Baishideng Publishing Group

Wang HL, Zhang SD, Liu T, Liu LM, Pan XY. Innovations in the treatment of endometrial diseases: Role of human umbilical cord mesenchymal stem cells and their exosomes. World J Stem Cells 2026; 18(5): 115486

"We had an excellent experience publishing in the World Journal of Clinical Oncology. The online submission platform features a clear ..." [Read more]

"We had an excellent experience publishing in the World Journal of Clinical Oncology. The online submission platform features a clear and user-friendly interface, making the submission process straightforward. The peer review was conducted in a timely and efficient manner, with constructive feedback from reviewers. Throughout the entire process, the editorial team demonstrated exceptional professionalism and responsibility, maintaining prompt and clear communication. It has been a pleasant publishing experience, and I will certainly consider this journal for my future submissions and recommend it to my colleagues. " [Collapse]

Zhou CY, Ren XY, Li HH, Pan XM, Lan X, Duan D. Anlotinib plus albumin-bound paclitaxel induction-maintenance for sorafenib-refractory radioiodine-refractory differentiated thyroid cancer: A case report and review of literature. World J Clin Oncol 2026; 17(5): 119615

"I am truly grateful for the high-quality and authoritative platform you have offered to showcase my research findings. If I have new ..." [Read more]

"I am truly grateful for the high-quality and authoritative platform you have offered to showcase my research findings. If I have new research content in the future, I will gladly prioritize submitting it to your journal, and I will wholeheartedly recommend my fellow researchers to engage with and support your publication. " [Collapse]

Taxi W, Sun J, Zhu YH, Zhang TC, Guo Y, Pan YL, Liu MM, Chen X, Zhang CL, Tong K, Wang LN, Jiang T, Ma Y. Hypoxia-preconditioned adipose-derived stem cell exosomes promote osteogenic differentiation and bone formation in bone marrow mesenchymal stem cells through the Piezo1/Ca²⁺ signaling axis. World J Stem Cells 2026; 18(5): 117045

"We are very grateful to the editorial team and peer reviewers of the World Journal of Clinical Cases for their professionalism and ..." [Read more]

"We are very grateful to the editorial team and peer reviewers of the World Journal of Clinical Cases for their professionalism and efficiency throughout the publication process. The constructive feedback from the reviewers greatly helped us improve the quality and clarity of our case report. It has been a pleasure publishing with Baishideng. " [Collapse]

Tsai CY, Lo TC, Yu JC, Hong ZJ, Sung YK. Paget’s disease of the nipple with occult ductal carcinoma in situ despite negative conventional imaging: A case report. World J Clin Cases 2026; 14(16): 120049

"I had an excellent experience with the World Journal of Cardiology. The entire peer-review process was smooth, transparent, and well ..." [Read more]

"I had an excellent experience with the World Journal of Cardiology. The entire peer-review process was smooth, transparent, and well organized from submission to final decision. Communication with the editorial team was prompt and professional, making the experience efficient and enjoyable. I truly appreciated the clarity, fairness, and overall quality of the review process. " [Collapse]

Singh S, Lima NA. Letter to the Editor: Culprit coronary occlusion as a stronger short-term prognostic marker over electrocardiographic pattern in acute myocardial infarction. World J Cardiol 2026; 18(5): 117800

"The World Journal of Clinical Cases has ensured the fast and early publication of the case report “Os subepicondylare mediale ossicle ..." [Read more]

"The World Journal of Clinical Cases has ensured the fast and early publication of the case report “Os subepicondylare mediale ossicle – cause for cubital tunnel syndrome.” This timely dissemination underscores the journal’s commitment to advancing clinical knowledge by highlighting rare anatomical variations with significant surgical implications. Rapid publication not only accelerates awareness among clinicians but also fosters early integration of novel insights into patient care. By prioritizing such unique case reports, the journal strengthens academic dialogue, supports evidence-based surgical decision-making, and enhances global access to clinically relevant findings that may otherwise remain underrecognized in orthopaedic practice. " [Collapse]

Nallakumarasamy A, Sivakumar S, Vetrivel VN, Balaji VP, Stephen N, Jeyaraman N, Jeyaraman M. Os subepicondylare mediale ossicle as a cause for cubital tunnel syndrome: A case report. World J Clin Cases 2026; 14(16): 120594

"The peer review report for our manuscript is fair and objective. The peer review report of great help to our manuscript. Thanks for ..." [Read more]

"The peer review report for our manuscript is fair and objective. The peer review report of great help to our manuscript. Thanks for all of your efforts and we are looking forward to submitting again here in recent days. In addition, we would be like to review the papers form this journal and F6 publishing systems. " [Collapse]

Qian M, Chen YX, Liu JJ, Yang HJ, Li GQ. Risk prediction models for re-fractures following hip fracture in older adults: A methodological evaluation. World J Orthop 2026; 17(5): 116449

"The published article reports a rare clinical case that contributes to the existing body of literature and provides additional evidence ..." [Read more]

"The published article reports a rare clinical case that contributes to the existing body of literature and provides additional evidence on an uncommon clinical presentation. This report may offer valuable insights for clinicians by enhancing awareness of the condition, supporting earlier recognition and accurate diagnosis, and facilitating informed clinical decision-making. In addition, the findings may contribute to improved patient management strategies and encourage further discussion and research in this area to strengthen understanding and optimise clinical practice. " [Collapse]

Wan-Nik FH, Zulkeflee HA, Ab Rahim NS, Tuan-Ismail ST. Rare coexistence of aldosterone resistance and adrenal insufficiency in asymptomatic infant with persistent hyperkalaemia: A case report. World J Clin Pediatr 2026; 15(2): 113666

"The peer-reviewing and editorial process was highly commendable. The entire workflow was exceptionally well streamlined, smooth, ..." [Read more]

"The peer-reviewing and editorial process was highly commendable. The entire workflow was exceptionally well streamlined, smooth, transparent, and author-friendly. Communication from the editorial office was prompt and professional, and the reviewers’ comments were constructive, insightful, and helpful in improving the quality of the manuscript. The timelines for review and decision-making were reasonable, reflecting the journal’s efficient management system. Overall, the experience was pleasant and encouraging, and the journal demonstrates a strong commitment to maintaining high academic and publication standards. " [Collapse]

Khandelwal A, Karim HMR, Bhattacharjee A. Letter to the Editor: Chest X-ray–based severity scores in COVID-19 - what do they tell us about oxygen needs? World J Crit Care Med 2026; 15(2): 119458

"The publication process proceeded smoothly and efficiently from submission to final publication. The journal’s publication requirements ..." [Read more]

"The publication process proceeded smoothly and efficiently from submission to final publication. The journal’s publication requirements and standards clearly reflected its commitment to maintaining the high quality and scientific integrity of the published articles. The peer-review process was conducted in a timely and professional manner. The reviewers’ comments and recommendations were constructive, valuable, and manageable, which greatly contributed to improving the quality and clarity of the manuscript. In addition, the editors were highly cooperative, responsive, and supportive throughout the review and publication process. Their professionalism and effective communication made the overall experience positive and encouraging. Thank you very much for your efforts and support. " [Collapse]

AlNuaimi A, Nair VA, Al-Khayyal N, Suliman A, Bou Malhab LJ, Hamoudi R, Hamad M, Talaat IM, Abdel-Rahman WM. Overexpression of low-molecular-weight caldesmon is associated with aggressive phenotypes and epithelial-mesenchymal transition in breast cancer cells. World J Clin Oncol 2026; 17(5): 116662

"On behalf of my co-authors we wish to thank the World Journal of Clinical Urology team and the Baishideng Publishing Group Inc. for ..." [Read more]

"On behalf of my co-authors we wish to thank the World Journal of Clinical Urology team and the Baishideng Publishing Group Inc. for publishing our manuscript. The experience was memorable and worthwhile. We suggest that the production team is provided with relevant past issues or review comments that have already been resolved, to avoid repeated requests. " [Collapse]

Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum and its management. World J Clin Urol 2026; 15(1): 114046

"The editorial team is very cooperative and supportive at each and every step of publication process. We are very much pleased and ..." [Read more]

"The editorial team is very cooperative and supportive at each and every step of publication process. We are very much pleased and satisfied with the services, which have been meticulously offered by the editorial team. The overall processing of the article, right from submission to the review process to proofreading to final publication, is more than satisfactory. " [Collapse]

Gavkare AM, Nanaware NL, Darade R, Dhotre SV, Mumbre SS, Nagoba BS. Systematic review of multidisciplinary team strategies and novel research in rare and complex clinical cases. World J Clin Cases 2026; 14(16): 119831

"I appreciate the opportunity to share my feedback. Overall, I had a positive experience with the journal. The peer review process ..." [Read more]

"I appreciate the opportunity to share my feedback. Overall, I had a positive experience with the journal. The peer review process was rigorous and fair, and the editorial office responded promptly to my inquiries. The article was edited carefully. However, I would like to offer one minor suggestions for further improvement: The time between acceptance and online publication could potentially be shortened. Thank you for considering this feedback. " [Collapse]

Tang SG, Wei XL, Ye RJ, Xu HQ, Shang SH, Han YX, Wu LW, Xia WZ. Successful seven-year management of recurrent adult pancreatoblastoma with liver metastasis: A case report. World J Gastrointest Oncol 2026; 18(5): 116776

"Thank you to the journal for providing a platform for the discussion of Chinese medicine (CM) in the treatment of malignant tumors, ..." [Read more]

"Thank you to the journal for providing a platform for the discussion of Chinese medicine (CM) in the treatment of malignant tumors, allowing colleagues from various countries to view clinical research on CM and deepen their understanding of it. We can sense the professionalism of the journal editors and review experts, which has been of great help to us. Thank you again! " [Collapse]

Bian JY, Sun YX, Wang LF, He WT, Liu CB, Wang XQ, Zhang T. Integrated Chinese and Western medicine prolong survival in colorectal cancer with liver metastasis: A retrospective cohort study. World J Clin Oncol 2026; 17(5): 118265

"The editorial process for our article, “Letter to the Editor: Revisiting the anatomical pattern of bone metastases in stage IV breast ..." [Read more]

"The editorial process for our article, “Letter to the Editor: Revisiting the anatomical pattern of bone metastases in stage IV breast cancer: Missing clinical stratification and biological depth”, was relatively smooth, and communication from the journal was timely throughout the publication process. The reviewers provided constructive comments that helped improve the manuscript. Overall, the submission, peer review, and publication experience was satisfactory. " [Collapse]

Zhang PZ, Wang YJ, Xu YK. Letter to the Editor: Revisiting the anatomical pattern of bone metastases in stage IV breast cancer: Missing clinical stratification and biological depth. World J Clin Oncol 2026; 17(5): 114734

"This is my second publication in this reputable journal. The process is highly transparent, with an easily accessible submission ..." [Read more]

"This is my second publication in this reputable journal. The process is highly transparent, with an easily accessible submission platform, timely tracking, dedicated editors, and independent and non-biased peer reviewers. The entire process was rigorous and quality feedback was given in terms of peer reviewers' comments to enhance this article. The copyedit stage was helpful in fine tunning and trimming the article. " [Collapse]

Farhan M, Patel T, Obais MAHN, Taslimi H, Hanif M, Khalid K, Qaqour A, Waisi J, Khalid H, Abbas Husain AHA, Hammouda R, Khan SU, Patel BD, Sardarova N, Awosika A. Liquid or soft-gel levothyroxine vs tablet levothyroxine in athyreotic adults after total thyroidectomy: Systematic review and meta-analysis. World J Clin Cases 2026; 14(16): 119700

"We are very satisfied with the journal's manuscript editing and publication process. In particular, we greatly appreciate the highly ..." [Read more]

"We are very satisfied with the journal's manuscript editing and publication process. In particular, we greatly appreciate the highly professional revision comments on our article, the remarkably fast publication time, and the very efficient responses from the editor throughout the entire process. We are deeply impressed by the overall handling of our manuscript, and we will actively consider submitting our future work to this journal. " [Collapse]

Feng SJ, Zhou YF, Yang JF, Mao YS, Ruan WL, Zhang XF. MFSD2A suppresses CD8+ T cell exhaustion in colorectal cancer by inhibiting ERK/p38 MAPK-PD-L1 signaling. World J Gastroenterol 2026; 32(20): 115336

"We are highly satisfied with the publication experience in the World Journal of Clinical Cases. The editorial and peer-review processes ..." [Read more]

"We are highly satisfied with the publication experience in the World Journal of Clinical Cases. The editorial and peer-review processes were professional, transparent, and timely. Communication from the editorial office was prompt and supportive throughout the submission process. We appreciate the journal’s commitment to scientific quality and global dissemination of research. Publishing our article in this esteemed journal has been a valuable and rewarding experience. " [Collapse]

Sahoo PS, Jena DP, Mishra P, Sahu PK, Das RR. Serum vitamin D level and its association with anti-seizure medications in children with seizure disorder. World J Clin Cases 2026; 14(16): 120945

"The peer review comments were professional, rigorous, and highly constructive. They not only identified areas that needed further ..." [Read more]

"The peer review comments were professional, rigorous, and highly constructive. They not only identified areas that needed further improvement, but also provided valuable suggestions on the study design, presentation of results, and clarity of writing. The entire review process was fair, objective, and efficient, and we sincerely appreciate the dedicated efforts and professional support of the editor and reviewers. " [Collapse]

Li MT, Zheng Y, Zhao JY, Wu ZQ, Lu LZ, Sun J, Li Q, Shu XC, Naji WQ, Yang J, Chen FF, Ma XM, Zhang HY, Yang FC, Du LL, Xie YD, Du PW, Kong WR, Yuan H, Ji R, Guo QH, Chen ZF, Wang YP, Zhou YN. Associations between dietary polyphenols and risks of gastric precancerous lesions and cancer. World J Gastroenterol 2026; 32(20): 117603

"I highly appreciate the professionalism demonstrated by the WJG team during the submission process. The submission system is ..." [Read more]

"I highly appreciate the professionalism demonstrated by the WJG team during the submission process. The submission system is user-friendly, and the editorial workflow is highly efficient. The peer review reports were not only fair and objective but also provided invaluable suggestions that helped refine our research. Thank you for maintaining such high academic standards. " [Collapse]

Lin C, Fu RK, Zheng H, Li TY, Han JS, Margonis GA, Wang JJ, Dong LB, Wang NS, Sun YX, Wang YZ, Liu C, Xu Q, Han XL, Zhang TP, Guo JC, Dai MH, Xia P, Chen LM, Wang WB. Development and validation of an interpretable machine learning model for predicting acute kidney injury after pancreatic surgery. World J Gastroenterol 2026; 32(19): 116271

21386 items Read more >>

Article Quality Tracking-Peer-Review

"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, ..." [Read more]

"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, and how these factors promote the transition from chronic gastritis to metaplasia and malignancy. In addition, the authors describe recent developments in multi-omics technologies that are uncovering new dimensions of host-microbe interactions in the gastric niche, thereby extending the classic Correa cascade into a more comprehensive, ecosystem-based model of gastric carcinogenesis. It seems that future perspectives on the gastric microenvironment will shift from simple descriptions of microbes to active therapeutic and diagnostic interventions, aiming to enable personalized management of patients with gastric cancer. It is also believed that advances in metabolomic analyses, microbiome modulation, utilization of specialized pro- and prebiotics, gastric microbiome transplantation, use of targeted antimicrobial drugs, modifications of the tumor microenvironment, as well as the use of ex vivo models and artificial intelligence will contribute decisively not only to the prevention and early detection of gastric cancer but also to a more effective complementary therapeutic intervention. " [Collapse]

Zheng HC, Zhou T, Sun L, Ding X. Gastric microenvironment and gastric cancer: Interplay of acid, microbiota, and inflammation. World J Gastroenterol 2026; 32(20): 117044

"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood ..." [Read more]

"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood natural killer (NK) cells and changes in their functional markers can help predict the progression and severity of liver failure, particularly in conditions like acute-on-chronic liver failure (ACLF). A sharp reduction or dysfunction in circulating NK cells in the bloodstream—often alongside an accumulation of these cells in the liver itself—indicates an overwhelming immune response and correlates with a poorer prognosis. In severe liver diseases like hepatitis-induced ACLF, peripheral NK cells become depleted and show a higher expression of apoptosis and exhaustion markers. Studies suggest that at the time of hospital admission, evaluating circulating NK cell levels alongside standard clinical markers can effectively help identify patients who may survive spontaneously versus those who will require an urgent liver transplant. Finally, our results suggest that more recruitment of NK cells to the liver is somehow responsible for the failure of the native. Explain why peripheral natural killer cells reflect the prognosis more sensitively than other parameters of acute liver failure. a significant drop in peripheral Natural Killer (NK) cell counts and a shift in their functional profile are reliable biomarkers for predicting poor clinical outcomes. Patients with severe liver failure exhibit significantly reduced proportions of NK cells in their peripheral blood compared to healthy individuals. These peripheral NK cells often show signs of exhaustion and dysfunction. Many of them undergo apoptosis (cell death) or migrate directly into the inflamed liver tissue. Researchers have found that the degree of this peripheral NK cell reduction directly correlates with disease severity (e.g., HBV-DNA levels) and can serve as a strong predictive indicator for patient survival or the need for a liver transplant. Please tell me the mechanism between the predictor of acute hepatic failure and the degree of peripheral NK cell." [Collapse]

Xu JX, Li HG, Xu X, Lu D. Letter to the Editor: Characteristics of peripheral blood lymphocyte subpopulations in acute-on-chronic liver failure: A call for further exploration. World J Gastroenterol 2026; 32(20): 116109

"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. ..." [Read more]

"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. The pathogenesis underlying IRI is complex, involving a series of signaling mediators and mechanisms. This study aimed to investigate the effects of Magnesium Isoglycyrrhizinate (MgIG) on the liver function after IRI in liver resection treated with or without MgIG. MgIG is a magnesium salt of glycyrrhizic acid stereoisomer, commonly derived from licorice root. The full name of MgiG is tetrahydrate magnesium 18α, 20β-hydroxy-11-oxon orolean-12-en-3β-yl-2-O-β-D-glucopyranurosyl-α-D-glucopy ranosiduronate. Glycyrrhizin is commonly used clinically as a liver protective medicine. MgIG is the fourth generation of glycyrrhizin preparations. It has better affinity with target cell receptors, and stronger anti-inflammatory and anti-oxidation effects. It has been shown to stabilize hepatocyte membrane and improve liver function. MgIG has shown the effects of lowering the liver toxicity of free fatty acid by preventing mitochondrial damage and protecting hepatocytes from ischemia and reperfusion induced injury. Function: It provides anti-inflammatory, antioxidant, and hepatocyte membrane-stabilizing effects.　 Used post-surgery, it is associated with a more rapid decrease in liver enzymes (such as ALT and AST) and better regulation of inflammatory cytokines.Ischemia-reperfusion injury: Studies have shown it can mitigate liver damage caused by blocking the hepatic blood supply during the surgical　procedure.　Previous studies showed that MgIG administration significantly ameliorated CCl4-induced biochemical alterations and lipid peroxidation in the liver of mice or rats The protective effects of MgIG might be resulted from the elimination of oxygen free radicals before the damage to macromolecular and metabolism of the cells. I ask some questions for authors.1. Please describe the extent of liver resection and the presence or absence of cirrhosis in the patient's background. 2.Please also describe parameters other than GOT used to assess the drug's effectiveness. 3.Please provide more detailed information about the effects of MGIG on reperfusion injuries. 4.During liver surgery, how many minutes of ischemia were administered using the Pringel procedure? 5.Author’s data suggests that MG has a hepatoprotective effect on the liver, but please consider comparing it with other medications. " [Collapse]

Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513

"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy ..." [Read more]

"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) are growing global health concerns, with DR remaining a major cause of vision loss. The study identifies indirect bilirubin (IBIL) as a potential biomarker that is inversely linked to DR risk in patients with T2DM. Although the findings are clinically important, limitations such as the cross-sectional design, single-center setting, and possible confounding factors reduce generalizability." [Collapse]

Zhang Z, Shan XQ, Liang FM, Zhang LX. Letter to the Editor: Indirect bilirubin: A potential predictive biomarker for diabetic retinopathy and its clinical translational potential. World J Diabetes 2026; 17(5): 115813

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism ..." [Read more]

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism and diabetic retinopathy (DR) in T2DM patients. It found vitamin D deficiency and VDR FokI ff genotype were independent risk factors for DR. The study adopted rigorous grouping and standard laboratory detection, applied Sanger sequencing for accurate genotyping, and controlled common clinical confounding factors, offering valuable population evidence for DR early risk prediction. However, single-center cross-sectional design cannot confirm causality. It lacked DR severity stratification and ignored lifestyle and sunlight exposure confounders. Future work should adopt multicenter prospective cohorts and further explore the molecular mechanism of VDR variants affecting DR pathogenesis. " [Collapse]

Liu ZH, Ran ZQ, Yang R, Chen LX, Wang ZZ, Li YY, Han R. Vitamin D, vitamin D receptor FokI polymorphism, and diabetic retinopathy: A case-control study in Kunming, China. World J Diabetes 2026; 17(5): 118141

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma ..." [Read more]

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma who received nivolumab as the initial treatment. Several biochemical parameters, including alpha-fetoprotein and the neutrophil-to-lymphocyte ratio (NLR), were retrospectively analyzed. The cut-off value for NLR was determined using a receiver operating characteristic (ROC) curve to distinguish patients with survival times longer than the median survival time. However, the efficacy of this cut-off value was subsequently validated using the same cohort in which the cut-off value had originally been established. Under these conditions, it is expected that the validation would yield favorable predictive results. Therefore, because both the establishment and validation of the cut-off value were conducted within the same cohort, the significance and predictive performance of the cut-off value cannot be considered methodologically validated." [Collapse]

Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives ..." [Read more]

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery." [Collapse]

Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the ..." [Read more]

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration. NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration. " [Collapse]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of ..." [Read more]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery. However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed. " [Collapse]

Zhang S, Li SY, Zhou B. Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection. World J Gastrointest Surg 2026; 18(4): 116412

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Pavlidis L, Geropoulos G, Kechagias KS, Psarras K, Patel V, Reza L, Prakash N, Athanasiou C, Geropoulos V, Anestiadou E, Triantafyllou T, Sapalidis K, Laskou S, Dimitroulis D. Near-infrared fluorescence with indocyanine green for minimally invasive hernia surgery: A systematic review and evidence synthesis. World J Clin Cases 2026; 14(14): 118964

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Walędziak M, Różańska-Walędziak A. Three-port robotic sleeve gastrectomy-another step forward: A case report. World J Clin Cases 2026; 14(14): 117795

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Raveglia F, Degiovanni S, Bertolaccini L, Cara A, Cassina EM, Danuzzo F, Libretti L, Pirondini E, Sibilia MC, Spinelli F, Tuoro A, De Simone M, Chiarelli M, Cioffi U, Petrella F. Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery. World J Clin Cases 2026; 14(13): 119644

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative ..." [Read more]

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts. Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation." [Collapse]

Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; 32(16): 116781

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria ..." [Read more]

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? The study is moderately effective as it is retrospective clinical design how ever detailed methodology is missing. furthermore, it is judged on statistical variation not on experimental results variations 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? The results are appropriately authentic and consistent. Sample size is lower, hence hypothesis is moderately validated. Present study demonstrate the prognosis relevance which is insufficient for application in clinical settings. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Figure and tables are adequately presented 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Standard statistical approach is used in the current study with respect to study design 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Appropriate 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Acceptable format, formal and scientifically clear 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? Single center results Lower sample size which might effect on statistical significance Transparency in methodology " [Collapse]

Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer ..." [Read more]

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer development. It highlights how diets rich in additives, refined sugars, and industrial fats contribute to dysbiosis, inflammation, and oxidative stress, thereby increasing cancer risk. Conversely, dietary interventions such as fasting, caloric restriction, and ketogenic regimens show promise in reprogramming tumor metabolism and enhancing therapeutic responses. The authors emphasize that while mechanistic evidence is strong, clinical studies remain limited, heterogeneous, and often small in scale. Overall, the paper underscores the potential of personalized nutrition as a complementary strategy in colorectal cancer prevention and treatment, but stresses the need for well‑designed trials to validate safety, adherence, and long‑term outcomes." [Collapse]

Lima RSP, Sousa JDS, Neres MSO, de Sousa DJM, Martins JA, Pereira IC, da Silva ACA, Severo JS, Torres-Leal FL, da Silva MTB. Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming. World J Gastrointest Oncol 2026; 18(4): 115511

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing ..." [Read more]

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing their contribution to T‑cell exhaustion. The study highlights that PD‑1 inhibitors reduce PD‑1⁺ subsets but fail to affect CD161 expression, suggesting independent regulatory mechanisms. These findings underscore CD161 as a distinct and promising immunotherapeutic target, complementing but not overlapping with PD‑1 blockade strategies. While the evidence is compelling, broader patient cohorts and longitudinal studies will be essential to confirm clinical relevance and therapeutic potential." [Collapse]

Liu CR, Zhang M, Wang MQ, Zhang W, Li J, Shi GZ, Liang FF, Li YP, Huang N. CD161⁺CD8⁺ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 114547

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates ..." [Read more]

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates strong experimental evidence with both in vitro and in vivo validation, highlighting mechanistic clarity via the AMPK‑SREBP1 pathway. While promising and translational, limitations in sample size and treatment duration suggest further clinical validation is needed." [Collapse]

Huang JH, Ma JQ. HMGCR loss is synthetic lethal with PIK3CD inhibition in colorectal cancer cells. World J Gastrointest Oncol 2026; 18(4): 114220

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes ..." [Read more]

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes and coronary heart disease (CAD) and how to address both simultaneously in a prevention strategy. This paper could be a trailblazer for further research investigating the use of other drugs currently used to treat both diabetes and CAD." [Collapse]

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report ..." [Read more]

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good. The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future." [Collapse]

Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral ..." [Read more]

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen. The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons. The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published." [Collapse]

Nallakumarasamy A, Vetrivel VN, Balaji VP, Yadav R, Jeyaraman N, Muthu S, Jeyaraman M. Management and prevention of iatrogenic ipsilateral femoral neck fracture during intramedullary nailing of femoral shaft. World J Orthop 2026; 17(4): 116107

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 37568

Manuscripts received today: 29

Manuscript reviews today: 57

Unhandled manuscripts today: 171

Active peer-reviewers today: 4217

Reviewer acceptance today: 87

Reviewer refusals today: 130

Total accepted manuscripts: 41514

Total rejected manuscripts: 45740

Total peer-reviewers: 4854917

Total submissions: 39171