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Contents Volume 18 Issue 5 May 26, 2026
Editorial
Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration
Hui-Fang Wang, Peng-Yu Yan, Shoaib Muhammad, Yu-Xiang Liu, Chun Liu 
World J Stem Cells 18(5):116050. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116050
Opinion Review
GrpE-like 1-engineered synovial mesenchymal stromal cell exosomes: Mechanistic and translational priorities in osteoarthritis
Zhen Shi, Hao-Yu Li, Bo-Kang Lv, Dong Li, Peng-Yu Lu, Xin-Yu Zhou, Meng-En Xue, Rui-Bo Wang 
World J Stem Cells 18(5):119231. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119231
Review
Innovations in the treatment of endometrial diseases: Role of human umbilical cord mesenchymal stem cells and their exosomes
He-Lin Wang, Shi-Dong Zhang, Ting Liu, Li-Mei Liu, Xiao-Yan Pan 
World J Stem Cells 18(5):115486. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115486
Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications
Ashwini Raja, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Aadithya Siddarth Sridhar, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu, Madhan Jeyaraman 
World J Stem Cells 18(5):117689. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117689
Cell-cell fusion and stem cell plasticity: Emerging paradigms in tissue regeneration
Ji Seob Kim, In Sun Hwang, Seo Jeong Kim, Min Hee Moon, Hae-Dam Park, Byeong Ho Jin, Da Young Kim, Min Ji Lee, Se-Yun Eum, Seo-Jin Yoo, Byung-Hyun Cha 
World J Stem Cells 18(5):118307. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.118307
Minireviews
From laboratory to clinic: Bridging regulatory and manufacturing gaps in stem cell-based therapies
Noura A A Ebrahim, Thoraya A Farghaly, Ghada S Masaret, Amani M R Alsaedi, Soliman M A Soliman 
World J Stem Cells 18(5):117591. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117591
Retrospective Study
Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma
Xing-Qing Jia, Shuai Han, Yan-Sheng Shang, Fan-Guo Kong, Lin Qi, Cheng-Liang Wang, Wu-Jun Xiong 
World J Stem Cells 18(5):119123. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119123
Basic Study
Isolation and proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Unlocking new frontiers in regenerative and translational medicine
Mir Sadat-Ali, Haifa A Al-Turki, Aleem A Khan, Saira M Bannu, Shivaranjani Vutharadhi, Mirza M Baig 
World J Stem Cells 18(5):114668. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.114668
FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway
Jin-Hua Wu, Feng Lin, Yan-Hua Wang, Jiang-Ping Xie, Shu-Lin Guo, Pei-Yan Liu 
World J Stem Cells 18(5):115482. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115482
Erythropoietin-overexpressing mesenchymal stem cells accelerate diabetic wound healing via steroid signaling pathway modulation
Bao-Dong Ma, Shu-Juan Zhang, Yi-Ming Shao, Ran-Ran Jin, Lei Sun, Peng-Ju Lv, Han Yue, Shou-Kui Hu, Xi-Wen Ma 
World J Stem Cells 18(5):116280. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116280
Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy
Wen Wen, Chen-Xi Liu, Yong Wang, Xiao-Jiong Lu, Chao Yang, Shuang-Jing Chen, Zhi-Tao Jin, Ming-Yue Qu, Jing-Yu Deng, Zheng Zhang 
World J Stem Cells 18(5):116611. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116611
Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca2+ signaling axis
Wumiti Taxi, Jie Sun, Yi-Hua Zhu, Tian-Chi Zhang, Yang Guo, Ya-Lan Pan, Meng-Min Liu, Xi Chen, Chun-Lei Zhang, Kai Tong, Li-Ning Wang, Tao Jiang, Yong Ma 
World J Stem Cells 18(5):117045. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117045
Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells
Bushra Bashir, Mahmood S Choudhery, Ijaz Hussain 
World J Stem Cells 18(5):117241. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117241
Calcium dysregulation underlies phenotypic diversity in LQT2: Insights from induced pluripotent stem cell-derived cardiomyocytes of a KCNH2 p.Y427H family trio
Qing Li, Cong-Ting Guo, Jia-Cheng Ren, Yi-Fei Wang, Zi-Juan Zhao, Chang-Hua Lv, Qiu-Yu Wang, Qing Liu, Kun Li, Jing Yang, Rong He, Fu-Lan Liu, Ting-Ting Lv, Ping Zhang 
World J Stem Cells 18(5):117584. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117584
Correspondence
Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease
Emma Hughes, Brandon Lucke-Wold 
World J Stem Cells 18(5):115788. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115788
Letter to the Editor: Advancing induced pluripotent stem cell-derived mesenchymal stem cells - insights from comparative differentiation protocols and emerging innovations
Abinash Nayak, Gunanidhi Sahoo, Sudhansu Sekhar Nishank 
World J Stem Cells 18(5):115940. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115940
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