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©The Author(s) 2016.
World J Gastroenterol. Mar 21, 2016; 22(11): 3268-3274
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3268
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3268
Table 1 Hepatitis B virus DNA content and liver function indexes
Parameter | HBV DNA (IU/mL) | ALT | AST | TBIL | DBIL | ALP | GGT | ALB | TP |
Median | 6.64 | 45 | 55 | 15.8 | 5.05 | 96.0 | 36 | 43 | 72 |
Interquartile range | 2.48 | 69 | 57 | 9.8 | 4.35 | 51.3 | 52 | 5.3 | 7 |
Table 2 Distribution of mutations in the basic core promoter and pre-C regions of hepatitis B virus according to hepatitis B e antigen status
BCP region | Total | χ2(corrected) | P value | Pre-C region | Total | χ2(corrected) | P value | ||||
Mutations | WT | Mutations | WT | ||||||||
HBeAg | + | 46 | 24 | 70 | 2.43 | 0.12 | 24 | 46 | 70 | 26.62 | 0.00 |
- | 22 | 4 | 26 | 25 | 1 | 26 | |||||
Total | 68 | 28 | 96 | 49 | 47 | 96 |
Table 3 Comparison of hepatitis B virus DNA contents between patients with mutant basic core promoter or pre-C loci and those with wild-type loci
BCP region | No. of cases | Mean rank | Wilcoxon | P value | Pre-C region | No. of cases | Mean rank | Wilcoxon | P value | |
DNA content | Mutations | 68 | 42.74 | Mutations | 49 | 36.79 | ||||
WT | 28 | 62.48 | 2906.5 | 0.00 | WT | 47 | 60.71 | 1802.5 | 0.00 | |
Total | 96 | Total | 96 |
Table 4 Comparison of liver function between patients with mutant or wild-type basic core promoter loci
Item | AST | GGT | |||||
BCP region | No. of cases | Mean rank | Wilcoxon | P value | Mean rank | Wilcoxon | P value |
WT | 28 | 33.75 | 33.0 | ||||
Mutant | 68 | 53.96 | 945.0 | 0.00 | 54.8 | 924.0 | 0.00 |
Total | 96 |
Table 5 Comparison of liver function between patients with mutant or wild-type pre-C loci
Item | AST | GGT | |||||
No. of cases | Mean rank | Wilcoxon | P value | Mean rank | Wilcoxon | P value | |
pre-C loci | |||||||
WT | 47 | 40.55 | 41.33 | ||||
Mutant | 49 | 55.29 | 1906.0 | 0.00 | 55.38 | 1942.5 | 0.01 |
Total | 96 |
Table 6 Consistency of two methods for detection of mutations in the basic core promoter and pre-C regions of hepatitis B virus
BIOTGENE for BCP region | Total | Kappa | P value | BIOTGENE for pre-C region | Total | Kappa | P value | ||||||
DAAN for BCP region | WT | Mutant | DAAN for | WT | Mutant | ||||||||
WT | 23 | 2 | 25 | pre-C region | WT | 29 | 5 | 34 | |||||
Mutant | 1 | 50 | 51 | 0.91 | 0.00 | Mutant | 11 | 31 | 42 | 0.58 | 0.00 | ||
Total | 24 | 52 | 76 | Total | 40 | 36 | 76 |
- Citation: Wang XL, Ren JP, Wang XQ, Wang XH, Yang SF, Xiong Y. Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients. World J Gastroenterol 2016; 22(11): 3268-3274
- URL: https://www.wjgnet.com/1007-9327/full/v22/i11/3268.htm
- DOI: https://dx.doi.org/10.3748/wjg.v22.i11.3268