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©The Author(s) 2025.
World J Hepatol. Mar 27, 2025; 17(3): 103261
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103261
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103261
Table 1 Univariate and multivariate Cox regression analyses for recurrent variceal bleeding before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Group B | 0.546 | 0.366-0.815 | 0.003b | 0.623 | 0.387-1.004 | 0.052 | 0.520 | 0.330-0.818 | 0.005b | 0.520 | 0.330-0.818 | 0.005b |
Kalium | 0.305 | 0.120-0.774 | 0.012a | 0.305 | 0.119-0.783 | 0.014a | ||||||
Cancer antigen 153 | 0.691 | 0.493-0.968 | 0.032a | 0.713 | 0.500-1.016 | 0.061 | ||||||
Creatinine | 1.952 | 1.123-3.394 | 0.018a | 1.679 | 0.943-2.990 | 0.078 | ||||||
Pre-TIPS inferior vena cava pressure | 1.629 | 1.010-2.628 | 0.046a | 1.556 | 0.950-2.547 | 0.079 | ||||||
Pre-TIPS Child-Turcotte-Pugh score | 2.513 | 1.095-5.766 | 0.030a | 1.983 | 0.841-4.679 | 0.118 | ||||||
Portal vein diameter | 2.487 | 1.216-5.084 | 0.013a | 1.279 | 0.548-2.984 | 0.569 | ||||||
Alkaline phosphatase | 0.680 | 0.460-1.006 | 0.054 | |||||||||
Alanine aminotransferase | 0.774 | 0.563-1.065 | 0.116 |
Table 2 Univariate and multivariate Cox regression analyses for shunt dysfunction before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Group B | 0.372 | 0.233-0.594 | < 0.001b | 0.452 | 0.261-0.783 | 0.005b | 0.482 | 0.297-0.783 | 0.003b | 0.496 | 0.305-0.807 | 0.005b |
Alkaline phosphatase | 0.538 | 0.349-0.830 | 0.005b | 0.545 | 0.350-0.849 | 0.007b | 0.615 | 0.394-0.958 | 0.031a | 0.64 | 0.411-0.998 | 0.049a |
Kalium | 0.338 | 0.117-0.974 | 0.045a | 0.302 | 0.099-0.922 | 0.035a | ||||||
Portal vein diameter | 4.075 | 1.885-8.808 | < 0.001b | 1.663 | 0.656-4.214 | 0.284 | ||||||
C-Reactive protein | 0.926 | 0.854-1.004 | 0.062 | |||||||||
Serum urea nitrogen | 0.69 | 0.422-1.128 | 0.139 | |||||||||
Right hepatic vein free pressure | 1.535 | 0.846-2.786 | 0.159 | |||||||||
Natrium | 0.699 | 0.412-1.187 | 0.185 | |||||||||
Age | 1.549 | 0.671-3.577 | 0.305 |
Table 3 Univariate and multivariate Cox regression analyses for hepatic encephalopathy before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Portal vein diameter | 0.309 | 0.193-0.494 | < 0.001b | 0.309 | 0.193-0.494 | < 0.001b | 0.299 | 0.179-0.500 | < 0.001b | 0.372 | 0.204-0.676 | 0.001b |
Group B | 1.672 | 1.260-2.219 | < 0.001b | 1.263 | 0.909-1.755 | 0.163 |
Table 4 Univariate and multivariate Cox regression analyses for hepatocellular carcinoma before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Group B | 0.332 | 0.154-0.713 | 0.005b | 0.37 | 0.171-0.800 | 0.012a | 0.346 | 0.149-0.802 | 0.013a | 0.374 | 0.160-0.874 | 0.023a |
Creatinine | 3.098 | 1.406-6.828 | 0.005b | 2.144 | 0.868-5.297 | 0.098 | 3.091 | 1.434-6.662 | 0.004b | 3.253 | 1.442-7.340 | 0.004b |
Prothrombin time activity | 0.593 | 0.293-1.201 | 0.147 | 0.178 | 0.039-0.813 | 0.026a | 0.128 | 0.026-0.623 | 0.011a | |||
Pre-TIPS MELD score | 58.775 | 1.249-2766.772 | 0.038a | 13.367 | 0.160-1115.608 | 0.251 | ||||||
Female | 0.422 | 0.163-1.093 | 0.075 | |||||||||
Alanine aminotransferase | 0.63 | 0.377-1.053 | 0.078 | |||||||||
Pre-TIPS inferior vena cava pressure | 0.579 | 0.281-1.193 | 0.139 | |||||||||
White blood cell count | 0.635 | 0.337-1.194 | 0.159 | |||||||||
Chlorine | 26.688 | 0.261-2726.917 | 0.164 | |||||||||
Blood ammonia | 0.737 | 0.390-1.393 | 0.348 | |||||||||
C-reactive protein | 1.058 | 0.931-1.203 | 0.387 | |||||||||
Hemoglobin | 1.59 | 0.402-6.288 | 0.508 |
Table 5 Univariate and multivariate Cox regression analyses for liver failure before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Group B | 2.166 | 1.288-3.643 | 0.004b | 2.523 | 1.486-4.283 | 0.001b | 2.238 | 1.284-3.901 | 0.005b | 2.241 | 1.276-3.937 | 0.005b |
Creatinine | 2.802 | 1.536-5.110 | 0.001b | 3.096 | 1.702-5.630 | < 0.001b | 2.529 | 1.287-4.970 | 0.007b | 3.12 | 1.500-6.486 | 0.002b |
Right hepatic venous wedge pressure | 2.614 | 1.223-5.586 | 0.013a | 2.643 | 1.229-5.680 | 0.013a | 1.941 | 0.858-4.392 | 0.112 | |||
Alanine aminotransferase | 1.45 | 0.979-2.146 | 0.064 | 1.683 | 1.091-2.598 | 0.019a | 1.541 | 1.003-2.366 | 0.048a | |||
Cancer antigen 153 | 0.727 | 0.484-1.092 | 0.124 | 0.814 | 0.511-1.299 | 0.389 | ||||||
Platelet count | 1.265 | 0.893-1.794 | 0.186 | 1.261 | 0.855-1.859 | 0.242 | ||||||
Carcinoembryonic antigen | 0.877 | 0.639-1.202 | 0.414 | 0.852 | 0.597-1.218 | 0.38 | ||||||
C-Reactive protein | 1.166 | 1.049-1.296 | 0.004b | 1.138 | 1.022-1.267 | 0.019a | ||||||
Alkaline phosphatase | 1.461 | 0.909-2.348 | 0.117 | |||||||||
Pre-TIPS right atrial pressure | 1.595 | 0.882-2.884 | 0.123 | |||||||||
International normalized ratio | 0.283 | 0.044-1.845 | 0.187 | |||||||||
Blood ammonia | 0.704 | 0.440-1.129 | 0.145 | |||||||||
Pre-TIPS MELD score | 0.6 | 0.024-14.884 | 0.755 | |||||||||
Activated partial thromboplastin time | 2.952 | 0.880-9.905 | 0.08 | |||||||||
Hemoglobin | 2.551 | 0.903-7.205 | 0.077 |
Table 6 Univariate and multivariate Cox regression analyses for mortality before and after propensity score matching
Characteristics | Before PSM, univariate analyses (n = 815) | Before PSM, multivariate analyses (n = 815) | After PSM, univariate analyses (n = 662) | After PSM, univariate analyses (n = 662) | ||||||||
HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | HR | 95%CI | P | |
Group B | 0.491 | 0.301-0.801 | 0.004b | 0.507 | 0.309-0.832 | 0.007b | 0.549 | 0.323-0.933 | 0.027a | 0.550 | 0.322-0.940 | 0.029a |
C-reactive protein | 1.217 | 1.104-1.342 | < 0.001b | 1.218 | 1.103-1.344 | < 0.001b | 1.213 | 1.095-1.344 | < 0.001b | 1.213 | 1.094-1.345 | < 0.001b |
Creatinine | 2.974 | 1.687-5.243 | < 0.001b | 2.652 | 1.419-4.956 | 0.002b | 2.548 | 1.375-4.721 | 0.003b | 2.349 | 1.198-4.606 | 0.013a |
Right hepatic venous wedge pressure | 2.514 | 1.187-5.322 | 0.016a | 1.819 | 0.845-3.916 | 0.126 | 2.194 | 1.008-4.772 | 0.048a | 1.687 | 0.759-3.749 | 0.199 |
Glutamyl transferase | 1.231 | 0.961-1.577 | 0.100 | 1.297 | 0.999-1.683 | 0.051 | ||||||
Portal vein diameter | 0.642 | 0.271-1.521 | 0.314 | 0.488 | 0.196-1.214 | 0.123 |
- Citation: Wang ZB, Zhu B, Meng MM, Wu YF, Zhang Y, Li DZ, Tian H, Wang FC, Lv YF, Ye QX, Liu FQ. Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients. World J Hepatol 2025; 17(3): 103261
- URL: https://www.wjgnet.com/1948-5182/full/v17/i3/103261.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i3.103261