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2026-05-29 | Browse: 9 | Download: 0
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1086 items Read more >>
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"The review process for our article was excellent. We received each review report promptly as soon as it was submitted, which helped ..."
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"The review process for our article was excellent. We received each review report promptly as soon as it was submitted, which helped us prepare our responses in a timely manner. Overall, the process was quick, transparent, and fair. However, I would like to suggest developing an online system for proofreading, as sending and revising Word documents can sometimes be confusing. "
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Bashir B, Choudhery MS, Hussain I. Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells. World J Stem Cells 2026; 18(5): 117241
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"Overall, the authors are satisfied with the revision process conducted by the World Journal of Gastroenterology. The editorial and ..."
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"Overall, the authors are satisfied with the revision process conducted by the World Journal of Gastroenterology. The editorial and peer-review procedures were clear, constructive, and professionally managed. The reviewers’ comments helped improve the quality, clarity, and scientific presentation of the manuscript. We appreciate the time, effort, and guidance provided throughout the revision process. "
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Vázquez-Lorente H, Olivares-Arancibia J, Plaza-Diaz J. Beyond the score: Diet and exercise as modifiers of inflammation-based prognosis in lenvatinib-treated hepatocellular carcinoma. World J Gastroenterol 2026; 32(22): 118191
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"The overall editorial and peer-review process was satisfactory, and I appreciated the professionalism of the editorial team throughout ..."
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"The overall editorial and peer-review process was satisfactory, and I appreciated the professionalism of the editorial team throughout the different stages of manuscript handling. The communication was generally clear, and the revision process proceeded smoothly. The only aspect that could be improved concerns the time interval between final acceptance of the manuscript and its online publication, which appeared longer than expected. Reducing this interval would further enhance the efficiency of the publication process and the timely dissemination of accepted scientific contributions. Overall, my experience with the World Journal of Hepatology was positive. "
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Fiore M. Letter to the Editor: From prediction to prevention: Integrating nomograms and pathogen biology in multidrug-resistant pyogenic liver abscess. World J Hepatol 2026; 18(5): 115709
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"Great satisfaction is achieved regarding the wind field system. It presents steady wind distribution, consistent parameters and ideal ..."
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"Great satisfaction is achieved regarding the wind field system. It presents steady wind distribution, consistent parameters and ideal flow patterns, fully complying with our design and application standards. We are quite satisfied with the simulated wind field system. The wind speed and direction distribution are reasonable, with smooth transitions and reliable data, which perfectly supports subsequent research and analysis work. "
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Wang HF, Yan PY, Muhammad S, Liu YX, Liu C. Hypoxia-inducible factor-1α/β-catenin axis: A conserved regulatory hub for enhancing stem cell function in tissue regeneration. World J Stem Cells 2026; 18(5): 116050
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"All the editors and reviewers are very serious and responsible.The editors and review experts are very serious and responsible. I ..."
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"All the editors and reviewers are very serious and responsible.The editors and review experts are very serious and responsible. I am very grateful that they were able to review my manuscript despite their busy schedules. Their work efficiency is very high. Moreover, they give the authors a lot of useful suggestions.Many thanks to them for their guidance and professional comments. "
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Wei JM, Chen SX, He T, Wang JF. Application of artificial intelligence-driven three-dimensional imaging in preoperative planning for rectosigmoid colon cancer. World J Gastrointest Surg 2026; 18(5): 119310
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"The article “Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to ..."
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"The article “Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications” was published fast and early in the World Journal of Stem Cells, underscoring its translational importance. By focusing on exosome-mediated signaling, the paper highlights how cell-free biologics derived from bone marrow MSCs can modulate inflammation, cartilage repair, and joint homeostasis. Its expedited publication reflects the urgency of advancing mechanistic insights into clinical applicability, offering a bridge between laboratory evidence and therapeutic innovation. This timely release ensures clinicians and researchers gain immediate access to evolving strategies that may redefine regenerative care in osteoarthritis. "
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Raja A, Jeyaraman N, Sukumaran AM, Sridhar AS, Ramasubramanian S, Nallakumarasamy A, Muthu S, Jeyaraman M. Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications. World J Stem Cells 2026; 18(5): 117689
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"We greatly appreciate this medical journal for its rigorous peer review process and timely, efficient publication practices. The ..."
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"We greatly appreciate this medical journal for its rigorous peer review process and timely, efficient publication practices. The constructive revision suggestions significantly improved our manuscript. The entire submission process was smooth and well-organized, and we were deeply impressed by the professional and responsible editorial team, whose dedicated efforts we truly acknowledge. "
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Ke FY, Chen H, Liu JS, Li WC, Dhamija G, Viroja RD, Chen GP, Zhou XC. Clinical value of computed tomography-based three-dimensional reconstruction of the pelvis and mesorectum in middle to low rectal carcinoma. World J Gastrointest Surg 2026; 18(5): 119094
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"I think was a great experience work with You and togheter made an article with correct advice with peer review and advice about freat ..."
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"I think was a great experience work with You and togheter made an article with correct advice with peer review and advice about freat help with our manuscript. Your help was great and made the article a rigorous science article, we are very sactisfated. Your advice about a rigorous bibliography and rigorous advice about lenguage and bibliography let us to made a good article and a contribute to other Hepatologist aned gastoenterologist "
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Sciarrone SS, Di Leo M, Fini L, Losco A, De Luca L. Letter to the Editor: Splitting the risk: Interpretable machine learning enters the era of split liver transplantation. World J Gastroenterol 2026; 32(22): 116533
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"I am very satisfied with the current manuscript submission system and peer review process. The overall workflow is efficient, well ..."
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"I am very satisfied with the current manuscript submission system and peer review process. The overall workflow is efficient, well organized, and easy to follow. The review process was completed quickly, and each step was clearly communicated to the authors. I especially appreciate the transparency of the system, which allowed me to track the progress of the manuscript throughout the submission and review stages. "
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Meng D, Zhang BB, Zhao JN. Letter to the Editor: Deciphering macrophage heterogeneity and optimizing probiotics via spatial multi-omics. World J Gastrointest Pharmacol Ther 2026; 17(2): 118195
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"Excellent work. I am extremely pleased with the editing, and the peer review process. It really helped me improve the quality of my ..."
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"Excellent work. I am extremely pleased with the editing, and the peer review process. It really helped me improve the quality of my article. With the changes, I feel that it is much better and will reach out better to a lot more readers. I would like to thank world journal of transplantation for their efforts. "
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Pahari DK, Pahari H. Efficacy and safety of low-dose everolimus and tacrolimus in kidney transplant recipients: A retrospective study. World J Transplant 2026; 16(2): 118249
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"The entire workflow, from submission through peer review, was smooth, timely, and well-coordinated. Communication was clear at every ..."
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"The entire workflow, from submission through peer review, was smooth, timely, and well-coordinated. Communication was clear at every stage, editorial decisions were transparent and constructive, and reviewer feedback proved both rigorous and constructive in improving the manuscript. Overall, the process was efficient and professionally managed, reinforcing my confidence in the journal. "
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Ahmed FW, Ahmed F. Positron emission tomography tracers in medullary thyroid carcinoma: Current evidence and emerging targets. World J Radiol 2026; 18(5): 120146
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"The journal demonstrates a strong commitment to publishing high-quality, peer-reviewed research and provides an effective platform ..."
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"The journal demonstrates a strong commitment to publishing high-quality, peer-reviewed research and provides an effective platform for disseminating scientific knowledge. The editorial process appears transparent and well-structured, with reasonable review timelines and constructive feedback that contributes to manuscript improvement. The journal maintains a broad scope while ensuring scientific rigour, methodological soundness, and ethical publishing standards. "
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Biswas MS, Mawa MJ, Nizum SM. Unseen suffering: Addressing psychological distress in esophageal cancer with bone metastasis. World J Psychiatry 2026; 16(6): 116379
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"Thank you to the editors and peer reviewers for their work. I am very pleased to have received fair and objective evaluations from ..."
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"Thank you to the editors and peer reviewers for their work. I am very pleased to have received fair and objective evaluations from the editorial office and the peer reviewers, which greatly enhanced the readability and rigor of this article. I also appreciate the editors' efforts; the entire submission and publication process was very smooth. "
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Zhu TT, Zhu XY, Yang M, Liu WM, Yang WJ, Liu X. Photon-counting computed tomography enables low-dose, high-quality abdominal imaging: A comparative study with energy-integrating detector computed tomography. World J Radiol 2026; 18(5): 119048
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"We are very pleased with the efficient and professional handling of our manuscript by the editorial team of World Journal of Stem ..."
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"We are very pleased with the efficient and professional handling of our manuscript by the editorial team of World Journal of Stem Cells. The review process was remarkably fast, and the editorial office responded promptly at every stage, which greatly facilitated the timely dissemination of our work. The editors provided thoughtful and constructive guidance, and their courteous communication made the entire submission experience smooth and positive. We sincerely appreciate the excellent service and would highly recommend this journal to fellow researchers. "
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Wen W, Liu CX, Wang Y, Lu XJ, Yang C, Chen SJ, Jin ZT, Qu MY, Deng JY, Zhang Z. Hypoxia-preconditioned mesenchymal stem cell-derived exosomes attenuate myocardial ischemia/reperfusion injury by miR-29b-3p via PINK1/Parkin-mediated mitophagy. World J Stem Cells 2026; 18(5): 116611
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"Great communication throughout the entire process. The publication workflow was smooth, efficient, and well organized. The tools and ..."
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"Great communication throughout the entire process. The publication workflow was smooth, efficient, and well organized. The tools and resources provided to authors were excellent, intuitive, and easy to use. Overall, the experience was highly positive, making manuscript submission, revision, and publication straightforward, transparent, and enjoyable from start to finish. I would gladly submit future work here. "
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Maroun W, Osborn ZF, Garg P, Angappan S, El-Bashir J, Heppell O, Soetedjo J, Pillai S, Miyake K, Mohamed A, Nagai S, Guerra-Londono CE. Thromboelastographic description of intraoperative coagulopathy in patients undergoing liver transplant surgery: A single-center observational study. World J Transplant 2026; 16(2): 118880
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"The manuscript submission and tracking process through the F6Publishing system was intuitive, streamlined, and efficient from initial ..."
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"The manuscript submission and tracking process through the F6Publishing system was intuitive, streamlined, and efficient from initial upload to final acceptance. We highly value the constructive, rigorous, and timely feedback provided by the peer reviewers, which significantly enhanced the overall quality and clarity of our systematic review. The editorial team maintained excellent communication throughout, providing prompt responses and professional guidance during the language editing and manuscript revision phases. "
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Lin C, Song KR, Li QH, Nair GS, Cheng S, Kumar K. High-flow nasal cannula for hypoxia in the post-anesthetic recovery unit: A systematic review and meta-analysis. World J Crit Care Med 2026; 15(2): 118285
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"Thank you for the peer review process and for the editorial support provided throughout the publication procedure. The review report ..."
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"Thank you for the peer review process and for the editorial support provided throughout the publication procedure. The review report was useful, fair, and objective, and the comments helped us to improve the quality, clarity, and scientific presentation of the manuscript. We are satisfied with the editorial process and the final version of the article. "
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Moreno-Fenoll B, Gil-Caselles L, Gomez-Espejo V, Garcia-Naveira A, Ruiz-Barquín R, Olmedilla-Zafra A. Effectiveness of a cognitive behavioural intervention on mental health in young footballers: A quasi-experimental study. World J Psychiatry 2026; 16(6): 118232
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"We sincerely thank the editorial office, production staff, and peer reviewers of the World Journal of Psychiatry for an efficient, ..."
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"We sincerely thank the editorial office, production staff, and peer reviewers of the World Journal of Psychiatry for an efficient, professional, and high-quality editorial experience. We are highly satisfied with the overall editorial and publication process. The review process was thoughtful, objective, and constructive, and substantially improved the final manuscript. We particularly appreciate the academic rigor of the peer review, which contributed meaningfully to strengthening the clarity, scientific presentation, and overall quality of the published article "
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Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917
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"It is a pleasure to publish an article in this journal, and I am grateful for the opportunity. The journal provides valuable medical ..."
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"It is a pleasure to publish an article in this journal, and I am grateful for the opportunity. The journal provides valuable medical updates and maintains high academic standards. I sincerely appreciate your support and responsiveness. If possible, kindly process manuscripts with all necessary corrections communicated at once to avoid prolonged revision cycles. Thank you for your continued support. "
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Jain J, Navriya SC, Chintapalli RC, Choudhary GR, Singh M, Bhirud DP, Sandhu AS. Extracorporeal shockwavelithotripsy vs ureteroscopy for management of acute ureteric colic due to stones: A randomized controlled trial. World J Crit Care Med 2026; 15(2): 114619
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"I am satified by the whole review process. I will suggest to ask for native language editing certificate during the final version. ..."
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"I am satified by the whole review process. I will suggest to ask for native language editing certificate during the final version. This will both save time and money. As a whole the journal is doing its best in communication and the review process is excellent. I wish best luck to the management of the journal and i am sure the journal will further flourish in the future. "
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Al-Qurashi SH, Khalil MAM, Mahmood HHK, Alsharif MM, Alqurashi YF, Alghamdi L, Al-Ghamdi RA, Alsaedi ZA, Cruz AJD, Aboasamh GA, Sadagah NM. Immunologic clustering of donor-specific antibodies and clinical outcomes in kidney transplant recipients. World J Transplant 2026; 16(2): 118450
21484 items Read more >>
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"Proton pump inhibitors (PPIs) are acid-suppressive agents that irreversibly bind to the gastric mucosa’s H+/K+ ATPase proton pump. ..."
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"Proton pump inhibitors (PPIs) are acid-suppressive agents that irreversibly bind to the gastric mucosa’s H+/K+ ATPase proton pump. They are the first-line treatment for various gastrointestinal conditions, including peptic ulcers and gastroesophageal reflux disease, demonstrating superior efficacy compared to traditional acid-suppressive therapies. PPIs have become one of the most widely prescribed long-term medications globally, however, an increasing number of adverse effects have been reported. Numerous studies have confirmed PPIs’ extensive and significant impact on the gut microbiota from the oral cavity to the rectum. Gut dysbiosis is a significant adverse effect of PPIs, potentially exceeding the microbiota-altering impact of antibiotics. While gastric acid suppression plays an important role, PPIs also affect the gut microbiota through multiple mechanisms. Several studies have identified a potential association between PPIs and IBD, suggesting that PPIs may influence the onset, progression, and treatment efficacy of IBD. Although the underlying mechanisms remain unclear, many researchers speculate that dysbiosis induced by PPIs plays a critical role, given the similarities in gut microbiota changes observed in PPIs users and IBD patients. Authors concluded that this association may be influenced by study design, age differences, and protopathic bias, thereby limiting causal inference. Clinicians should interpret this association cautiously, and future prospective studies with rigorous bias control are needed to determine whether PPI use contributes to inflammatory bowel disease pathogenesis. I agree to authors’ opinion.
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Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469
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"1. Overall assessment
Ethics approval, study registration, and funding disclosure are complete, and the study generally complies ..."
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"1. Overall assessment
Ethics approval, study registration, and funding disclosure are complete, and the study generally complies with international ethical standards for medical research. The work is based on a 499-patient multi-centre retrospective cohort and uses OS together with 3- and 5-year cumulative survival rates as primary endpoints; Kaplan-Meier survival analysis and Cox proportional-hazards modelling are used to evaluate prognostic factors, and the overall analytical framework is consistent with common analytical approaches in oncology prognostic research. Statistical procedures, including survival time definition, censoring handling, and baseline comparison, are reported relatively completely, and the figures and baseline characteristics are presented clearly. In the context of relatively limited real-world long-term survival evidence on ICWM in CRLM, this study provides a useful foundation for future research.
Although the research question is clinically valuable and the cohort size is reasonable, several methodological limitations may affect causal interpretation; the findings are therefore more appropriately regarded as hypothesis-generating evidence.
2. Major methodological concerns
(a) Immortal time bias
The study defines cohort A by "continuous TCM >=3 months" and uses the date of initial diagnosis as the OS time origin. This combination of exposure definition and survival time origin may introduce immortal time bias, because patients have to survive long enough to qualify for cohort A. The reclassification of some patients from cohort B to cohort A during follow-up also points to a potential time-dependent exposure issue. A landmark analysis (e.g., a 3- or 6-month landmark) or modelling TCM as a time-dependent covariate would help reduce this risk of bias.
(b) Residual confounding
The grouping is not randomized, and the choice of TCM may be related to factors such as adherence, socioeconomic status, family support, and treatment tolerability. These unmeasured variables may also influence survival, and Cox regression alone may not fully address residual confounding. Propensity-score-based approaches (e.g., PSM or IPTW) could be considered to improve covariate balance. If these unmeasured data cannot be retrospectively extracted, this should be explicitly listed as a study limitation in the Discussion.
(c) Exposure heterogeneity and treatment-intensity imbalance
The TCM exposure in cohort A includes individualized decoctions together with several patent medicines (Anteke, Pingxiao, Compound Cantharidin, Xihuang, Weimaining). These patent medicines may differ in mechanism and potential efficacy, and combining them under a single “TCM exposure” may weaken interpretability. Additional variation across treatment stages may further increase within-exposure heterogeneity. In addition, the manuscript states only that patients received "best available treatment according to guidelines," without reporting treatment-intensity indicators such as chemotherapy lines, biologic agent use rate, or relative dose intensity (RDI). Stratified sensitivity analyses by patent-medicine category or by decoction-only exposure, together with reporting of systemic treatment intensity, would be useful additions.
3. Statistical and reporting considerations
Covariate adjustment in the Cox model
The multivariable Cox model includes only four covariates: primary tumour site, RAS/BRAF status, local treatment of liver metastases, and cohort assignment. For CRLM survival analysis, prognostic models generally need to cover key dimensions such as patient status, tumour biology, disease burden, and treatment intensity in a relatively comprehensive way. The variables currently included are concentrated on selected treatment factors and molecular features, while several well-recognized prognostic factors have not yet been entered into the model. For example, age differs significantly between the two groups (62.47 vs 58.51 years, P<0.01) but is not adjusted for; ECOG/KPS is used only as an inclusion criterion (0-2) rather than as a covariate; and liver metastatic burden indicators (such as number of metastases, maximum lesion diameter, synchronous vs metachronous status, and extrahepatic disease) are also not included. Treatment-intensity indicators such as chemotherapy lines and RDI are not reported.
Multiplicity and subgroup analyses
Figure 2 presents multiple subgroup analyses (age, sex, primary site, gene status, local treatment, treatment lines, and metastasis location, among others), but the manuscript does not address the multiple-comparisons issue. A large number of subgroup tests may increase the risk of false-positive findings; we suggest that the authors interpret subgroup results cautiously and consider reporting adjusted P values for key subgroups in order to reduce the likelihood of false-positive findings.
Proportional-hazards assumption
Follow-up in this study is relatively long (up to 132 months), and time-varying treatment effects are plausible. Formal assessment of the Cox proportional-hazards assumption (e.g., Schoenfeld residuals) would strengthen confidence in the reported hazard ratios.
Safety reporting
The methods section notes that major adverse reactions would be tracked during follow-up, but the manuscript does not report a safety comparison between the two cohorts, nor does it present indicators such as HILI, myelosuppression, or hepatic/renal function. Given that ICWM is evaluated as a long-term treatment exposure, additional safety data would help support a more comprehensive assessment of its clinical value. If these data cannot be systematically obtained, this limitation should be further clarified in the Discussion.
References
The reference base broadly covers CRLM epidemiology, local liver-directed therapies, and TCM-related mechanisms, and is reasonably current and on-topic. Incorporating the most recent systematic reviews or meta-analyses on integrative medicine in advanced colorectal cancer, where available, would further strengthen the literature base.
4. Language and interpretation
The manuscript is clearly structured and well organized, and on the whole follows standard reporting conventions for observational cohort studies. However, causal and associative language are mixed in places. For example, the title uses verbs with a more causal connotation such as "prolong," and the Discussion contains expressions such as "reduced the risk of death by 35%" and "protective factors," whereas the Abstract Conclusion is phrased associatively as "is associated with longer OS." Maintaining greater consistency in the use of associative rather than causal language throughout the manuscript would better match the evidence level of a retrospective observational design.
5. Conclusion
Overall, this study addresses a clinically relevant question and contributes useful real-world evidence regarding ICWM in CRLM. The findings are best interpreted as hypothesis-generating. Addressing the methodological limitations identified above, particularly immortal time bias, residual confounding, and limited covariate adjustment, in future studies would strengthen causal inference and improve the interpretability of the results.
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Bian JY, Sun YX, Wang LF, He WT, Liu CB, Wang XQ, Zhang T. Integrated Chinese and Western medicine prolong survival in colorectal cancer with liver metastasis: A retrospective cohort study. World J Clin Oncol 2026; 17(5): 118265
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"Post-stroke depression (PSD) is a frequent complication that worsens recovery and quality of life. Clinicians should prioritize early ..."
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"Post-stroke depression (PSD) is a frequent complication that worsens recovery and quality of life. Clinicians should prioritize early screening of PSD, especially in patients with cognitive impairment, severe disability, or social isolation. Biological markers such as inflammation and neurotransmitter imbalance may guide risk stratification, while predictive models can support monitoring. Management requires a multimodal approach: antidepressants, psychotherapy, and rehabilitation programs, complemented by family and social support. If integrated into routine stroke care, these strategies enable timely intervention, reduces complications, and promote fast functional recovery."
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Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996
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"This study is methodologically rigorous, employing a large sample size, LASSO regression, and dual validation to ensure robust results. ..."
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"This study is methodologically rigorous, employing a large sample size, LASSO regression, and dual validation to ensure robust results. The dynamic online nomogram enhances clinical usability and identifies clear risk factors, including cognition, albumin, and surgical parameters. Limitations include its single‑institution scope, short validation period, and the need for prospective testing of clinical impact. Overall, it provides a solid foundation and meaningful step toward proactive management of emergence delirium in older adults."
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Xin Y, He B, Wei XH, Yan YL, Huang C, Gao CY, Wang S, Zhang GM, Li R, Wu Y. Construction and validation of a predictive model for the risk of emergence delirium in older adult patients. World J Psychiatry 2026; 16(6): 115839
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"This is a well-written and presented a rare case report on "Clinical management of porcelain gallbladder: A case report". This ..."
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"This is a well-written and presented a rare case report on "Clinical management of porcelain gallbladder: A case report". This manuscript gives additional new knowledge to the existing literature.Porcelain gallbladder is a rare clinical entity that should always be considered due to its well-established association with gallbladder carcinoma. I think that this manuscript is worth to be published in the World Journal of Gastrointestinal Surgery."
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Chen SJ, Chen S, Hu AY, Li QS, Fan Y, Chen YG, Tian S, Li HL, Peng CJ, Han M. Clinical management of porcelain gallbladder: A case report. World J Gastrointest Surg 2026; 18(5): 116359
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"This article is well structured and fully compliant with the STROBE checklist. This retrospective study systematically compared the ..."
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"This article is well structured and fully compliant with the STROBE checklist. This retrospective study systematically compared the efficacy and safety of traction-preclosure-assisted endoscopic full-thickness resection (TPC-EFTR) with conventional EFTR for the treatment of gastric subepithelial tumors (SETs). The authors clearly formulated the inclusion and exclusion criteria, with a particular emphasis on endoscopic contraindications for lesions characterized by large size, extraluminal growth, dissemination, or potential recurrence. Both primary and secondary outcome measures were well defined in detail.
Regarding primary efficacy outcomes, the en bloc resection rates were comparable between the two groups, whereas the TPC-EFTR group achieved a significantly higher complete resection rate. For secondary outcomes, the TPC-EFTR group demonstrated superior safety profiles, including shortened operation time and wound closure time, as well as a reduced incidence of pneumoperitoneum. In terms of postoperative prognosis, no significant between-group difference was observed in tumor recurrence rate, while the TPC-EFTR group presented higher EQ-VAS scores. Overall, the methodological design of this study meets the standard requirements of retrospective clinical research.
Nevertheless, several limitations of this study remain to be addressed. First, although no statistically significant differences were detected, potential selection bias may exist with respect to the size and anatomical location of enrolled lesions. Second, postoperative CT examinations were performed only based on clinical symptoms, which might lead to an underestimation of the actual pneumoperitoneum rate, a limitation that has also been acknowledged by the authors. Furthermore, EFTR is a technically demanding procedure that is currently restricted to high-level tertiary hospitals. Accordingly, the clinical popularization of conventional EFTR remains challenging, and further validation and prospective investigations are still required to confirm the clinical value of TPC-EFTR.
In conclusion, this study is pioneering and clinically promising, and the TPC-EFTR technique exhibits favorable application prospects. Multi-center, large-sample, and long-term follow-up studies are warranted prior to the widespread clinical application of TPC-EFTR."
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Li X, Zhang RY, Wen XD, Li XQ, Liu WH. Traction-preclosure-assisted vs conventional endoscopic full-thickness resection for gastric subepithelial tumors: Safety, efficacy in a retrospective cohort (with video). World J Gastroenterol 2026; 32(19): 112955
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"This article discusses an interesting topic. This is problem solving oriented study, with benefit to clinical practice. The comparative ..."
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"This article discusses an interesting topic. This is problem solving oriented study, with benefit to clinical practice. The comparative study showed that the MV-Flow™ has ability to visualize smaller vessels with slower blood flow, which is particularly relevant, as they challenge the prevailing concept that smaller vessels in deep endometriotic nodules are poorly vascularized.
The ethics meet the requirement of the Journal.
Caveats or drawbacks:“There is no previous data to allow a meaningful estimation. For this reason, we do consider this study as a preliminary exploratory study” in the “Statistical analysis”section is not adequate.
The study design is not sound and the results are not sound and robust. An important limitation is that there is no golden standard(contrast-enhanced ultrasound or other methods) for reference, even the pulsed wave Doppler has not been used for attempting measurement to verify the presence of microvascularity. Using conventional power Doppler as reference is not sufficient.
The dimensions displayed by the two different imaging protocols are not exactly the same dimension, as in the Figure 2 A,B,C,D, and the sampling volume is larger than good.
Some punctuate color regions are artifacts, leading to an unauthentic conclusion that MV-Flow™ has very high sensitivity for microcirculation. "
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Alcazar JL, Pich Barroso DM, Sanchez O, Brunel I, Vilches JC, Orozco R. Enhanced detection of vascularization in rectal endometriosis: A comparative study of microvascular flow and power Doppler. World J Radiol 2026; 18(5): 119223
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"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, ..."
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"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, and how these factors promote the transition from chronic gastritis to metaplasia and malignancy. In addition, the authors describe recent developments in multi-omics technologies that are uncovering new dimensions of host-microbe interactions in the gastric niche, thereby extending the classic Correa cascade into a more comprehensive, ecosystem-based model of gastric carcinogenesis.
It seems that future perspectives on the gastric microenvironment will shift from simple descriptions of microbes to active therapeutic and diagnostic interventions, aiming to enable personalized management of patients with gastric cancer. It is also believed that advances in metabolomic analyses, microbiome modulation, utilization of specialized pro- and prebiotics, gastric microbiome transplantation, use of targeted antimicrobial drugs, modifications of the tumor microenvironment, as well as the use of ex vivo models and artificial intelligence will contribute decisively not only to the prevention and early detection of gastric cancer but also to a more effective complementary therapeutic intervention.
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Zheng HC, Zhou T, Sun L, Ding X. Gastric microenvironment and gastric cancer: Interplay of acid, microbiota, and inflammation. World J Gastroenterol 2026; 32(20): 117044
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"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood ..."
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"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood natural killer (NK) cells and changes in their functional markers can help predict the progression and severity of liver failure, particularly in conditions like acute-on-chronic liver failure (ACLF). A sharp reduction or dysfunction in circulating NK cells in the bloodstream—often alongside an accumulation of these cells in the liver itself—indicates an overwhelming immune response and correlates with a poorer prognosis. In severe liver diseases like hepatitis-induced ACLF, peripheral NK cells become depleted and show a higher expression of apoptosis and exhaustion markers. Studies suggest that at the time of hospital admission, evaluating circulating NK cell levels alongside standard clinical markers can effectively help identify patients who may survive spontaneously versus those who will require an urgent liver transplant. Finally, our results suggest that more recruitment of NK cells to the liver is somehow responsible for the failure of the native. Explain why peripheral natural killer cells reflect the prognosis more sensitively than other parameters of acute liver failure. a significant drop in peripheral Natural Killer (NK) cell counts and a shift in their functional profile are reliable biomarkers for predicting poor clinical outcomes. Patients with severe liver failure exhibit significantly reduced proportions of NK cells in their peripheral blood compared to healthy individuals. These peripheral NK cells often show signs of exhaustion and dysfunction. Many of them undergo apoptosis (cell death) or migrate directly into the inflamed liver tissue. Researchers have found that the degree of this peripheral NK cell reduction directly correlates with disease severity (e.g., HBV-DNA levels) and can serve as a strong predictive indicator for patient survival or the need for a liver transplant. Please tell me the mechanism between the predictor of acute hepatic failure and the degree of peripheral NK cell."
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Xu JX, Li HG, Xu X, Lu D. Letter to the Editor: Characteristics of peripheral blood lymphocyte subpopulations in acute-on-chronic liver failure: A call for further exploration. World J Gastroenterol 2026; 32(20): 116109
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"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. ..."
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"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. The pathogenesis underlying IRI is complex, involving a series of signaling mediators and mechanisms. This study aimed to investigate the effects of Magnesium Isoglycyrrhizinate (MgIG) on the liver function after IRI in liver resection treated with or without MgIG. MgIG is a magnesium salt of glycyrrhizic acid stereoisomer, commonly derived from licorice root. The full name of MgiG is tetrahydrate magnesium 18α, 20β-hydroxy-11-oxon orolean-12-en-3β-yl-2-O-β-D-glucopyranurosyl-α-D-glucopy ranosiduronate. Glycyrrhizin is commonly used clinically as a liver protective medicine. MgIG is the fourth generation of glycyrrhizin preparations. It has better affinity with target cell receptors, and stronger anti-inflammatory and anti-oxidation effects. It has been shown to stabilize hepatocyte membrane and improve liver function. MgIG has shown the effects of lowering the liver toxicity of free fatty acid by preventing mitochondrial damage and protecting hepatocytes from ischemia and reperfusion induced injury. Function: It provides anti-inflammatory, antioxidant, and hepatocyte membrane-stabilizing effects. Used post-surgery, it is associated with a more rapid decrease in liver enzymes (such as ALT and AST) and better regulation of inflammatory cytokines.Ischemia-reperfusion injury: Studies have shown it can mitigate liver damage caused by blocking the hepatic blood supply during the surgical procedure. Previous studies showed that MgIG administration significantly ameliorated CCl4-induced biochemical alterations and lipid peroxidation in the liver of mice or rats The protective effects of MgIG might be resulted from the elimination of oxygen free radicals before the damage to macromolecular and metabolism of the cells. I ask some questions for authors.1. Please describe the extent of liver resection and the presence or absence of cirrhosis in the patient's background. 2.Please also describe parameters other than GOT used to assess the drug's effectiveness. 3.Please provide more detailed information about the effects of MGIG on reperfusion injuries. 4.During liver surgery, how many minutes of ischemia were administered using the Pringel procedure? 5.Author’s data suggests that MG has a hepatoprotective effect on the liver, but please consider comparing it with other medications.
"
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Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513
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"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy ..."
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"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) are growing global health concerns, with DR remaining a major cause of vision loss. The study identifies indirect bilirubin (IBIL) as a potential biomarker that is inversely linked to DR risk in patients with T2DM. Although the findings are clinically important, limitations such as the cross-sectional design, single-center setting, and possible confounding factors reduce generalizability."
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Zhang Z, Shan XQ, Liang FM, Zhang LX. Letter to the Editor: Indirect bilirubin: A potential predictive biomarker for diabetic retinopathy and its clinical translational potential. World J Diabetes 2026; 17(5): 115813
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"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism ..."
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"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism and diabetic retinopathy (DR) in T2DM patients. It found vitamin D deficiency and VDR FokI ff genotype were independent risk factors for DR.
The study adopted rigorous grouping and standard laboratory detection, applied Sanger sequencing for accurate genotyping, and controlled common clinical confounding factors, offering valuable population evidence for DR early risk prediction.
However, single-center cross-sectional design cannot confirm causality. It lacked DR severity stratification and ignored lifestyle and sunlight exposure confounders. Future work should adopt multicenter prospective cohorts and further explore the molecular mechanism of VDR variants affecting DR pathogenesis. "
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Liu ZH, Ran ZQ, Yang R, Chen LX, Wang ZZ, Li YY, Han R. Vitamin D, vitamin D receptor FokI polymorphism, and diabetic retinopathy: A case-control study in Kunming, China. World J Diabetes 2026; 17(5): 118141
13
"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma ..."
[Read more]
"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma who received nivolumab as the initial treatment. Several biochemical parameters, including alpha-fetoprotein and the neutrophil-to-lymphocyte ratio (NLR), were retrospectively analyzed. The cut-off value for NLR was determined using a receiver operating characteristic (ROC) curve to distinguish patients with survival times longer than the median survival time. However, the efficacy of this cut-off value was subsequently validated using the same cohort in which the cut-off value had originally been established. Under these conditions, it is expected that the validation would yield favorable predictive results. Therefore, because both the establishment and validation of the cut-off value were conducted within the same cohort, the significance and predictive performance of the cut-off value cannot be considered methodologically validated."
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Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416
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"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives ..."
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"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery."
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Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954
15
"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the ..."
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"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration.
NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration.
"
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Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416
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"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of ..."
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"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery.
However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed.
"
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Zhang S, Li SY, Zhou B. Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection. World J Gastrointest Surg 2026; 18(4): 116412
17
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Pavlidis L, Geropoulos G, Kechagias KS, Psarras K, Patel V, Reza L, Prakash N, Athanasiou C, Geropoulos V, Anestiadou E, Triantafyllou T, Sapalidis K, Laskou S, Dimitroulis D. Near-infrared fluorescence with indocyanine green for minimally invasive hernia surgery: A systematic review and evidence synthesis. World J Clin Cases 2026; 14(14): 118964
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Walędziak M, Różańska-Walędziak A. Three-port robotic sleeve gastrectomy-another step forward: A case report. World J Clin Cases 2026; 14(14): 117795
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Raveglia F, Degiovanni S, Bertolaccini L, Cara A, Cassina EM, Danuzzo F, Libretti L, Pirondini E, Sibilia MC, Spinelli F, Tuoro A, De Simone M, Chiarelli M, Cioffi U, Petrella F. Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery. World J Clin Cases 2026; 14(13): 119644
20
"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative ..."
[Read more]
"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts.
Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation."
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Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; 32(16): 116781
16010 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2263
- Peer-reviewers
- 37648
- Manuscripts received today
- 20
- Manuscript reviews today
- 21
- Unhandled manuscripts today
- 217
- Active peer-reviewers today
- 180
- Reviewer acceptance today
- 9
- Reviewer refusals today
- 15
- Total accepted manuscripts
- 41578
- Total rejected manuscripts
- 45823
- Total peer-reviewers
- 4864628
- Total submissions
- 39367
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1
"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a ..."
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"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a discrepancy rooted in sampling bias rather than diagnostic error. The AI-assisted system compensates for this by guiding targeted biopsies: 95.1% of the detection gain came from precise recognition and localization of subtle lesions, not from simply taking more biopsies. The rigorous double-reading with blinded pathology review strongly supports the findings. Grouping low-grade, high-grade intraepithelial neoplasia, and early gastric cancer as endpoints is clinically pragmatic, and the marked AI advantage at blind spots like the gastric angle aligns with everyday practice. To deepen the evidence, future work could add positive predictive value, compare biopsy-to-surgery upgrade rates between groups, and characterize the pathology of false-positive AI detections (e.g., reactive changes). Correlating endoscopic morphology with histopathology would further transform AI from a detection tool into a diagnostic aid. Overall, this high-quality study offers a promising means to reduce sampling error and bridge the gap between endoscopic detection and pathological confirmation. "
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Ying JX, Yan SY, Fu XY, Zhou YJ, Zhou JJ, Yang Y, Zhou XB, Wang ZZ, Li SW, Fang LN, Mao XL. Artificial intelligence-assisted endoscopists improve the detection rate of high-risk gastric lesions: A propensity score-matched retrospective study. World J Gastroenterol 2026; 32(21): 117299
2
"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone ..."
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"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone complications. dietary habits have a significant impact on pathogenesis of gall stone complications. so that a questionnaire of diet intake should be done to investigate the effect of different food staff on symptoms and complications of gall stone disease. "
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Oyón D, Velamazán R, Arnau A, López-Guillén P, Martínez-Domínguez SJ, Abad Baroja D, Ruiz-Belmonte LM, Tejedor-Tejada J, Zapater R, Martín-Vicente N, Julián Gomara AB, Sastre Lozano V, Manzanares García JJ, Cañamares-Orbis P, García-Rayado G, Millastre Bocos J, Garcia de Paredes AG, Vaamonde Lorenzo M, Izagirre Arostegi A, Sirtl S, de-Madaria E. Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly. World J Gastroenterol 2026; 32(21): 117971
3
"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department ..."
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"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The Yang 1-associated protein 1 (YY1AP1) is frequently overexpressed or activated in gastric cancer and is linked to more aggressive disease, poorer prognosis, and metastasis. Although YY1AP1 signaling contributes to pathways that promote proliferation, epithelial–mesenchymal transition, stemness, and drug resistance, the precise mechanism of YY1AP1 in gastric cancer has not been precisely defined. In this commentary, we focus on recent findings on the functional mechanisms of YY1AP1 in gastric adenocarcinoma. The commentary is a significant step forward in understanding the nuanced approach to managing mortality rate in gastric cancer patients, offering valuable insights for clinical decision-making. Keywords: Yang 1-associated protein 1, Gastric adenocarcinoma, Prognosis, Mortality. Core tip YY1AP1 is best understood as both a prognostic biomarker and a functional oncogenic driver in gastric cancer, with evidence pointing to its role in tumor growth, invasion, metastasis, stemness, and treatment resistance. Background YY1AP1 overexpression has been associated with progression, lymph node metastasis, and poor prognosis in gastric carcinoma [1]. Studies found that YY1AP1 activation or high expression predicts worse survival and, in some cohorts, chemoresistance to adjuvant therapy [2-4]. In peritoneal metastatic gastric adenocarcinoma, YY1AP1-high tumor cells showed stem-cell-like properties and were clinically relevant as metastatic drivers [5]. YY1AP1 appears to drive gastric cancer biology through canonical Hippo pathway dysregulation and downstream transcriptional programs that support growth and invasion [6, 7]. Mechanistic studies show YY1AP1 can enhance proliferation, migration, invasion, EMT, and metastasis through signaling changes involving ERK, β-catenin, E-cadherin, vimentin, and lncRNA networks (Sun et al., 2016). Several upstream regulators and interacting partners contribute to YY1AP1 activation in gastric cancer, including H. pylori CagA, NUSAP1, SLC35B4, and CPNE3[7-11]. In gastric adenocarcinoma metastasis, YY1AP1 also linked with altered fatty-acid oxidation and cancer stem cell phenotypes [12]. The recent study of Gu et al. (2026)[13] investigates the clinical significance and functional mechanisms of YY1AP1 in gastric adenocarcinoma, finding its upregulation correlates with poor prognosis and aggressive tumor behavior. It critically assesss the argumentation within the article, focusing on the clarity of the research gap, the strength of the contribution claims, the justification of methods, the alignment of results with the discussion, and the thoroughness of the stated limitations. It also clearly articulates its perceived novelty regarding YY1AP1's role as an independent prognostic factor in gastric adenocarcinoma and its comprehensive investigation. Particularly, YY1AP1’s expression patterns, clinical relevance, biological functions, i.e. in proliferation, migration, gene modulation, and its status as an independent prognostic factor of gastric cancer. The stated aims are highly testable, as evidenced by the detailed methods employed, i.e. immunohistochemistry, RT-qPCR, survival analysis, or in vitro experiments. The authors’ argumentation generally establishes a clear research gap and strong contribution claims, supported by a combination of clinical, in vitro, and bioinformatic data. However, as compared to the aforementioned extensive literature on the specific mechanism/signaling of YY1AP1 in gastric cancer, there are opportunities to enhance methodological justification, ensure stricter alignment between results and discussion, and deepen the analysis of limitations. The Gu et al.[13] study provides sufficient detail for most experimental procedures and statistical analyses. However, specific justifications for certain choices, such as the selection of the MKN45 cell line or the specific online datasets, could be strengthened to enhance the methodological rigor and transparency. For example, “MKN45 is a well-characterized...mechanisms of gastric cancer." This provides a good, albeit brief, justification for using the MKN45 cell line, linking its characteristics to the study's aims. To further strengthen, it worth it to mention if this cell line accurately represents specific subtypes of gastric cancer relevant to the study. Another example, "A semi-quantitative scoring system...combined assessment." The description of the Immunohistochemistry as a scoring system is somewhat vague, lacking specific criteria for how "combined assessment" was performed or how the cutoff for high/low expression was determined. Providing a more precise description of the scoring system and the methodology for categorizing samples is so important. A third example, "The normality of data distribution...Shapiro-Wilk test." While stating the use of the Shapiro-Wilk test, the consequences of non-normal distribution (i.e., use of non-parametric tests) are not explicitly mentioned for cellular assays, which could impact the choice of t-test/ANOVA. It is important to clarify how non-normal data was handled, or confirm that all cellular assay data met normality assumptions for parametric tests. Further, "To further validate and extend...and GSE62254." The choice of these specific online datasets is not justified. It is unclear why these particular datasets were selected and if they represent a diverse or comprehensive set of gastric cancer patient cohorts. Elaborating on the criteria used for selecting these online datasets (i.e., sample size, type of data available, clinical annotation, specific gastric cancer subtypes if applicable) helps the reader. While many of the study claims are correlational, the in vitro experiments aim to establish more direct functional roles. Distinction between correlation and causation more precisely, especially when discussing clinical observations versus experimental manipulations is key. For example, "YY1AP1 significantly influences the pathogenesis... by modulating key cancer-related pathways." This statement implies a direct causal influence, which is partially supported by in vitro modulation of p21, c-myc, and snail, but the broader "pathogenesis" is complex and likely involves multiple factors. While in vitro data supports modulation of some pathways, the term "significantly influences the pathogenesis" might be too strong for the overall conclusion without more comprehensive mechanistic studies. Another example, "Our multivariate analysis identified high YY1AP1 expression... a novel finding in gastric adenocarcinoma." While multivariate analysis identifies independent prognostic factors, the wording implies a direct causal "role" in progression, which is an inference from prognostic value. It worth clarifying that high YY1AP1 expression is associated with poor outcomes and serves as an independent prognostic factor, rather than implying it causes the poor outcome in the context of clinical correlation. The in vitro data strengthens the causal link for proliferation/invasion, but this specific statement is about clinical correlation. The study acknowledges several important limitations, particularly regarding its retrospective design and generalizability, and points to the need for causal relationship studies. However, some limitations, such as the sample size for fresh tissue analysis or the lack of mechanistic studies beyond gene expression changes, could be elaborated or more explicitly stated. I.e., "The retrospective design and the specific patient cohort limit the generalizability of the results." The limitation is stated, but the extent of this limitation on the current conclusions is not fully elaborated. Discussing how this limitation might affect the confidence in YY1AP1 as a prognostic biomarker until prospective validation is inevitable. Accordingly, this suggests while promising, that the prognostic value of YY1AP1 requires validation in larger, prospective, and multi-center cohorts before clinical application. Also, while acknowledged, “The exact molecular mechanisms through which YY1AP1 affects tumor biology... require further elucidation." The discussion could briefly connect this to how the current findings should be interpreted, i.e., as strong associations and initial functional insights, but not definitive mechanistic pathways yet. Therefore, their study provides strong correlational and initial functional evidence, but the precise molecular cascade remains to be fully mapped. This points out the need for more in-depth mechanistic studies (e.g., rescue experiments) to establish direct causality, which is a significant limitation for a study proposing functional roles. Further, "A total of 118 paraffin-embedded and 29 fresh gastric adenocarcinoma samples were analyzed." and "Fresh gastric adenocarcinoma and adjacent nontumor tissues were snap-frozen..." Clearly, the number of fresh samples (29) for RT-qPCR is relatively small compared to the FFPE samples (118) for immunohistochemistry. This smaller sample size for mRNA analysis could be a limitation, especially if there were discrepancies or if it impacts the robustness of mRNA findings. This is not explicitly discussed in the limitations. Adding the smaller sample size for fresh tissue analysis (RT-qPCR) as a limitation, acknowledging its potential impact on the generalizability or statistical power of mRNA-level findings. Declarations Funding This commentary did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References [1] Hu X, Xin Y, Xiao Y, Zhao J. Overexpression of YAP1 is correlated with progression, metastasis and poor prognosis in patients with gastric carcinoma. Pathol Oncol Res. 2014;20:805-11. [2] Yu D, Chen Y, Luo M, Peng Y, S. Y. Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis. Genet Res (Camb) 2022. [3] Geng ZH, Du JX, Chen YD, Fu PY, Zhou PH, Qin WZ, et al. YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance. Cancer Cell Int. 2024;12:71. [4] Lee KW, Lee SS, Hwang JE, Jang HJ, Lee HS, Oh SC, et al. [5] Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, et al. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut. 2021;70:55-66. [6] Messina B, Lo Sardo F, Scalera S, Memeo L, Colarossi C, Mare M, et al. Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression. Cell Death Dis. 2023;14:21. [7] Guo H, Zou J, Zhou L, Zhong M, He Y, Huang S, et al. NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein. Front Oncol 2021. [8] Liu Z, Huang S, Cao Y, Yao Y, Li J, Chen J. YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106. Biochem Biophys Res Commun 2018;4:2370–75. [9] Liu H, Qiu Y, Pei X. Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth. Sci Rep. 2020; 10. [10] Liu J ZX, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. PMID: 31175271; PMCID: PMC6555804. [11] Li X, Zhong, H., Shi, Q. et al. YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression. Cell. Mol. Life Sci. 81, 143 (2024). https://doi.org/10.1007/s00018-024-05178-3. [12] Wang W YY, Zhang RH, Deng JY, Sun Z, Seeruttun SR, Wang ZN, Xu HM, Liang H, Zhou ZW. Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data. Mil Med Res 2022; 9: 15 [RCA] [PMID: 35387671 DOI: 10.1186/s40779-022-00375-2] [FullText] [Full Text(PDF)]. [13] Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, et al. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026;32:URL: https://www.wjgnet.com/1007-9327/full/v32/i21/116527.htm DOI: https://dx.doi.org/10.3748/wjg.v32.i21. "
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Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527
4
"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key ..."
[Read more]
"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key clinical challenges and is highly readable and practical. Its major highlight lies in being the first large-scale research to verify that serum S100A6 serves as an effective complement to CA19-9. It performs well in differentiating early pancreatic cancer from chronic pancreatitis and compensating for false-negative results of CA19-9. The combined three-biomarker panel markedly improves diagnostic efficiency, offering valuable guidance for early diagnosis, timely treatment and higher surgical resection rates. The study also objectively acknowledges its limitations including single-center design, absence of external validation and missing Lewis antigen typing, presenting rigorous and prudent conclusions. Overall, this is a clinically oriented and solid translational study. It proposes a new panel strategy for serological screening of pancreatic cancer, and merits further multi-center validation and clinical application. "
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Bae GE, Kim SM, Lee JK, Lee SY. First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection. World J Gastroenterol 2026; 32(21): 116581
5
"This study focused on the problem of postoperative recurrence of hepatocellular carcinoma and detected four liver cancer stem cell ..."
[Read more]
"This study focused on the problem of postoperative recurrence of hepatocellular carcinoma and detected four liver cancer stem cell markers. It features a rigorous design and reliable data. The results confirmed that CK19 and CD133 are key indicators for evaluating patient prognosis. Combined detection of these markers can substantially improve the predictive efficacy of conventional assessment models, offering practical references for postoperative risk stratification, individualized follow-up and treatment of hepatocellular carcinoma. However, this is a single-center retrospective study with a relatively short follow-up period, so its conclusions need to be further validated by multi-center and long-term researches. "
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Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123
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"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a ..."
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"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a biomarker in liver transplant recipients. Following PRISMA guidelines and using the QUIPS tool to assess study quality, the authors performed a rigorous quantitative synthesis, clearly demonstrating that elevated SBA is significantly associated with increased risks of early graft dysfunction, acute rejection, biliary complications, and poor long-term survival. These findings are highly meaningful for clinical practice, as the study confirms that SBA outperforms conventional liver function tests in the early prediction of adverse post-transplant events, with the potential to refine surveillance strategies and enable timely intervention. The manuscript is well-structured, with clear presentation of results, appropriate use of biostatistics, and a balanced discussion of strengths and limitations. While the study represents an important contribution to the field, some key points deserve consideration. Significant heterogeneity across included studies in SBA assay methods, detection time points, and cut-off values limits direct clinical standardization. Additionally, most analyses focused only on total SBA, and the prognostic roles of individual bile acid subtypes remain underexplored. Future large-scale, multicenter prospective studies are needed to address these gaps and validate the clinical utility of SBA monitoring. "
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Gadour E, Kuriry H, Miutescu B, Raheem B, Gardezi SA, AlQahtani MS. Diagnostic and prognostic utility of serum bile acid in liver transplant recipients: A systematic review and quantitative synthesis. World J Hepatol 2026; 18(5): 119408
7
"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients ..."
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"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients using reduced odds ratio which can display the critical role of sleep management. There is a phenomenon hardly to understand where the improper cases is excluded in specific step with corresponding numbers in the flowchart of figure 1. "
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Yu QT, Lin YY, Gui ZH, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(21): 118057
8
"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths ..."
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"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths include detailed site-specific treatment analysis, showing high response rates to PPI monotherapy in gastroduodenitis (88.9%), and identifying colonic involvement as a key relapse predictor (43.3%). These findings offer practical clinical guidance. A minor suggestion: adopting the updated 2022 international consensus nomenclature (e.g., non-EoE EGIDs, EoG, EoN, EoC) would further enhance cross-study communication. Overall, a clinically useful study with robust regional data. "
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Lee J, Kim SE, Cha RR, Lee BE, Choi CW, Jee SR. Presentation and treatment of eosinophilic gastroenteritis in Busan and Gyeongnam, Korea: A multicenter study. World J Gastroenterol 2026; 32(19): 117166
9
"This retrospective study evaluates the real-world clinical performance of the deep learning-based ENDOANGEL system in detecting ..."
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"This retrospective study evaluates the real-world clinical performance of the deep learning-based ENDOANGEL system in detecting high-risk gastric lesions (HrGLs), demonstrating high readiness for academic publication. Utilizing a massive, propensity score-matched cohort of 15,528 patients to effectively control for major confounding variables, the authors convincingly establish that AI integration nearly doubles the HrGL detection rate (0.94% vs. 0.48%) while providing critical mechanistic validation through causal mediation analysis, proving that this diagnostic gain stems directly from AI-driven image recognition rather than a mere increase in blind biopsies. As an unwearied "second observer," the system holds extensive application prospects for mitigating diagnostic subjectivity, reducing early gastric cancer miss rates, and stabilizing quality control across lower-tier or high-workload endoscopic centers. Moving forward, while future development trends will naturally pivot toward multi-center video-stream integration and diverse ethnic cohort validation, the immediate clinical hurdles that must be surmounted include bridging the performance-gain variance observed across different endoscopist seniority levels, enhancing algorithmic robustness against real-world artifacts like gastric mucus and motion blur, and perfecting low-latency, seamless hardware-software integration. "
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Ying JX, Yan SY, Fu XY, Zhou YJ, Zhou JJ, Yang Y, Zhou XB, Wang ZZ, Li SW, Fang LN, Mao XL. Artificial intelligence-assisted endoscopists improve the detection rate of high-risk gastric lesions: A propensity score-matched retrospective study. World J Gastroenterol 2026; 32(21): 117299
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"The article focuses on the relationship between the Healthy Sleep Score and MASLD. The significance of this study lies in suggesting ..."
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"The article focuses on the relationship between the Healthy Sleep Score and MASLD. The significance of this study lies in suggesting that overall sleep health may be an important and relatively modifiable factor in the prevention and management of MASLD. For clinical and health management readers in particular, the study emphasizes not just a single sleep problem, but the combined effects of multiple dimensions of sleep, including sleep duration, sleep rhythm, insomnia, sleep apnea, and daytime sleepiness. This provides valuable insights for the early screening, lifestyle intervention, and risk stratification of MASLD. In addition, the authors propose that insulin resistance and inflammation may partially mediate the relationship between sleep and MASLD, offering directions for future mechanistic research and integrated intervention strategies. Although the study is cross-sectional in design and therefore cannot directly establish causality, its relatively large community-based sample and comprehensive analytical framework still make it a useful reference for understanding the link between sleep and metabolic liver disease. "
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Yu QT, Lin YY, Gui ZH, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(21): 118057
11
"The study focuses on enteric glial cells in the enteric nervous system and the cAMP/PKA/CREB signaling pathway, providing a new ..."
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"The study focuses on enteric glial cells in the enteric nervous system and the cAMP/PKA/CREB signaling pathway, providing a new perspective for understanding how interactions among the nervous system, immune responses, and intestinal barrier function contribute to the development and progression of colitis. This places salidroside not merely as an anti-inflammatory natural compound, but within a more specific mechanistic framework of enteric neuroimmune regulation, thereby enhancing the scientific significance of the study. However, the current findings are mainly derived from experimental animal models, and further validation is still needed before clinical application, including evaluation of dose safety, long-term efficacy, the potential value of combination use with existing therapies, and the consistency of these mechanisms in human UC patients. "
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Li Y, Tao SS, Wang Y, Sun Q, Li MY, Zhang H, Li YQ. Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses. World J Gastroenterol 2026; 32(21): 116337
12
"Bae and colleagues provide the first large‑scale prospective evaluation of serum S100A6 as a diagnostic biomarker for pancreatic ..."
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"Bae and colleagues provide the first large‑scale prospective evaluation of serum S100A6 as a diagnostic biomarker for pancreatic cancer (PC), with an emphasis on its complementary role to CA19‑9 and CEA. The study has several clear strengths: a well‑defined cohort of 414 subjects (301 PC, 52 chronic pancreatitis [CP], 61 healthy controls), prospective sample collection before treatment, and a clinically relevant focus on distinguishing early‑stage (resectable) PC from benign CP. The authors show that serum S100A6 levels are significantly higher in both early and late PC than in CP or healthy controls. While CA19‑9 alone is the most accurate single marker (AUC 0.839), adding S100A6 and CEA improves overall diagnostic performance (AUC 0.868, P = 0.007 compared to CA19‑9 alone). More importantly, for differentiating early PC from CP, the triple panel achieved an AUC of 0.821 and was the only combination that significantly outperformed CA19‑9 alone (P = 0.017). Bootstrap internal validation (2000 resamples) supports the robustness of the findings. Nevertheless, some limitations deserve attention. External validation in an independent cohort is still lacking, and all samples come from a single tertiary centre. The “early‑stage” group is dominated by stage II tumours (140/149), with only nine stage I cases, so the conclusions mainly apply to resectable rather than truly early, asymptomatic disease. Lewis antigen status was not assessed, which is a known confounder for CA19‑9 false‑negatives; therefore, the extent to which S100A6 compensates specifically for Lewis‑negative individuals remains unclear. S100A6 is not pancreas‑specific and is elevated in other cancers, which limits its use to patients already under suspicion for PC or CP rather than for population screening. Finally, cost‑effectiveness and longitudinal follow‑up data are not provided. In summary, this well‑designed study convincingly shows that serum S100A6 adds diagnostic value to CA19‑9, especially for identifying resectable PC in patients with CP. However, external validation, Lewis antigen stratification, and assessment of clinical net benefit are needed before routine clinical use. At present, S100A6 should be viewed as a promising complementary biomarker, not a standalone screening test. "
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Bae GE, Kim SM, Lee JK, Lee SY. First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection. World J Gastroenterol 2026; 32(21): 116581
13
"This study is the first large-scale case-control evaluation of the value of serum S100A6 in the early diagnosis of pancreatic cancer. ..."
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"This study is the first large-scale case-control evaluation of the value of serum S100A6 in the early diagnosis of pancreatic cancer. The results show that combining S100A6 with CA19-9 significantly improves diagnostic performance, and that adding CEA further helps distinguish early-stage pancreatic cancer from chronic pancreatitis, suggesting promising clinical translational potential. A key strength of the study is its focus on early diagnosis, a major challenge in pancreatic cancer management, and its proposal of a biomarker combination that complements existing markers. However, the specificity of S100A6, its stability across different populations, and its performance in real-world screening settings still require independent, multicenter, and prospective validation. Overall, this study provides valuable new evidence for the development of biomarkers for early pancreatic cancer detection. "
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Bae GE, Kim SM, Lee JK, Lee SY. First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection. World J Gastroenterol 2026; 32(21): 116581
14
"This study focuses on postoperative acute kidney injury (AKI), one of the most challenging complications in the field of pancreatic ..."
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"This study focuses on postoperative acute kidney injury (AKI), one of the most challenging complications in the field of pancreatic surgery. It adopts advanced machine learning methods to construct the first interpretable predictive model specifically tailored for patients undergoing pancreatic surgery and develops an online risk calculator. Overall, this is a high-quality study with rigorous design, advanced methodology and clear clinical orientation, which has made significant contributions to the development of this field. However, it also has several issues worthy of in-depth discussion: a. The single-center retrospective design limits the generalizability of the results; b. There is a lack of independent external validation; c. The model incorporates 24-hour postoperative data, which restricts its application in preoperative risk assessment; d. It fails to distinguish between AKI subtypes with different etiologies and severity grades. Despite these limitations, this study has laid a solid foundation for research on the prediction of AKI after pancreatic surgery and also provides a valuable reference for predictive studies of other surgical complications. "
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Lin C, Fu RK, Zheng H, Li TY, Han JS, Margonis GA, Wang JJ, Dong LB, Wang NS, Sun YX, Wang YZ, Liu C, Xu Q, Han XL, Zhang TP, Guo JC, Dai MH, Xia P, Chen LM, Wang WB. Development and validation of an interpretable machine learning model for predicting acute kidney injury after pancreatic surgery. World J Gastroenterol 2026; 32(19): 116271
15
"This article is remarkable and stands out for its thorough synthesis of the multidimensional characteristics of degenerative disc ..."
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"This article is remarkable and stands out for its thorough synthesis of the multidimensional characteristics of degenerative disc disease (DDD). The authors proficiently unify molecular biology, biomechanics, genetics, and lifestyle influences into a logical explanation that reflects the true complexity of disc degeneration. The in-depth analysis of cytokine-mediated pathways (IL 1β, TNF α, IL 6) and their subsequent signalling cascades (NF κB, MAPK, Wnt/β catenin) provides functional understanding into how inflammation and matrix breakdown the disc pathology. Equally compelling is the emphasis on the avascular and hypoxic microenvironment of the intervertebral disc, which helps explain its susceptibility to metabolic and oxidative stress. The exploration of genetic predisposition adds significant depth to the discussion. The inclusion of heritability estimates of 50–70% and polymorphisms involving collagen, aggrecan, and inflammatory mediators clarifies why certain individuals may be more vulnerable to degeneration. Furthermore, the incorporation of epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, highlights the dynamic interaction between environmental influences and gene regulation, making the article highly relevant to emerging precision medicine approaches. I found the section addressing metabolic contributors particularly illuminating. The discussion of diabetes and obesity leading to advanced glycation end-product (AGE) accumulation and extracellular matrix stiffening effectively connects systemic metabolic dysfunction with localized disc degeneration. Clinically, the article makes an important distinction between structural degeneration and symptomatic disease, emphasizing that radiographic abnormalities do not always correlate with pain. The discussion of aberrant nerve ingrowth, cytokine-driven sensitization, and biomechanical instability as mechanisms of pain successfully bridges the gap between imaging findings and patient experience. In addition, the diagnostic overview, highlighting MRI as the gold standard alongside emerging AI-driven radiomics, reflects both current clinical practice and future directions in the field. The management section is balanced and comprehensive, covering conservative approaches such as physical therapy and lifestyle modification, as well as surgical interventions including spinal fusion and disc replacement. The inclusion of regenerative therapies, such as platelet-rich plasma (PRP), stem cell therapy, biomaterial scaffolds, and gene therapy adds considerable value for both clinicians and researchers. Particularly exciting is the forward-looking discussion of epigenetic modulation and senolytic therapies as potential disease-modifying strategies, which underscores the evolving future of DDD treatment. "
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Gradisnik L, Prestor B, Zele T, Kocivnik N, Maver U, Velnar T. Pathophysiology and current understanding of degenerative disc disease. World J Orthop 2026; 17(5): 117153
16
"Hopley et al. conducted a well‑designed, single‑center observational study using a large 17‑year real‑world cohort of 1,191 patients ..."
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"Hopley et al. conducted a well‑designed, single‑center observational study using a large 17‑year real‑world cohort of 1,191 patients with presumed benign branch‑duct intraductal papillary mucinous neoplasms (BD‑IPMNs). The long median follow‑up of 9.74 years and the inclusion of both imaging‑only and imaging‑plus‑EUS groups strengthen the reliability of the findings. A key strength is the identification of a clear “window of opportunity” for surgical intervention within the first two years of surveillance, after which the incremental benefit of continued monitoring declines sharply. The authors also provide compelling data that patient age and comorbidity burden (Charlson comorbidity index) critically affect net benefit, supported by competing risk analyses from independent groups (Crippa et al., Gut 2024). Limitations inherent to the single‑center, retrospective design, such as potential selection bias and lack of external validation, are appropriately acknowledged. The manuscript is written in clear, standard academic English. Abbreviations are defined at first use, tables are properly formatted, and the flow of information is logical. The language is concise, respectful, and meets the journal’s requirements for scientific reporting. Overall, the scientific quality is high, and the presentation is professionally polished. "
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Hopley PJ, Whelan P, Jackson R, Evans J, Andrews T, Ghaneh P, Raraty M, Greenhalf W, Halloran CM. Branch duct intraductal papillary mucinous neoplasms: How ready are we to de-escalate surveillance? World J Gastroenterol 2026; 32(19): 115852
17
"his review article provides an insightful and clinically important discussion on the functional disorders associated with chronic ..."
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"his review article provides an insightful and clinically important discussion on the functional disorders associated with chronic constipation. The authors successfully combine evidence from the literature with their extensive personal experience, making the manuscript both academically informative and practically relevant.The concept of the “iceberg model” is particularly noteworthy, as it clearly illustrates how underlying functional abnormalities may remain undetected in patients presenting with apparent structural pathology. The emphasis on comprehensive functional evaluation prior to surgical intervention is highly valuable and reflects current multidisciplinary approaches in colorectal practice.The manuscript also effectively highlights the role of anorectal physiology, pelvic floor dysfunction, and psychological factors in the pathogenesis of chronic constipation. The review will be useful for gastroenterologists, colorectal surgeons, pelvic floor specialists, and trainees involved in managing complex constipation disorders. Overall, this is a well-written and educational review that contributes meaningfully to the understanding of chronic constipation and its functional components. "
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Pescatori M, Perrotta G, De Nardi P. Functional disorders in patients with chronic constipation: Review of the literature and personal experience. World J Gastroenterol 2026; 32(19): 113841
18
"This is a highly practical and timely observational study by Hopley et al. The management of presumed innocent branch duct IPMNs often ..."
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"This is a highly practical and timely observational study by Hopley et al. The management of presumed innocent branch duct IPMNs often necessitates an overwhelming volume of serial cross-sectional imaging and EUS procedures, which places a heavy demand on diagnostic resources and creates a prolonged psychological burden for patients. By demonstrating that the diagnostic yield of continued investigations dramatically drops after the first two years, the authors provide a strong, data-driven argument for refining our protocols. Establishing clear, objective thresholds, specifically a maximum cyst size of < 30 mm on imaging and a serum CA 19-9 of < 43 KU/L, offers a reliable baseline for predicting high-grade dysplasia or malignancy. Safely de-escalating follow-up for stable lesions after two years, and potentially discharging patients at the five-year mark, is a necessary evolution in pancreatic surveillance pathways. This approach allows multidisciplinary teams to concentrate advanced imaging and interventional resources during that critical, early front-loaded period where the opportunity to detect and definitively resect PDAC is actually at its highest. "
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Hopley PJ, Whelan P, Jackson R, Evans J, Andrews T, Ghaneh P, Raraty M, Greenhalf W, Halloran CM. Branch duct intraductal papillary mucinous neoplasms: How ready are we to de-escalate surveillance? World J Gastroenterol 2026; 32(19): 115852
19
"This review focuses on functional factors that are often overlooked in chronic constipation, particularly issues underlying OD, such ..."
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"This review focuses on functional factors that are often overlooked in chronic constipation, particularly issues underlying OD, such as anxiety and depression, pelvic floor dyssynergia, rectal hyposensitivity, slow-transit constipation, and pudendal neuropathy. It therefore has considerable clinical practical value. The article emphasizes that, before deciding on surgery, organic causes should be thoroughly excluded and hidden functional disorders should be identified through functional assessment. This is important for reducing unnecessary surgery and avoiding postoperative symptom worsening or treatment failure. The model proposed by the authors vividly illustrates the relationship between superficial lesions and deeper functional disorders in patients with OD, helping readers understand why some patients have poor outcomes after surgery. "
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Pescatori M, Perrotta G, De Nardi P. Functional disorders in patients with chronic constipation: Review of the literature and personal experience. World J Gastroenterol 2026; 32(19): 113841
20
"The article indicates that high PRMT5 expression is associated with poor prognosis in hepatocellular carcinoma (HCC). It further ..."
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"The article indicates that high PRMT5 expression is associated with poor prognosis in hepatocellular carcinoma (HCC). It further reveals that PRMT5 can suppress DDIT3 transcription by enhancing H4R3me2 modification at the DDIT3 promoter region and recruiting STAT3, thereby promoting anti-apoptotic behavior and malignant progression of tumor cells. This mechanism links epigenetic regulation, transcription factor cooperation, and tumor cell escape from apoptosis, providing a new perspective for understanding the development and progression of HCC. A key strength of the article is that it not only identifies the association between PRMT5 and prognosis, but also further elucidates the dual inhibitory mechanism by which PRMT5 regulates DDIT3, making the study’s conclusions more biologically convincing. "
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Jiang H, Yan JH, Tang WJ, Shen B, Mo S, Wang Y, Hu DH, Dong ZX, Zhang SB. PRMT5 imposed a dual repression on DDIT3 transcription to promote the malignancy of hepatocellular carcinoma. World J Gastroenterol 2026; 32(19): 115332
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