Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Hepatol. Jun 27, 2026; 18(6): 120427
Published online Jun 27, 2026. doi: 10.4254/wjh.120427

Table 1 Relative binding score of ARNT2 within the promoter region of Smad2 (sequence ID: NC_000018.10:c47932872-47930672)

Matrix ID	Name	Relative score	Start	End	Strand	Predicted sequence
MA1464.2	MA1464.2.ARNT2	0.9659331479380997	1374	1381	+	CCCACGTG
MA1464.2	MA1464.2.ARNT2	0.9447176944922032	1372	1379	-	CCCACGTG

The higher the relative score, the stronger the binding ability.

Full Size Table

Table 2 Relative binding score of ARNT2 within the promoter region of Smad3 (sequence ID: NC_000015.10:67063602-67065802)

Matrix ID	Name	Relative score	Start	End	Strand	Predicted sequence
MA1464.2	MA1464.2.ARNT2	0.9053040287573585	1826	1833	+	CCCACGTG
MA1464.2	MA1464.2.ARNT2	0.9053040287573585	1828	1835	-	CCCACGTG

The higher the relative score, the stronger the binding ability.

Full Size Table

Table 3 Relative binding score of ARNT2 within the promoter region of Wnt3A (sequence ID: NC_000001.11:228004998-228007198)

Matrix ID	Name	Relative score	Start	End	Strand	Predicted sequence
MA1464.2	MA1464.2.ARNT2	0.9041148759925752	59	66	+	GTCACGAG

The higher the relative score, the stronger the binding ability.

Full Size Table

Table 4 Relative binding score of ARNT2 within the promoter region of YAP (sequence ID: NC_000011.10:102108447-102110647)

Matrix ID	Name	Relative score	Start	End	Strand	Predicted sequence
MA1464.2	MA1464.2.ARNT2	1.0000000012185972	1796	1803	+	GTCACGTG
MA1464.2	MA1464.2.ARNT2	0.9208872643353855	1798	1805	-	CGCACGTG

The higher the relative score, the stronger the binding ability.

Full Size Table

Table 5 Relative binding score of ARNT2 within the promoter region of Notch1 (sequence ID: NC_000009.12:c136548048-136545848)

Matrix ID	Name	Relative score	Start	End	Strand	Predicted sequence
MA1464.2	MA1464.2.ARNT2	0.9447176944922032	1167	1174	+	AGCACGTG
MA1464.2	MA1464.2.ARNT2	0.9053040287573585	1169	1176	-	CCCACGTG

The higher the relative score, the stronger the binding ability.

Full Size Table

Citation: Yin DD, Jiang WY, Huang YT, Zhou SP, Zhang YC. Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway. World J Hepatol 2026; 18(6): 120427
URL: https://www.wjgnet.com/1948-5182/full/v18/i6/120427.htm
DOI: https://dx.doi.org/10.4254/wjh.120427

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