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LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury
Yu Yang, Shi-Li Wu, Zhi-Hao Huang, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Wei-Jie Zhou, Yuan Lin, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Yi Gao, General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
Author contributions: Lin Y and Zhou WJ contributed to conceptualization, resources, supervision, and writing of original drafts; Yang Y, Wu SL, Huang ZH, Liu ZM, Dong MQ, and Xu M contributed to methodology and investigation; Yang Y, Huang ZH, and Dong MQ contributed to validation; Yang Y and Dong MQ contributed to formal analysis; Lin Y, Gao Y, and Zhou WJ contributed to data curation; Yang Y and Lin Y contributed to visualization; Lin Y contributed to project administration; Lin Y, Xu M, and Zhou WJ contributed to funding acquisition; and all authors reviewed and edited the manuscript, and approved the final version to publish.
Supported by National Key Research and Development Program, No. 2022YFA1106700; and National Natural Science Foundation of China, No. 82270645, No. 82570748, No. 82200633, and No. 92068206.
Institutional animal care and use committee statement: This study was approved by the Animal Ethics Committee of Nanfang Hospital, No. NFYY-2018-031.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data and materials of this study are available from Lin Y and Zhou WJ upon reasonable request.
Corresponding author: Yuan Lin, PhD, Professor, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hos
Received: February 2, 2026
Revised: February 24, 2026
Accepted: April 17, 2026
Published online: June 27, 2026
Processing time: 141 Days and 21.6 Hours
Revised: February 24, 2026
Accepted: April 17, 2026
Published online: June 27, 2026
Processing time: 141 Days and 21.6 Hours
Core Tip
Core Tip: This study elucidates a novel signaling mechanism in which leukocyte-derived chemotaxin-2 exacerbates hepatic ischemia-reperfusion injury by binding to Tie1 and activating Src kinase, thereby amplifying oxidative stress and endothelial cell damage. Targeting the leukocyte-derived chemotaxin-2/Tie1/Src axis represents a promising therapeutic strategy for mitigating liver ischemia-reperfusion injury, offering potential translational applications in liver surgery and transplantation.