Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
Liver stiffness-based composite indices for compensated and decompensated cirrhosis in chronic hepatitis B
Zhi-Zun Guo, Yan Wang, Xiao-Xuan Liu, Shan-Shan Yang, Fan Yu, Department of Infectious Diseases, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan 030032, Shanxi Province, China
Author contributions: Guo ZZ participated in the conception and design of the study, wrote the manuscript, and was involved in the acquisition, analysis, and interpretation of data; Wang Y and Liu XX performed the statistical analysis; Yang SS and Yu F collected the data. All authors critically reviewed and provided final approval of the manuscript; and all authors were responsible for the decision to submit the manuscript for publication.
Institutional review board statement: The study was reviewed and approved by the Shanxi Bethune Hospital Institutional Review Board, Approval No. YXLL-2025-071.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: There was no conflict of interest to be reported.
Data sharing statement: The anonymized dataset can be made available from the corresponding author at guozhizun@sxbqeh.com.cn.
Corresponding author: Zhi-Zun Guo, Department of Infectious Diseases, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China.
Received: March 21, 2026
Revised: April 9, 2026
Accepted: April 24, 2026
Published online: June 27, 2026
Processing time: 94 Days and 12.3 Hours
Revised: April 9, 2026
Accepted: April 24, 2026
Published online: June 27, 2026
Processing time: 94 Days and 12.3 Hours
Core Tip
Core Tip: This is a retrospective study aimed at developing novel non-invasive composite indices to evaluate the condition of chronic hepatitis B virus (HBV)-infected patients. Three models, named the A-index, MAPTAL index, and APTAL index, were constructed to predict disease progression stages. Importantly, the MAPTAL and APTAL indices, which incorporate readily available demographic, hematologic, and liver stiffness measurement parameters, can reliably predict compensated and decompensated HBV-related cirrhosis, respectively.