Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789 [DOI: 10.4254/wjh.120789]
Corresponding Author of This Article
Vikram Patial, PhD, Principal Scientist, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, No. 6 Post Box, Palampur 176061, Himachal Pradesh, India. vikram.patial@csir.res.in
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Gastroenterology & Hepatology
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Sharma V, Patial V. Protective effects of kaempferol against diet-induced metabolic disorders. World J Hepatol 2026; 18(6): 120789 [DOI: 10.4254/wjh.120789]
World J Hepatol. Jun 27, 2026; 18(6): 120789 Published online Jun 27, 2026. doi: 10.4254/wjh.120789
Protective effects of kaempferol against diet-induced metabolic disorders
Vinesh Sharma, Vikram Patial
Vinesh Sharma, Vikram Patial, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India
Vinesh Sharma, Vikram Patial, Academy of Scientific and Innovative Research, Ghaziabad 201002, India
Author contributions: Sharma V conducted the literature review and prepared the manuscript; Patial V contributed to the study design, manuscript writing, and editing. Both authors have read and approved the final version of the manuscript (No. 6095).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Vikram Patial, PhD, Principal Scientist, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, No. 6 Post Box, Palampur 176061, Himachal Pradesh, India. vikram.patial@csir.res.in
Received: March 9, 2026 Revised: March 29, 2026 Accepted: June 2, 2026 Published online: June 27, 2026 Processing time: 106 Days and 8.9 Hours
Abstract
The study examines the effects of kaempferol on obesity and steatotic liver disease in C57BL/6J mice using an Indian diet-mimicking experimental animal model. Obesity and metabolic dysfunction-associated steatotic liver disease prevalence is rising in India due to high-calorie dietary habits. The condition starts with simple hepatic fat accumulation and may progress to fibrosis and cirrhosis. An Indian high-fat diet significantly induced the macrovesicular as well as microvesicular steatosis in mice with increased serum transforming growth factor beta level. Kaempferol, a natural flavonoid, is generally known for its lipid-lowering potential. In this study, kaempferol treatment for four weeks reduced body weight, steatosis, and hepatic inflammation induced by the Indian high-fat diet. Moreover, kaempferol stabilized the liver injury markers and reduced the triglyceride levels. In conclusion, the study demonstrated the potential of kaempferol as a therapeutic agent for managing metabolic dysfunction-associated steatotic liver disease associated with high-calorie region-specific dietary patterns.
Core Tip: The increasing prevalence of obesity and metabolic dysfunction-associated steatotic liver disease in the Indian population is closely linked to high-fat, high-sugar dietary patterns and a sedentary lifestyle. Developing region-specific dietary models can aid in effective preclinical screening of therapeutic agents. In this context, Kaempferol, a natural flavonoid with antioxidant, anti-inflammatory, and lipid-regulating properties, shows promising potential as a nutraceutical strategy for the management of metabolic dysfunction-associated steatotic liver disease.
