Sholkamy A, El-Meligui A, H Saad E, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; 18(5): 117441 [DOI: 10.4254/wjh.v18.i5.117441]
Corresponding Author of This Article
Mirette Makram, MD, Consultant, Endocrinology Section, Department of Internal Medicine, Kasr Al Ainy Hospitals, Cairo University, 1 Gamaa Street, Giza, Cairo 11956, Egypt. mirettemakram@kasralainy.edu.eg
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Gastroenterology & Hepatology
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research-article
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Sholkamy A, El-Meligui A, H Saad E, Amin S, Makram M, Elmansy N, Mousa S. Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging. World J Hepatol 2026; 18(5): 117441 [DOI: 10.4254/wjh.v18.i5.117441]
World J Hepatol. May 27, 2026; 18(5): 117441 Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117441
Association between overt, subclinical hypothyroidism and metabolic dysfunction-associated steatotic liver disease using magnetic resonance imaging
Amany Sholkamy, Ahmed El-Meligui, Eman H Saad, Samar Amin, Mirette Makram, Noha Elmansy, Shrook Mousa
Amany Sholkamy, Ahmed El-Meligui, Eman H Saad, Gastroenterology and Hepatology Section, Internal Medicine Dep, Kasr Al Ainy Faculty of Medicine, Cairo 11956, Egypt
Samar Amin, Mirette Makram, Shrook Mousa, Endocrinology Section, Internal Medicine Dep, Kasr Al Ainy Faculty of Medicine, Cairo 11956, Egypt
Noha Elmansy, Department of Diagnostic and Interventional Radiology, Kasr Al Ainy Faculty of Medicine, Cairo 11956, Egypt
Author contributions: Sholkamy A and Mousa S contributed to the concept, study design, supervision, and statistical revision; El-Meligui A contributed to the ultrasound assessment, statistical revision, and writing the manuscript draft; Saad EH contributed to the ultrasound assessment and manuscript revision; Amin S contributed to the supervision; Makram M contributed to the patient recruitment, sample conduction, data analysis, and manuscript finalization; Elmansy N contributed to the magnetic resonance scans review; and all authors thoroughly reviewed and endorsed the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Faculty of Medicine, Cairo University, approval No. MD-219-2023.
Informed consent statement: An informed written consent was obtained from each participant after explaining that participation was voluntary and that any participant had the right to withdraw from the study without any negative consequences.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The dataset used in the current study is available from the corresponding author upon reasonable request.
Corresponding author: Mirette Makram, MD, Consultant, Endocrinology Section, Department of Internal Medicine, Kasr Al Ainy Hospitals, Cairo University, 1 Gamaa Street, Giza, Cairo 11956, Egypt. mirettemakram@kasralainy.edu.eg
Received: December 8, 2025 Revised: January 7, 2026 Accepted: February 11, 2026 Published online: May 27, 2026 Processing time: 170 Days and 8.3 Hours
Core Tip
Core Tip: Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the foremost etiology of cirrhosis and hepatocellular carcinoma. Our study assessed the overlooked association between this global liver disease and the spectrum of hypothyroidism. The three study groups (overt, subclinical hypothyroid, control) were assessed for MASLD by ultrasonography. The diagnosis was confirmed by magnetic resonance imaging, hepatic fat percentage was calculated. Ultrasound results were compared with magnetic resonance imaging findings to determine degree of agreement between both diagnostic methods. Multivariate analysis identified the independent risk variables associated with the onset and severeness of MASLD. The receiver operating characteristic curve concluded that there is a certain thyroid-stimulating hormone level above which the risk of MASLD development increases.
