Cui X, Chen ZQ, Chen L. Letter to the Editor: Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury. World J Hepatol 2026; 18(6): 114088 [DOI: 10.4254/wjh.114088]
Corresponding Author of This Article
Xu Cui, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou 350001, Fujian Province, China. 16802937@qq.com
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Food Science & Technology
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letter
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Cui X, Chen ZQ, Chen L. Letter to the Editor: Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury. World J Hepatol 2026; 18(6): 114088 [DOI: 10.4254/wjh.114088]
World J Hepatol. Jun 27, 2026; 18(6): 114088 Published online Jun 27, 2026. doi: 10.4254/wjh.114088
Letter to the Editor: Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury
Xu Cui, Zhi-Qiang Chen, Liu Chen
Xu Cui, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, Fujian Province, China
Zhi-Qiang Chen, Liu Chen, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), Fuzhou 350001, Fujian Province, China
Co-corresponding authors: Xu Cui and Liu Chen.
Author contributions: Cui X conceived and designed the overall framework of the letter, guided the critical evaluation of the original study, formulated research gaps; Chen ZQ analyzed research gaps in the original study, contributed to the design of proposed methodologies, and conducted a systematic review of literature; Chen L participated in the critical appraisal of the original study’s phenotypic assessments, identified limitations in mechanistic exploration, supported the formulation of future experimental approaches; Cui X and Chen L contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Fujian Provincial Science and Technology Innovation Joint Fund Project, No. 2024Y9555; Youth Research Project of the Science and Technology Plan of Fujian Provincial Health Commission, No. 2024QNB005; Fujian Provincial Natural Science Foundation Project, No. 2025J01226; and Fuian Provincial Medical Project for Creating Dual High-Quality Development (High Level and High Standard), No. ETK2025004.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Xu Cui, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou 350001, Fujian Province, China. 16802937@qq.com
Received: September 15, 2025 Revised: November 12, 2025 Accepted: January 8, 2026 Published online: June 27, 2026 Processing time: 279 Days and 17.4 Hours
Core Tip
Core Tip: This article highlights critical gaps in current research on ginger extract’s hepatoprotective effects against acrylamide-induced liver injury - namely, the undefined material basis of active components and superficial mechanistic insights. It proposes actionable solutions: Leveraging portal venous metabolomics, liver liquid chromatography-mass spectrometry profiling, and single-cell transcriptomics to map protective metabolites and molecular changes; validating mechanisms via primary hepatocyte assays (apoptosis, inflammation, oxidative stress); and applying high-throughput screening (genetic editing) to uncover target pathways. These directions are pivotal to transforming phenotypic observations into mechanistically robust, translatable insights for ginger-based liver protection.
