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Contents Volume 27 Issue 24 June 28, 2021

Opinion Review

Trial eligibility in advanced hepatocellular carcinoma: Does it support clinical practice in underrepresented subgroups?

Federico Piñero, Leonardo Gomes da Fonseca

World J Gastroenterol 27(24):3429-3439. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3429

Abstract (1085) | Core Tip (1045) | Full Article (HTML) (3428) | Figures (1-2) (702) | Tables (1-1) (581) | Full Article (PDF)-1084K (520) | Audio-227K (20) | Peer-Review Report-267K (227) | Answering Reviewers-113K (347) | Received: 03/17/2021 | Revised: 05/06/2021 | Accepted: 05/20/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (11335) | Similar Articles (1876) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Review

Chronic intestinal failure and short bowel syndrome in Crohn’s disease

Aysegül Aksan, Karima Farrag, Irina Blumenstein, Oliver Schröder, Axel U Dignass, Jürgen Stein

World J Gastroenterol 27(24):3440-3465. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3440

Abstract (1447) | Core Tip (1073) | Full Article (HTML) (21597) | Figures (1-3) (1566) | Tables (1-8) (924) | Full Article (PDF)-1839K (1709) | Audio-808K (25) | Peer-Review Report-306K (238) | Answering Reviewers-254K (257) | Received: 12/25/2020 | Revised: 01/24/2021 | Accepted: 03/08/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (49) | Total Visits (33918) | Similar Articles (8) | Timeline of Article Publication (1) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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Non-cirrhotic hepatocellular carcinoma in chronic viral hepatitis: Current insights and advancements

Abhilash Perisetti, Hemant Goyal, Rachana Yendala, Ragesh B Thandassery, Emmanouil Giorgakis

World J Gastroenterol 27(24):3466-3482. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3466

Abstract (1373) | Core Tip (1090) | Full Article (HTML) (8020) | Figures (1-2) (597) | Tables (1-3) (516) | Full Article (PDF)-1882K (895) | Audio-174K (31) | Peer-Review Report-243K (291) | Answering Reviewers-96K (291) | Received: 01/26/2021 | Revised: 03/13/2021 | Accepted: 05/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (32) | Total Visits (18071) | Similar Articles (1876) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Natural killer cells in pancreatic cancer stroma

Rachel Elizabeth Ann Fincham, Francesca Romana Delvecchio, Michelle R Goulart, Joe Poe Sheng Yeong, Hemant M Kocher

World J Gastroenterol 27(24):3483-3501. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3483

Abstract (1033) | Core Tip (951) | Full Article (HTML) (7252) | Figures (1-5) (944) | Tables (1-1) (608) | Full Article (PDF)-4262K (708) | Audio-246K (23) | Peer-Review Report-311K (206) | Answering Reviewers-125K (214) | Received: 02/01/2021 | Revised: 05/06/2021 | Accepted: 05/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (30) | Total Visits (17435) | Similar Articles (456) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (0) | Cite |

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COVID-19 and its effects on the digestive system

Ting-Ting Cao, Gu-Qin Zhang, Emily Pellegrini, Qiu Zhao, Jin Li, Lin-jie Luo, Hua-Qin Pan

World J Gastroenterol 27(24):3502-3515. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3502

Abstract (1560) | Core Tip (1538) | Full Article (HTML) (7787) | Figures (1-1) (715) | Tables (1-1) (636) | Full Article (PDF)-1824K (873) | Audio-722K (13) | Peer-Review Report-206K (259) | Answering Reviewers-179K (279) | Received: 02/28/2021 | Revised: 04/16/2021 | Accepted: 05/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (26) | Total Visits (18312) | Similar Articles (737) | Timeline of Article Publication (3) | Authors Evaluation (8) | Article Quality Tracking (1) | Cite |

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Neuropilin-1: A feasible link between liver pathologies and COVID-19

Aitor Benedicto, Iñigo García-Kamiruaga, Beatriz Arteta

World J Gastroenterol 27(24):3516-3529. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3516

Abstract (1123) | Core Tip (1033) | Full Article (HTML) (5251) | Figures (1-1) (615) | Full Article (PDF)-1546K (1118) | Audio-736K (23) | Peer-Review Report-224K (235) | Answering Reviewers-421K (279) | Received: 02/28/2021 | Revised: 04/16/2021 | Accepted: 05/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (21) | Total Visits (14491) | Similar Articles (1082) | Timeline of Article Publication (0) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Minireviews

Hepatitis delta virus: From infection to new therapeutic strategies

Grazia A Niro, Arianna Ferro, Francesca Cicerchia, Isabella Brascugli, Marilena Durazzo

World J Gastroenterol 27(24):3530-3542. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3530

Abstract (1658) | Core Tip (1001) | Full Article (HTML) (7311) | Figures (1-1) (602) | Tables (1-1) (523) | Full Article (PDF)-1536K (816) | Audio-128K (15) | Peer-Review Report-229K (267) | Answering Reviewers-86K (221) | Received: 02/07/2021 | Revised: 04/07/2021 | Accepted: 05/27/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (21) | Total Visits (16597) | Similar Articles (7) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Usefulness of artificial intelligence in gastric neoplasms

Ji Hyun Kim, Seung-Joo Nam, Sung Chul Park

World J Gastroenterol 27(24):3543-3555. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3543

Abstract (1330) | Core Tip (1149) | Full Article (HTML) (5245) | Figures (1-3) (669) | Tables (1-1) (557) | Full Article (PDF)-2857K (642) | Audio-1274K (26) | Peer-Review Report-225K (279) | Answering Reviewers-61K (286) | Received: 01/25/2021 | Revised: 04/09/2021 | Accepted: 05/21/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (10) | Total Visits (14653) | Similar Articles (321) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (1) | Cite |

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Current impact of viral hepatitis on liver cancer development: The challenge remains

Ângelo Zambam de Mattos, Jose D Debes, Andre Boonstra, Ju-Dong Yang, Domingo C Balderramo, Giovana D P Sartori, Angelo Alves de Mattos

World J Gastroenterol 27(24):3556-3567. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3556

Abstract (1054) | Core Tip (934) | Full Article (HTML) (4531) | Figures (1-1) (592) | Tables (1-1) (577) | Full Article (PDF)-1092K (653) | Audio-765K (17) | Peer-Review Report-151K (245) | Answering Reviewers-61K (250) | Received: 01/29/2021 | Revised: 03/11/2021 | Accepted: 04/22/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (23) | Total Visits (13153) | Similar Articles (2596) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Room for improvement in the treatment of pancreatic cancer: Novel opportunities from gene targeted therapy

Michail Galanopoulos, Aris Doukatas, Filippos Gkeros, Nikos Viazis, Christos Liatsos

World J Gastroenterol 27(24):3568-3580. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3568

Abstract (1311) | Core Tip (1128) | Full Article (HTML) (5548) | Figures (1-4) (675) | Tables (1-1) (616) | Full Article (PDF)-3015K (692) | Audio-882K (13) | Peer-Review Report-672K (237) | Answering Reviewers-109K (256) | Received: 02/16/2021 | Revised: 04/11/2021 | Accepted: 05/22/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (9) | Total Visits (16224) | Similar Articles (445) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells

Qiu-Ju Han, Yong-Liang Mu, Hua-Jun Zhao, Rong-Rong Zhao, Quan-Juan Guo, Yu-Hang Su, Jian Zhang

World J Gastroenterol 27(24):3581-3594. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3581

Abstract (1005) | Core Tip (869) | Article Highlights (1010) | Full Article (HTML) (5288) | Figures (1-5) (894) | Tables (1-2) (589) | Full Article (PDF)-4742K (579) | Audio-429K (27) | Peer-Review Report-562K (202) | Answering Reviewers-125K (220) | Received: 01/15/2021 | Revised: 04/09/2021 | Accepted: 05/27/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (19) | Total Visits (16821) | Similar Articles (204) | Timeline of Article Publication (66) | Authors Evaluation (2) | Article Quality Tracking (0) | Cite |

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Early genetic diagnosis of clarithromycin resistance in Helicobacter pylori

Xiao-Hua Li, Yong-Yi Huang, Lin-Ming Lu, Li-Juan Zhao, Xian-Ke Luo, Ru-Jia Li, Yuan-Yuan Dai, Chun Qin, Yan-Qiang Huang, Hao Chen

World J Gastroenterol 27(24):3595-3608. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3595

Abstract (1504) | Core Tip (1699) | Article Highlights (1921) | Full Article (HTML) (4423) | Figures (1-4) (643) | Tables (1-9) (952) | Full Article (PDF)-3672K (643) | Audio-1234K (22) | Peer-Review Report-191K (246) | Answering Reviewers-81K (253) | Received: 03/02/2021 | Revised: 04/13/2021 | Accepted: 05/21/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (10) | Total Visits (19551) | Similar Articles (0) | Timeline of Article Publication (3) | Authors Evaluation (3) | Article Quality Tracking (1) | Cite |

(0) | (0) | (0) | (0) | Open

Case Control Study

Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis

Zhen-Huan Yang, Fang Liu, Xiao-Ran Zhu, Fei-Ya Suo, Zi-jun Jia, Shu-Kun Yao

World J Gastroenterol 27(24):3609-3629. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3609

Abstract (1787) | Core Tip (1463) | Article Highlights (1222) | Full Article (HTML) (7660) | Figures (1-6) (654) | Tables (1-1) (539) | Full Article (PDF)-9342K (841) | Audio-398K (54) | Peer-Review Report-217K (266) | Answering Reviewers-137K (282) | Received: 02/06/2021 | Revised: 03/22/2021 | Accepted: 05/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (128) | Total Visits (21246) | Similar Articles (589) | Timeline of Article Publication (1) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Retrospective Study

High rate of complete histopathological response in hepatocellular carcinoma patients after combined transarterial chemoembolization and stereotactic body radiation therapy

Ulrike Bauer, Sabine Gerum, Falk Roeder, Stefan Münch, Stephanie E Combs, Alexander B Philipp, Enrico N De Toni, Martha M Kirstein, Arndt Vogel, Carolin Mogler, Bernhard Haller, Jens Neumann, Rickmer F Braren, Marcus R Makowski, Philipp Paprottka, Markus Guba, Fabian Geisler, Roland M Schmid, Andreas Umgelter, Ursula Ehmer

World J Gastroenterol 27(24):3630-3642. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3630

Abstract (1128) | Core Tip (872) | Article Highlights (1563) | Full Article (HTML) (3883) | Figures (1-5) (545) | Tables (1-2) (591) | Full Article (PDF)-6215K (483) | Audio-1517K (18) | Peer-Review Report-295K (205) | Answering Reviewers-858K (304) | Supplementary Material-428K (257) | Received: 02/05/2021 | Revised: 03/20/2021 | Accepted: 05/18/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (11) | Total Visits (14857) | Similar Articles (1904) | Timeline of Article Publication (4) | Article Quality Tracking (0) | Cite |

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Stem cell injection for complex anal fistula in Crohn’s disease: A single-center experience

Oliver Schwandner

World J Gastroenterol 27(24):3643-3653. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3643

Abstract (1576) | Core Tip (1085) | Article Highlights (1242) | Full Article (HTML) (5671) | Tables (1-4) (565) | Full Article (PDF)-881K (1009) | Audio-993K (14) | Peer-Review Report-218K (294) | Answering Reviewers-60K (266) | Received: 01/09/2021 | Revised: 03/10/2021 | Accepted: 06/04/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (36) | Total Visits (19560) | Similar Articles (194) | Timeline of Article Publication (10) | Article Quality Tracking (0) | Cite |

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Observational Study

Laparoscopic lateral lymph node dissection in two fascial spaces for locally advanced lower rectal cancer

Hui-Hong Jiang, Hai-Long Liu, A-Jian Li, Wen-Chao Wang, Liang Lv, Jian Peng, Zhi-Hui Pan, Yi Chang, Mou-Bin Lin

World J Gastroenterol 27(24):3654-3667. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3654

Abstract (1584) | Core Tip (921) | Article Highlights (1041) | Full Article (HTML) (7736) | Figures (1-11) (1472) | Full Article (PDF)-26895K (641) | Audio-1528K (18) | Peer-Review Report-694K (195) | Answering Reviewers-669K (406) | Received: 12/17/2020 | Revised: 01/20/2021 | Accepted: 02/25/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (19871) | Similar Articles (1) | Timeline of Article Publication (5) | Authors Evaluation (4) | Article Quality Tracking (0) | Cite |

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Systematic Reviews

Disorders of the brain-gut interaction and eating disorders

Mihaela Fadgyas Stanculete, Giuseppe Chiarioni, Dan Lucian Dumitrascu, Dinu Iuliu Dumitrascu, Stefan-Lucian Popa

World J Gastroenterol 27(24):3668-3681. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3668

Abstract (1367) | Core Tip (1180) | Article Highlights (1631) | Full Article (HTML) (5658) | Figures (1-1) (983) | Tables (1-3) (557) | Full Article (PDF)-969K (704) | Audio-680K (72) | Peer-Review Report-205K (302) | Answering Reviewers-49K (278) | Received: 01/22/2021 | Revised: 03/12/2021 | Accepted: 06/03/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (20) | Total Visits (17659) | Similar Articles (7) | Timeline of Article Publication (2) | Authors Evaluation (3) | Article Quality Tracking (1) | Cite |

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Weight loss interventions in living donor liver transplantation as a tool in expanding the donor pool: A systematic review and meta-analysis

Sushrut Trakroo, Nakul Bhardwaj, Rajat Garg, Jamak Modaresi Esfeh

World J Gastroenterol 27(24):3682-3692. Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3682

Abstract (1055) | Core Tip (955) | Article Highlights (1639) | Full Article (HTML) (3882) | Figures (1-4) (1141) | Tables (1-1) (594) | Full Article (PDF)-2412K (603) | Audio-2371K (21) | Peer-Review Report-253K (238) | Answering Reviewers-199K (219) | Received: 01/24/2021 | Revised: 03/08/2021 | Accepted: 05/27/2021 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (24) | Total Visits (16958) | Similar Articles (2) | Timeline of Article Publication (2) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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