Baishideng Publishing Group

Feng Y, Liu SN, Xu SJ, Feng YZ, Yu HP, Zheng RL, Wei JX, Sun QH, Zhong Y, Ma JZ. Musculoskeletal and bone health characteristics in young men: A comparison of low and high bone mineral density. World J Orthop 2026; 17(5): 116330

"The Publishing Group demonstrates exceptional efficiency and quality in journal production, consistently minimizing the time from ..." [Read more]

"The Publishing Group demonstrates exceptional efficiency and quality in journal production, consistently minimizing the time from submission to online publication. Their rigorous peer review process relies on highly specialized and responsive reviewers, ensuring fair, constructive, and timely feedback. Moreover, the publisher actively promotes scholarly work through global indexing and open-access options, enabling rapid, worldwide dissemination of research. " [Collapse]

Liu L, Hu HS. Letter to the Editor: Beyond the dichotomy: Integrating precision rehabilitation, patient-centered goals, and nursing leadership in lumbar spinal stenosis care. World J Orthop 2026; 17(5): 115690

"We are satisfied overall with the submission, peer review, editing, and publication process. The peer review was constructive and ..." [Read more]

"We are satisfied overall with the submission, peer review, editing, and publication process. The peer review was constructive and helped us strengthen the scientific clarity and presentation of the manuscript. We especially appreciate the professionalism and responsiveness of the editorial and production teams throughout the process. Thank you to the reviewers, editors, and publishing staff for their time and support. " [Collapse]

Mohammed AS, Desai R, Manne S, Gogikar A, Reddy Tera C, Oble MJP, Nair A, Nawab S, Polamarasetty H, Srivastava AA, Chiluka S, Eppalapally AK, Reddy SSK. Burden and impact of metabolically healthy obesity on in-hospital outcomes of acute ischemic stroke: A nationwide study. World J Clin Cases 2026; 14(15): 118960

"What impressed me most throughout the submission and publication process was the editorial office's sense of responsibility and ..." [Read more]

"What impressed me most throughout the submission and publication process was the editorial office's sense of responsibility and attention to detail. Every email inquiry received a prompt and patient response. After submission, the editors carefully checked the manuscript page by page—pointing out even minor issues in reference punctuation and figure numbering. Such rigor exceeded my expectations. The reviewers' comments were professional and insightful; although they were not always easy to address, each suggestion truly targeted the core weaknesses of the paper, and the revisions significantly improved the final quality. The entire workflow was efficient, with timely updates via both the system status and email notifications at every stage, which provided me with great peace of mind. In summary, the editorial team worked efficiently and responsibly, making this a very smooth and positive publishing experience. " [Collapse]

Li X, Yuan PC, Gao Q, Cao QQ, Ma Z, Chen X, Wang CJ, Mao ZX, Huo WQ. Dual effects of synthetic phenolic antioxidants in type 2 diabetes mellitus: Mechanisms and advances. World J Diabetes 2026; 17(5): 115619

"The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for ..." [Read more]

"The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. The world journal of paediatrics is one of the Journals I respect and always like to publish in especially that I get invitation for free publications which I respect greatly. " [Collapse]

Alshehhi K, Abughosh R, Abdelrahman G, Abujouda A, Elghoudi A, Bitar R. Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management. World J Clin Pediatr 2026; 15(2): 112843

"It is deeply gratifying to see our multicenter retrospective cohort study on hepatocellular carcinoma (HCC) in Nigeria published in ..." [Read more]

"It is deeply gratifying to see our multicenter retrospective cohort study on hepatocellular carcinoma (HCC) in Nigeria published in the World Journal of Gastrointestinal Oncology. This work represents a collaborative effort spanning multiple tertiary centers across the country, and the publication journey was one of rigorous intellectual refinement. The peer-review process at WJGO was thorough and constructive. The reviewers engaged critically with our methodology—challenging us to strengthen the statistical analysis, clarify our inclusion criteria across heterogeneous hospital records, and expand the discussion on how our findings compare with emerging HCC patterns in sub-Saharan Africa. Each round of revision sharpened the manuscript, ensuring the data we present on HCC prevalence, risk factors, and treatment outcomes is both robust and clinically meaningful. From submission to final acceptance, the editorial team maintained clear communication and reasonable turnaround times, which is especially appreciated when coordinating responses across multiple authors with demanding clinical schedules. The single-blind review process allowed honest, detailed feedback that improved the manuscript considerably. We hope this work contributes meaningfully to the evidence base on HCC in Nigeria—a disease that remains under-characterized in our region despite its heavy burden—and encourages further multicenter collaborative research across West Africa. " [Collapse]

Musa Y, Dankiri NA, Saleh HT, Onyia CP, Abdulkareem LO, Okonkwo KC, Abdulkareem FB, Shu'aibu RB, Aminu AS, Ewa AM, Abdullahi HZ, Njideka AW, Sunusi HI, Ijoma UN, Sunday NV, Chukwudike ES, Okeke UF, Asogwa PU, Mukoro GD, Abdullahi MK, Odeghe EA, Nwoko C, Takwashe IM, Oguntoye OO, Owoseni OO, Jimoh AO, Oyeleke GK. Assessing hepatocellular carcinoma in Nigeria: A multicenter retrospective cohort review of prevalence, risk factors, and treatment outcomes. World J Gastrointest Oncol 2026; 18(5): 117654

"We are grateful to World Journal of Gastroenterology for the rigorous and efficient peer review process that improved our clinical ..." [Read more]

"We are grateful to World Journal of Gastroenterology for the rigorous and efficient peer review process that improved our clinical study on the resection of esophageal submucosal tumors. The editorial team’s constructive feedback helped us strengthen the clarity of our methodology and the interpretation of our findings. We also appreciate the journal’s prompt production schedule, which allowed our work to reach the gastroenterology community in a timely manner. It has been a positive experience publishing in WJG, and we hope our study contributes meaningfully to the clinical management of gastrointestinal diseases. " [Collapse]

Li XX, Zheng QF, Garcia AM, Shi ZY, Shi M, Islam MS, Liu D. Exposed endoscopic full-thickness resection vs thoracoscopic surgery for complex esophageal subepithelial lesions arising from the muscularis propria. World J Gastroenterol 2026; 32(18): 116018

"I appreciate the time and effort of the reviewers and editors dedicated to providing their valuable comments and suggestions which ..." [Read more]

"I appreciate the time and effort of the reviewers and editors dedicated to providing their valuable comments and suggestions which helped to improve our manuscript to its high quality level. I appreciate the efforts spent for the meticulous and repeated revisions provided by the editorial and publisher members to our manuscript till its final version. I heartily appreciate the support and generosity of the company editor for facilitating publishing our articles in their respectful world's Journal series. " [Collapse]

Hamed SA, Hamed EA, Fawzy M. Chronic musculoskeletal pain disorder and its associated mental health conditions, comorbidities and psychosocial risk predictors. World J Clin Cases 2026; 14(15): 120217

"We would like to express our sincere appreciation to the editorial team and reviewers of the World Journal of Clinical Pediatrics ..." [Read more]

"We would like to express our sincere appreciation to the editorial team and reviewers of the World Journal of Clinical Pediatrics for their valuable efforts and professional handling of the manuscript throughout the publication process. The constructive comments, prompt communication, and high editorial standards greatly contributed to improving the quality and clarity of our work. We are truly grateful for the time and dedication invested by the editors and reviewers, and we highly appreciate the opportunity to publish our research in this respected journal. Corresponding author: Prof.Dr. Mohammed H Hassan, MD Medical Biochemistry and Molecular Biology " [Collapse]

Abd-Elmawgood EA, Hassan MH, Abd-Elbaseer KA, Ibrahem MH, Yousef KMH, Bakri AH. Circulating levels of growth differentiation factor-15 and its genetic variants -3148C>G (rs4808793) in pediatric cardiac patients. World J Clin Pediatr 2026; 15(2): 117283

"Process worked well. Happy with the published article. This was a paper that had been previously presented at the podium for the ..." [Read more]

"Process worked well. Happy with the published article. This was a paper that had been previously presented at the podium for the British Association of Pediatric Surgeons. The article outlay is excellent. The editor and reviewers were persistent in demanding the very best article with nothing left to chance. We were able to respond in a constructive manner to facilitate delivery of an excellent product. " [Collapse]

Burjonrappa SC, Blamon F, Hurley SP. Pediatric acute cholecystitis: Risk factors and outcomes. World J Clin Pediatr 2026; 15(2): 114534

"I am truly grateful for the opportunity to contribute to this publication. It is incredibly rewarding to see our work recognized in ..." [Read more]

"I am truly grateful for the opportunity to contribute to this publication. It is incredibly rewarding to see our work recognized in such a respected journal. I deeply appreciate the mentorship, collaboration, and effort from everyone involved, and I hope these findings contribute meaningfully to the field and future patient care. " [Collapse]

Sierra L, Chatterjee A, Prado R, Khurana A, Patel R, Firkins S, Simons-Linares R. Impact of metabolic endoscopy on fibrosis regression in steatotic liver disease. World J Hepatol 2025; 17(9): 108144

"I recommande WJCO for publication the article process is very meticulously driven and the quality of articles is very good reviewer ..." [Read more]

"I recommande WJCO for publication the article process is very meticulously driven and the quality of articles is very good reviewer comments are very helpful to us and the editor do a very good work to make sure that the article is correct and well written the figures are also well organised and accurately presented " [Collapse]

Ismaili N, Guessous F, El Majjaoui S. Breast cancer in Morocco: Synthesizing two decades of national research to inform future action. World J Clin Oncol 2026; 17(4): 117805

"The editing work is excellent. The only aspect that needs improvement is that the type of submitted manuscripts should ideally be ..." [Read more]

"The editing work is excellent. The only aspect that needs improvement is that the type of submitted manuscripts should ideally be maintained during publication, rather than being changed. The peer review is very fair. The speed of receiving publications can be enhanced. Everything else is great. Everything else is great. Everything else is great. " [Collapse]

Liu ZY, Song LX, Yue ZR, Huo SY, Xu FJ. ICAM-1 enigma in diabetic retinopathy: How population genetics challenges a universal pathogenesis model. World J Diabetes 2026; 17(5): 116585

"We would like to express our sincere and heartfelt gratitude to the BPG team for their professional guidance, meticulous feedback, ..." [Read more]

"We would like to express our sincere and heartfelt gratitude to the BPG team for their professional guidance, meticulous feedback, and invaluable support throughout the entire manuscript revision process. Their insightful comments on experimental design, rigorous suggestions for data interpretation, and patient responses to our queries have been instrumental in refining our work and ensuring it meets the highest academic standards. Without their dedicated efforts and expertise, this manuscript could not have reached its present form. " [Collapse]

Wang YJ, Wang SY, Li ZM, Zhao MY, Zhou M, Xie CY, Wang JA, Xu B, Yang GH, Liu Y, Xu TC. Unlocking pancreatic metabolic memory: Can early interventions reverse obesity and block diabetes before it strikes? World J Diabetes 2026; 17(5): 118754

"I was happy with the review process. The scientific grading of C was slightly harsh given that this is an extremely rare condition. ..." [Read more]

"I was happy with the review process. The scientific grading of C was slightly harsh given that this is an extremely rare condition. Most doctors worldwide will never experience this condition nor management it, thus any publications (even a case report) that can help provide guidance on safe management and appropriate follow up are very important. " [Collapse]

Saravanan K, Nagappan PG, Simpson AI. Benign but not inconsequential, paediatric sciatic nerve neuromuscular choristoma and its longitudinal impact: A case report. World J Clin Cases 2026; 14(15): 120061

"Our experience publishing with the World Journal of Gastrointestinal Endoscopy was highly positive and professionally rewarding. The ..." [Read more]

"Our experience publishing with the World Journal of Gastrointestinal Endoscopy was highly positive and professionally rewarding. The editorial and production process was transparent, efficient, and well-organized from submission through publication. We were kept consistently informed at every stage, with timely updates and clear communication. The review and decision-making process appeared fair, objective, and unbiased throughout. We sincerely appreciate the professionalism and support of the editorial team, which made the overall publishing experience smooth and pleasant. " [Collapse]

Aujla UI, Syed IA, Malik AK, Khan MMZ, Rafi K, Dar FS. Endoscopic management of post-living donor liver transplant anastomotic biliary strictures: A quaternary care transplant center experience. World J Gastrointest Endosc 2026; 18(5): 119587

"The journal’s submission and editorial workflow was difficult to navigate and unnecessarily time-consuming. The overall processing ..." [Read more]

"The journal’s submission and editorial workflow was difficult to navigate and unnecessarily time-consuming. The overall processing timeline appeared excessively prolonged, with limited efficiency in communication and manuscript handling. A particularly concerning aspect of the process was being presented with the option to transfer the manuscript to another journal during review, with the implication that refusal could result in rejection, which created an uncomfortable experience for authors. Additionally, the formatting requirements felt outdated and overly rigid, requiring authors to complete several unnecessary administrative and formatting steps that added complexity without clearly improving the scientific review process. Overall, while the journal may maintain academic standards, the submission experience itself was cumbersome and could benefit significantly from modernization, clearer workflows, and a more author-friendly review system. " [Collapse]

Patel V, Zameer R, Kumar B, Das M. Adjunctive pharmacologic therapies for diuretic resistance in acute decompensated heart failure: Systematic review of randomized trials. World J Meta-Anal 2026; 14(1): 118496

"Dear Editorial Team of World Journal of Clinical Pediatrics I would like to express my deepest and most sincere gratitude to the entire ..." [Read more]

"Dear Editorial Team of World Journal of Clinical Pediatrics I would like to express my deepest and most sincere gratitude to the entire editorial team of World Journal of Clinical Pediatrics for your outstanding work, professionalism, and unwavering commitment to academic excellence. From the very first interaction, I have been impressed by the efficiency and clarity of your submission and review processes. Your detailed feedback has not only helped improve my work significantly but has also contributed to my professional growth as a researcher. It is clear that every member of your team dedicates considerable time and effort to ensure that each publication meets the highest standards of quality and rigour. I particularly appreciate the respectful and supportive manner in which you communicate with authors. Despite the demanding nature of your work, you consistently maintain a constructive and encouraging tone — this makes a tremendous difference and truly motivates scholars to contribute their best work. Moreover, the journal itself stands as a beacon of knowledge in its field, providing valuable insights and fostering meaningful academic dialogue. Knowing that my work has found a home in such a respected publication is a source of great pride. Thank you for your dedication, patience, and for playing such a vital role in advancing scholarly communication. I look forward to continuing to follow and engage with the journal’s future issues. With warmest regards and utmost appreciation, Mikhail Kostik, MD, PhD, Professor " [Collapse]

Podzolkova V, Avrusin IS, Nikolaeva M, Afonina E, Davtian S, Nurseitova A, Kravtsova K, Malahova A, Yakovlev AA, Avrusin SL, Kalashnikova OV, Chasnyk VG, Kostik MM. Use of nailfold capillaroscopy for evaluation of disease activity in juvenile dermatomyositis: Results of a two-center retrospective study. World J Clin Pediatr 2026; 15(2): 114270

"The peer review process was very efficient and the quality of the peer review was also very good. However, it would be helpful if ..." [Read more]

"The peer review process was very efficient and the quality of the peer review was also very good. However, it would be helpful if the editorial board would provide all the recommendations at the same time to improve overall workflow. The editorial board is very helpful and supported us throughout the process. " [Collapse]

Kumar G, Shah YR, Shahzad A, Jameel K, Guevara-Lazo D, Khan NA, Dahiya DS, Gangwani MK, Ravichandran R, Patel R, Hayat U, Thandassery RB. Genetic predeterminants and recent advancements in steatotic liver disease: A roadmap toward precision hepatology. World J Hepatol 2025; 17(11): 111576

"I would like to sincerely thank the journal for its meticulous and thorough peer-review process, as well as its careful quality checks, ..." [Read more]

"I would like to sincerely thank the journal for its meticulous and thorough peer-review process, as well as its careful quality checks, which ensured that the manuscript is as rigorous and accurate as possible for publication. I am also deeply impressed by the journal’s careful support in language editing, reference verification, AI screening, and similarity index checking, all of which were conducted with exceptional thoroughness. " [Collapse]

Nguyen NTY, Tran HP, Luong TV, Nguyen DX, Tran DH, Hoai PHT, Lee MC, Dang HNN. From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes. World J Diabetes 2026; 17(5): 114042

21341 items Read more >>

Article Quality Tracking-Peer-Review

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism ..." [Read more]

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism and diabetic retinopathy (DR) in T2DM patients. It found vitamin D deficiency and VDR FokI ff genotype were independent risk factors for DR. The study adopted rigorous grouping and standard laboratory detection, applied Sanger sequencing for accurate genotyping, and controlled common clinical confounding factors, offering valuable population evidence for DR early risk prediction. However, single-center cross-sectional design cannot confirm causality. It lacked DR severity stratification and ignored lifestyle and sunlight exposure confounders. Future work should adopt multicenter prospective cohorts and further explore the molecular mechanism of VDR variants affecting DR pathogenesis. " [Collapse]

Liu ZH, Ran ZQ, Yang R, Chen LX, Wang ZZ, Li YY, Han R. Vitamin D, vitamin D receptor FokI polymorphism, and diabetic retinopathy: A case-control study in Kunming, China. World J Diabetes 2026; 17(5): 118141

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma ..." [Read more]

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma who received nivolumab as the initial treatment. Several biochemical parameters, including alpha-fetoprotein and the neutrophil-to-lymphocyte ratio (NLR), were retrospectively analyzed. The cut-off value for NLR was determined using a receiver operating characteristic (ROC) curve to distinguish patients with survival times longer than the median survival time. However, the efficacy of this cut-off value was subsequently validated using the same cohort in which the cut-off value had originally been established. Under these conditions, it is expected that the validation would yield favorable predictive results. Therefore, because both the establishment and validation of the cut-off value were conducted within the same cohort, the significance and predictive performance of the cut-off value cannot be considered methodologically validated." [Collapse]

Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives ..." [Read more]

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery." [Collapse]

Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the ..." [Read more]

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration. NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration. " [Collapse]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of ..." [Read more]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery. However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed. " [Collapse]

Zhang S, Li SY, Zhou B. Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection. World J Gastrointest Surg 2026; 18(4): 116412

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Pavlidis L, Geropoulos G, Kechagias KS, Psarras K, Patel V, Reza L, Prakash N, Athanasiou C, Geropoulos V, Anestiadou E, Triantafyllou T, Sapalidis K, Laskou S, Dimitroulis D. Near-infrared fluorescence with indocyanine green for minimally invasive hernia surgery: A systematic review and evidence synthesis. World J Clin Cases 2026; 14(14): 118964

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Walędziak M, Różańska-Walędziak A. Three-port robotic sleeve gastrectomy-another step forward: A case report. World J Clin Cases 2026; 14(14): 117795

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Raveglia F, Degiovanni S, Bertolaccini L, Cara A, Cassina EM, Danuzzo F, Libretti L, Pirondini E, Sibilia MC, Spinelli F, Tuoro A, De Simone M, Chiarelli M, Cioffi U, Petrella F. Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery. World J Clin Cases 2026; 14(13): 119644

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative ..." [Read more]

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts. Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation." [Collapse]

Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; 32(16): 116781

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria ..." [Read more]

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? The study is moderately effective as it is retrospective clinical design how ever detailed methodology is missing. furthermore, it is judged on statistical variation not on experimental results variations 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? The results are appropriately authentic and consistent. Sample size is lower, hence hypothesis is moderately validated. Present study demonstrate the prognosis relevance which is insufficient for application in clinical settings. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Figure and tables are adequately presented 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Standard statistical approach is used in the current study with respect to study design 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Appropriate 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Acceptable format, formal and scientifically clear 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? Single center results Lower sample size which might effect on statistical significance Transparency in methodology " [Collapse]

Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer ..." [Read more]

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer development. It highlights how diets rich in additives, refined sugars, and industrial fats contribute to dysbiosis, inflammation, and oxidative stress, thereby increasing cancer risk. Conversely, dietary interventions such as fasting, caloric restriction, and ketogenic regimens show promise in reprogramming tumor metabolism and enhancing therapeutic responses. The authors emphasize that while mechanistic evidence is strong, clinical studies remain limited, heterogeneous, and often small in scale. Overall, the paper underscores the potential of personalized nutrition as a complementary strategy in colorectal cancer prevention and treatment, but stresses the need for well‑designed trials to validate safety, adherence, and long‑term outcomes." [Collapse]

Lima RSP, Sousa JDS, Neres MSO, de Sousa DJM, Martins JA, Pereira IC, da Silva ACA, Severo JS, Torres-Leal FL, da Silva MTB. Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming. World J Gastrointest Oncol 2026; 18(4): 115511

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing ..." [Read more]

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing their contribution to T‑cell exhaustion. The study highlights that PD‑1 inhibitors reduce PD‑1⁺ subsets but fail to affect CD161 expression, suggesting independent regulatory mechanisms. These findings underscore CD161 as a distinct and promising immunotherapeutic target, complementing but not overlapping with PD‑1 blockade strategies. While the evidence is compelling, broader patient cohorts and longitudinal studies will be essential to confirm clinical relevance and therapeutic potential." [Collapse]

Liu CR, Zhang M, Wang MQ, Zhang W, Li J, Shi GZ, Liang FF, Li YP, Huang N. CD161⁺CD8⁺ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 114547

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates ..." [Read more]

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates strong experimental evidence with both in vitro and in vivo validation, highlighting mechanistic clarity via the AMPK‑SREBP1 pathway. While promising and translational, limitations in sample size and treatment duration suggest further clinical validation is needed." [Collapse]

Huang JH, Ma JQ. HMGCR loss is synthetic lethal with PIK3CD inhibition in colorectal cancer cells. World J Gastrointest Oncol 2026; 18(4): 114220

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes ..." [Read more]

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes and coronary heart disease (CAD) and how to address both simultaneously in a prevention strategy. This paper could be a trailblazer for further research investigating the use of other drugs currently used to treat both diabetes and CAD." [Collapse]

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report ..." [Read more]

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good. The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future." [Collapse]

Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral ..." [Read more]

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen. The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons. The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published." [Collapse]

Nallakumarasamy A, Vetrivel VN, Balaji VP, Yadav R, Jeyaraman N, Muthu S, Jeyaraman M. Management and prevention of iatrogenic ipsilateral femoral neck fracture during intramedullary nailing of femoral shaft. World J Orthop 2026; 17(4): 116107

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Perforative peritonitis caused by long-term retention of a rectal foreign body: A case report. World J Clin Cases 2026; 14(11): 119572

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated ..." [Read more]

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated efforts in daily clinical practice and academic work have borne fruit. I read your paper with great interest, particularly because my own specialty is emergency medicine. I also occasionally encounter cases of anorectal foreign bodies in clinical practice, and I believe your paper will serve as a highly valuable reference for the management of such cases in the future. The manuscript is very well organized, clear, and easy to follow. In addition, it incorporates up-to-date information and presents the topic in a balanced and informative manner. Overall, I consider this to be a high-quality paper of substantial clinical value. In recognition of these strengths, I would give this work the highest evaluation. Writing and publishing a paper while maintaining a busy clinical workload is no small accomplishment, and I sincerely hope that you will continue to build on this success and further expand your academic achievements. Congratulations once again on this excellent work." [Collapse]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside ..." [Read more]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside of this treatment is the development of resistance, which, understandably, negatively affects patients’ clinical outcomes. Therefore, innovative therapeutic strategies are needed to overcome 5-FU resistance and improve the prognosis of GC. The authors of the study under review investigated the effects of Xiangshaliujunzi decoction (XSLJZD) on GC cell lines. They found that XSLJZD inhibited cell viability and proliferation, while promoting PANoptosis in 5-FU-resistant cells. Suppression of ZEB1 increased pyroptosis, apoptosis, and the expression of other proteins associated with programmed cell death. The selection of this work for comment was based on two reasons: i) the use of complementary therapy, whether or not based on traditional Chinese Medicine in the treatment of various benign and malignant digestive disorders, should be adopted internationally. The results are no longer empirical but are based on valid clinical and laboratory data, ii) The authors, in designing their study, among other things, investigated the effect of PANoptosis processes (apoptosis, pyroptosis, and necroptosis) which are a very hot topic of research internationally not only in malignant digestive diseases, but also in a host of other benign conditions such as inflammatory bowel disease. Their results, although experimental, reinforce the view that XSLJZD overcomes 5-fluorouracil (5-FU) resistance in GC by inducing PANoptosis." [Collapse]

Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; 32(14): 114331

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication ..." [Read more]

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication and highlighting its neurovascular nature. Diabetic retinopathy (DR), and its effective explanation as a complex, multifactorial, and increasingly recognized neurovascular disorder rather than solely a microvascular complication. The paper effectively emphasizes the global burden of the disease and the limitations of current treatments, especially anti-VEGF therapies, while drawing attention to the importance of early retinal changes. One of the main strengths of the review is its broader perspective beyond glucose control. The discussion of inflammation, lipid metabolism, and immune processes is well integrated and reflects current thinking in the field. The discussion of broader perspective as “beyond-glycemia” framework, reinforcing the need for multidimensional therapeutic strategies. The writing flows logically, making complex mechanisms easier to follow. The section on the gut-retina axis is particularly interesting and adds a fresh dimension to the topic. It clearly explains how gut microbiota may influence retinal health through metabolic and immune pathways. The inclusion of microbial metabolites, extracellular vesicles, and immune modulation as mediators of gut-retina communication demonstrates a developed understanding of the current evidence. Overall, the draft is well-organized, informative, and forward-looking, with a strong focus on potential new therapies and future research directions. " [Collapse]

Zeppieri M, Drigo A, Capobianco M, Visalli F, Cappellani F, Musa M, Giglio R, Tognetto D, Khouyyi M, Gagliano C, D’Esposito F, Inferrera L. Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy. World J Diabetes 2026; 17(3): 114603

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 37445

Manuscripts received today: 17

Manuscript reviews today: 38

Unhandled manuscripts today: 157

Active peer-reviewers today: 3908

Reviewer acceptance today: 54

Reviewer refusals today: 102

Total accepted manuscripts: 41422

Total rejected manuscripts: 45641

Total peer-reviewers: 4840238

Total submissions: 39081