©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2016; 22(11): 3302-3304
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3302
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3302
Liuweiwuling tablets protect against acetaminophen hepatotoxicity: What is the protective mechanism?
Kuo Du, Hartmut Jaeschke, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, United States
Author contributions: Du K wrote this letter; Jaeschke H revised the letter.
Supported by Grants from the National Institutes of Health (No. R01 DK102142 and No. R01 AA12916); and the National Institute of General Medical Sciences (No. 8 P20 GM103549-07) of the National Institutes of Health.
Conflict-of-interest statement: The authors declare no conflict of interest.
Correspondence to: Hartmut Jaeschke, PhD, ATS, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., MS 1018, Kansas City, KS 66160, United States. hjaeschke@kumc.edu
Telephone: +1-913-5887969 Fax: +1-913-5887501
Received: August 19, 2015
Peer-review started: August 20, 2015
First decision: September 19, 2015
Revised: September 29, 2015
Accepted: December 8, 2015
Article in press: December 8, 2015
Published online: March 21, 2016
Processing time: 208 Days and 5.9 Hours
Peer-review started: August 20, 2015
First decision: September 19, 2015
Revised: September 29, 2015
Accepted: December 8, 2015
Article in press: December 8, 2015
Published online: March 21, 2016
Processing time: 208 Days and 5.9 Hours
Core Tip
Core tip: The reduced inflammatory response and the increased liver regeneration by Liuweiwuling treatment are more likely secondary effects of the protection by inhibition of metabolic activation of acetaminophen rather than the primary mechanism of protection.