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World J Hepatol. May 27, 2026; 18(5): 117184
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117184
Published online May 27, 2026. doi: 10.4254/wjh.v18.i5.117184
Congenital porto-sinusoidal vascular disorder-induced portal hypertension: A comprehensive review based on a classic clinical case
Meng-Jiao Xu, Xin Wei, Yao Lu, Yao Xie, Department of Hepatology II, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
Yu Huang, Department of Gastroenterology I, The People’s Hospital of Chuxiong Yi Auto
Lei Sun, Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Peking University Ditan Teaching Hospital, Beijing 100015, China
Ming-Hui Li, Department of Hepatology II, Beijing Ditan Hospital, Capital Medical University, Peking University Ditan Teaching Hospital, Beijing 100015, China
Co-first authors: Meng-Jiao Xu and Xin Wei.
Co-corresponding authors: Yao Xie and Ming-Hui Li.
Author contributions: Xu MJ and Wei X wrote the main manuscript text and prepared table, and they contributed equally to this manuscript as co-first authors; Xu MJ, Wei X, and Sun L prepared figure; Huang Y, Lu Y, Xie Y, and Li MH approved the submitted version after modification; Xie Y and Li MH edited the manuscript, and they contributed equally to this manuscript as co-corresponding authors. All authors made a significant contribution to the work reported and read and approved the final manuscript.
AI contribution statement: No AI tools were used for language polishing, translation, data analysis, or writing assistance of the manuscript. No images in the manuscript were generated by AI.
Supported by Beijing Municipal Health Commission High-Level Public Health Technical Personnel Construction Project, No. Discipline Leader-03-26; Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support, No. ZLRK202301; Beijing Hospitals Authority “Peak” Talent Training Program, No. DFL20241803; and National Key Research and Development Program, No. 2023YFC2306901 and No. 2023YFC2308105.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ming-Hui Li, Department of Hepatology II, Beijing Ditan Hospital, Capital Medical University, Peking University Ditan Teaching Hospital, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China. wuhm2000@sina.com
Received: December 1, 2025
Revised: January 11, 2026
Accepted: February 26, 2026
Published online: May 27, 2026
Processing time: 176 Days and 18 Hours
Revised: January 11, 2026
Accepted: February 26, 2026
Published online: May 27, 2026
Processing time: 176 Days and 18 Hours
Core Tip
Core Tip: Our review initiated a comprehensive exploration of congenital porto-sinusoidal vascular disorder through a representative clinical case. By incorporating recent and relevant findings, this review aims to deepen the understanding of porto-sinusoidal vascular disorder in etiology, pathology, and treatment approaches, in order to enhance both clinical decision-making and the framework for future investigative efforts in this complex condition.