Review
Copyright ©The Author(s) 2025.
World J Hepatol. Mar 27, 2025; 17(3): 104167
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.104167
Figure 1
Figure 1 Diagrammatic illustration of the role the gut microbiota plays in the onset of non-alcoholic fatty liver disease. The gut-liver axis components are operating normally in the left panel. In the right panel, non-alcoholic fatty liver disease (NAFLD) is shown. The translocation of certain bacterial products into the portal vein is facilitated by the dysbiotic microbiota and the altered intestinal barrier brought on by tight junction dysfunction. These bacterial products cause inflammation and the development of NAFLD by interacting with toll-like receptors on the surface of the liver cells. TMA: Trimethylamine; SCF: Short-chain fatty acid; BA: Bile acid; LPS: Lipopolysaccharide; TLR: Toll-like receptor. Citation: Joon A, Sharma A, Jalandra R, Bayal N, Dhar R, Karmakar S. Nonalcoholic Fatty Liver Disease and Gut-liver Axis: Role of Intestinal Microbiota and Therapeutic Mechanisms. J Transl Gastroenterol 2024; 2: 38-51. Copyright © 2024 Author(s). Xia & He Publishing Inc[55].
Figure 2
Figure 2 The bile acid 3-succinylated cholic acid, which is produced from microorganisms, is identified via a click chemistry approach. The production of 3-succinylated cholic acid (3-sucCA) is mediated by Bacteroides uniformis-expressed bile acid acyl synthetase for succinyl. In patients with metabolic dysfunction-associated fatty liver disease, 3-sucCA has a negative correlation with liver damage 3-sucCA reduces metabolic dysfunction-associated steatohepatitis in mice by encouraging the growth of Akkermansia muciniphila. 3-sucCA: 3-succinylated cholic acid; BAS-suc: Bile acid acyl synthetase for succinyl; MAFLD: Metabolic dysfunction-associated fatty liver disease; MASH: Metabolic dysfunction-associated steatohepatitis. Citation: Nie Q, Luo X, Wang K, Ding Y, Jia S, Zhao Q, Li M, Zhang J, Zhuo Y, Lin J, Guo C, Zhang Z, Liu H, Zeng G, You J, Sun L, Lu H, Ma M, Jia Y, Zheng MH, Pang Y, Qiao J, Jiang C. Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell 2024; 187: 2717-2734.e33. Copyright © 2024 The Authors. Published by Elsevier Inc.