Baishideng Publishing Group

Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416

"The publication process at World Journal of Psychiatry proceeds through a single-blind peer-review system, conducted by at least two ..." [Read more]

"The publication process at World Journal of Psychiatry proceeds through a single-blind peer-review system, conducted by at least two independent referees who evaluate novelty, significance, methodology, and reproducibility. The publication timelines are largely predictable, initial administrative checks typically take 2–4 days, reviewer invitations may vary depending on reviewer responsiveness, and a typical review round averages around four weeks. Submissions undergo a thorough evaluation for both scientific merit and compliance with formal requirements, followed by opportunities for revision based on reviewer feedback. Overall, the process is transparent, well-structured, and oriented toward maintaining high quality while supporting author‑friendly communication. " [Collapse]

Wang WH, Wu MY, Zhang XK, Wang X, Yuan XX, Ma L, Li L, Zhang L. Correlation of objective mobile phone use time and mobile phone addiction with depressive and anxiety symptoms in young adults. World J Psychiatry 2026; 16(5): 117104

"Overall a straight forward system and process. Guidance snd instructions to authors are clear and helpful. The tracking system for ..." [Read more]

"Overall a straight forward system and process. Guidance snd instructions to authors are clear and helpful. The tracking system for the paper is also helpful. Time to review was adequate as was the time to final publication. Congratulations to all your team on an excellent job. I would confided publishing with the same platform again. " [Collapse]

Butler T, O’Hara F, Costigan C, Sihag S, Kripakaran D, McNamara D. Enteroscopy and ablation of small bowel angiodysplasia improves quality-of-life and fatigue: A prospective study including biomarker assessment. World J Gastroenterol 2026; 32(18): 117264

"I would like to express my genuine appreciation for both the review system and the editorial handling. The streamlined online platform ..." [Read more]

"I would like to express my genuine appreciation for both the review system and the editorial handling. The streamlined online platform made the submission process hassle-free, and the editors were consistently available to answer queries. Furthermore, the detailed and insightful comments from the reviewers were invaluable, greatly strengthening the final manuscript. The entire experience was outstanding " [Collapse]

Li YJ, Zhang Y, Peng XL, Mei YJ, Yang XJ, Luo YJ. Collaborative mental health care improves well-being and reduces complications in hemodialysis patients. World J Psychiatry 2026; 16(5): 116997

"We would like to express our sincere appreciation to the editorial team and reviewers of WJG for their highly efficient and ..." [Read more]

"We would like to express our sincere appreciation to the editorial team and reviewers of WJG for their highly efficient and professional handling of our manuscript. From submission to final acceptance, the entire process was remarkably rapid and well-organized. The reviewers’ comments were insightful and constructive, which significantly improved the quality of our paper. The timely communication and clear guidance from the editorial office greatly facilitated the revision process. It has been a real pleasure to publish in such a high-quality journal with exceptional editorial efficiency. " [Collapse]

Jin X, Xu TM, Ruan GC, Zhang XF, Chen XY, Li XQ, Tang H, Xu H, Wang QP, Liu W, Li J. Clinical manifestations and imaging features of inferior mesenteric vein-related colon ischemia. World J Gastroenterol 2026; 32(18): 116229

"I am very satisfied with the prompt peer review process, from the initial submission through to the final acceptance. The feedback ..." [Read more]

"I am very satisfied with the prompt peer review process, from the initial submission through to the final acceptance. The feedback provided was spot-on and proved invaluable in improving the quality of my paper. The submission checklist was clear and easy to follow, allowing me to prepare the necessary documents smoothly. Thank you very much. " [Collapse]

Tomita D, Yamamoto M, Wakamatsu M, Shibayama R, Maeda Y, Hiramatsu K, Hanaoka Y, Toda S, Ueno M, Matoba S, Kuroyanagi H. Anastomotic colonic varices after colectomy treated by obliteration via a transhepatic portal approach: A case report. World J Gastroenterol 2026; 32(18): 118499

"The journal demonstrated a highly professional and well-organised publication process. The online submission system was user-friendly ..." [Read more]

"The journal demonstrated a highly professional and well-organised publication process. The online submission system was user-friendly and efficient, making manuscript handling straightforward. The peer review process was timely, fair, and provided constructive feedback that improved the quality of the manuscript. The editorial team maintained clear communication throughout, and the final editing, formatting, and presentation of the article were of a high standard. Overall, the experience was smooth, transparent, and aligned with strong academic and ethical publishing practices. " [Collapse]

Al Hajaj SW, Soliman K, Zafar M, Garnham C, Al Hajaj D, Elshafie O, Alsswah A, Elwan MH. From subtle breaks to missed diagnoses: Real-world evaluation of an artificial intelligence fracture detection tool. World J Orthop 2026; 17(4): 113710

"We sincerely appreciate the efforts of the editorial team and reviewers for their constructive comments and efficient handling of ..." [Read more]

"We sincerely appreciate the efforts of the editorial team and reviewers for their constructive comments and efficient handling of our manuscript. The peer review process was rigorous and significantly improved the clarity and scientific quality of our work. The communication throughout the submission and publication process was timely and professional. We are satisfied with the overall experience and would consider submitting future work to this journal. " [Collapse]

Xu LH, Cui HR, Wei YY, Tang XC, Qian ZY, Zhang D, Zheng WS, Zhu TY, Hong XF, Zhu JJ, Hu YG, Liu X, Jiao X, Qing Y, Chen XC, Tang YY, Zhang TH, Wang JJ. Visuospatial memory modulates insight and its predictive value for 6-year psychosis risk in clinical high-risk individuals. World J Psychiatry 2026; 16(5): 113866

"nothing to declare nothing to declare nothing to declare nothing to declare nothing to declare nothing to declare nothing to declare ..." [Read more]

Duarte MB, Czermainski J, Ferreira LF, Tovo CV, Carteri RB. Inflammatory parameters and liver fibrosis in patients with steatosis: A cross-sectional analysis. World J Hepatol 2026; 18(3): 111569

"The published paper is well-structured with clear research logic and a distinctive research perspective. The research content is ..." [Read more]

"The published paper is well-structured with clear research logic and a distinctive research perspective. The research content is comprehensive and in-depth, the research methods are reasonable and feasible, and the data analysis is rigorous and credible. The conclusions drawn are convincing and have certain academic value and practical application significance. The journal has a strict review process, efficient editing work and a standardized publishing process. The editorial staff are professional, patient and responsible, and respond to consultation questions in a timely manner. The overall publishing experience is very good, and I am highly satisfied with the journal's service and publication quality. I am willing to continue paying attention to this journal and recommend it to other researchers for submission. " [Collapse]

Meng TF, Wang S, Chen C, Deng SK. Analysis of the efficacy of first hepatic portal blockade in laparoscopic microwave ablation treatment of hepatic vascular tumors. World J Gastrointest Surg 2026; 18(4): 113354

"The editorial process behind the article “Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis” ..." [Read more]

"The editorial process behind the article “Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis” in the World Journal of Stem Cells reflects rigorous peer review and efficient handling, ensuring scientific clarity and credibility. The timely publication highlights the journal’s commitment to advancing regenerative orthopaedics by rapidly disseminating emerging concepts in cell-free therapeutics. By streamlining editorial workflows and prioritizing impactful manuscripts, the journal enables clinicians and researchers to access novel insights without delay. This efficiency strengthens translational momentum, fosters academic collaboration, and underscores the importance of editorial diligence in shaping evidence-based innovation for osteoarthritis care. " [Collapse]

Muruganandam A, Jeyaraman N, Sukumaran AM, Ramasubramanian S, Devanand V, Nallakumarasamy A, Muthu S, Jeyaraman M. Future perspectives on mesenchymal stromal cell-derived secretomes in knee osteoarthritis. World J Stem Cells 2026; 18(4): 117271

"This study investigated the effects of exercise-based rehabilitation training in patients with schizophrenia and demonstrated ..." [Read more]

"This study investigated the effects of exercise-based rehabilitation training in patients with schizophrenia and demonstrated significant improvements in psychiatric symptoms, cognitive function, and social outcomes. The overall submission and publication process was smooth and efficient. The peer-review comments were helpful and contributed to improving the clarity and scientific quality of the manuscript. The editorial team maintained professional communication throughout the process. The findings of this study support the role of structured exercise as an effective adjunctive treatment in schizophrenia rehabilitation. Future research is recommended to further explore the underlying mechanisms, such as BDNF-related neuroplasticity, with larger and multi-center study designs. " [Collapse]

Wang FL, Sima CX, Zhang SJ, Hou TF. Effects of exercise-based rehabilitation training in schizophrenia patients. World J Psychiatry 2026; 16(5): 113822

"Thank you very much for the editorial work and reviewers’ valuable comments. We have carefully revised the manuscript according to ..." [Read more]

"Thank you very much for the editorial work and reviewers’ valuable comments. We have carefully revised the manuscript according to the requirements, and all revisions have been marked in the revised version. We agree with the evaluation results and are satisfied with the whole publication process. We wish the journal greater achievements in the future. " [Collapse]

Cheng XY, Chen T. Effect of modified Da-Cheng-Qi decoction on stoma reversal and postoperative ileus after laparoscopic anterior resection. World J Gastrointest Surg 2026; 18(4): 116655

"The overall manuscript submission and publication process was smooth and well-organized. The peer review was constructive, objective, ..." [Read more]

"The overall manuscript submission and publication process was smooth and well-organized. The peer review was constructive, objective, and contributed to improving the scientific quality and clarity of the manuscript. The editorial team maintained good communication throughout the process, and the production quality of the final article, including formatting, figures, and online presentation, is satisfactory. We appreciate the timely handling of our manuscript and the transparency in editorial and publication procedures. Continued focus on maintaining high peer review standards and efficient processing timelines will further enhance the journal’s impact and author satisfaction. " [Collapse]

Kothawade SN, Padwal V. Letter to the Editor: DAF-FM fluorescent probe: Advancing early detection of esophagitis-to-cancer transformation through nitric oxide imaging. World J Gastrointest Surg 2026; 18(4): 115868

"Overall good experience with the submission process and the revision process. I am satisfied with the anonymous review process. Peer ..." [Read more]

"Overall good experience with the submission process and the revision process. I am satisfied with the anonymous review process. Peer review report was fair and objective. Good editing and fast communication with the editorial team. I will recommend this journal to my peers for the future. I will consider this journal for future case reports " [Collapse]

Porto AG, Zappulla P, Conti S, Sgarito G. When the atrium is not enough, ablation of anteroseptal focal atrial tachycardia from the non-coronary aortic cusp: A case report. World J Clin Cases 2026; 14(14): 120147

"I would like to express my sincere gratitude to your journal for recognizing and supporting my manuscript, and I am especially ..." [Read more]

"I would like to express my sincere gratitude to your journal for recognizing and supporting my manuscript, and I am especially appreciative of the rigorous and professional attitude demonstrated by the editorial team during the review and evaluation process. Each of the revision suggestions you provided was precise and hit the key points, not only helping me clarify my research ideas but also substantially improving the quality of the manuscript. I am deeply grateful for the professional guidance and assistance you provided throughout the review process, and I am very satisfied with the outcome. " [Collapse]

Chen K, Zheng QB, Gu XB. Relationship between dyspnea, fear, anxiety and depression in patients with mild acute respiratory distress syndrome. World J Psychiatry 2026; 16(5): 115026

"Overall, I am satisfied with the journal’s editorial and peer review process. The online submission system was user‑friendly and ..." [Read more]

"Overall, I am satisfied with the journal’s editorial and peer review process. The online submission system was user‑friendly and efficient. The peer review reports were received within a reasonable time, and the reviewers’ comments were constructive and helped improve the manuscript significantly. The editing quality and the final PDF/online full‑text presentation were professional. I also appreciate the clear academic integrity check and the journal’s adherence to publication norms. A minor suggestion: it would be helpful if the average review time could be indicated during submission. " [Collapse]

Zhong SY, Deng XR, Han BC, Yang LQ, Ye ST, Niu XK. Diagnostic performance of magnetic resonance imaging-based radiomics for detecting prostate cancer: A systematic review and meta-analysis. World J Radiol 2026; 18(3): 116826

"The editors of this journal are very conscientious, and the manuscript processing is swift. The feedback and suggestions provided ..." [Read more]

"The editors of this journal are very conscientious, and the manuscript processing is swift. The feedback and suggestions provided by the peer reviewers have been extremely helpful in improving the quality of the manuscript. I would like to express my gratitude to all the editors and reviewers involved for their hard work and guidance! " [Collapse]

Liu JZ, Ma T, Liang ZY, Ning XB, Li WJ, Wang JP, Jin YL, Zhou N, Li JF. Hypertension induced by sudden clozapine withdrawal in a schizophrenia patient with metabolic syndrome: A case report. World J Psychiatry 2026; 16(5): 113723

"When I submitted for the first time, one of the reviewers was AI. The review comments were illogical and contradictory.From the ..." [Read more]

"When I submitted for the first time, one of the reviewers was AI. The review comments were illogical and contradictory.From the perspective of current technological development, the services of language polishing companies are not necessary. The service of the journal is still very good. After paying the fee, there is no page to choose to publish, not sure if it doesn't exist or is hidden too deep. " [Collapse]

Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954

"The peer-review process was efficient, constructive, and well-organized. The reviewers provided thoughtful and relevant comments that ..." [Read more]

"The peer-review process was efficient, constructive, and well-organized. The reviewers provided thoughtful and relevant comments that significantly improved the clarity, depth, and scientific quality of the manuscript. Their feedback was specific and actionable, which facilitated meaningful revisions. Communication from the editorial office was prompt, clear, and professional throughout each stage. Overall, I am very satisfied with the review and publication process. " [Collapse]

Thiriveedi M, Patel H, Reddy PJ. Refractory rosuvastatin-associated necrotizing autoimmune myopathy: A case report and review of literature. World J Clin Cases 2026; 14(14): 120126

21276 items Read more >>

Article Quality Tracking-Peer-Review

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives ..." [Read more]

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery." [Collapse]

Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the ..." [Read more]

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration. NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration. " [Collapse]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of ..." [Read more]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery. However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed. " [Collapse]

Zhang S, Li SY, Zhou B. Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection. World J Gastrointest Surg 2026; 18(4): 116412

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Pavlidis L, Geropoulos G, Kechagias KS, Psarras K, Patel V, Reza L, Prakash N, Athanasiou C, Geropoulos V, Anestiadou E, Triantafyllou T, Sapalidis K, Laskou S, Dimitroulis D. Near-infrared fluorescence with indocyanine green for minimally invasive hernia surgery: A systematic review and evidence synthesis. World J Clin Cases 2026; 14(14): 118964

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Walędziak M, Różańska-Walędziak A. Three-port robotic sleeve gastrectomy-another step forward: A case report. World J Clin Cases 2026; 14(14): 117795

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Raveglia F, Degiovanni S, Bertolaccini L, Cara A, Cassina EM, Danuzzo F, Libretti L, Pirondini E, Sibilia MC, Spinelli F, Tuoro A, De Simone M, Chiarelli M, Cioffi U, Petrella F. Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery. World J Clin Cases 2026; 14(13): 119644

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative ..." [Read more]

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts. Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation." [Collapse]

Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; 32(16): 116781

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria ..." [Read more]

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? The study is moderately effective as it is retrospective clinical design how ever detailed methodology is missing. furthermore, it is judged on statistical variation not on experimental results variations 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? The results are appropriately authentic and consistent. Sample size is lower, hence hypothesis is moderately validated. Present study demonstrate the prognosis relevance which is insufficient for application in clinical settings. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Figure and tables are adequately presented 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Standard statistical approach is used in the current study with respect to study design 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Appropriate 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Acceptable format, formal and scientifically clear 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? Single center results Lower sample size which might effect on statistical significance Transparency in methodology " [Collapse]

Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer ..." [Read more]

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer development. It highlights how diets rich in additives, refined sugars, and industrial fats contribute to dysbiosis, inflammation, and oxidative stress, thereby increasing cancer risk. Conversely, dietary interventions such as fasting, caloric restriction, and ketogenic regimens show promise in reprogramming tumor metabolism and enhancing therapeutic responses. The authors emphasize that while mechanistic evidence is strong, clinical studies remain limited, heterogeneous, and often small in scale. Overall, the paper underscores the potential of personalized nutrition as a complementary strategy in colorectal cancer prevention and treatment, but stresses the need for well‑designed trials to validate safety, adherence, and long‑term outcomes." [Collapse]

Lima RSP, Sousa JDS, Neres MSO, de Sousa DJM, Martins JA, Pereira IC, da Silva ACA, Severo JS, Torres-Leal FL, da Silva MTB. Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming. World J Gastrointest Oncol 2026; 18(4): 115511

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing ..." [Read more]

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing their contribution to T‑cell exhaustion. The study highlights that PD‑1 inhibitors reduce PD‑1⁺ subsets but fail to affect CD161 expression, suggesting independent regulatory mechanisms. These findings underscore CD161 as a distinct and promising immunotherapeutic target, complementing but not overlapping with PD‑1 blockade strategies. While the evidence is compelling, broader patient cohorts and longitudinal studies will be essential to confirm clinical relevance and therapeutic potential." [Collapse]

Liu CR, Zhang M, Wang MQ, Zhang W, Li J, Shi GZ, Liang FF, Li YP, Huang N. CD161⁺CD8⁺ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 114547

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates ..." [Read more]

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates strong experimental evidence with both in vitro and in vivo validation, highlighting mechanistic clarity via the AMPK‑SREBP1 pathway. While promising and translational, limitations in sample size and treatment duration suggest further clinical validation is needed." [Collapse]

Huang JH, Ma JQ. HMGCR loss is synthetic lethal with PIK3CD inhibition in colorectal cancer cells. World J Gastrointest Oncol 2026; 18(4): 114220

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes ..." [Read more]

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes and coronary heart disease (CAD) and how to address both simultaneously in a prevention strategy. This paper could be a trailblazer for further research investigating the use of other drugs currently used to treat both diabetes and CAD." [Collapse]

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report ..." [Read more]

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good. The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future." [Collapse]

Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral ..." [Read more]

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen. The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons. The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published." [Collapse]

Nallakumarasamy A, Vetrivel VN, Balaji VP, Yadav R, Jeyaraman N, Muthu S, Jeyaraman M. Management and prevention of iatrogenic ipsilateral femoral neck fracture during intramedullary nailing of femoral shaft. World J Orthop 2026; 17(4): 116107

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Perforative peritonitis caused by long-term retention of a rectal foreign body: A case report. World J Clin Cases 2026; 14(11): 119572

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated ..." [Read more]

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated efforts in daily clinical practice and academic work have borne fruit. I read your paper with great interest, particularly because my own specialty is emergency medicine. I also occasionally encounter cases of anorectal foreign bodies in clinical practice, and I believe your paper will serve as a highly valuable reference for the management of such cases in the future. The manuscript is very well organized, clear, and easy to follow. In addition, it incorporates up-to-date information and presents the topic in a balanced and informative manner. Overall, I consider this to be a high-quality paper of substantial clinical value. In recognition of these strengths, I would give this work the highest evaluation. Writing and publishing a paper while maintaining a busy clinical workload is no small accomplishment, and I sincerely hope that you will continue to build on this success and further expand your academic achievements. Congratulations once again on this excellent work." [Collapse]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside ..." [Read more]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside of this treatment is the development of resistance, which, understandably, negatively affects patients’ clinical outcomes. Therefore, innovative therapeutic strategies are needed to overcome 5-FU resistance and improve the prognosis of GC. The authors of the study under review investigated the effects of Xiangshaliujunzi decoction (XSLJZD) on GC cell lines. They found that XSLJZD inhibited cell viability and proliferation, while promoting PANoptosis in 5-FU-resistant cells. Suppression of ZEB1 increased pyroptosis, apoptosis, and the expression of other proteins associated with programmed cell death. The selection of this work for comment was based on two reasons: i) the use of complementary therapy, whether or not based on traditional Chinese Medicine in the treatment of various benign and malignant digestive disorders, should be adopted internationally. The results are no longer empirical but are based on valid clinical and laboratory data, ii) The authors, in designing their study, among other things, investigated the effect of PANoptosis processes (apoptosis, pyroptosis, and necroptosis) which are a very hot topic of research internationally not only in malignant digestive diseases, but also in a host of other benign conditions such as inflammatory bowel disease. Their results, although experimental, reinforce the view that XSLJZD overcomes 5-fluorouracil (5-FU) resistance in GC by inducing PANoptosis." [Collapse]

Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; 32(14): 114331

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication ..." [Read more]

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication and highlighting its neurovascular nature. Diabetic retinopathy (DR), and its effective explanation as a complex, multifactorial, and increasingly recognized neurovascular disorder rather than solely a microvascular complication. The paper effectively emphasizes the global burden of the disease and the limitations of current treatments, especially anti-VEGF therapies, while drawing attention to the importance of early retinal changes. One of the main strengths of the review is its broader perspective beyond glucose control. The discussion of inflammation, lipid metabolism, and immune processes is well integrated and reflects current thinking in the field. The discussion of broader perspective as “beyond-glycemia” framework, reinforcing the need for multidimensional therapeutic strategies. The writing flows logically, making complex mechanisms easier to follow. The section on the gut-retina axis is particularly interesting and adds a fresh dimension to the topic. It clearly explains how gut microbiota may influence retinal health through metabolic and immune pathways. The inclusion of microbial metabolites, extracellular vesicles, and immune modulation as mediators of gut-retina communication demonstrates a developed understanding of the current evidence. Overall, the draft is well-organized, informative, and forward-looking, with a strong focus on potential new therapies and future research directions. " [Collapse]

Zeppieri M, Drigo A, Capobianco M, Visalli F, Cappellani F, Musa M, Giglio R, Tognetto D, Khouyyi M, Gagliano C, D’Esposito F, Inferrera L. Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy. World J Diabetes 2026; 17(3): 114603

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective ..." [Read more]

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective for clopidogrel induced gastrointestinal bleeding. However,co-administration with rebamipide provides sufficient hemostatic effect. Please comment the reason why pPI with rebamipide is good effect for the gastrointestinal bleeding with clopidogrel. Please comment the side effect of long term with pPI use." [Collapse]

Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and ..." [Read more]

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and clearly highlights its strengths and limitations. The text structure is good, and the logical presentation of information facilitates the understanding of the process and the mechanisms involved. In addition, the text is grammatically correct, managing to present new perspectives on how feature selection and the integration of clinical and endoscopic biomarkers can contribute to risk stratification and personalized management of patients with AIG. This approach makes a clear contribution to the specialized literature, opening avenues for future research and practical application of predictive models. " [Collapse]

Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 37293

Manuscripts received today: 18

Manuscript reviews today: 25

Unhandled manuscripts today: 146

Active peer-reviewers today: 3386

Reviewer acceptance today: 72

Reviewer refusals today: 81

Total accepted manuscripts: 41303

Total rejected manuscripts: 45529

Total peer-reviewers: 4820573

Total submissions: 38957