Core Tip (49) | Full Article (HTML) (216) | Figures (1-4) (45) | Tables (1-3) (40) | Full Article (PDF)-8473K (109) | Full Article with Cover (PDF)-8724K (139) | Full Article (XML)-153K (11) | Audio-434K (8) | Peer-Review Report-260K (14) | Answering Reviewers-183K (11) | Supplementary Material-1481K (10) | Received: 11/03/2025 | Revised: 12/08/2025 | Accepted: 02/06/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1120) | Similar Articles (51) | Timeline of Article Publication (1) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B

Xiang-Yang Ye, Xiong-Zhi He, Zhen-Ting Hu, Feng-Feng Zheng, Xiao-Gang Huang, Xue-Mei Xie, Fei-Hua Chen, Han-Bing Ou, Rong-Xian Qiu

World J Hepatol 18(4):114804. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114804

Abstract (45) | Core Tip (40) | Full Article (HTML) (87) | Figures (1-7) (45) | Tables (1-2) (43) | Full Article (PDF)-14845K (49) | Full Article with Cover (PDF)-15074K (8) | Full Article (XML)-133K (10) | Audio-453K (8) | Peer-Review Report-242K (11) | Answering Reviewers-124K (13) | Supplementary Material-338K (7) | Received: 09/28/2025 | Revised: 11/11/2025 | Accepted: 01/09/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (604) | Similar Articles (243) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Systematic Reviews

Correlation between non-alcoholic fatty liver disease and erectile dysfunction: A systematic narrative review

Yan-Fei He, Ning Bian, Huan-Zhi Wang, Xiao-Dong Hu, Jun-Qiang Liu, Shuang-Feng Lu, Ni Wu, Qin-Tong He, Hu-Ming Li

World J Hepatol 18(4):115456. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115456

Abstract (47) | Core Tip (41) | Full Article (HTML) (172) | Figures (1-1) (42) | Tables (1-3) (43) | Full Article (PDF)-569K (100) | Full Article with Cover (PDF)-825K (84) | Full Article (XML)-104K (11) | Audio-991K (4) | Peer-Review Report-238K (14) | Answering Reviewers-99K (12) | Received: 10/16/2025 | Revised: 11/23/2025 | Accepted: 02/05/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1000) | Similar Articles (236) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Treatment of chronic hepatitis B infection in infants and young children: A systematic review

Simona Carrera, Chiara Rubino, Elisa Bartolini, Giuseppe Indolfi

World J Hepatol 18(4):116657. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116657

Abstract (46) | Core Tip (45) | Full Article (HTML) (104) | Figures (1-1) (35) | Tables (1-3) (36) | Full Article (PDF)-510K (56) | Full Article with Cover (PDF)-769K (56) | Full Article (XML)-111K (11) | Audio-342K (6) | Peer-Review Report-245K (16) | Answering Reviewers-31K (15) | Received: 11/18/2025 | Revised: 01/07/2026 | Accepted: 02/03/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (601) | Similar Articles (274) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Meta-Analysis

Diagnostic accuracy of blood-based non-invasive tests for prediction of varices in pediatric portal-hypertension: A systematic review and meta-analysis

Kalpana Panda, Devi P Dash, Girish K Pati, Arjun Maria, Vipul Gautam

World J Hepatol 18(4):118038. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.118038

Abstract (41) | Core Tip (44) | Full Article (HTML) (133) | Figures (1-5) (43) | Tables (1-4) (39) | Full Article (PDF)-4235K (147) | Full Article with Cover (PDF)-4466K (130) | Full Article (XML)-207K (12) | Audio-819K (6) | Peer-Review Report-191K (13) | Answering Reviewers-115K (17) | Supplementary Material-707K (21) | Received: 12/24/2025 | Revised: 01/08/2026 | Accepted: 02/05/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1020) | Similar Articles (108) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Case Report

Acute liver failure linked to OxyShred pre-workout supplement: A case report and review of literature

Sarah Householder, Noah Brazer, Ysabel C Ilagan-Ying

World J Hepatol 18(4):116710. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.116710

Abstract (74) | Core Tip (40) | Full Article (HTML) (837) | Figures (1-3) (57) | Tables (1-1) (41) | Full Article (PDF)-3477K (124) | Full Article with Cover (PDF)-3734K (188) | Full Article (XML)-92K (12) | Audio-691K (16) | Peer-Review Report-333K (15) | Answering Reviewers-33K (32) | Received: 11/17/2025 | Revised: 12/14/2025 | Accepted: 01/27/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (1980) | Similar Articles (4611) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Tumor necrosis factor receptor superfamily member 13B mutation-associated chronic cholangitis with cirrhosis: A case report and review of literature

Ying Zhou, Qi-Jiao Cheng, Ming-Xing Liang, Su-Qun Li, Yu-Zhi Su, Yong-Ming Cai, Zong-Qin Pan, Yu-Xin Xie, Ying-Hua Chen, Yi-Huai He

World J Hepatol 18(4):117993. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.117993

Abstract (44) | Core Tip (43) | Full Article (HTML) (103) | Figures (1-4) (43) | Tables (1-1) (43) | Full Article (PDF)-8065K (35) | Full Article with Cover (PDF)-8297K (53) | Full Article (XML)-139K (14) | Audio-750K (6) | Peer-Review Report-218K (16) | Answering Reviewers-210K (13) | Received: 12/20/2025 | Revised: 01/19/2026 | Accepted: 02/13/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (553) | Similar Articles (4536) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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Correspondence

Letter to the Editor: Serum alpha-fetoprotein dynamics in liver failure - prognostic implications and clinical insights

Xing-Xue Niu, Xiao-Jun Yang

World J Hepatol 18(4):114861. Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114861

Abstract (42) | Core Tip (46) | Full Article (HTML) (94) | Figures (1-1) (41) | Tables (1-1) (41) | Full Article (PDF)-619K (33) | Full Article with Cover (PDF)-879K (49) | Full Article (XML)-63K (12) | Audio-1449K (3) | Peer-Review Report-262K (14) | Answering Reviewers-65K (16) | Received: 09/30/2025 | Revised: 12/08/2025 | Accepted: 01/08/2026 | RCA | CrossRef | Google Scholar | Times Cited (0) | Total Visits (581) | Similar Articles (79) | Timeline of Article Publication (0) | Authors Evaluation (0) | Article Quality Tracking (0) | Cite |

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