Genetic polymorphism of IFI16 and AIM2 among Pakistani hepatitis C virus-induced fibrosis patients

Figure 1 Genetic association analysis of IFI16 (rs1057028) and AIM2 (rs2814770). A-F: Genetic association analysis with IFI16 (rs1057028) and AIM2 (rs2814770) significant hepatic fibrosis after stratification of chronic hepatitis C patients based on body mass index (A and B) status and age groups (C and D) and alanine aminotransferase groups (E and F). ALT: Alanine aminotransferase.

Figure 2 Pooled analysis of IFI16 rs1057028 and AIM2 rs2814770 polymorphisms showing the association between the number of risk alleles and serum liver enzymes. A and B: The Y-axis represents the alanine aminotransferase (ALT; A) and aspartate aminotransferase (AST) levels (B) while the number of risk alleles at X-axis and the plot data represents the distribution of serum marker levels at each number of risk allele. For ALT, the frequencies of individuals carrying 0, 1, 2, 3, and 4 risk alleles were 25, 52, 22, 28 and 9, respectively. For AST, the frequencies of individuals carrying 0, 1, 2, 3, and 4 risk alleles were 24, 52, 21, 27 and 8, respectively. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Figure 3 Proportion of significant fibrosis (≥ F2) and advanced fibrosis (≥ F3) in all chronic hepatitis C patients with increasing number of risk alleles of IFI16 rs1057028 and AIM2 rs2814770. A: Significant fibrosis (≥ F2); B: Advanced fibrosis (≥ F3). CHC: Chronic hepatitis C.

Figure 4 Protein interaction network analysis of IFI16 and AIM2 using STRING online tool. A: IFI16; B: AIM2. The nodes represent individual protein members of the interaction networks, where a filled node depicts a protein with known/predicted 3D structure), while the dark pink color node in each interaction network shows the query proteins. Meanwhile, the edges and their color correspond to the interaction between proteins and the type of evidence available for a particular interaction (as defined by the legend shown at the bottom of figure).