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Contents Volume 18 Issue 6 June 27, 2026
Editorial
Metabolic links between metabolic dysfunction-associated steatotic liver disease and primary biliary cholangitis
Stanislav Kotlyarov 
World J Hepatol 18(6):118902. Published online Jun 27, 2026. doi: 10.4254/wjh.118902
Opinion Review
Evaluation of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis
Tian-Tian Chen, Hao-Xian Gou, Zhu-Lin Luo 
World J Hepatol 18(6):120134. Published online Jun 27, 2026. doi: 10.4254/wjh.120134
LGALS3 signaling and macrophage ferroptosis in steatohepatitis
Wei Liu, Zhuo-Jin Shi 
World J Hepatol 18(6):120591. Published online Jun 27, 2026. doi: 10.4254/wjh.120591
Protective effects of kaempferol against diet-induced metabolic disorders
Vinesh Sharma, Vikram Patial 
World J Hepatol 18(6):120789. Published online Jun 27, 2026. doi: 10.4254/wjh.120789
Review
Smoking-induced liver injury and related diseases: Molecular mechanisms, pathogenic amplification, and clinical implications
Xin Wen, Tian-Yi Xue, Yan-Hui Yang, Yan-Pei Mai, Qin-Shuo Wang, Xiao-Xiao Wang, Dong-Bo Chen, Hong-Song Chen, Zi-Xing Wang 
World J Hepatol 18(6):119664. Published online Jun 27, 2026. doi: 10.4254/wjh.119664
Emerging treatment options for metabolic dysfunction-associated steatotic liver disease and its related liver diseases
Chun-Ye Zhang, Ming Yang 
World J Hepatol 18(6):120178. Published online Jun 27, 2026. doi: 10.4254/wjh.120178
Minireviews
Bile acid receptor signaling in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and emerging therapeutic strategies
Sanjay Bandyopadhyay, Shambo Samrat Samajdar, Shatavisa Mukherjee, Shashank R Joshi 
World J Hepatol 18(6):118548. Published online Jun 27, 2026. doi: 10.4254/wjh.118548
Phase-dependent interpretation of quantitative hepatitis B surface antigen and hepatocellular carcinoma risk in chronic hepatitis B infection
Yazan Omari, Mohammad Almeqdadi 
World J Hepatol 18(6):119837. Published online Jun 27, 2026. doi: 10.4254/wjh.119837
Retrospective Cohort Study
Association between preoperative serum zinc levels and postoperative infectious complications after minimally invasive hepatectomy: A retrospective cohort study
Hiromichi Murase, Yoichi Matsuo, Eiji Nakatani, Yuki Denda, Keisuke Nonoyama, Tomokatsu Kato, Kenta Saito, Takafumi Sato, Mamoru Morimoto, Yushi Yamakawa, Hiroyuki Sagawa, Shuji Takiguchi 
World J Hepatol 18(6):118905. Published online Jun 27, 2026. doi: 10.4254/wjh.118905
Routine laboratory model for identifying significant fibrosis in chronic hepatitis B
Ting-Ting Wang, Yi-Li Chu, Yi-Qiang Lou, Rou-Yi Yang, Mao-Mao Pu, Lian-Jiang Shan, Lu Huang, Shan-Shan Chen, Hai-Jun Huang 
World J Hepatol 18(6):119005. Published online Jun 27, 2026. doi: 10.4254/wjh.119005
Recurrence after surgery for hepatocellular carcinoma: “The seed and the soil” - a multicentre retrospective cohort study
Conner Blackmore, Ian Lockart, Geovanny Gandy, Yuen Kang Joseph Yeoh, Ciara Flynn, David S Prince, Gregory Dore, Mark Danta, Jacob George, Maryam Alavi, Yasser Farooque, Behzad Hajarizadeh, Miriam T Levy 
World J Hepatol 18(6):120213. Published online Jun 27, 2026. doi: 10.4254/wjh.120213
Machine learning model integrating transient elastography and clinical data for prediction of graft fibrosis after liver transplantation
Annabel Koivu, Ghazal Azarfar, Maryam Shojaee, Naomi K T Hlaing, Sameera Rizvi, Divya Sharma, Saba Maleki, Mamatha Bhat 
World J Hepatol 18(6):120258. Published online Jun 27, 2026. doi: 10.4254/wjh.120258
Retrospective Study
Comparing validated hepatocellular carcinoma risk scores for chronic hepatitis B against current Australian surveillance guidelines
Ibrahim Mian, Deloshaan Subhaharan, Adam Haig, Rupert Cox, Tariq Masood, Alicia Braund, Natalie Funakoshi 
World J Hepatol 18(6):117996. Published online Jun 27, 2026. doi: 10.4254/wjh.117996
Liver stiffness-based composite indices for compensated and decompensated cirrhosis in chronic hepatitis B
Zhi-Zun Guo, Yan Wang, Xiao-Xuan Liu, Shan-Shan Yang, Fan Yu 
World J Hepatol 18(6):121259. Published online Jun 27, 2026. doi: 10.4254/wjh.121259
Basic Study
Plasma exosomal miR-137 activates natural killer cells in primary biliary cholangitis by targeting NFATC1
Yi-Fei Yang, Qi-Xuan Liu, Wen-Hao Su, Bo Zang, Bing-Qian Liu, Chen-Yang Zhao, Yi-Bing Han, Ling-Wei Liu, Patrick S C Leung, Bin Liu 
World J Hepatol 18(6):116738. Published online Jun 27, 2026. doi: 10.4254/wjh.116738
Discussion on the effect of Honghua Qinggan Shisanwei Wan on regulating macrophage polarization and alleviating liver injury
Chun-Li Ma, Xin Zhang, Xu Bao, Lin-Yun Zhao, Li-Li Cao, Cheng-You Ma, Ting Zhang, Mei Hong, Yu-Long Bao, Rui-Ping Hu 
World J Hepatol 18(6):118215. Published online Jun 27, 2026. doi: 10.4254/wjh.118215
Yinchen Wuling San ameliorates high-fat diet-induced metabolic-associated fatty liver disease in rats by remodeling the gut microbiota
Yi Zhang, Jie Liu, Ai-Si Huang, Yu-Fei Wang, Jie Cao, Mu-Lan Li, Dan-Dan Shi, Yi-Lin Hu, Qin Deng, Piao Long, Bi-Chen Ai 
World J Hepatol 18(6):118607. Published online Jun 27, 2026. doi: 10.4254/wjh.118607
LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury
Yu Yang, Shi-Li Wu, Zhi-Hao Huang, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Yi Gao, Wei-Jie Zhou, Yuan Lin 
World J Hepatol 18(6):119561. Published online Jun 27, 2026. doi: 10.4254/wjh.119561
Differential impact of high-fructose and ethanol diets on early steatohepatitis and hepatic melanocortin-4 receptor responses in rats
Salamah M Alwahsh, Min Xu, Maisa Nabulsi, Sabine Mihm, Faisal A Alzahrani, Giuliano Pasquale Ramadori 
World J Hepatol 18(6):119792. Published online Jun 27, 2026. doi: 10.4254/wjh.119792
Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway
Dong-Dong Yin, Wei-Yu Jiang, Yu-Ting Huang, Shu-Ping Zhou, Yin-Ci Zhang 
World J Hepatol 18(6):120427. Published online Jun 27, 2026. doi: 10.4254/wjh.120427
Meta-Analysis
Tyrosine kinase inhibitors after progression on atezolizumab-bevacizumab in advanced hepatocellular carcinoma: A systematic review and meta-analysis
Ronald Blanco Montecino, Nehemias Guevara Rodriguez, Noemy Coreas, Daniel Mendoza-Quispe, Yassine Kilani, Syeda Ashna Fatima Kamal, Kamran Qureshi, John M Richart 
World J Hepatol 18(6):121656. Published online Jun 27, 2026. doi: 10.4254/wjh.121656
Case Report
Recurrent pruritus, jaundice, and pancreatitis in an adult due to a rare etiology: A case report
Jing Zuo, Li-Yuan Wang, Yu-Chen Fan 
World J Hepatol 18(6):121392. Published online Jun 27, 2026. doi: 10.4254/wjh.121392
Correspondence
Letter to the Editor: Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury
Xu Cui, Zhi-Qiang Chen, Liu Chen 
World J Hepatol 18(6):114088. Published online Jun 27, 2026. doi: 10.4254/wjh.114088
Letter to the Editor: Steatotic liver disease in chronic hepatitis C - a marker of systemic risk, not direct-acting antiviral treatment failure
Abdo Imad El Tawil, Claudia Alexandra Pontes Ivantes 
World J Hepatol 18(6):117018. Published online Jun 27, 2026. doi: 10.4254/wjh.117018
Letter to the Editor: Microplastics as promoters of metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and implications
Nabil Eid 
World J Hepatol 18(6):118615. Published online Jun 27, 2026. doi: 10.4254/wjh.118615
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