Survival gap in gallbladder cancer: Bridging tumor biology and healthcare system logistics

Figure 1 Integrated management framework for incidentally diagnosed gallbladder cancer. This infographic illustrates a multi-level strategy designed to optimize outcomes in regions of intermediate incidence. The framework transitions from identifying systemic and biological factors to a specialized care pathway. Key logistical interventions, marked as (LOGISTICAL GAPS/AUTO-ALERTS), include synchronized pathology reporting and the implementation of institutional automatic triggers for multidisciplinary team referral. The therapeutic decision relies on molecular stratification to guide the use of neoadjuvant chemotherapy as a biological sieve, followed by standardized radical re-resection and targeted systemic therapy. GBC: Gallbladder cancer; MRI: Magnetic resonance imaging; PET-CT: Positron emission tomography-computed tomography; HER2: Human epidermal growth factor receptor 2; NAT: Neoadjuvant therapy; .