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Contents Volume 17 Issue 3 March 27, 2025

Editorial

Exploring the next frontier in diagnosing spontaneous bacterial peritonitis

Ahmed Tawheed, Mehmet Yalniz, Mubin Ozercan, Ibrahim Halil Bahcecioglu

World J Hepatol 17(3):102044. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.102044

Abstract (417) | Core Tip (440) | Full Article (HTML) (1399) | Tables (1-3) (384) | Full Article (PDF)-399K (170) | Full Article with Cover (PDF)-687K (162) | Full Article (XML)-81K (114) | Audio-116K (39) | Peer-Review Report-229K (87) | Answering Reviewers-41K (92) | Received: 10/07/2024 | Revised: 02/17/2025 | Accepted: 02/25/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (4136) | Similar Articles (27) | Timeline of Article Publication (5) | Authors Evaluation (6) | Cite |

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Non-alcoholic fatty liver disease and drug induced liver injury: A metabolic storm waiting to happen

Vanessa Pamela Salolin Vargas, Marisa Gasbarra, Ernesto Calderon-Martinez, Yash R Shah, Dushyant Singh Dahiya, Mauricio Garcia Saenz de Sicilia

World J Hepatol 17(3):105255. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.105255

Abstract (427) | Core Tip (499) | Full Article (HTML) (1752) | Figures (1-1) (428) | Full Article (PDF)-682K (156) | Full Article with Cover (PDF)-972K (161) | Full Article (XML)-43K (111) | Audio-844K (28) | Peer-Review Report-213K (91) | Answering Reviewers-84K (95) | Received: 01/16/2025 | Revised: 02/23/2025 | Accepted: 03/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4908) | Similar Articles (501) | Timeline of Article Publication (3) | Cite |

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Review

Research progress on the roles of complement in liver injury

Li-Li Ou, Jin-Lian Jiang, Man-Lu Guo, Jin-Hua Wu, Wei-Wei Zhong, Yi-Huai He

World J Hepatol 17(3):103839. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103839

Abstract (434) | Core Tip (475) | Full Article (HTML) (2515) | Tables (1-1) (437) | Full Article (PDF)-474K (150) | Full Article with Cover (PDF)-762K (247) | Full Article (XML)-217K (110) | Audio-2202K (41) | Peer-Review Report-247K (97) | Answering Reviewers-115K (175) | Received: 12/02/2024 | Revised: 01/29/2025 | Accepted: 02/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (5798) | Similar Articles (71) | Timeline of Article Publication (3) | Cite |

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Gut microbiota in the development and progression of chronic liver diseases: Gut microbiota-liver axis

Aysun Yakut

World J Hepatol 17(3):104167. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104167

Abstract (425) | Core Tip (430) | Full Article (HTML) (2721) | Figures (1-2) (418) | Full Article (PDF)-3042K (136) | Full Article with Cover (PDF)-3329K (1032) | Full Article (XML)-291K (109) | Audio-975K (33) | Peer-Review Report-241K (94) | Answering Reviewers-195K (117) | Received: 12/11/2024 | Revised: 01/28/2025 | Accepted: 02/25/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (7299) | Similar Articles (184) | Timeline of Article Publication (0) | Authors Evaluation (1) | Cite |

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Minireviews

Hypochloremia is an underutilised prognostic marker in patients with advanced liver cirrhosis and liver failure

Ramesh Kumar, Sudheer Marrapu, Jinit R Soni

World J Hepatol 17(3):103807. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103807

Abstract (455) | Core Tip (465) | Full Article (HTML) (1714) | Figures (1-1) (435) | Tables (1-2) (443) | Full Article (PDF)-536K (130) | Full Article with Cover (PDF)-825K (123) | Full Article (XML)-106K (107) | Audio-800K (22) | Peer-Review Report-229K (107) | Answering Reviewers-173K (89) | Received: 11/30/2024 | Revised: 02/16/2025 | Accepted: 02/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (5953) | Similar Articles (328) | Timeline of Article Publication (1) | Authors Evaluation (4) | Cite |

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Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression

Jian-Zhong Shu, Yu-Han Huang, Xiao-Hong He, Feng-Ying Liu, Qian-Qian Liang, Xue-Tong Yong, Yong-Fang Xie

World J Hepatol 17(3):103854. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103854

Abstract (448) | Core Tip (400) | Full Article (HTML) (1974) | Figures (1-4) (383) | Tables (1-2) (403) | Full Article (PDF)-4768K (158) | Full Article with Cover (PDF)-5051K (210) | Full Article (XML)-260K (116) | Audio-219K (18) | Peer-Review Report-332K (74) | Answering Reviewers-238K (119) | Received: 12/12/2024 | Revised: 01/17/2025 | Accepted: 02/12/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (5244) | Similar Articles (155) | Timeline of Article Publication (1) | Authors Evaluation (6) | Cite |

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Hepatic cirrhosis and decompensation: Key indicators for predicting mortality risk

Lorenzo Ridola, Jessica Faccioli, Sara Del Cioppo

World J Hepatol 17(3):104580. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104580

Abstract (421) | Core Tip (439) | Full Article (HTML) (2168) | Tables (1-3) (409) | Full Article (PDF)-437K (200) | Full Article with Cover (PDF)-725K (204) | Full Article (XML)-143K (119) | Audio-434K (19) | Peer-Review Report-466K (134) | Answering Reviewers-94K (92) | Received: 12/24/2024 | Revised: 02/28/2025 | Accepted: 03/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (5335) | Similar Articles (145) | Timeline of Article Publication (1) | Authors Evaluation (3) | Cite |

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Progress of research on glucose transporter proteins in hepatocellular carcinoma

Zheng Ruan, Yan Wang, Lei Shi, Xiao-Jun Yang

World J Hepatol 17(3):104715. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104715

Abstract (451) | Core Tip (390) | Full Article (HTML) (2621) | Figures (1-2) (407) | Tables (1-1) (414) | Full Article (PDF)-2137K (161) | Full Article with Cover (PDF)-2424K (154) | Full Article (XML)-217K (113) | Audio-706K (23) | Peer-Review Report-252K (91) | Answering Reviewers-1520K (126) | Received: 12/29/2024 | Revised: 02/02/2025 | Accepted: 02/17/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (6112) | Similar Articles (1880) | Timeline of Article Publication (2) | Authors Evaluation (2) | Cite |

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Retrospective Cohort Study

Establish and validate an artificial neural networks model used for predicting portal vein thrombosis risk in hepatitis B-related cirrhosis patients

Pei-Pei Meng, Fei-Xiang Xiong, Jia-Liang Chen, Yang Zhou, Xiao-Li Liu, Xiao-Min Ji, Yu-Yong Jiang, Yi-Xin Hou

World J Hepatol 17(3):97767. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.97767

Abstract (376) | Core Tip (423) | Full Article (HTML) (989) | Figures (1-5) (352) | Tables (1-4) (359) | Full Article (PDF)-1700K (130) | Full Article with Cover (PDF)-1988K (123) | Full Article (XML)-121K (96) | Audio-322K (51) | Peer-Review Report-212K (89) | Answering Reviewers-179K (96) | Received: 06/07/2024 | Revised: 11/24/2024 | Accepted: 02/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4628) | Similar Articles (78) | Timeline of Article Publication (1) | Authors Evaluation (2) | Cite |

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Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients

Zhi-Bin Wang, Bing Zhu, Ming-Ming Meng, Yi-Fan Wu, Yu Zhang, Dong-Ze Li, Hua Tian, Fu-Chuan Wang, Yi-Fan Lv, Qiu-Xia Ye, Fu-Quan Liu

World J Hepatol 17(3):103261. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103261

Abstract (411) | Core Tip (415) | Full Article (HTML) (1104) | Figures (1-6) (358) | Tables (1-6) (332) | Full Article (PDF)-2779K (125) | Full Article with Cover (PDF)-3066K (134) | Full Article (XML)-137K (101) | Audio-1319K (17) | Peer-Review Report-237K (92) | Answering Reviewers-105K (89) | Supplementary Material-177K (78) | Received: 11/13/2024 | Revised: 02/01/2025 | Accepted: 03/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4852) | Similar Articles (218) | Timeline of Article Publication (1) | Authors Evaluation (2) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Retrospective Study

Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference

Thierry Poynard, Karina Noskova, Sergey Khomeriki, Elena Vinnitskaya, Oksana Duroselle, Olivier Deckmyn, Yuliya Sandler, Valentina Peta

World J Hepatol 17(3):104534. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104534

Abstract (420) | Core Tip (387) | Full Article (HTML) (1242) | Figures (1-2) (387) | Tables (1-4) (385) | Full Article (PDF)-1322K (121) | Full Article with Cover (PDF)-1606K (230) | Full Article (XML)-156K (126) | Audio-665K (18) | Peer-Review Report-221K (88) | Answering Reviewers-336K (95) | Supplementary Material-182K (79) | Received: 12/23/2024 | Revised: 02/23/2025 | Accepted: 03/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (5335) | Similar Articles (168) | Timeline of Article Publication (1) | Cite |

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Observational Study

Patterns of dietary supplement use among United States patients with steatotic liver disease: Vitamins, minerals and botanicals

Melinda Wang, Gabrielle Jutras, Giuseppe Cullaro, Anand Dhruva, Jennifer C Lai

World J Hepatol 17(3):103537. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103537

Abstract (415) | Core Tip (430) | Full Article (HTML) (1167) | Tables (1-4) (364) | Full Article (PDF)-424K (155) | Full Article with Cover (PDF)-711K (102) | Full Article (XML)-92K (104) | Audio-639K (9) | Peer-Review Report-254K (78) | Answering Reviewers-78K (89) | Received: 11/21/2024 | Revised: 12/26/2024 | Accepted: 01/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4349) | Similar Articles (14) | Timeline of Article Publication (1) | Cite |

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Basic Study

Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats

Chao Ren, Li Cha, Shu-Yue Huang, Guo-Hui Bai, Jin-Hui Li, Xin Xiong, Yu-Xing Feng, Dui-Ping Feng, Long Gao, Jin-Yu Li

World J Hepatol 17(3):101340. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.101340

Abstract (351) | Core Tip (373) | Full Article (HTML) (1226) | Figures (1-7) (378) | Full Article (PDF)-7694K (141) | Full Article with Cover (PDF)-7982K (140) | Full Article (XML)-98K (105) | Audio-3266K (27) | Peer-Review Report-174K (89) | Answering Reviewers-92K (80) | Received: 09/12/2024 | Revised: 01/19/2025 | Accepted: 02/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (4) | Total Visits (5355) | Similar Articles (237) | Timeline of Article Publication (2) | Cite |

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Yinchenhao decoction alleviates obstructive jaundice liver injury by modulating epidermal growth factor receptor and constitutive androstane receptor signaling

Jun-Jian Liu, Han-Wei Mei, Yan-Yan Jing, Zhong-Lian Li, Su-Guo Wu, Hong-Xia Yuan, Xi-Bo Zhang

World J Hepatol 17(3):101724. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.101724

Abstract (406) | Core Tip (396) | Full Article (HTML) (1450) | Figures (1-7) (349) | Tables (1-2) (337) | Full Article (PDF)-24136K (181) | Full Article with Cover (PDF)-24424K (139) | Full Article (XML)-137K (115) | Audio-312K (39) | Peer-Review Report-240K (110) | Answering Reviewers-95K (123) | Received: 09/24/2024 | Revised: 01/18/2025 | Accepted: 03/04/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (5123) | Similar Articles (58) | Timeline of Article Publication (13) | Cite |

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Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice

Chong Zhang, Jun-Fei Jin, Chun-Mei Li, Qing Li, Tian Sun, Jia-Lin Shi

World J Hepatol 17(3):104520. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104520

Abstract (374) | Core Tip (458) | Full Article (HTML) (1303) | Figures (1-6) (328) | Full Article (PDF)-8887K (141) | Full Article with Cover (PDF)-9175K (118) | Full Article (XML)-85K (109) | Audio-696K (16) | Peer-Review Report-231K (88) | Answering Reviewers-60K (102) | Received: 12/23/2024 | Revised: 02/24/2025 | Accepted: 03/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (4584) | Similar Articles (121) | Timeline of Article Publication (2) | Authors Evaluation (2) | Cite |

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Systematic Reviews

Metabolic dysfunction-associated steatotic liver disease and omega-6 polyunsaturated fatty acids: Friends or foes

Mona A Hegazy, Safaa M Ahmed, Shaimaa M Sultan, Osama F Afifi, Manal A Mohamed, Alshimaa E Azab, Mohamed A Hassanen, Rakan K Zaben

World J Hepatol 17(3):102286. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.102286

Abstract (392) | Core Tip (434) | Full Article (HTML) (2560) | Figures (1-3) (367) | Tables (1-2) (563) | Full Article (PDF)-1219K (148) | Full Article with Cover (PDF)-1507K (171) | Full Article (XML)-136K (101) | Audio-1020K (16) | Peer-Review Report-294K (85) | Answering Reviewers-120K (92) | Received: 10/13/2024 | Revised: 02/20/2025 | Accepted: 03/05/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (6) | Total Visits (6120) | Similar Articles (100) | Timeline of Article Publication (1) | Authors Evaluation (2) | Cite |

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Scientometrics

Global trends in artificial intelligence applications in liver disease over seventeen years

Xue-Qin Zhou, Shu Huang, Xia-Min Shi, Sha Liu, Wei Zhang, Lei Shi, Mu-Han Lv, Xiao-Wei Tang

World J Hepatol 17(3):101721. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.101721

Abstract (449) | Core Tip (433) | Full Article (HTML) (1413) | Figures (1-8) (351) | Tables (1-6) (392) | Full Article (PDF)-32161K (187) | Full Article with Cover (PDF)-32447K (260) | Full Article (XML)-146K (114) | Audio-2018K (13) | Peer-Review Report-201K (105) | Answering Reviewers-324K (104) | Received: 09/24/2024 | Revised: 01/01/2025 | Accepted: 02/10/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (5518) | Similar Articles (393) | Timeline of Article Publication (2) | Authors Evaluation (4) | Cite |

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Immune cells in metabolic associated fatty liver disease: Global trends and hotspots (2004-2024)

Wen-Ying Qi, Shi-Hao Zheng, Si-Ze Li, Wei Wang, Qiu-Yue Wang, Qi-Yao Liu, Xiao-Ke Li, Jia-Xin Zhang, Da-Nan Gan, Yong-An Ye, Xiao-Bin Zao

World J Hepatol 17(3):103327. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103327

Abstract (354) | Core Tip (390) | Full Article (HTML) (1411) | Figures (1-8) (398) | Full Article (PDF)-37780K (122) | Full Article with Cover (PDF)-38067K (142) | Full Article (XML)-127K (108) | Audio-798K (9) | Peer-Review Report-360K (83) | Answering Reviewers-382K (81) | Received: 11/15/2024 | Revised: 02/07/2025 | Accepted: 03/05/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (5414) | Similar Articles (12) | Timeline of Article Publication (3) | Cite |

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Letter to the Editor

Smartphone-based Stroop Test, EncephalApp: What is the optimal cutoff for diagnosing minimal hepatic encephalopathy?

Ryota Masuzaki, Hirofumi Kogure

World J Hepatol 17(3):101649. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.101649

Abstract (469) | Core Tip (436) | Full Article (HTML) (1170) | Full Article (PDF)-372K (106) | Full Article with Cover (PDF)-660K (157) | Full Article (XML)-49K (90) | Audio-201K (13) | Peer-Review Report-257K (72) | Answering Reviewers-43K (80) | Received: 09/22/2024 | Revised: 02/04/2025 | Accepted: 02/13/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (3699) | Similar Articles (0) | Timeline of Article Publication (0) | Cite |

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Role of autoimmune phenomena in nonalcoholic fatty liver disease: Insights and limitations

Arunkumar Krishnan, Diptasree Mukherjee

World J Hepatol 17(3):103835. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103835

Abstract (355) | Core Tip (369) | Full Article (HTML) (851) | Full Article (PDF)-351K (110) | Full Article with Cover (PDF)-639K (116) | Full Article (XML)-40K (101) | Audio-1277K (20) | Peer-Review Report-298K (74) | Answering Reviewers-69K (150) | Received: 12/01/2024 | Revised: 02/21/2025 | Accepted: 03/05/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (3134) | Similar Articles (631) | Timeline of Article Publication (0) | Cite |

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Association of cardiovascular health metrics and metabolic associated fatty liver disease: Methodological limitations, and future directions

Arunkumar Krishnan, Diptasree Mukherjee

World J Hepatol 17(3):105635. Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.105635

Abstract (344) | Core Tip (390) | Full Article (HTML) (1086) | Full Article (PDF)-364K (95) | Full Article with Cover (PDF)-653K (145) | Full Article (XML)-68K (91) | Audio-249K (18) | Peer-Review Report-246K (83) | Answering Reviewers-84K (86) | Received: 01/31/2025 | Revised: 02/21/2025 | Accepted: 02/27/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (4188) | Similar Articles (16) | Timeline of Article Publication (0) | Cite |

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