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World J Stem Cells. May 26, 2026; 18(5): 115482
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115482
Published online May 26, 2026. doi: 10.4252/wjsc.v18.i5.115482
FOXP1 promotes the proliferation and self-renewal of spermatogonial stem cells via the nuclear factor kappa B pathway
Jin-Hua Wu, Feng Lin, Yan-Hua Wang, Jiang-Ping Xie, Shu-Lin Guo, Pei-Yan Liu, Department of Andrology, Ganzhou People’s Hospital of Jiangxi Province, Ganzhou 341000, Jiangxi Province, China
Author contributions: Wu JH and Liu PY designed the study, supervised the laboratory experiments, conducted the experiments and drafted the manuscript; Lin F, Wang YH, Xie JP, and Guo SL assisted with the experiments and sample collection. All authors read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Ganzhou People’s Hospital of Jiangxi Province (approval No. PJB2025-279-01).
Institutional animal care and use committee statement: The protocol for the animal experiment was reviewed and approved by the Ethics Committee of Fujian Anburui Biotechnology Co., Ltd., for experimental animal welfare (No. IACUC FJABR2024032101).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Corresponding author: Pei-Yan Liu, Department of Andrology, Ganzhou People’s Hospital of Jiangxi Province, No. 17 Hongqi Avenue, Ganzhou 341000, Jiangxi Province, China.
Received: November 7, 2025
Revised: December 25, 2025
Accepted: February 25, 2026
Published online: May 26, 2026
Processing time: 198 Days and 23 Hours
Revised: December 25, 2025
Accepted: February 25, 2026
Published online: May 26, 2026
Processing time: 198 Days and 23 Hours
Core Tip
Core Tip: Spermatogonial stem cells (SSCs) are the basis of spermatogenesis in mammals and can self-renew or differentiate into the various cell types in the germ cell lineage. SSC homeostasis dysregulation is closely associated with male infertility. This study revealed the role of forkhead box P1 in regulating the function of SSCs via the nuclear factor kappa B pathway, thus offering a basis for the diagnosis and treatment of male infertility.