Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype

Figure 1 Box-plot analysis of the hepatitis B virus-DNA levels (A) and the hepatitis B surface antigen titers (B). Data of HBV-DNA and HBsAg titers are expressed as Log₁₀ (copies/mL) and Log₁₀ (IU/mL), respectively. Both markers show a similar pattern except in the group of patients with CHD, which had low levels of HBV-DNA, but a relatively high level of HBsAg titers. Extreme values are represented as circles or asterisks. HBV: Hepatitis B virus; HDV: Hepatitis delta virus; HIV: Human immunodeficiency virus; CHD: Chronic hepatitis delta; HBsAg: Hepatitis B surface antigen.

Figure 2 Box-plot analysis of the hepatitis B virus-DNA levels (A) and the hepatitis B surface antigen titers (B) in the different HBV genotypes of the four groups of patients analyzed. HBV-genotype E patients were present only in the HIV negative patients with CHD. Data of HBV-DNA and HBsAg titers are expressed as log₁₀ of copies/mL and IU/mL, respectively. Extreme values are represented as circles or asterisks. HBV: Hepatitis B virus; HDV: Hepatitis delta virus; HIV: Human immunodeficiency virus; CHD: Chronic hepatitis delta; HBsAg: Hepatitis B surface antigen.

Figure 3 Distribution of replication markers among the different hepatitis B virus genotypes. A: Box-Plot of HBV-DNA and HDV-RNA titers. In all the genotypes, the HDV-RNA levels were higher than HBV-DNA. However, only significant differences between both markers were observed in those patients infected with HBV genotypes A and E (P < 0.001). HBV-DNA titers were significant higher in those patients infected with genotype D than in those infected with HBV-A or E. B: Box-plot of HBsAg titers for the group of patients infected with different genotypes. Only significant differences were achieved between patients infected with HBV-D and HBV-E. C: Box-Plot of the ALT values for patients infected with different HBV genotypes. Significant higher ALT values were observed in the group of patients infected with HBV-A genotype. Extreme values are represented as circles or asterisks. HBV: Hepatitis B virus; HDV: Hepatitis delta virus; HBsAg: Hepatitis B surface antigen.