Progress of research on glucose transporter proteins in hepatocellular carcinoma

doi:10.4254/wjh.v17.i3.104715

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World Journal of Hepatology

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1948-5182

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World J Hepatol. Mar 27, 2025; 17(3): 104715
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104715

Progress of research on glucose transporter proteins in hepatocellular carcinoma

Zheng Ruan, Yan Wang, Lei Shi, Xiao-Jun Yang

Zheng Ruan, The First Clinical Medical School, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China

Yan Wang, Division of Personnel, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China

Lei Shi, Department of General Surgery, The Second people’s Hospital of Lanzhou, Lanzhou 730000, Gansu Province, China

Xiao-Jun Yang, Department of General Surgery, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China

Co-first authors: Zheng Ruan and Yan Wang.

Author contributions: Ruan Z, Wang Y, and Lei S have been involved equally and have read and approved the final manuscript; Yang XJ verify the validity of the results reported.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Xiao-Jun Yang, Professor, Department of General Surgery, Gansu Provincial People’s Hospital, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. yangxjmd@aliyun.com

Received: December 29, 2024
Revised: February 2, 2025
Accepted: February 17, 2025
Published online: March 27, 2025
Processing time: 86 Days and 17 Hours

Core Tip

Core Tip: Hepatocellular carcinoma (HCC), a predominant liver cancer subtype, exhibits a high mortality rate mainly due to difficulties in early detection and rapid disease advancement. Glucose transporter proteins, essential for glucose uptake, significantly influence HCC progression and are pivotal in glucose metabolism and tumor development.