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Contents Volume 22 Issue 11 March 21, 2016

Editorial

Metastatic gastric cancer treatment: Second line and beyond

Marwan Ghosn, Samer Tabchi, Hampig Raphael Kourie, Mustapha Tehfe

World J Gastroenterol 22(11):3069-3077. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3069

Abstract (1654) | Core Tip (1549) | Full Article (HTML) (6542) | Figures (1-1) (634) | Tables (1-2) (550) | Full Article (PDF)-794K (858) | Audio-200K (22) | Peer-Review Report-97K (305) | Answering Reviewers-50K (303) | Received: 10/16/2015 | Revised: 11/27/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (31) | Total Visits (20564) | Similar Articles (287) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Review

Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections

Lynne Vernice McFarland, Metehan Ozen, Ener Cagri Dinleyici, Shan Goh

World J Gastroenterol 22(11):3078-3104. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3078

Abstract (1880) | Core Tip (1723) | Full Article (HTML) (24710) | Tables (1-5) (1070) | Full Article (PDF)-1279K (2088) | Audio-1493K (63) | Peer-Review Report-141K (452) | Answering Reviewers-32K (399) | Received: 12/16/2015 | Revised: 01/12/2016 | Accepted: 02/22/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (136) | Total Visits (39644) | Similar Articles (36) | Timeline of Article Publication (2) | Article Quality Tracking (0) | Cite |

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Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas

Ian W Folkert, Paul Hernandez, Robert E Roses

World J Gastroenterol 22(11):3105-3116. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3105

Abstract (1511) | Core Tip (1401) | Full Article (HTML) (5175) | Figures (1-2) (604) | Full Article (PDF)-928K (808) | Audio-492K (21) | Peer-Review Report-95K (286) | Answering Reviewers-121K (293) | Received: 11/03/2015 | Revised: 01/05/2016 | Accepted: 01/11/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (17258) | Similar Articles (126) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

Jonathan Landy, Emma Ronde, Nick English, Sue K Clark, Ailsa L Hart, Stella C Knight, Paul J Ciclitira, Hafid Omar Al-Hassi

World J Gastroenterol 22(11):3117-3126. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3117

Abstract (2376) | Core Tip (2001) | Full Article (HTML) (40037) | Figures (1-1) (883) | Tables (1-1) (650) | Full Article (PDF)-1040K (2224) | Audio-979K (112) | Peer-Review Report-87K (477) | Answering Reviewers-50K (468) | Received: 06/18/2015 | Revised: 09/19/2015 | Accepted: 12/21/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (457) | Total Visits (70199) | Similar Articles (8) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases

Alan Alper Sag, Fatih Selcukbiricik, Nil Molinas Mandel

World J Gastroenterol 22(11):3127-3149. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3127

Abstract (1584) | Core Tip (1472) | Full Article (HTML) (7991) | Tables (1-7) (601) | Full Article (PDF)-1058K (1273) | Audio-330K (35) | Peer-Review Report-96K (303) | Answering Reviewers-150K (404) | Received: 10/27/2015 | Revised: 12/22/2015 | Accepted: 01/18/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (34) | Total Visits (19044) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Vaccine against Helicobacter pylori: Inevitable approach

Amin Talebi Bezmin Abadi

World J Gastroenterol 22(11):3150-3157. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3150

Abstract (1699) | Core Tip (1644) | Full Article (HTML) (8475) | Full Article (PDF)-777K (1294) | Audio-560K (42) | Peer-Review Report-90K (365) | Answering Reviewers-67K (465) | Received: 12/14/2015 | Revised: 01/05/2016 | Accepted: 01/30/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (56) | Total Visits (21650) | Similar Articles (15) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Minireviews

Effective treatment of gastrointestinal bleeding with thalidomide - Chances and limitations

Juergen Bauditz

World J Gastroenterol 22(11):3158-3164. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3158

Abstract (1623) | Core Tip (1480) | Full Article (HTML) (8289) | Figures (1-3) (846) | Tables (1-1) (559) | Full Article (PDF)-828K (1278) | Audio-673K (79) | Peer-Review Report-75K (339) | Answering Reviewers-46K (512) | Received: 07/15/2015 | Accepted: 01/30/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (40) | Total Visits (22047) | Similar Articles (68) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Basic Study

Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype

Antonio Madejón, Míriam Romero, Ángela Hernández, Araceli García-Sánchez, Marta Sánchez-Carrillo, Antonio Olveira, Javier García-Samaniego

World J Gastroenterol 22(11):3165-3174. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3165

Abstract (1949) | Core Tip (1418) | Full Article (HTML) (4445) | Figures (1-3) (595) | Tables (1-4) (810) | Full Article (PDF)-917K (724) | Audio-1429K (43) | Peer-Review Report-140K (387) | Answering Reviewers-81K (280) | Received: 09/25/2015 | Revised: 11/04/2015 | Accepted: 01/18/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (11) | Total Visits (19013) | Similar Articles (0) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer’s patches

Hai-Mei Zhao, Yan Wang, Xiao-Ying Huang, Min-Fang Huang, Rong Xu, Hai-Yang Yue, Bu-Gao Zhou, Hong-Yan Huang, Qi-Meng Sun, Duan-Yong Liu

World J Gastroenterol 22(11):3175-3185. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3175

Abstract (1614) | Core Tip (1570) | Full Article (HTML) (6220) | Figures (1-5) (623) | Full Article (PDF)-1317K (835) | Audio-1378K (34) | Peer-Review Report-69K (378) | Answering Reviewers-124K (333) | Received: 10/22/2015 | Revised: 11/25/2015 | Accepted: 01/18/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (46) | Total Visits (20426) | Similar Articles (94) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Melittin induces human gastric cancer cell apoptosis via activation of mitochondrial pathway

Gui-Mei Kong, Wen-Hua Tao, Ya-Li Diao, Peng-Hua Fang, Ji-Jun Wang, Ping Bo, Feng Qian

World J Gastroenterol 22(11):3186-3195. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3186

Abstract (1774) | Core Tip (1563) | Full Article (HTML) (6894) | Figures (1-3) (757) | Full Article (PDF)-1870K (811) | Audio-146K (40) | Peer-Review Report-93K (431) | Answering Reviewers-225K (326) | Received: 09/05/2015 | Revised: 11/17/2015 | Accepted: 12/14/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (88) | Total Visits (21530) | Similar Articles (1544) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Retrospective Cohort Study

Predictors of re-bleeding after endoscopic hemostasis for delayed post-endoscopic sphincterotomy bleeding

Mu-Hsien Lee, Yung-Kuan Tsou, Cheng-Hui Lin, Ching-Song Lee, Nai-Jen Liu, Kai-Feng Sung, Hao-Tsai Cheng

World J Gastroenterol 22(11):3196-3201. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3196

Abstract (1367) | Core Tip (1327) | Full Article (HTML) (5535) | Tables (1-5) (545) | Full Article (PDF)-780K (753) | Audio-1308K (49) | Peer-Review Report-72K (327) | Answering Reviewers-117K (310) | Received: 07/21/2015 | Revised: 10/30/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (21) | Total Visits (17886) | Similar Articles (61) | Timeline of Article Publication (5) | Authors Evaluation (1) | Article Quality Tracking (0) | Cite |

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Retrospective Study

Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?

Alfredo Di Leo, Gabriella Nesi, Mariabeatrice Principi, Domenico Piscitelli, Bruna Girardi, Maria Pricci, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi, Francesco Tonelli

World J Gastroenterol 22(11):3202-3211. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3202

Abstract (1859) | Core Tip (1592) | Full Article (HTML) (4215) | Figures (1-7) (534) | Tables (1-1) (565) | Full Article (PDF)-1609K (712) | Audio-567K (19) | Peer-Review Report-112K (337) | Answering Reviewers-80K (325) | Received: 09/11/2015 | Revised: 12/14/2015 | Accepted: 01/11/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (8) | Total Visits (18817) | Similar Articles (17) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Comparison of hepatic venous pressure gradient and endoscopic grading of esophageal varices

EunJi Lee, Yong Jae Kim, Dong Erk Goo, Seung Boo Yang, Hyun-Joo Kim, Jae Young Jang, Soung Won Jeong

World J Gastroenterol 22(11):3212-3219. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3212

Abstract (1781) | Core Tip (1430) | Full Article (HTML) (5324) | Figures (1-4) (576) | Tables (1-2) (549) | Full Article (PDF)-988K (805) | Audio-771K (25) | Peer-Review Report-102K (329) | Answering Reviewers-111K (438) | Received: 10/15/2015 | Revised: 11/27/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (18) | Total Visits (19784) | Similar Articles (39) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Is forceps more useful than visualization for measurement of colon polyp size?

Jae Hyun Kim, Seun Ja Park, Jong Hoon Lee, Tae Oh Kim, Hyun Jin Kim, Hyung Wook Kim, Sang Heon Lee, Dong Hoon Baek, Busan Ulsan Gyeongnam Intestinal Study Group Society (BIGS)

World J Gastroenterol 22(11):3220-3226. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3220

Abstract (1757) | Core Tip (1629) | Full Article (HTML) (7781) | Figures (1-2) (597) | Tables (1-4) (540) | Full Article (PDF)-915K (660) | Audio-508K (54) | Peer-Review Report-91K (249) | Answering Reviewers-99K (311) | Received: 04/29/2015 | Revised: 09/03/2015 | Accepted: 11/09/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (44) | Total Visits (21222) | Similar Articles (4) | Timeline of Article Publication (6) | Article Quality Tracking (0) | Cite |

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Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients

Yu-Yuan Li, Quan-Xing Ge, Jie Cao, Yong-Jian Zhou, Yan-Lei Du, Bo Shen, Yu-Jui Yvonne Wan, Yu-Qiang Nie

World J Gastroenterol 22(11):3227-3233. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3227

Abstract (1645) | Core Tip (1854) | Full Article (HTML) (14891) | Figures (1-2) (646) | Tables (1-1) (524) | Full Article (PDF)-7137K (1223) | Audio-221K (66) | Peer-Review Report-97K (405) | Answering Reviewers-166K (378) | Received: 09/14/2015 | Revised: 10/28/2015 | Accepted: 12/08/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (162) | Total Visits (30576) | Similar Articles (1140) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Negative short-term impact of intraoperative biliary lavage in patients with hepatolithiasis

Ou Jiang, Rong-Xing Zhou, Ke Yang, Chun-Xian Cai, Yu Liu, Nan-Sheng Cheng

World J Gastroenterol 22(11):3234-3241. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3234

Abstract (1601) | Core Tip (1351) | Full Article (HTML) (3862) | Figures (1-2) (514) | Tables (1-5) (519) | Full Article (PDF)-883K (605) | Audio-1139K (25) | Peer-Review Report-101K (263) | Answering Reviewers-117K (411) | Received: 05/28/2015 | Revised: 09/27/2015 | Accepted: 12/08/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (1) | Total Visits (13730) | Similar Articles (24) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Application of gemstone spectral imaging for efficacy evaluation in hepatocellular carcinoma after transarterial chemoembolization

Qi-Yu Liu, Chuan-Dong He, Ying Zhou, Dan Huang, Hua Lin, Zhong Wang, Dong Wang, Jin-Qiu Wang, Li-Ping Liao

World J Gastroenterol 22(11):3242-3251. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3242

Abstract (1778) | Core Tip (1624) | Full Article (HTML) (5053) | Figures (1-7) (556) | Tables (1-1) (536) | Full Article (PDF)-1590K (678) | Audio-2124K (33) | Peer-Review Report-122K (363) | Answering Reviewers-84K (336) | Received: 11/03/2015 | Revised: 12/31/2015 | Accepted: 01/18/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (12) | Total Visits (18388) | Similar Articles (1877) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Observational Study

Constipation, hard stools, fecal urgency, and incomplete evacuation, but not diarrhea is associated with diabetes and its related factors

Noriko Ihana-Sugiyama, Naoyoshi Nagata, Ritsuko Yamamoto-Honda, Eiko Izawa, Hiroshi Kajio, Takuro Shimbo, Masafumi Kakei, Naomi Uemura, Junichi Akiyama, Mitsuhiko Noda

World J Gastroenterol 22(11):3252-3260. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3252

Abstract (1864) | Core Tip (1542) | Full Article (HTML) (6714) | Tables (1-4) (546) | Full Article (PDF)-812K (794) | Audio-1520K (53) | Peer-Review Report-88K (329) | Answering Reviewers-115K (386) | Received: 11/09/2015 | Revised: 12/12/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (32) | Total Visits (19640) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Clinical features, endoscopic polypectomy and STK11 gene mutation in a nine-month-old Peutz-Jeghers syndrome Chinese infant

Zhi-Heng Huang, Zai Song, Ping Zhang, Jie Wu, Ying Huang

World J Gastroenterol 22(11):3261-3267. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3261

Abstract (1532) | Core Tip (1477) | Full Article (HTML) (4638) | Figures (1-5) (594) | Tables (1-1) (585) | Full Article (PDF)-1347K (655) | Audio-972K (34) | Peer-Review Report-102K (288) | Answering Reviewers-86K (285) | Received: 08/08/2015 | Revised: 11/01/2015 | Accepted: 12/08/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (8) | Total Visits (17660) | Similar Articles (20) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients

Xiao-Ling Wang, Jian-Ping Ren, Xue-Qing Wang, Xiao-Hong Wang, Shao-Fang Yang, Yi Xiong

World J Gastroenterol 22(11):3268-3274. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3268

Abstract (1670) | Core Tip (1404) | Full Article (HTML) (4463) | Figures (1-1) (542) | Tables (1-6) (508) | Full Article (PDF)-850K (625) | Audio-479K (25) | Peer-Review Report-84K (311) | Answering Reviewers-128K (333) | Received: 11/08/2015 | Revised: 12/14/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (12) | Total Visits (16691) | Similar Articles (0) | Timeline of Article Publication (1) | Article Quality Tracking (0) | Cite |

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Prospective Study

Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study

Anika Vogt, Philipp A Reuken, Sven Stengel, Andreas Stallmach, Tony Bruns

World J Gastroenterol 22(11):3275-3284. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3275

Abstract (1635) | Core Tip (1536) | Full Article (HTML) (5492) | Figures (1-4) (507) | Tables (1-4) (537) | Full Article (PDF)-960K (1133) | Audio-1805K (38) | Peer-Review Report-87K (336) | Answering Reviewers-166K (446) | Received: 07/01/2015 | Revised: 10/20/2015 | Accepted: 12/30/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (14) | Total Visits (20459) | Similar Articles (13) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Case Report

Contained colonic perforation due to cecal retroflexion

Zhuo Geng, Deepak Agrawal, Amit G Singal, Stephen Kircher, Samir Gupta

World J Gastroenterol 22(11):3285-3288. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3285

Abstract (1536) | Core Tip (1381) | Full Article (HTML) (4035) | Figures (1-1) (548) | Tables (1-1) (524) | Full Article (PDF)-822K (568) | Audio-358K (25) | Peer-Review Report-79K (289) | Answering Reviewers-322K (311) | Received: 08/04/2015 | Revised: 09/22/2015 | Accepted: 10/26/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (6) | Total Visits (15762) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Delayed diagnosis of alpha-1-antitrypsin deficiency following post-hepatectomy liver failure: A case report

Benjamin Norton, Jemimah Denson, Christopher Briggs, Matthew Bowles, David Stell, Somaiah Aroori

World J Gastroenterol 22(11):3289-3295. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3289

Abstract (1456) | Core Tip (1431) | Full Article (HTML) (4904) | Figures (1-3) (740) | Full Article (PDF)-1522K (650) | Audio-234K (53) | Peer-Review Report-116K (311) | Answering Reviewers-97K (406) | Received: 05/24/2015 | Accepted: 12/01/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (5) | Total Visits (16202) | Similar Articles (103) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Primary advanced esophago-gastric melanoma: A rare case

Lin Wang, Liang Zong, Hidetsugu Nakazato, Wen-Yue Wang, Chao-Feng Li, Yan-Fen Shi, Guo-Chao Zhang, Tao Tang

World J Gastroenterol 22(11):3296-3301. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3296

Abstract (1305) | Core Tip (1314) | Full Article (HTML) (6399) | Figures (1-6) (533) | Tables (1-2) (475) | Full Article (PDF)-1378K (546) | Audio-339K (34) | Peer-Review Report-83K (279) | Answering Reviewers-143K (321) | Received: 11/03/2015 | Revised: 12/28/2015 | Accepted: 01/11/2016 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (14) | Total Visits (18159) | Similar Articles (667) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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Letter to the Editor

Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?

Kuo Du, Hartmut Jaeschke

World J Gastroenterol 22(11):3302-3304. Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3302

Abstract (1404) | Core Tip (1366) | Full Article (HTML) (4090) | Full Article (PDF)-665K (645) | Audio-679K (18) | Peer-Review Report-103K (270) | Answering Reviewers-8K (284) | Received: 08/19/2015 | Revised: 09/24/2015 | Accepted: 12/08/2015 | RCA | PubMed Central | PubMed | CrossRef | Google Scholar | Times Cited (7) | Total Visits (15013) | Similar Articles (0) | Timeline of Article Publication (0) | Article Quality Tracking (0) | Cite |

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