Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Mar 27, 2025; 17(3): 104534
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104534
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104534
Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference
Valentina Peta, Olivier Deckmyn, Oksana Duroselle, Thierry Poynard, BioPredictive, Paris 75007, France
Yuliya Sandler, Elena Vinnitskaya, Department of Hepatology, Center for Diagnostics and Treatment of Liver Diseases, Moscow Clinical Scientific and Practical Center, Moscow 111123, Russia
Sergey Khomeriki, Laboratory of Pathomorphology, Moscow Clinical Scientific and Practical Center, Moscow 111123, Russia
Karina Noskova, Clinical Diagnostic Laboratory, Moscow Clinical Scientific and Practical Center, Moscow 111123, Russia
Thierry Poynard, Sorbonne Université, INSERM Centre de Recherche Saint-Antoine, Paris 75012, France
Co-first authors: Valentina Peta and Yuliya Sandler.
Author contributions: Peta V and Sandler Y designed the study and interpreted the data; They contributed equally to this article, and they are the co-first authors of this manuscript; Peta V, Sandler Y, and Poynard T wrote the manuscript; Peta V, Poynard T, and Deckmyn O analyzed the data; Sandler Y, Duroselle O, Vinnitskaya E, Khomeriki S, and Noskova K acquired the data; All authors critically reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Moscow Clinical Scientific Center, approval No. АААА-А18-118021590195-4 at www.rosrid.ru.
Informed consent statement: All study participants provided informed written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Thierry Poynard, Professor Emerita, Sorbonne Université, INSERM Centre de Recherche Saint-Antoine, 27 rue de Chaligny, Paris 75012, France.
Received: December 24, 2024
Revised: February 23, 2025
Accepted: March 6, 2025
Published online: March 27, 2025
Processing time: 92 Days and 19.6 Hours
Revised: February 23, 2025
Accepted: March 6, 2025
Published online: March 27, 2025
Processing time: 92 Days and 19.6 Hours
Core Tip
Core Tip: Our study investigated the efficacy of noninvasive tests in assessing liver fibrosis in autoimmune hepatitis (AIH). Using the Obuchowski measure, we found that FibroTest and vibration-controlled transient elastography outperformed the fibrosis-4 index in the detection of liver fibrosis. FibroTest showed promising results in AIH. ActiTest demonstrated superior performance in the estimation of inflammatory activity compared to alanine aminotransferase and IgG levels. The Bayesian latent class model confirmed the robustness of these noninvasive tests, highlighting their potential to complement liver biopsy in AIH management, particularly during follow-up when repeated biopsies are impractical.