Liver stiffness-based composite indices for compensated and decompensated cirrhosis in chronic hepatitis B

Figure 1 Receiver operating characteristic curves of the proposed models and established indices for diagnosing liver disease in chronic hepatitis B patients. A: The A-index and albumin-bilirubin grade for diagnosing chronic hepatitis B; B: The MAPTAL index, Aspartate Platelet Ratio Index (APRI), liver stiffness measurement to Platelet Ratio Index (LPRI), and Fibrosis-4 (Fib-4) for diagnosing compensated cirrhosis; C: The APTAL index, APRI, LPRI, and Fib-4 for diagnosing decompensated cirrhosis. A-index = 0.101 × alanine aminotransferase (ALT); MAPTAL index = -2.732 × male + 0.125 × age - 0.039 × platelet count (PLT) + 1.813 × total cholesterol (TC) + 0.098 × ALT + 0.518 × liver stiffness measurement (LSM); APTAL index = 0.204 × age - 0.05 × PLT + 2.188 × TC - 0.183 × albumin + 0.467 × LSM. ALBI grade: Albumin-bilirubin grade; APRI: Aspartate Platelet Ratio Index; LPRI: LSM to Platelet Ratio Index; Fib-4: Fibrosis-4; AUC: Area under the curve.