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Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease
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World Journal of Stem Cells is an international, peer-reviewed, open-access academic journal dedicated to publishing original, high-quality research findings in the field of stem cells, including clinical, translational, and basic studies, as well as research involving artificial intelligence. The journal focuses on, but is not limited to, the following areas: Embryonic stem cells, germline stem cells, tissue-specific stem cells, adult stem cells, mesenchymal stromal cells, induced pluripotent stem cells, embryoid bodies, embryonal carcinoma stem cells, hemangioblasts, hematopoietic stem cells, lymphoid progenitor cells, myeloid progenitor cells, myoblasts (cardiac, skeletal, and smooth muscle), neoplastic stem cells, neural stem cells, other pluripotent stem cells, side-population cells, and totipotent stem cells. Types of articles published by the journal include clinical study, basic study, case report, editorial, review, minireview, systematic review, meta-analysis, guidelines, and correspondence. All submissions undergo a rigorous and transparent peer-review process by at least two independent reviewers. Manuscripts are evaluated based on scientific rigor, originality, clinical relevance, and reproducibility, with particular attention to methodological robustness and data integrity. Constructive and timely feedback is provided to ensure the highest standards of scholarly communication. The journal adheres to the highest standards of publication ethics and editorial integrity, in accordance with the guidelines of the Committee on Publication Ethics, the International Committee of Medical Journal Editors, and the World Association of Medical Editors. To advance scientific discovery, promote evidence-based clinical practice, and foster innovation in stem cells, ultimately improving global health outcomes. We invite researchers, clinicians, and multidisciplinary experts worldwide to submit high-quality manuscripts and contribute to shaping the future of stem cells science. Submit an Article >>

2026 Published Issues
5 4 3 2 1
Editors-in-Chief
  • Shengwen Calvin Li, PhD, Professor, (E-mail: choc.uci@gmail.com) Center for Neuroscience and Stem Cell Research, Children's Hospital of Orange County Children's Research Institute, Children's Hospital of Orange County, Neuroscience Institute, University of California Irvine, Orange, CA 92868, United States
Indexing/Abstracting
The WJSC is now abstracted and indexed in Science Citation Index Expanded (SCIE, also known as SciSearch®), Journal Citation Reports/Science Edition, PubMed, PubMed Central, Scopus, Biological Abstracts, BIOSIS Previews, Reference Citation Analysis, China Science and Technology Journal Database, and Superstar Journals Database.
Journal Metrics

The 2025 edition of Journal Citation Reports® cites the 2024 journal impact factor (JIF) for WJSC as 3.6; JIF without journal self cites: 3.3; 5-year JIF: 4.4; JIF Rank: 14/32 in cell and tissue engineering; JIF Quartile: Q2; and 5-year JIF Quartile: Q2; JIF Rank: 100/204 in cell biology; JIF Quartile: Q2; and 5-year JIF Quartile: Q2.

The WJSC’s CiteScore for 2024 is 6.9 and Scopus CiteScore rank 2024: Histology is 13/61; Genetics is 97/348; Genetics (clinical) is 24/100; Molecular Biology is 152/410; Cell Biology is 122/285.

ISSN
1948-0210 (online)
Latest Manuscript Statistics
Received (2012), Duration of Peer Review (26 days/Mean), Days from Submission to First Decision (46 days/Mean), Second Decision Time (47 days/Mean), Accepted (52.1%/Mean), Production Time (49 days/Mean), Time to Publication (172 days/Mean), and Rejected (40.2%/Mean).
Current Issue
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Contents Volume 18 Issue 5 May 26, 2026
Editorial
Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration
Hui-Fang Wang, Peng-Yu Yan, Shoaib Muhammad, Yu-Xiang Liu, Chun Liu 
World J Stem Cells 18(5):116050. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116050
Opinion Review
GrpE-like 1-engineered synovial mesenchymal stromal cell exosomes: Mechanistic and translational priorities in osteoarthritis
Zhen Shi, Hao-Yu Li, Bo-Kang Lv, Dong Li, Peng-Yu Lu, Xin-Yu Zhou, Meng-En Xue, Rui-Bo Wang 
World J Stem Cells 18(5):119231. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119231
Review
Innovations in the treatment of endometrial diseases: Role of human umbilical cord mesenchymal stem cells and their exosomes
He-Lin Wang, Shi-Dong Zhang, Ting Liu, Li-Mei Liu, Xiao-Yan Pan 
World J Stem Cells 18(5):115486. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115486
Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications
Ashwini Raja, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Aadithya Siddarth Sridhar, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu, Madhan Jeyaraman 
World J Stem Cells 18(5):117689. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117689
Cell-cell fusion and stem cell plasticity: Emerging paradigms in tissue regeneration
Ji Seob Kim, In Sun Hwang, Seo Jeong Kim, Min Hee Moon, Hae-Dam Park, Byeong Ho Jin, Da Young Kim, Min Ji Lee, Se-Yun Eum, Seo-Jin Yoo, Byung-Hyun Cha 
World J Stem Cells 18(5):118307. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.118307
Minireviews
From laboratory to clinic: Bridging regulatory and manufacturing gaps in stem cell-based therapies
Noura A A Ebrahim, Thoraya A Farghaly, Ghada S Masaret, Amani M R Alsaedi, Soliman M A Soliman 
World J Stem Cells 18(5):117591. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117591
Retrospective Study
Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma
Xing-Qing Jia, Shuai Han, Yan-Sheng Shang, Fan-Guo Kong, Lin Qi, Cheng-Liang Wang, Wu-Jun Xiong 
World J Stem Cells 18(5):119123. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.119123
Basic Study
Isolation and proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Unlocking new frontiers in regenerative and translational medicine
Mir Sadat-Ali, Haifa A Al-Turki, Aleem A Khan, Saira M Bannu, Shivaranjani Vutharadhi, Mirza M Baig 
World J Stem Cells 18(5):114668. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.114668
FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway
Jin-Hua Wu, Feng Lin, Yan-Hua Wang, Jiang-Ping Xie, Shu-Lin Guo, Pei-Yan Liu 
World J Stem Cells 18(5):115482. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115482
Erythropoietin-overexpressing mesenchymal stem cells accelerate diabetic wound healing via steroid signaling pathway modulation
Bao-Dong Ma, Shu-Juan Zhang, Yi-Ming Shao, Ran-Ran Jin, Lei Sun, Peng-Ju Lv, Han Yue, Shou-Kui Hu, Xi-Wen Ma 
World J Stem Cells 18(5):116280. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116280
Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy
Wen Wen, Chen-Xi Liu, Yong Wang, Xiao-Jiong Lu, Chao Yang, Shuang-Jing Chen, Zhi-Tao Jin, Ming-Yue Qu, Jing-Yu Deng, Zheng Zhang 
World J Stem Cells 18(5):116611. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.116611
Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca2+ signaling axis
Wumiti Taxi, Jie Sun, Yi-Hua Zhu, Tian-Chi Zhang, Yang Guo, Ya-Lan Pan, Meng-Min Liu, Xi Chen, Chun-Lei Zhang, Kai Tong, Li-Ning Wang, Tao Jiang, Yong Ma 
World J Stem Cells 18(5):117045. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117045
Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells
Bushra Bashir, Mahmood S Choudhery, Ijaz Hussain 
World J Stem Cells 18(5):117241. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117241
Calcium dysregulation underlies phenotypic diversity in LQT2: Insights from induced pluripotent stem cell-derived cardiomyocytes of a KCNH2 p.Y427H family trio
Qing Li, Cong-Ting Guo, Jia-Cheng Ren, Yi-Fei Wang, Zi-Juan Zhao, Chang-Hua Lv, Qiu-Yu Wang, Qing Liu, Kun Li, Jing Yang, Rong He, Fu-Lan Liu, Ting-Ting Lv, Ping Zhang 
World J Stem Cells 18(5):117584. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.117584
Correspondence
Letter to the Editor: Exercise and induced pluripotent stem cells for Parkinson’s disease
Emma Hughes, Brandon Lucke-Wold 
World J Stem Cells 18(5):115788. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115788
Letter to the Editor: Advancing induced pluripotent stem cell-derived mesenchymal stem cells - insights from comparative differentiation protocols and emerging innovations
Abinash Nayak, Gunanidhi Sahoo, Sudhansu Sekhar Nishank 
World J Stem Cells 18(5):115940. Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115940
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