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World J Stem Cells. May 26, 2026; 18(5): 115788
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115788
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115788
Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease
Emma Hughes, College of Medicine, Florida State University, Tallahassee, FL 32304, United States
Brandon Lucke-Wold, Lillian S Wells Department of Neurosurgery, University of Florida, Gainesville, FL 32608, United States
Author contributions: Hughes E and Lucke-Wold B contributed to the manuscript writing and editing, and literature review; Lucke-Wold B contributed to the format, outline, and concept of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Brandon Lucke-Wold, Lillian S Wells Department of Neurosurgery, University of Florida, 1505 SW Archer Road, Gainesville, FL 32608, United States.
Received: October 27, 2025
Revised: December 1, 2025
Accepted: January 12, 2026
Published online: May 26, 2026
Processing time: 212 Days and 9.2 Hours
Revised: December 1, 2025
Accepted: January 12, 2026
Published online: May 26, 2026
Processing time: 212 Days and 9.2 Hours
Core Tip
Core Tip: This letter to the editor discusses the recent study by Jiang et al on induced pluripotent stem cells and exercise for Parkinson’s disease. Treatment with induced pluripotent stem cells provides a promising option for Parkinson’s disease patients by replacing lost dopaminergic neurons, while exercise alone has been shown to improve outcomes in these patients. A combination of these therapies has shown a potentially synergistic effect by activating the Wnt1-Lmx1a loop in a mouse model.