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Contents Volume 18 Issue 5 May 27, 2026
Editorial
Beyond fibrosis: The imperative for dual steatosis and fibrosis assessment in chronic hepatitis B and metabolic dysfunction-associated steatotic liver disease co-pathology
Francesco Giangregorio, Elisa Civaschi, Samanta Mazzocchi, Davide Romano, Paolo Clini, Esther Centenara, Umberto Casale, Davide Catucci 
World J Hepatol 18(5):118817. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118817
Opinion Review
Survival gap in gallbladder cancer: Bridging tumor biology and healthcare system logistics
Bruno Mirandola Bulisani 
World J Hepatol 18(5):118508. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118508
Respiratory syncytial virus in cirrhosis: Time to separate data from dogma?
Jorge Quarleri, María Victoria Delpino 
World J Hepatol 18(5):118665. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118665
Rethinking noninvasive steatosis indices: Structural limitations and misclassification across the body mass index spectrum
Kengo Moriyama 
World J Hepatol 18(5):118804. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118804
Review
Artificial intelligence and machine learning in hepatology: Revolutionizing diagnosis and treatment
Mohammed OK Elsayed, Ahmed Y Elshabrawi 
World J Hepatol 18(5):117141. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117141
Steatotic liver disease in people with human immunodeficiency virus: A narrative review of metabolic steatotic liver disorders
Nicolás Jesús Garrido, Miguel Suárez, Jorge Mateo 
World J Hepatol 18(5):117567. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117567
Minireviews
Navigating the therapeutic tightrope: Precision use of plasmapheresis and continuous renal replacement therapy in liver failure
Manish Manrai, Aditya V Pachisia, Saurabh Dawra, Siddharth Shukla, Atul A Jha 
World J Hepatol 18(5):115047. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.115047
Liver injury after COVID-19 vaccination: Current status and future perspectives
Ken Sato 
World J Hepatol 18(5):116542. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116542
Muscle cramps in liver cirrhosis: Pathophysiology, burden, and emerging therapeutic approaches
Hajira Z Malik, Caitlin Marshall, Ahmed Al-Khazraji, Rajab Idriss 
World J Hepatol 18(5):117010. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117010
Congenital porto-sinusoidal vascular disorder-induced portal hypertension: A comprehensive review based on a classic clinical case
Meng-Jiao Xu, Xin Wei, Yu Huang, Yao Lu, Lei Sun, Yao Xie, Ming-Hui Li 
World J Hepatol 18(5):117184. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117184
Hepatitis A virus-induced autoimmune hepatitis: A case-based review
Jakub Janczura, Michał Brzdęk, Kinga Brzdęk, Piotr Lewitowicz, Nina Zbylut, Dorota Zarębska-Michaluk, Piotr M Stępień, Krystyna Dobrowolska 
World J Hepatol 18(5):117837. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117837
Anti-obesity medications, the new frontiers in metabolic dysfunction-associated fatty liver disease: Efficacy, limitations, and future directions
Yasser Fouad, Wafaa A Abdelghany, Reem El Sheemy 
World J Hepatol 18(5):118303. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118303
Retrospective Study
Laparoscopic microwave ablation for hepatic hemangiomas with different locations: A comparative study
Chang-Le Wu, Xi-Chi Chen, Wei Zhao, Bin Hu, Hong-Bo Huan, Yu-Liang Tu, Zi-Man Zhu, Kai Jiang 
World J Hepatol 18(5):117157. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117157
Liver stiffness-platelet ratio index and machine learning models for the noninvasive diagnosis of significant fibrosis in chronic hepatitis B
Jun-Yi Lin, Zao-Xiu Ai, Man-Jin Luo, Li-Zhen Su, Xin-Gen Gao, Hua-Li Jiang, Ju-Qiang Lin, Hong-Yi Zhang, Ying-Ying Sun, Hong-Tao Yu, Li Zhang, Xian-Qiong Gong 
World J Hepatol 18(5):119798. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.119798
Observational Study
Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study
Chun-Xia Wang, Pan Yan, Li-Juan Lan, Ben-Nan Zhao, Jun Kang, Mao-Quan Li, Da-Feng Liu 
World J Hepatol 18(5):116008. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116008
Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging
Amany Sholkamy, Ahmed El-Meligui, Eman H Saad, Samar Amin, Mirette Makram, Noha Elmansy, Shrook Mousa 
World J Hepatol 18(5):117441. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117441
Prospective Study
Differentiation of minimal and grade 1 hepatic encephalopathy using neurophysiological, neuropsychological, magnetic resonance spectroscopic, and systemic inflammatory parameters
Lalit C Kummetha, Shrey Bhatt, Venkatesh Vaithiyam, Barjesh C Sharma, Siddharth Srivastava, Bhawna Mahajan, Kalpana Bansal, Neera Chaudhry, Monica S Tandon, Sanjeev Sachdeva, Ajay Kumar, Ashok Dalal, Ujjwal Sonika 
World J Hepatol 18(5):118040. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118040
Basic Study
Kaempferol attenuates diet-induced obesity and hepatic steatosis in C57BL/6J mice fed an Indian diet-mimicking regimen
Bhagyalakshmi Nair, Rajesh Gopalakrishna, Lekshmi R Nath 
World J Hepatol 18(5):115659. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.115659
Saikosaponin-d alleviates hepatic stellate cell activation and liver fibrosis by inhibiting the TGF-β1/Smads signaling pathway and blocking the EMT process
Jing Li, Meng-Xing Cao, Jun-Min Wang, Yi-Yuan Zheng, Ren-Ye Que, Liu-Bing Lin 
World J Hepatol 18(5):116712. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116712
Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients
Iqra Arshad, Mashaim Majid, Bisma Rauff, Ali Amar, Mahmood S Choudhery 
World J Hepatol 18(5):116995. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.116995
Systematic Reviews
Diagnostic and prognostic utility of serum bile acid in liver transplant recipients: A systematic review and quantitative synthesis
Eyad Gadour, Hadi Kuriry, Bogdan Miutescu, Bodour Raheem, Syed A Gardezi, Mohammed S AlQahtani 
World J Hepatol 18(5):119408. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.119408
Meta-Analysis
Carvedilol and nonselective-beta-blockers vs endoscopic ligation for prophylaxis of esophageal variceal hemorrhage in cirrhosis: Systematic review and meta-analysis
Resha Dermawansyah Rusman, Muhammad Luthfi Parewangi, Fardah Akil, Nu'man A S Daud, Rini R Bachtiar, Susanto Hendra Kusuma, Amelia Rifai, Akiko Syawalidhany Tahir 
World J Hepatol 18(5):117049. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117049
Case Report
Ten-year enzyme replacement therapy in early childhood-onset lysosomal acid lipase deficiency: A case report
Irem Kaplan, Deniz Kor, Fatma D Bulut, Gokhan Tumgor, Derya Alabaz, Neslihan Önenli Mungan 
World J Hepatol 18(5):118469. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118469
Early-onset hepatic fibrosis linking to a novel PYROXD2 mutation: A case report
Zhen-Yao Jiang, Rong-Qiang Liu, Meng-Juan Tang, Han-Dong Fan, Wen-Jun Yang, Ling Gong, Xiao-Xiao Mi, Jun-Ping Shi 
World J Hepatol 18(5):118622. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.118622
Correspondence
Letter to the Editor: Gut microbiota–bile acid crosstalk - Prevotellaceae NK3B31 and 7-ketolithocholic acid drive metabolic benefits of distal bowel resection with preservation of terminal ileum
Xu Cui, Long-Yao Xu, Bing-Qian Yin, Liu Chen, Zheng Liang, Chao-Ming Zhou 
World J Hepatol 18(5):115514. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.115514
Letter to the Editor: From prediction to prevention: Integrating nomograms and pathogen biology in multidrug-resistant pyogenic liver abscess
Marco Fiore 
World J Hepatol 18(5):115709. Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.115709
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