Clinical features, endoscopic polypectomy and STK11 gene mutation in a nine-month-old Peutz-Jeghers syndrome Chinese infant

Table 1 Systematic literature reports of pediatric Peutz-Jeghers syndrome

Ref.	Year	Study type	Country	Age range	Manifestation	Treatment	Gene information
Fernandez Seara et al[4]	1995	Case report	Spain	15 d	PRPs	ED and Died	NA
Corley et al[21]	1997	Case report	United States	15 yr	Gastric outlet obstruction, abdominal pain	ED and OP	NA
Al Faour et al[5]	2002	Case report	France	4 d	Abdominal mass	OP	NA
Boseto et al[22]	2002	Case report	Australia	14 mo	Gastric outlet obstruction	OP	NA
Homan et al[23]	2005	Case report	Slovenia	10 yr	Abdominal pain, vomiting, intussusception	OP	NA
Hearle et al[7]	2006	Letter	United Kingdom	1-38 yr	NA	NA	Yes
Zuo et al[8]	2007	Article	China	5-10 yr	MP	NA	Yes
Adolph et al[24]	2008	Review	United States	Children	MP, intussusception, abdominal pain, etc.	ED and OP	NA
Vidal et al[25]	2009	Article	France	4.8-15.1 yr	MP, PRPs, intussusception, etc.	ED and OP	NA
Ausavarat et al[26]	2009	Case report	Thailand	14 yr	MP, abdominal pain, intestinal obstruction, etc.	ED or OP	Yes
Resta et al[9]	2010	Article	Italy	1-17 yr	NA	NA	Yes
Yang et al[27]	2010	Article	Korea	6 mo-13.8 yr	MP, hematochezia, intussusception, anemia,etc.	ED or OP	Yes
Liu et al[11]	2011	Article	China	6 yt	MP, abdominal pain, hematochezia	ED and OP	Yes
Burgmeier et al[6]	2012	Case report	Germany	2 d	Vomiting, abdominal mass	OP	NA
Chen et al[28]	2012	Article	China	14 yr	MP	ED	Yes
Thakkar et al[29]	2012	Review	United States	children	MP, PRPs, intussusception, etc.	ED and OP	Yes
Liu et al[30]	2012	Article	China	12 and 16 yr	MP, abdominal pain, hematochezia, etc.	ED	Yes
Goldstein et al[31]	2013	Article	United States	1-14 yr	MP, PRPs, intussusception, etc.	ED and OP	NA
Zheng et al[32]	2013	Article	China	1-5 yr	MP, abdominal pain	NA	Yes
Vageli et al[33]	2013	Case report	Greece	12 yy	MP	NA	NA
Chae et al[34]	2014	Case report	Korea	12 yr	MP, abdominal pain, anemia	OP	Yes
Morrison et al[12]	2014	Case report	United Kingdom	9 mo	Umbilical pigmentation	NA	Yes
Wang et al[35]	2014	Article	China	1-43 yr	MP, histopathologic examination, etc.	ED and OP	Yes
Cohen et al[36]	2014	Article	Israel	4-16 yr	MP, abdominal pain, hematochezia	ED or OP	Yes
Kimura et al[37]	2015	Case report	Japan	13 yr	MP, abdominal pain	OP	NA
Kuroda et al[10]	2015	Article	Japan	12 yr	MP, intellectual disability	ED	Yes
Armijo et al[38]	2015	Case report	United States	4 yr	gynecomastia, MP, testicular lesions	Orchiectomy	Yes
Our group	2015	Article	China	9 mo	PRPs	ED and OP	Yes

ED: Endoscopy; MP: Mucocutaneous pigmentation; NA: Not available; OP: Operation; PRPs: Prolapsed rectal poly.