Hypochloremia is an underutilised prognostic marker in patients with advanced liver cirrhosis and liver failure

Core Tip

Core Tip: Patients with advanced liver cirrhosis and liver failure frequently experience abnormalities in their serum electrolyte levels. Emerging evidence suggests that serum chloride may provide prognostic information in such patients. Hypochloremia has been associated with higher mortality, worsened liver dysfunction, and a greater need for vasopressors and renal replacement therapy. Despite its prognostic significance, serum chloride is often overshadowed by other electrolytes. Notwithstanding the limited available evidence, we believe that serum chloride is an underutilised prognostic marker in clinical practice. Thus, this article aims to elucidate the prognostic significance of lower serum chloride levels in patients with advanced liver disease.