Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Hepatol. Apr 27, 2026; 18(4): 115475
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115475
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115475
Metabolic dysfunction-associated steatotic liver disease mediates the relationship between Helicobacter pylori infection and colorectal adenoma risk
Zhao-Bei Cai, Department of Geriatrics, Aerospace Center Hospital, Peking University Aerospace Clinical Medical College, Beijing 100049, China
Bin-Bin Su, Hui Shi, Department of Gastroenterology and Hepatology, The Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Pan-Yang Shi, Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250000, Shandong Province, China
Sheng-Shu Wang, Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatrics Diseases, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Qian-Qian Chen, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Zhao-Bei Cai and Bin-Bin Su.
Co-corresponding authors: Hui Shi and Qian-Qian Chen.
Author contributions: Cai ZB, Su BB, Shi H, and Chen QQ designed the study; Shi H and Chen QQ verified the disease diagnosis, have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors; Su BB and Wang SS performed the primary literature and data extraction; Cai ZB, Su BB, and Wang SS analyzed the data and drafted the manuscript; Shi PY, Shi H, and Chen QQ revised the manuscript for important intellectual content; Shi PY handled the submission process; Cai ZB and Su BB have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper; all authors read and approved the final version.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the PLA General Hospital (No. S2023-224-01).
Informed consent statement: Patients were exempt from providing informed consent for the study, as it involved the use of de-identified clinical data collected subsequent to each patient's written agreement for testing.
Conflict-of-interest statement: All authors declare that there is no conflict of interest.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Corresponding author: Qian-Qian Chen, MD, Associate Chief Physician, Associate Professor, Department of Gastroenterology and Hepatology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
Received: October 31, 2025
Revised: December 15, 2025
Accepted: January 20, 2026
Published online: April 27, 2026
Processing time: 172 Days and 6.4 Hours
Revised: December 15, 2025
Accepted: January 20, 2026
Published online: April 27, 2026
Processing time: 172 Days and 6.4 Hours
Core Tip
Core Tip: This study identifies both Helicobacter pylori (H. pylori) infection and metabolic dysfunction-associated steatotic liver disease (MASLD) as independent risk factors for colorectal adenoma. No interaction was found between them, but MASLD mediated the infection-adenoma risk relationship. These results support enhanced screening for colorectal adenoma in individuals with H. pylori infection and MASLD.