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Contents Volume 15 Issue 2 June 20, 2025

Editorial

Matrix metalloproteinases and their tissue inhibitors as indicators of aortic aneurysm and dissection development in extracellular matrix remodeling

Marc Irqsusi, Fiona R Rodepeter, Madeline Günther, Andreas Kirschbaum, Sebastian Vogt

World J Exp Med 15(2):100166. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100166

Abstract (567) | Core Tip (575) | Full Article (HTML) (1550) | Figures (1-4) (406) | Full Article (PDF)-7428K (221) | Full Article with Cover (PDF)-7713K (124) | Full Article (XML)-112K (95) | Audio-1012K (18) | Peer-Review Report-223K (77) | Answering Reviewers-466K (121) | Received: 08/08/2024 | Revised: 01/04/2025 | Accepted: 01/15/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (4905) | Similar Articles (10) | Timeline of Article Publication (5) | Authors Evaluation (5) | Article Quality Tracking (0) | Cite |

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Opinion Review

Biomarkers for tracking metabolic changes pre-post nutritional epigenetics diet/intervention to prevent autism and attention deficit/hyperactivity disorders in children

Renee J Dufault

World J Exp Med 15(2):101555. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.101555

Abstract (511) | Core Tip (503) | Full Article (HTML) (4134) | Figures (1-2) (431) | Tables (1-2) (415) | Full Article (PDF)-1155K (236) | Full Article with Cover (PDF)-1441K (185) | Full Article (XML)-171K (87) | Audio-12065K (14) | Peer-Review Report-271K (92) | Answering Reviewers-72K (100) | Received: 09/19/2024 | Revised: 01/20/2025 | Accepted: 02/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (7634) | Similar Articles (20) | Timeline of Article Publication (3) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Review

Dynamics of inflammatory signals within the tumor microenvironment

Hala Issa, Lokjan Singh, Kok-Song Lai, Tina Parusheva-Borsitzky, Shamshul Ansari

World J Exp Med 15(2):102285. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102285

Abstract (610) | Core Tip (556) | Full Article (HTML) (2550) | Figures (1-3) (399) | Tables (1-2) (365) | Full Article (PDF)-14128K (198) | Full Article with Cover (PDF)-14412K (156) | Full Article (XML)-269K (83) | Audio-1031K (22) | Peer-Review Report-247K (83) | Answering Reviewers-32K (90) | Received: 10/13/2024 | Revised: 12/31/2024 | Accepted: 01/11/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (9) | Total Visits (6161) | Similar Articles (21) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions

Naveen Jeyaraman, Madhan Jeyaraman, Priya Dhanpal, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu, Gabriel Silva Santos, Lucas Furtado da Fonseca, José Fábio Lana

World J Exp Med 15(2):102969. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102969

Abstract (561) | Core Tip (546) | Full Article (HTML) (2643) | Figures (1-3) (392) | Tables (1-2) (395) | Full Article (PDF)-1781K (209) | Full Article with Cover (PDF)-2064K (191) | Full Article (XML)-183K (100) | Audio-47K (25) | Peer-Review Report-232K (81) | Answering Reviewers-57K (84) | Received: 11/03/2024 | Revised: 03/03/2025 | Accepted: 04/01/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (7188) | Similar Articles (43) | Timeline of Article Publication (3) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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Immunomodulatory effect of allium sativum in type 2 diabetes mellitus

Elva Manuela Mejía Delgado, Juan Eduardo Quiroz-Aldave, María del Carmen Durand-Vásquez, Lea Noemí Aldave-Pita, Jenyfer María Fuentes-Mendoza, Luis Alberto Concepción-Urteaga, José Paz-Ibarra, Marcio José Concepción-Zavaleta

World J Exp Med 15(2):103481. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.103481

Abstract (514) | Core Tip (601) | Full Article (HTML) (3507) | Figures (1-1) (405) | Tables (1-1) (407) | Full Article (PDF)-8996K (227) | Full Article with Cover (PDF)-9280K (180) | Full Article (XML)-215K (90) | Audio-206K (28) | Peer-Review Report-317K (93) | Answering Reviewers-48K (88) | Received: 11/20/2024 | Revised: 03/10/2025 | Accepted: 03/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (8012) | Similar Articles (149) | Timeline of Article Publication (5) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

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Minireviews

Weak D phenotype in transfusion medicine and obstetrics: Challenges and opportunities

Prasanna Bharathi Sainath, Velmurugan Ramaiyan

World J Exp Med 15(2):102345. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102345

Abstract (527) | Core Tip (533) | Full Article (HTML) (3607) | Figures (1-1) (395) | Tables (1-2) (430) | Full Article (PDF)-1017K (257) | Full Article with Cover (PDF)-1303K (159) | Full Article (XML)-139K (88) | Audio-797K (9) | Peer-Review Report-322K (99) | Answering Reviewers-113K (88) | Received: 10/15/2024 | Revised: 03/04/2025 | Accepted: 04/03/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (7189) | Similar Articles (12) | Timeline of Article Publication (4) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

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Hepatitis B virus genotype distribution and mutation patterns: Insights and clinical implications for hepatitis B virus positive patients

Manisha M Ratnaparkhi, Chanda R Vyawahare, Nageswari R Gandham

World J Exp Med 15(2):102395. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102395

Abstract (562) | Core Tip (566) | Full Article (HTML) (3372) | Figures (1-1) (389) | Tables (1-2) (433) | Full Article (PDF)-1546K (216) | Full Article with Cover (PDF)-1829K (127) | Full Article (XML)-115K (99) | Audio-1250K (35) | Peer-Review Report-477K (101) | Answering Reviewers-94K (96) | Received: 10/16/2024 | Revised: 01/05/2025 | Accepted: 01/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (7011) | Similar Articles (17) | Timeline of Article Publication (11) | Authors Evaluation (5) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma

Felipe Martins Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Nelly Molina-Frechero, Sandra Lopez-Verdin, Marcelo Gómez Palacio-Gastélum, Miguel Arocena, Sven Niklander, Estefania Sicco, Ronell Bologna-Molina

World J Exp Med 15(2):102175. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102175

Abstract (585) | Core Tip (548) | Full Article (HTML) (1341) | Figures (1-3) (434) | Tables (1-1) (415) | Full Article (PDF)-19318K (148) | Full Article with Cover (PDF)-19603K (113) | Full Article (XML)-112K (82) | Audio-248K (6) | Peer-Review Report-253K (76) | Answering Reviewers-224K (72) | Received: 10/10/2024 | Revised: 02/02/2025 | Accepted: 02/28/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (6138) | Similar Articles (11) | Timeline of Article Publication (4) | Article Quality Tracking (0) | Cite |

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Clinical Trials Study

Evaluation of the clinical efficacy of green tea extract gel as local drug delivery for periodontitis

Santhiya Rengaraj, Sri Sivashankari Thilagar, Pradeep Kumar Yadalam, Priyanka Pampani, Ebenezer Mani, Carlos M Ardila

World J Exp Med 15(2):105636. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.105636

Abstract (528) | Core Tip (547) | Full Article (HTML) (2735) | Figures (1-3) (389) | Tables (1-3) (426) | Full Article (PDF)-3742K (215) | Full Article with Cover (PDF)-4024K (140) | Full Article (XML)-93K (81) | Audio-329K (29) | Peer-Review Report-306K (84) | Answering Reviewers-372K (87) | Received: 01/30/2025 | Revised: 03/03/2025 | Accepted: 03/14/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (6984) | Similar Articles (26) | Timeline of Article Publication (7) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Observational Study

Evaluating fever of unknown origin definitions in a tertiary care setting: Implications for diagnostic criteria revision

Pathik Dhangar, Prasan Kumar Panda, Ravi Kant, Rohit Gupta, Ruchi Dua, Ashutosh Tiwari, Sandeep Saini, Kavita Khoiwal, Yogesh Bahurupi

World J Exp Med 15(2):101388. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.101388

Abstract (499) | Core Tip (496) | Full Article (HTML) (2055) | Figures (1-1) (351) | Tables (1-3) (347) | Full Article (PDF)-498K (149) | Full Article with Cover (PDF)-785K (110) | Full Article (XML)-49K (81) | Audio-1290K (13) | Peer-Review Report-198K (68) | Answering Reviewers-220K (76) | Received: 09/13/2024 | Revised: 11/28/2024 | Accepted: 12/23/2024 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (5654) | Similar Articles (79) | Timeline of Article Publication (3) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Environmental mineral density and thyroid malignancy: A multicenter cross-sectional study

John Bukasa-Kakamba, Ayrton I Bangolo, Shruti Wadhwani, Pascal Bayauli, Nikita Wadhwani, Vignesh K Nagesh, Maria J Mou, Princejeet S Chahal, Branly Mbunga, Sindhuja Chindam, Taieba Mushfiq, Abhishek Thapa, Nidhi L Rao, Isis Kapinga Kalambayi, Rahul Y Rajesh, Ipek B Sarioguz, Vishal KR Thoomkuntla, Shamsul Arefin, Navneet Kaur, Manasse Bukasa Mutombo, Satyajeet Singh, Natalia Muto, Surya Vamsi, Pujita Mallampalli, Aliocha Natuhoyila Nkodila, Simcha Weissman, Jean-René M'Buyamba-Kabangu

World J Exp Med 15(2):103371. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.103371

Abstract (574) | Core Tip (532) | Full Article (HTML) (1480) | Tables (1-7) (390) | Full Article (PDF)-441K (146) | Full Article with Cover (PDF)-727K (98) | Full Article (XML)-132K (85) | Audio-401K (15) | Peer-Review Report-446K (87) | Answering Reviewers-111K (99) | Received: 11/17/2024 | Revised: 12/29/2024 | Accepted: 01/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (4944) | Similar Articles (20) | Timeline of Article Publication (2) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

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Basic Study

Platelet rich plasma, adipose tissue micrografts, and regenerative mimetic factors for abdominal wall defect reconstruction: Experimental study protocol

Konstantinos Zapsalis, Orestis Ioannidis, Christos Xylas, Konstantinos Siozos, Georgios Gemousakakis, Elissavet Anestiadou, Savvas Symeonidis, Stefanos Bitsianis, Efstathios Kotidis, Angeliki Cheva, Chryssa Bekiari, Antonia Loukousia, Konstantinos Angelopoulos, Manousos-Georgios Pramateftakis, Ioannis Mantzoros, Freiderikos Tserkezidis, Barbara Driagka, Stamatios Angelopoulos

World J Exp Med 15(2):99065. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.99065

Abstract (544) | Core Tip (550) | Full Article (HTML) (1427) | Figures (1-3) (416) | Full Article (PDF)-12523K (138) | Full Article with Cover (PDF)-12809K (116) | Full Article (XML)-74K (84) | Audio-1736K (10) | Peer-Review Report-221K (81) | Answering Reviewers-54K (90) | Received: 07/12/2024 | Revised: 11/17/2024 | Accepted: 12/12/2024 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (4834) | Similar Articles (6) | Timeline of Article Publication (3) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Establishment and characterization of a new human gallbladder cancer cell line, OCUG-2

Qiang Wang, Canfeng Fan, Gen Tsujio, Takashi Sakuma, Koji Maruo, Yurie Yamamoto, Daiki Imanishi, Kyoka Kawabata, Hinano Nishikubo, Saki Kanei, Rika Aoyama, Syuhei Kushiyama, Masaichi Ohira, Masakazu Yashiro

World J Exp Med 15(2):100443. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100443

Abstract (530) | Core Tip (581) | Full Article (HTML) (1118) | Figures (1-5) (393) | Tables (1-4) (385) | Full Article (PDF)-85637K (160) | Full Article with Cover (PDF)-85922K (121) | Full Article (XML)-92K (84) | Audio-736K (9) | Peer-Review Report-230K (76) | Answering Reviewers-107K (82) | Supplementary Material-122K (76) | Received: 08/16/2024 | Revised: 11/19/2024 | Accepted: 01/07/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (5088) | Similar Articles (60) | Timeline of Article Publication (3) | Article Quality Tracking (0) | Cite |

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miRNA dysregulation in Duchenne muscular dystrophy comorbidities

Subhashree Sivakumar, Archana Rajavel, Venkataraman Viswanathan, Evangeline Ann Daniel, Prakash Gangadaran, Raja Natesan Sella

World J Exp Med 15(2):100548. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100548

Abstract (509) | Core Tip (560) | Full Article (HTML) (1968) | Figures (1-4) (415) | Tables (1-1) (397) | Full Article (PDF)-26654K (159) | Full Article with Cover (PDF)-26940K (129) | Full Article (XML)-70K (76) | Audio-367K (10) | Peer-Review Report-445K (89) | Answering Reviewers-136K (97) | Received: 08/20/2024 | Revised: 12/19/2024 | Accepted: 01/02/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (6641) | Similar Articles (14) | Timeline of Article Publication (5) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

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Cytoplasmic and nuclear programmed death ligand 1 expression in peritumoral stromal cells in breast cancer: Prognostic and predictive value

Evgeniya Yu Zubareva, Marina A Senchukova, Natalia V Saidler

World J Exp Med 15(2):102761. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102761

Abstract (526) | Core Tip (499) | Full Article (HTML) (1252) | Figures (1-6) (558) | Tables (1-10) (399) | Full Article (PDF)-27275K (145) | Full Article with Cover (PDF)-27560K (151) | Full Article (XML)-187K (83) | Audio-1763K (21) | Peer-Review Report-219K (93) | Answering Reviewers-66K (80) | Received: 10/28/2024 | Revised: 01/21/2025 | Accepted: 02/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (2) | Total Visits (6176) | Similar Articles (211) | Timeline of Article Publication (4) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

(0) | (0) | (0) | (0) | Open

Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Anna Terasawa, Kazuhiro Shimazu, Hiroshi Nanjo, Masatomo Miura, Hiroyuki Shibata

World J Exp Med 15(2):102897. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.102897

Abstract (516) | Core Tip (546) | Full Article (HTML) (1333) | Figures (1-7) (446) | Tables (1-2) (381) | Full Article (PDF)-90710K (169) | Full Article with Cover (PDF)-90995K (135) | Full Article (XML)-197K (88) | Audio-13161K (17) | Peer-Review Report-262K (85) | Answering Reviewers-308K (99) | Received: 10/31/2024 | Revised: 12/31/2024 | Accepted: 01/21/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (0) | Total Visits (5142) | Similar Articles (39) | Timeline of Article Publication (3) | Article Quality Tracking (0) | Cite |

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Anti-hypertensive effect of enriched white melon seed protein concentrate biscuit on sodium fluoride exposed rats

Olamide Wilson Fasakin, Ayoola Awosika, Sanmi Tunde Ogunsanya, Iyanuoluwa Olushola Benson, Akinyode Isaac Olopoda

World J Exp Med 15(2):105798. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.105798

Abstract (515) | Core Tip (488) | Full Article (HTML) (1365) | Figures (1-4) (389) | Tables (1-2) (402) | Full Article (PDF)-28688K (205) | Full Article with Cover (PDF)-28973K (125) | Full Article (XML)-125K (84) | Audio-3128K (20) | Peer-Review Report-210K (83) | Answering Reviewers-199K (76) | Received: 02/06/2025 | Revised: 03/12/2025 | Accepted: 03/24/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (6) | Total Visits (5283) | Similar Articles (1) | Timeline of Article Publication (4) | Authors Evaluation (5) | Article Quality Tracking (0) | Cite |

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Systematic Reviews

Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review

Mohammed Al-Beltagi, Nermin Kamal Saeed, Adel Salah Bediwy, Reem Elbeltagi

World J Exp Med 15(2):104328. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.104328

Abstract (545) | Core Tip (531) | Full Article (HTML) (5977) | Figures (1-2) (406) | Tables (1-7) (1180) | Full Article (PDF)-1044K (395) | Full Article with Cover (PDF)-1323K (386) | Full Article (XML)-734K (102) | Audio-329K (48) | Peer-Review Report-266K (101) | Answering Reviewers-170K (110) | Received: 12/17/2024 | Revised: 02/24/2025 | Accepted: 03/18/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (3) | Total Visits (11058) | Similar Articles (20) | Timeline of Article Publication (4) | Authors Evaluation (5) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

MicroRNA-155 modulation by renin-angiotensin system inhibitors may underlie their enigmatic role in COVID-19

Konstantinos I Papadopoulos, Alexandra Papadopoulou, Tar Choon Aw

World J Exp Med 15(2):100748. Published online Jun 20, 2025. doi: 10.5493/wjem.v15.i2.100748

Abstract (538) | Core Tip (557) | Full Article (HTML) (1336) | Figures (1-1) (437) | Tables (1-1) (490) | Full Article (PDF)-890K (156) | Full Article with Cover (PDF)-1176K (128) | Full Article (XML)-93K (104) | Audio-1516K (11) | Peer-Review Report-222K (82) | Answering Reviewers-60K (96) | Received: 08/25/2024 | Revised: 01/18/2025 | Accepted: 02/06/2025 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (4934) | Similar Articles (775) | Timeline of Article Publication (3) | Authors Evaluation (4) | Article Quality Tracking (0) | Reader Comments (1) | Cite |

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