He YF, Bian N, Wang HZ, Hu XD, Liu JQ, Lu SF, Wu N, He QT, Li HM. Correlation between non-alcoholic fatty liver disease and erectile dysfunction: A systematic narrative review. World J Hepatol 2026; 18(4): 115456 [DOI: 10.4254/wjh.v18.i4.115456]
Corresponding Author of This Article
Yan-Fei He, MD, Associate Chief Physician, Department of Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, China. heyanfeilc@163.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Systematic Reviews
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Apr 27, 2026 (publication date) through Apr 22, 2026
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Journal Information of This Article
Publication Name
World Journal of Hepatology
ISSN
1948-5182
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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He YF, Bian N, Wang HZ, Hu XD, Liu JQ, Lu SF, Wu N, He QT, Li HM. Correlation between non-alcoholic fatty liver disease and erectile dysfunction: A systematic narrative review. World J Hepatol 2026; 18(4): 115456 [DOI: 10.4254/wjh.v18.i4.115456]
World J Hepatol. Apr 27, 2026; 18(4): 115456 Published online Apr 27, 2026. doi: 10.4254/wjh.v18.i4.115456
Correlation between non-alcoholic fatty liver disease and erectile dysfunction: A systematic narrative review
Yan-Fei He, Ning Bian, Huan-Zhi Wang, Xiao-Dong Hu, Jun-Qiang Liu, Shuang-Feng Lu, Ni Wu, Qin-Tong He, Hu-Ming Li
Yan-Fei He, Ning Bian, Shuang-Feng Lu, Ni Wu, Department of Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Huan-Zhi Wang, Department of College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Xiao-Dong Hu, Department of Endocrinology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Jun-Qiang Liu, Department of Thoracic Surgery, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Qin-Tong He, Department of School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Hu-Ming Li, Department of Respiratory Medicine, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Author contributions: He YF contribution to design the study, review the literature, and write the initial manuscript; Bian N and Wang HZ contribution to retrieve and summarize the literature; Hu XD, Liu JQ, and He QT contribution to offer advice on the review and reviewed the final manuscript; Lu SF, Wu N, and Li HM contribution to collect and analyze relevant data for the article during the revision process; and all authors contributed to the article and approved the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Yan-Fei He, MD, Associate Chief Physician, Department of Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, China. heyanfeilc@163.com
Received: October 17, 2025 Revised: November 23, 2025 Accepted: February 5, 2026 Published online: April 27, 2026 Processing time: 186 Days and 19.3 Hours
Core Tip
Core Tip: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. It often occurs alongside metabolic disorders, such as obesity and type 2 diabetes. Erectile dysfunction (ED) is a common sexual health issue in men. However, there is limited high-quality evidence systematically examining the relationship between ED and NAFLD. This systematic narrative review summarizes the existing research and confirms that NAFLD is a significant risk factor for ED. The strength of this association depends on various factors, including age, insulin resistance, testosterone levels, and anxiety. This study provides evidence-based support for the early identification of ED risk in NAFLD patients, which is significant for advancing comprehensive metabolic interventions, both socially and clinically.
