Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2021; 27(24): 3668-3681
Published online Jun 28, 2021. doi: 10.3748/wjg.v27.i24.3668
Disorders of the brain-gut interaction and eating disorders
Mihaela Fadgyas Stanculete, Giuseppe Chiarioni, Dan Lucian Dumitrascu, Dinu Iuliu Dumitrascu, Stefan-Lucian Popa
Mihaela Fadgyas Stanculete, Department of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca RO 400174, Romania
Giuseppe Chiarioni, Division of Gastroenterology of the University of Verona, AOUI Verona, Verona 37134, Italy
Dan Lucian Dumitrascu, Stefan-Lucian Popa, Department of The Second Medical, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca RO 400174, Cluj, Romania
Dinu Iuliu Dumitrascu, Department of Anatomy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca RO 400174, Cluj, Romania
Author contributions: Stanculete MF, Chiarioni G, Popa SL, Dumitrascu DI searched the literature, analyzed the results and made substantial contribution to the writing of the manuscript; Dumitrascu DL gave the idea of this review, suggested the methodology, analyzed the results, and revised the manuscript; all authors approved the final version of the manuscript.
Conflict-of-interest statement: No conflict of interest to be declared by all of the Authors.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Giuseppe Chiarioni, MD, Adjunct Professor, Division of Gastroenterology of the University of Verona, AOUI Verona, Piazzale LA Scuro 10, Verona 37134, Italy. chiarioni@alice.it
Received: January 22, 2021
Peer-review started: January 22, 2021
First decision: February 28, 2021
Revised: March 12, 2021
Accepted: June 3, 2021
Article in press: June 3, 2021
Published online: June 28, 2021
Processing time: 153 Days and 14.8 Hours
Core Tip

Core Tip: Functional gastrointestinal disorders actually defined disorders of the brain-gut interaction (DGBI) by the new Rome IV criteria share similar symptoms with eating disorders (ED). Etiology is ill defined for both disorders thou a negative impact on quality of life and a high socio-economic burden is reported. We looked for the comorbidity of DGBI and ED, in order to find out where there is an association and a cause-effect relationship.