Diagnostic efficacy and influencing factors of non-invasive liver fibrosis scores in chronic hepatitis B fibrosis: Cross-sectional study

Figure 1 Participant screening flow diagram. Flowchart of study subject selection for inpatients with chronic hepatitis B in Chengdu Public Health Clinical Center from December 2020 to December 2024. CHB: Chronic hepatitis B.

Figure 2 Heatmap of correlations between different non-invasive fibrosis assessment indicators and liver stiffness measurement (n = 627). The heatmap displays Spearman correlation coefficients between non-invasive liver fibrosis assessment indicators (the aspartate transaminase to platelet ratio index, the fibrosis-4 index, the gamma-glutamyl transferase to platelet ratio) and liver stiffness measurement results. Warmer (orange-toned) colors indicate stronger positive correlations, while cooler (blue-toned) colors indicate stronger negative correlations. APRI: Aspartate aminotransferase to platelet ratio index; GPR: Gamma-glutamyl transferase to platelet ratio; FIB-4: Fibrosis-4 index; AST/ALT: Aspartate aminotransferase to alanine aminotransferase ratio.

Figure 3 Receiver operating characteristic curves of different fibrosis assessment indicators. A: Receiver operating characteristic (ROC) curves for comparing any fibrosis (F1-F4) vs no fibrosis (F0); B: ROC curves for comparing significant fibrosis (F3-F4) vs no or mild fibrosis (F0-F2). The curves correspond to different liver fibrosis assessment indicators: Aspartate transaminase to platelet ratio index, gamma-glutamyl transferase to platelet ratio, fibrosis-4 index, and the aspartate aminotransferase to alanine aminotransferase ratio. The values in the figure represent the area under the curve for each non-invasive liver fibrosis indicator. APRI: Aspartate aminotransferase to platelet ratio index; GPR: Gamma-glutamyl transferase to platelet ratio; FIB-4: Fibrosis-4 index; AST/ALT: Aspartate aminotransferase to alanine aminotransferase ratio; ROC: Receiver operating characteristic.