World Journal of Stem Cells - Baishideng Publishing Group

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Welcome to the World Journal of Stem Cells

Schematic illustration of the epiregulin-mesenchymal stem cell-hydrogel therapeutic platform for bone/periodontal regeneration.

Overview of cell and exosome therapeutic preparation pipeline.

An example of the robust mechanism associated with the altered paracrine activity of mesenchymal stem cells, which leads to senescent drift and promotes inflammaging.

Mechanisms of engineering extracellular vesicle containing secretomes for targeted action.

Graphical abstract.

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Mesenchymal stem cells therapy ameliorates esophageal dysmotility in gastroesophageal reflux disease by modulating smooth muscle contractility, alleviating senescence by targeting the DNMT3a-HIF1α axis

Featured Articles More >>

Mesenchymal stem cells therapy ameliorates esophageal dysmot... 2026-08-20
Pretransplant T-cell immune imbalance predicts slow engraftm... 2026-08-20
Applying microfluidic techniques for biomaterial and mechani... 2026-08-20
Artificial intelligence in hematopoietic stem cell research ... 2026-08-20
X inactive specific transcript drives mitochondrial metaboli... 2026-08-20

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World Journal of Stem Cells is an international, peer-reviewed, open-access academic journal dedicated to publishing original, high-quality research findings in the field of stem cells, including clinical, translational, and basic studies, as well as research involving artificial intelligence. The journal focuses on, but is not limited to, the following areas: Embryonic stem cells, germline stem cells, tissue-specific stem cells, adult stem cells, mesenchymal stromal cells, induced pluripotent stem cells, embryoid bodies, embryonal carcinoma stem cells, hemangioblasts, hematopoietic stem cells, lymphoid progenitor cells, myeloid progenitor cells, myoblasts (cardiac, skeletal, and smooth muscle), neoplastic stem cells, neural stem cells, other pluripotent stem cells, side-population cells, and totipotent stem cells. Types of articles published by the journal include clinical study, basic study, case report, editorial, review, minireview, systematic review, meta-analysis, guidelines, and correspondence. All submissions undergo a rigorous and transparent peer-review process by at least two independent reviewers. Manuscripts are evaluated based on scientific rigor, originality, clinical relevance, and reproducibility, with particular attention to methodological robustness and data integrity. Constructive and timely feedback is provided to ensure the highest standards of scholarly communication. The journal adheres to the highest standards of publication ethics and editorial integrity, in accordance with the guidelines of the Committee on Publication Ethics, the International Committee of Medical Journal Editors, and the World Association of Medical Editors. To advance scientific discovery, promote evidence-based clinical practice, and foster innovation in stem cells, ultimately improving global health outcomes. We invite researchers, clinicians, and multidisciplinary experts worldwide to submit high-quality manuscripts and contribute to shaping the future of stem cells science. Submit an Article >>

2026 Published Issues

8 7 6 5 4 3 2 1

Editors-in-Chief

Shengwen Calvin Li, PhD, Professor, (E-mail: choc.uci@gmail.com) Center for Neuroscience and Stem Cell Research, Children's Hospital of Orange County Children's Research Institute, Children's Hospital of Orange County, Neuroscience Institute, University of California Irvine, Orange, CA 92868, United States

Indexing/Abstracting

The WJSC is now abstracted and indexed in Science Citation Index Expanded (SCIE, also known as SciSearch®), Journal Citation Reports/Science Edition, Scopus, Biological Abstracts, BIOSIS Previews, Reference Citation Analysis, China Science and Technology Journal Database, and Superstar Journals Database.

Journal Metrics

The 2026 edition of Journal Citation Reports® cites the 2025 journal impact factor (JIF) for WJSC as 4.9; JIF without journal self cites: 4.7; 5-year JIF: 4.8; JIF Rank: 11/32 in cell and tissue engineering; JIF Quartile: Q2; and 5-year JIF Quartile: Q2; JIF Rank: 78/207 in cell biology; JIF Quartile: Q2; and 5-year JIF Quartile: Q2.

The WJSC’s CiteScore for 2025 is 5.3 and Scopus CiteScore rank 2025: Histology is 22/62; Genetics is 150/357; Genetics (clinical) is 36/100; Molecular Biology is 216/414; Cell Biology is 167/289.

ISSN

1948-0210 (online)

Latest Manuscript Statistics

Received (2119), Duration of Peer Review (26 days/Mean), Days from Submission to First Decision (46 days/Mean), Second Decision Time (47 days/Mean), Accepted (50.2%/Mean), Production Time (52 days/Mean), Time to Publication (172 days/Mean), and Rejected (40.3%/Mean).

Current Issue

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Contents Volume 18 Issue 8 August 26, 2026

Editorial

Extracellular vesicle therapeutics for cardiac regeneration: Overcoming standardization hurdles

Rui-Qin Xue, Jun-Yan Hou, Wei-Xi Gao, Lin-Hao Zhang, Yu-Xiang Liu, Xiao-Shuang Zhou

World J Stem Cells 18(8):114716. Published online Aug 26, 2026. doi: 10.4252/wjsc.114716

X inactive specific transcript drives mitochondrial metabolic rewiring and neural stem cell fate after spinal cord injury

Jin-Ke Sun, Zhen Shi, Xiao-Dong Tang, Bo-Kang Lv, Peng-Yu Lu, Yi-Gong Tian, Yan-Wei Fan, Peng Yan

World J Stem Cells 18(8):116228. Published online Aug 26, 2026. doi: 10.4252/wjsc.116228

Opinion Review

Breaking the cycle of radiation-induced bone death: Human amniotic mesenchymal stem cell-derived small extracellular vesicles restore coupled osteo-angiogenic regeneration

Yang Yang, Guo-Dong Zhang, Ling Yi, Xu Yang, Zeng-Gao Han, Chen-Yu Song, Jing-Shun Lu, Kai-Yang Wang

World J Stem Cells 18(8):119963. Published online Aug 26, 2026. doi: 10.4252/wjsc.119963

Maximizing stem cell yield from limited adipose tissue: A novel two-step digestion approach and future artificial intelligence-integrated perspectives

Yi-Fan Wu, Xu Jiang, Jian-Guang Zhang, Wei Zhang

World J Stem Cells 18(8):120206. Published online Aug 26, 2026. doi: 10.4252/wjsc.120206

Review

Artificial intelligence in hematopoietic stem cell research and associated malignancies: From disease modeling to cell manufacturing

Heba Adel Abd El Ghaffar, Aya Mohamed Adel Arafat, Eman Hazem AbdelTawab Khattab, Mustafa Ashraf Khattab, Ahmed M Khallaf, Shirihan Mahmoud Anwar Mahgoub

World J Stem Cells 18(8):121077. Published online Aug 26, 2026. doi: 10.4252/wjsc.121077

Applying microfluidic techniques for biomaterial and mechanical regulation of mesenchymal stem cells

Bing-Qi Song, Jing Du, Xiao-Ming Li

World J Stem Cells 18(8):121713. Published online Aug 26, 2026. doi: 10.4252/wjsc.121713

Induced pluripotent stem cells in Hirschsprung disease: Modeling, mechanisms, and translational challenges

Yuan-Xiang Qiu, Zheng-Ke Zhi, Yu-Mu Leng, Xin-Tao Zhang, Chun-Xia Du, Jie Tang, Hong-Xing Li, Wei-Bing Tang

World J Stem Cells 18(8):123046. Published online Aug 26, 2026. doi: 10.4252/wjsc.123046

Minireviews

From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease

Bo-Lin Zhang, Shinichiro Kobayashi, Lu-Yang Li, Tian-Yang Li, Shinichiro Ogawa, Daisuke Miyamoto, Kayo Hasegawa, Shun Yamaguchi, Tomohiko Adachi, Susumu Eguchi, Kengo Kanetaka

World J Stem Cells 18(8):121648. Published online Aug 26, 2026. doi: 10.4252/wjsc.121648

Retrospective Study

Very small embryonic-like stem cells: A predictor synergizing with complement and inflammatory factors for immunoglobulin A nephropathy prognosis

Cheng-Li Lou, Ke-Xin Ren, Xiu-Qin Xu, Xiang-Jing Wang, Xiao-Ping Fan, Bo Feng, Ping-Xin Hu, Yi-Jing Zhou

World J Stem Cells 18(8):120694. Published online Aug 26, 2026. doi: 10.4252/wjsc.120694

Stem/progenitor cell-driven immune microenvironment remodeling in sepsis-associated acute respiratory distress syndrome

Wen-Xing Li, Si-Cong Jiang, Sheng-Li Fan, Yu-Xuan Xing, Lei Gong

World J Stem Cells 18(8):121124. Published online Aug 26, 2026. doi: 10.4252/wjsc.121124

Pretransplant T-cell immune imbalance predicts slow engraftment after autologous hematopoietic stem cell transplantation in lymphoma

Xi Quan, Huai-Bin Zhang, Long-Rong Ran, Zhi-Ming Luo, Nan Zhang, Xiao Hu, Jian-Chuan Deng, Yao Liu, Shi-Feng Lou

World J Stem Cells 18(8):122836. Published online Aug 26, 2026. doi: 10.4252/wjsc.122836

Basic Study

Dynamic regulation of neural stem cell state transitions by NOTCH1-REST transcriptional axis

Zhi-Chong Xie, Xiao-Yong Zhao, Rui-Hua Xiong, Xiao-Li Zhang, Wei Yang

World J Stem Cells 18(8):117617. Published online Aug 26, 2026. doi: 10.4252/wjsc.117617

Protective effect of hUC-MSCs regulating peritoneal mesothelial cell EMT through cGAS-STING signaling pathway in high glucose-induced peritoneal fibrosis

Fu-Xing Dong, Lu-Li Zheng, Kun Nie, Jian-Xin Wan

World J Stem Cells 18(8):120270. Published online Aug 26, 2026. doi: 10.4252/wjsc.120270

Yi Li, Wen-Ya Zhu, Bo Zhang, Ze-Rui Wang, Zhao-Yang Chen, Qian-Qian Chen, En-Qiang Linghu

World J Stem Cells 18(8):120831. Published online Aug 26, 2026. doi: 10.4252/wjsc.120831

Cellular hypoxia reprograms drug response and reveals curcumin-driven cancer stem-cell-associated marker enrichment in oral squamous cell carcinoma

Hazar S Alharbi, Ishrat Rahman, Manal A AlSheddi, Hanan Henidi, Manal Mubarak Alkahtani, Zaha Al Makhlafi, Sahar ElRefai, Shams A Altwaim, Hourya Sanat Alnofaie, Hend M Salem, Maha Galal Omar, Alia Alturki, Hiba Talic, Ghada Aladhyani, Fotoon Alotaibi, Hadeel Basuhail, Rasil Alotaibi, Nada Alturki, Aljawhara Alharbi, Rafa Alsultan, Sara Khalid Albassam

World J Stem Cells 18(8):121991. Published online Aug 26, 2026. doi: 10.4252/wjsc.121991

Correspondence

Letter to the Editor: Metabolic reprogramming - unlocking the full potential of stem cell therapy in wound repair

Si-Feng Wang, Xiang-Wen Peng

World J Stem Cells 18(8):118193. Published online Aug 26, 2026. doi: 10.4252/wjsc.118193

Letter to the Editor: Epiregulin-EGFR-ERK1/2 signaling as a therapeutic axis for rescuing mesenchymal stem cell dysfunction in inflammatory periodontal niches

Kruthika Prakash, Kandasamy Nagarajan ArulJothi, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn

World J Stem Cells 18(8):119568. Published online Aug 26, 2026. doi: 10.4252/wjsc.119568

Letter to the Editor: Exosomal circular RNAs from peripheral blood-derived mesenchymal stem cells as diagnostic and subtyping biomarkers in acute mesenteric ischemia

Ramya Lakshmi Rajendran, Atharva A Mahajan, Kandasamy Nagarajan ArulJothi, Sree Naga Sowndary Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn

World J Stem Cells 18(8):120369. Published online Aug 26, 2026. doi: 10.4252/wjsc.120369