Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Hepatol. Apr 27, 2026; 18(4): 114804
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114804
Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.114804
Integrated transcriptomics and metabolomics reveal neutrophil extracellular trap associated with interferon treatment for chronic hepatitis B
Xiang-Yang Ye, Xiong-Zhi He, Zhen-Ting Hu, Feng-Feng Zheng, Xiao-Gang Huang, Xue-Mei Xie, Fei-Hua Chen, Han-Bing Ou, Rong-Xian Qiu, Department of Infectious Diseases, The Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China
Xiang-Yang Ye, Department of Clinic Medicine, Fujian Medical University, Fuzhou 350122, Fujian Province, China
Author contributions: Ye XY, Ou HB, and Qiu RX designed experiments, data analyses, and wrote the manuscript; Ye XY, He XZ, and Hu ZT performed experiments and collected data; Zheng FF, Huang XG, Xie XM, and Chen FH provided technical support and collected data; and all authors have reviewed the manuscript.
Institutional review board statement: This work was approved by the Human Research Ethics Committee in the Affiliated Hospital of Putian University (No. PYFL202416).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Datasets are hosted in public repositories Science data bank under accession number 26078 and are available at the following URL: https://doi.org/10.57760/sciencedb.26078.
Corresponding author: Rong-Xian Qiu, Department of Infectious Diseases, The Affiliated Hospital of Putian University, No. 181 Meiyuan East Road, Putian 351100, Fujian Province, China. 18850959988@163.com
Received: September 29, 2025
Revised: November 11, 2025
Accepted: January 9, 2026
Published online: April 27, 2026
Processing time: 205 Days and 4.9 Hours
Revised: November 11, 2025
Accepted: January 9, 2026
Published online: April 27, 2026
Processing time: 205 Days and 4.9 Hours
Core Tip
Core Tip: Chronic hepatitis B is a significant global health issue, and interferon (IFN) is one of the main first-line therapies for chronic hepatitis B. Non-targeted transcriptomic and metabolomic analyses revealed that IFN-related immune pathways and neutrophil extracellular trap formation were the most significantly altered pathways after IFN treatment. Core components of neutrophil extracellular traps including histones were notably increased and potentially enhance the antiviral response.