Natural killer cells in pancreatic cancer stroma

Table 1 Current clinical trials employing natural killer cells therapy in pancreatic cancer

Primary therapy	Additional intervention	Tumour type	Phase	NCT number	Status	Ref.
NK cell infusions	Irreversible electroporation	Advanced pancreatic cancer	I/II	NCT02718859	Completed	[90,91]
Dendritic cell activated, cytokine induced killer treatment	S-1 (drug)	Advanced pancreatic cancer	I/II	NCT01781520	Completed	[87,92]
BiCAR NK cells (ROBO1 CAR-NK cells)		Pancreatic cancer	I/II	NCT03941457	Recruiting	[93]
Ex-vivo expanded autologous NK cells (SNK01)	Trastuzumab; Cetuximab	Advanced solid tumour; metastatic cancer; HER-2+ breast cancer; HER-2 positive gastric cancer; HER-2 protein overexpression; oesophageal cancer; ovarian cancer; endometrium cancer; bladder cancer; pancreatic cancer; colorectal cancer; NSCLC; EGFR+ NSCLC; head and neck squamous cell carcinoma; triple-negative breast cancer; cervical cancer; sarcoma	I/IIa	NCT04464967	Not yet recruiting	[94]
High activity NK cells		Pancreatic cancer	I/II	NCT03008304	Completed	[95]
Activated NK cells		Lung cancer; breast cancer; colon cancer; pancreatic cancer; ovarian cancer	I/II	NCT03634501	Recruiting	[96]
FT500-an allogenic, iPSC derived NK cell immunotherapy	Nivolumab; pembrolizumab; atezolizumab; cyclophosphamide; fludarabine; IL-2	Advanced solid tumours; lymphoma; gastric cancer; colorectal cancer; head and neck cancer; squamous cell carcinoma; EGFR positive solid tumour; HER2 positive breast cancer; hepatocellular carcinoma; small-cell lung cancer; renal cell carcinoma; pancreas cancer; melanoma; NSCLC; urothelial carcinoma, cervical cancer; microsatellite instability; merkel cell carcinoma	I	NCT03841110	Recruiting	[97]
FT500-101 allogenic NK cell immunotherapy		Advanced solid tumours; lymphoma; gastric cancer; colorectal cancer; head and neck cancer; squamous cell carcinoma; EGFR positive solid tumour; HER2 positive breast cancer; hepatocellular carcinoma; small-cell lung cancer; renal cell carcinoma; pancreas cancer; melanoma; NSCLC; urothelial carcinoma, cervical cancer; microsatellite instability; merkel cell carcinoma	Observational study	NCT04106167	Recruiting	[98]
FATE-NK100 (donor-derived ex-vivo activated immunotherapy)	Trastuzumab; Cetuximab	HER2+ gastric cancer; colorectal cancer; head and neck squamous cell carcinoma; EGFR+ solid tumours; advanced solid tumours; HER2 postie breast cancer; hepatocellular carcinoma; NSCLC; renal cell carcinoma; pancreatic cancer; melanoma	I	NCT03319459	Active, not recruiting	[99]
Autologous dendritic cell vaccine loaded with personalised peptides to stimulate innate and adaptive immune response via activating T and NK cells	Standard of care; Nivolumab	Pancreatic adenocarcinoma	Ib	NCT04627246	Recruiting	[100]
ACE1702 cellular therapy (anti-HER2 NK cells)	Cyclophosphamide; Fludarabine	Locally advanced solid tumours; metastatic cancer; solid tumour; HER-2+ gastric cancer; HER-2 + metastatic breast cancer	I	NCT04319757	Recruiting	[101]
NK cells	Bortezomib	CML; pancreatic cancer; colon/rectal cancer; multiple myeloma; carcinoma-NSCLC	I	NCT00720785	Recruiting	[102]
Cytokine-induced killer cells	Tegafur; Gimeracil; Oteracil potassium	Advanced cancer	II	NCT03002831	Terminated	[103,104]
Anti-MUC1 CAR-pNK cells		Hepatocellular carcinoma; NSCLC; pancreatic cancer; triple negative invasive breast carcinoma; malignant glioma of the brain; colorectal carcinoma; gastric carcinoma	I/II	NCT02839954	Unknown	[105]
Autologous NK/NK T cell immunotherapy		Breast cancer; glioma; hepatocellular carcinoma; squamous cell lung cancer; pancreatic cancer; colon cancer; prostate cancer	I	NCT00909558	Suspended	[106]

NK cell: Natural killer cell; CAR: Chimeric antigen receptor; NSCLC: Non-small cell lung cancer; CML: Chronic myeloid leukemia; iPSC: Induced pluripotent stem cells.