Baishideng Publishing Group

Zerem E, Vila Š, Bajgorić S, Zerem D. Letter to the Editor: Ascites in acute pancreatitis: Prognostic considerations. World J Gastrointest Surg 2026; 18(5): 116880

"I think the peer review report for our manuscript is or objective. I m very satisfied and proud to publish our paper in your valuable ..." [Read more]

"I think the peer review report for our manuscript is or objective. I m very satisfied and proud to publish our paper in your valuable journal and I wish to continue to collaborate with your team work in the future. Why your journal is not cited in pub med central? What is your latest impact factor? " [Collapse]

Attieh P, Dabboussi D, Meraabi W, Karam K, Al Bacha RR, Abboud B. Beyond intestinal failure: Expanding therapeutic frontiers of glucagon-like peptide-2 in gastrointestinal disease. World J Gastrointest Pharmacol Ther 2026; 17(2): 118861

"Dear Editor, It is such a privilege to publish in your reputable journal. I appreciate the due diligence in sticking to ethics of ..." [Read more]

"Dear Editor, It is such a privilege to publish in your reputable journal. I appreciate the due diligence in sticking to ethics of publication. On behalf of the authors, we look forward to more opportunities to publish our research works with any of your journals in the nearest future. Best, Prof BA Animasahun " [Collapse]

Animasahun BA, Madise-Wobo AD, Gbelee HO, Omokhodion SI. Children with transposition of the great arteries: Should they actually be born in Nigeria? World J Cardiol 2017; 9(3): 277-282

"Dear Editor, It is such a privilege to publish in your reputable journal. I appreciate the due diligence in sticking to ethics of ..." [Read more]

"Dear Editor, It is such a privilege to publish in your reputable journal. I appreciate the due diligence in sticking to ethics of publication. The review process was thorough and I had the opportunity to re-learn a few concepts. On behalf of the authors, we appreciate you, your organization and look forward to more opportunities to publish our research works with any of your journals in the nearest future. Best, Prof BA Animasahun " [Collapse]

Animasahun AB, Ransome-Kuti O, Soyele E, Animasahun GA, Ubuane P, Ariyibi A, Hughes-Darden C, Njokanma OF. Nutritional status of children with heart disease attending outpatient clinic at a tertiary health center in Lagos. World J Clin Pediatr 2026; 15(2): 118127

"The review process was handled in a timely and professional manner, and the feedback provided by the reviewers was helpful and ..." [Read more]

"The review process was handled in a timely and professional manner, and the feedback provided by the reviewers was helpful and contributed significantly to strengthening the manuscript. The submission platform is intuitive, well-organized, and facilitates smooth communication between authors, reviewers, and editors. Overall, the publication process was efficient, transparent, and provided a positive experience for the authors. " [Collapse]

Velnar T, Kocivnik N, Bosnjak R. Clinical infections in neurosurgical oncology: An overview. World J Clin Cases 2023; 11(15): 3418-3433

"The peer-review process was relatively efficient, and the reviewers’ comments were constructive, insightful, and valuable for improving ..." [Read more]

"The peer-review process was relatively efficient, and the reviewers’ comments were constructive, insightful, and valuable for improving the quality of the manuscript. The editorial system is well-structured, user-friendly, and provides authors with a professional and reliable platform for scientific publication. Communication throughout the submission and review process was clear and organized, which contributed to a positive publishing experience overall. " [Collapse]

Gradisnik L, Prestor B, Zele T, Kocivnik N, Maver U, Velnar T. Pathophysiology and current understanding of degenerative disc disease. World J Orthop 2026; 17(5): 117153

"I feel that the editorial process does not keep the reviewers report in mind when making editorial comments. The submission process ..." [Read more]

"I feel that the editorial process does not keep the reviewers report in mind when making editorial comments. The submission process is very lengthy and in my opinion unnecessary, take for example, the core-tip, a written core-tip would be as good. The language letter is another unnecessary hurdle, if the reviewer feels the language is good , then the editor still wants a language certificate. We are authors in Pakistan and cannot afford processing fees or language certificates. " [Collapse]

Khan T, Iqbal Q, Hassan M, Shakeel S, Khan N, Asnath L. Letter to the Editor: Response to outcomes of “right vs left kidney”. World J Transplant 2026; 16(2): 115987

"The peer review process was smooth and very efficient. The reviewers' comments were constructive, detailed and extremely helpful, ..." [Read more]

"The peer review process was smooth and very efficient. The reviewers' comments were constructive, detailed and extremely helpful, which significantly improved the quality of our manuscript. We deeply appreciated the detailed feedback, the professional suggestions, and the timely responses from the editorial office. Overall, we are fully satisfied with the peer review process of this journal and would like to thank the reviewers for their time. " [Collapse]

Lin JQ, Liu HZ, Li ZW, Yang K. Intestinal myeloid sarcoma mimicking gastrointestinal stromal tumor without leukemic manifestations: A case report and review of literature. World J Gastroenterol 2026; 32(22): 118810

"The peer-review process was excellent and highly professional. We received constructive, detailed, and insightful comments from the ..." [Read more]

"The peer-review process was excellent and highly professional. We received constructive, detailed, and insightful comments from the reviewers, which helped us significantly improve the quality, clarity, and scientific value of our manuscript. The suggestions provided were fair, relevant, and instrumental in strengthening both the presentation and interpretation of our findings. " [Collapse]

Vasilska A, Tsvetkova S, Doykova K, Chervenkov L, Velikova T, Vasilska M, Sariyan S. Magnetic resonance imaging as a non-invasive breast cancer tool - the relevance of breast edema score: A retrospective study. World J Radiol 2026; 18(4): 119347

"I amsatisfied with the online submission system. I think the peer review report for your manuscript is fair. I am satisfied with the ..." [Read more]

"I amsatisfied with the online submission system. I think the peer review report for your manuscript is fair. I am satisfied with the anonymous peer review process. I am satisfied with the published articles processes. I am satisfied with the prepared tables in the online full-text article. I am satisfied with the prepared figures in the online full-text article. " [Collapse]

Xu MJ, Wei X, Huang Y, Lu Y, Sun L, Xie Y, Li MH. Congenital porto-sinusoidal vascular disorder-induced portal hypertension: A comprehensive review based on a classic clinical case. World J Hepatol 2026; 18(5): 117184

"I am truly honored to share that our paper has been published in the World Journal of Pediatrics (WJP). First and foremost, I would ..." [Read more]

"I am truly honored to share that our paper has been published in the World Journal of Pediatrics (WJP). First and foremost, I would like to express my sincere gratitude to my supervisor for their invaluable guidance and encouragement throughout this journey. My thanks also go to all co-authors and team members for their dedicated collaboration. I deeply appreciate the editorial team and the anonymous reviewers for their rigorous and constructive comments, which greatly improved our manuscript. Special thanks go to the children and families who participated in this study — your trust and support give our research its true purpose and meaning. The road from submission to acceptance was challenging. Each round of revision and every critical comment pushed us to re-examine our study design and reasoning. Yet it is precisely this rigorous peer review process that has made our work stronger and more credible. There were moments of anxiety and self-doubt — especially after receiving a "major revision" decision — but looking back, those were the times when I grew the most as a researcher. Seeing our paper finally published online brought both a sense of relief and a deep feeling of fulfillment — a reminder that no late night or line of code was wasted. For a researcher in pediatrics, being able to leave a mark in a journal like WJP is not only a great encouragement but also a meaningful responsibility. Of course, publication is not the end — it is a new beginning. Moving forward, I will continue to translate clinical questions into scientific investigations and strive to make contributions that truly matter to pediatric practice. Once again, thank you to everyone who supported us along the way. I wish all my colleagues and fellow researchers the very best in getting your work published as well. " [Collapse]

Lian YJ, Lu JN, Ru QC, Zhu YK, Yu ZY, Guo X. Preoperative anxiety and depression predict two-year outcomes after total hip or knee arthroplasty. World J Psychiatry 2026; 16(6): 116745

"The process moved very quickly. The dialogues were very clear and understandable. I believe that the process of having the article ..." [Read more]

"The process moved very quickly. The dialogues were very clear and understandable. I believe that the process of having the article linguistically reviewed by a suitable (recommended ?) firm during the preparation phase is no longer necessary. Authors should be trusted in this matter. Thanks for your kind collaboration. Kind regards ..... ... " [Collapse]

Atay A, Acar K, Dilek ON. Impact of incision preference and umbilical care on laparoscopic cholecystectomy outcomes: A randomized controlled trial. World J Gastrointest Surg 2026; 18(5): 118264

"Overall very good experience and will be referring to my colleagues as well. The professionalism and the time spent in reviewing the ..." [Read more]

"Overall very good experience and will be referring to my colleagues as well. The professionalism and the time spent in reviewing the manuscript timely and replying to the emails is good. I believe this journal will be a valuable edition to the medical fraternity. The peer review process is thorough and the handling editor follow up with the author timely and guide where needed professionally. " [Collapse]

Waheed S, Ali S, Khan N, Raheem A, Kothari SA. Sex differences in serious outcomes among critically ill adults following endotracheal intubation. World J Crit Care Med 2026; 15(2): 115099

"We are highly satisfied with the editing and publishing services provided by the World Journal of Gastrointestinal Surgery. The ..." [Read more]

"We are highly satisfied with the editing and publishing services provided by the World Journal of Gastrointestinal Surgery. The submission and peer-review process was efficient, professional, and transparent. The constructive feedback from the reviewers and editors significantly helped enhance the quality and rigor of our manuscript. We also appreciate the journal's commitment to open-access publishing, which will undoubtedly maximize the global reach and academic impact of our research. We highly recommend this journal to our peers. " [Collapse]

Deng QY, Leng HQ, Wang TC, Hu C. Establishment and validation of an intratumoral fibrosis-based nomogram for predicting aggressive recurrence after liver resection in hepatocellular carcinoma. World J Gastrointest Surg 2026; 18(5): 116135

"As a researcher, I am satisfied with this journal's review process. It was efficient and transparent. The handling was timely and ..." [Read more]

"As a researcher, I am satisfied with this journal's review process. It was efficient and transparent. The handling was timely and thorough. The reviewers gave constructive feedback that improved my manuscript. The editorial office responded quickly to queries and kept me informed at every stage. I appreciate their courtesy and rigor. Overall, the review process exceeded my expectations. I will recommend this journal to my colleagues and friends for their future submissions. " [Collapse]

Ren SQ, Huang ZL, Qiu ZX, Cai C. Systemic immune-inflammation index and serum lactoferrin: A novel tool for individualized prognostic assessment in elderly colon cancer. World J Gastrointest Surg 2026; 18(5): 114634

"We sincerely appreciate the high-quality review process of this journal and the constructive, professional comments from the editor ..." [Read more]

"We sincerely appreciate the high-quality review process of this journal and the constructive, professional comments from the editor and reviewers. These valuable suggestions have significantly helped us improve the logic, presentation and academic rigor of our manuscript. We have carefully revised the paper in full accordance with the comments and hope it meets the publication standards. " [Collapse]

He YN, Yang WY, Zhang J, Wang XY, Gao XZ, Liu XH, Zhou ZH. Neural correlates of impairments in music emotion processing in major depressive disorder: Evidenced from an event-related potential study. World J Psychiatry 2026; 16(6): 117245

"I am highly appreciative of the peer review process conducted by the journal. The reviewers provided constructive, detailed, and ..." [Read more]

"I am highly appreciative of the peer review process conducted by the journal. The reviewers provided constructive, detailed, and scientifically rigorous comments that strengthened the manuscript and enhanced its clarity. The editorial team maintained professional communication throughout the review process and ensured fair, efficient, and transparent handling of the submission. The quality of the review and the timely editorial decisions reflected the journal’s commitment to maintaining high standards of scholarly publishing. " [Collapse]

Mishra N, Gupta A, Singh AK, Nagar J, Vyas AK, Yadav V, Ravindran GC, Pandey MK, Corovic IF, Mandal U, Tiwari RR, Mishra PK, Rawat SK, Nema RK. Prevalence of hepatitis-D virus in hepatitis B surface antigen-positive patients of India: A meta-analysis (research on behalf of ESGVH). World J Gastroenterol 2026; 32(21): 115964

"The publication process for our manuscript in the World Journal of Radiology was highly professional. The peer review was rigorous ..." [Read more]

"The publication process for our manuscript in the World Journal of Radiology was highly professional. The peer review was rigorous and constructive, significantly improving our paper's quality. We appreciate the efficient language editing and seamless online publishing. The F6Publishing system is user-friendly and ensures a transparent submission experience. we look forward to continue publishing in future. " [Collapse]

Lal H, Jowel P, Verma P, Shamim A, Prasad R, Singh A, Singh UP, Sureka SK, Siddiqui F, Jain M, Srivastava A, Yadav P. Role of diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient in subtyping renal cell carcinoma. World J Radiol 2026; 18(5): 119367

"The World Journal of Psychiatry maintains high academic standards and is committed to publishing peer-reviewed, open-access research. ..." [Read more]

"The World Journal of Psychiatry maintains high academic standards and is committed to publishing peer-reviewed, open-access research. The editorial team is professional, and the online platform ensures wide dissemination of scientific knowledge. The journal's strict adherence to publication ethics and transparency in its editorial processes reinforces its credibility in the field of psychiatry. We are highly satisfied with the publication experience in World Journal of Psychiatry. The submission and tracking system (F6Publishing) is intuitive and user-friendly. Our manuscript, which addresses the critical need for multidimensional modeling in postpartum anxiety following preeclampsia, was handled with great professionalism. The editorial team responded promptly at every stage, ensuring a smooth and timely publication process. We would highly recommend this journal to fellow researchers seeking a platform for impactful psychiatric research. " [Collapse]

Gao KR, Zhang PX, Luo FG, Wu WY, Wang JJ, Fang KJ, Zheng JH, Xing HY, Yan J. Letter to the Editor: Advancing predictive psychiatry in perinatal care: The imperative of multidimensional modeling for postpartum anxiety following preeclampsia. World J Psychiatry 2026; 16(6): 118284

"The review process for our article was excellent. We received each review report promptly as soon as it was submitted, which helped ..." [Read more]

"The review process for our article was excellent. We received each review report promptly as soon as it was submitted, which helped us prepare our responses in a timely manner. Overall, the process was quick, transparent, and fair. However, I would like to suggest developing an online system for proofreading, as sending and revising Word documents can sometimes be confusing. " [Collapse]

Bashir B, Choudhery MS, Hussain I. Hypoxic preconditioning restores the regenerative potential of aged adipose tissue derived mesenchymal stem cells. World J Stem Cells 2026; 18(5): 117241

21503 items Read more >>

Article Quality Tracking-Peer-Review

"Proton pump inhibitors (PPIs) are acid-suppressive agents that irreversibly bind to the gastric mucosa’s H+/K+ ATPase proton pump. ..." [Read more]

"Proton pump inhibitors (PPIs) are acid-suppressive agents that irreversibly bind to the gastric mucosa’s H+/K+ ATPase proton pump. They are the first-line treatment for various gastrointestinal conditions, including peptic ulcers and gastroesophageal reflux disease, demonstrating superior efficacy compared to traditional acid-suppressive therapies. PPIs have become one of the most widely prescribed long-term medications globally, however, an increasing number of adverse effects have been reported. Numerous studies have confirmed PPIs’ extensive and significant impact on the gut microbiota from the oral cavity to the rectum. Gut dysbiosis is a significant adverse effect of PPIs, potentially exceeding the microbiota-altering impact of antibiotics. While gastric acid suppression plays an important role, PPIs also affect the gut microbiota through multiple mechanisms. Several studies have identified a potential association between PPIs and IBD, suggesting that PPIs may influence the onset, progression, and treatment efficacy of IBD. Although the underlying mechanisms remain unclear, many researchers speculate that dysbiosis induced by PPIs plays a critical role, given the similarities in gut microbiota changes observed in PPIs users and IBD patients. Authors concluded that this association may be influenced by study design, age differences, and protopathic bias, thereby limiting causal inference. Clinicians should interpret this association cautiously, and future prospective studies with rigorous bias control are needed to determine whether PPI use contributes to inflammatory bowel disease pathogenesis. I agree to authors’ opinion. " [Collapse]

Gao M, Yin RR, Mao X, Shao ZX, Shi YY. Association between proton pump inhibitor use and the risk of inflammatory bowel disease: A systematic review and meta-analysis. World J Gastroenterol 2026; 32(22): 116469

"1. Overall assessment Ethics approval, study registration, and funding disclosure are complete, and the study generally complies ..." [Read more]

"1. Overall assessment Ethics approval, study registration, and funding disclosure are complete, and the study generally complies with international ethical standards for medical research. The work is based on a 499-patient multi-centre retrospective cohort and uses OS together with 3- and 5-year cumulative survival rates as primary endpoints; Kaplan-Meier survival analysis and Cox proportional-hazards modelling are used to evaluate prognostic factors, and the overall analytical framework is consistent with common analytical approaches in oncology prognostic research. Statistical procedures, including survival time definition, censoring handling, and baseline comparison, are reported relatively completely, and the figures and baseline characteristics are presented clearly. In the context of relatively limited real-world long-term survival evidence on ICWM in CRLM, this study provides a useful foundation for future research. Although the research question is clinically valuable and the cohort size is reasonable, several methodological limitations may affect causal interpretation; the findings are therefore more appropriately regarded as hypothesis-generating evidence. 2. Major methodological concerns (a) Immortal time bias The study defines cohort A by "continuous TCM >=3 months" and uses the date of initial diagnosis as the OS time origin. This combination of exposure definition and survival time origin may introduce immortal time bias, because patients have to survive long enough to qualify for cohort A. The reclassification of some patients from cohort B to cohort A during follow-up also points to a potential time-dependent exposure issue. A landmark analysis (e.g., a 3- or 6-month landmark) or modelling TCM as a time-dependent covariate would help reduce this risk of bias. (b) Residual confounding The grouping is not randomized, and the choice of TCM may be related to factors such as adherence, socioeconomic status, family support, and treatment tolerability. These unmeasured variables may also influence survival, and Cox regression alone may not fully address residual confounding. Propensity-score-based approaches (e.g., PSM or IPTW) could be considered to improve covariate balance. If these unmeasured data cannot be retrospectively extracted, this should be explicitly listed as a study limitation in the Discussion. (c) Exposure heterogeneity and treatment-intensity imbalance The TCM exposure in cohort A includes individualized decoctions together with several patent medicines (Anteke, Pingxiao, Compound Cantharidin, Xihuang, Weimaining). These patent medicines may differ in mechanism and potential efficacy, and combining them under a single “TCM exposure” may weaken interpretability. Additional variation across treatment stages may further increase within-exposure heterogeneity. In addition, the manuscript states only that patients received "best available treatment according to guidelines," without reporting treatment-intensity indicators such as chemotherapy lines, biologic agent use rate, or relative dose intensity (RDI). Stratified sensitivity analyses by patent-medicine category or by decoction-only exposure, together with reporting of systemic treatment intensity, would be useful additions. 3. Statistical and reporting considerations Covariate adjustment in the Cox model The multivariable Cox model includes only four covariates: primary tumour site, RAS/BRAF status, local treatment of liver metastases, and cohort assignment. For CRLM survival analysis, prognostic models generally need to cover key dimensions such as patient status, tumour biology, disease burden, and treatment intensity in a relatively comprehensive way. The variables currently included are concentrated on selected treatment factors and molecular features, while several well-recognized prognostic factors have not yet been entered into the model. For example, age differs significantly between the two groups (62.47 vs 58.51 years, P<0.01) but is not adjusted for; ECOG/KPS is used only as an inclusion criterion (0-2) rather than as a covariate; and liver metastatic burden indicators (such as number of metastases, maximum lesion diameter, synchronous vs metachronous status, and extrahepatic disease) are also not included. Treatment-intensity indicators such as chemotherapy lines and RDI are not reported. Multiplicity and subgroup analyses Figure 2 presents multiple subgroup analyses (age, sex, primary site, gene status, local treatment, treatment lines, and metastasis location, among others), but the manuscript does not address the multiple-comparisons issue. A large number of subgroup tests may increase the risk of false-positive findings; we suggest that the authors interpret subgroup results cautiously and consider reporting adjusted P values for key subgroups in order to reduce the likelihood of false-positive findings. Proportional-hazards assumption Follow-up in this study is relatively long (up to 132 months), and time-varying treatment effects are plausible. Formal assessment of the Cox proportional-hazards assumption (e.g., Schoenfeld residuals) would strengthen confidence in the reported hazard ratios. Safety reporting The methods section notes that major adverse reactions would be tracked during follow-up, but the manuscript does not report a safety comparison between the two cohorts, nor does it present indicators such as HILI, myelosuppression, or hepatic/renal function. Given that ICWM is evaluated as a long-term treatment exposure, additional safety data would help support a more comprehensive assessment of its clinical value. If these data cannot be systematically obtained, this limitation should be further clarified in the Discussion. References The reference base broadly covers CRLM epidemiology, local liver-directed therapies, and TCM-related mechanisms, and is reasonably current and on-topic. Incorporating the most recent systematic reviews or meta-analyses on integrative medicine in advanced colorectal cancer, where available, would further strengthen the literature base. 4. Language and interpretation The manuscript is clearly structured and well organized, and on the whole follows standard reporting conventions for observational cohort studies. However, causal and associative language are mixed in places. For example, the title uses verbs with a more causal connotation such as "prolong," and the Discussion contains expressions such as "reduced the risk of death by 35%" and "protective factors," whereas the Abstract Conclusion is phrased associatively as "is associated with longer OS." Maintaining greater consistency in the use of associative rather than causal language throughout the manuscript would better match the evidence level of a retrospective observational design. 5. Conclusion Overall, this study addresses a clinically relevant question and contributes useful real-world evidence regarding ICWM in CRLM. The findings are best interpreted as hypothesis-generating. Addressing the methodological limitations identified above, particularly immortal time bias, residual confounding, and limited covariate adjustment, in future studies would strengthen causal inference and improve the interpretability of the results. " [Collapse]

Bian JY, Sun YX, Wang LF, He WT, Liu CB, Wang XQ, Zhang T. Integrated Chinese and Western medicine prolong survival in colorectal cancer with liver metastasis: A retrospective cohort study. World J Clin Oncol 2026; 17(5): 118265

"Post-stroke depression (PSD) is a frequent complication that worsens recovery and quality of life. Clinicians should prioritize early ..." [Read more]

"Post-stroke depression (PSD) is a frequent complication that worsens recovery and quality of life. Clinicians should prioritize early screening of PSD, especially in patients with cognitive impairment, severe disability, or social isolation. Biological markers such as inflammation and neurotransmitter imbalance may guide risk stratification, while predictive models can support monitoring. Management requires a multimodal approach: antidepressants, psychotherapy, and rehabilitation programs, complemented by family and social support. If integrated into routine stroke care, these strategies enable timely intervention, reduces complications, and promote fast functional recovery." [Collapse]

Gu JX, Liu CQ, Chen GX, Yao T, Sun ZX, Wang Y. Post-stroke depression update 2025: Mechanisms, prediction, and management. World J Psychiatry 2026; 16(6): 115996

"This study is methodologically rigorous, employing a large sample size, LASSO regression, and dual validation to ensure robust results. ..." [Read more]

"This study is methodologically rigorous, employing a large sample size, LASSO regression, and dual validation to ensure robust results. The dynamic online nomogram enhances clinical usability and identifies clear risk factors, including cognition, albumin, and surgical parameters. Limitations include its single‑institution scope, short validation period, and the need for prospective testing of clinical impact. Overall, it provides a solid foundation and meaningful step toward proactive management of emergence delirium in older adults." [Collapse]

Xin Y, He B, Wei XH, Yan YL, Huang C, Gao CY, Wang S, Zhang GM, Li R, Wu Y. Construction and validation of a predictive model for the risk of emergence delirium in older adult patients. World J Psychiatry 2026; 16(6): 115839

"This is a well-written and presented a rare case report on "Clinical management of porcelain gallbladder: A case report". This ..." [Read more]

"This is a well-written and presented a rare case report on "Clinical management of porcelain gallbladder: A case report". This manuscript gives additional new knowledge to the existing literature.Porcelain gallbladder is a rare clinical entity that should always be considered due to its well-established association with gallbladder carcinoma. I think that this manuscript is worth to be published in the World Journal of Gastrointestinal Surgery." [Collapse]

Chen SJ, Chen S, Hu AY, Li QS, Fan Y, Chen YG, Tian S, Li HL, Peng CJ, Han M. Clinical management of porcelain gallbladder: A case report. World J Gastrointest Surg 2026; 18(5): 116359

"This article is well structured and fully compliant with the STROBE checklist. This retrospective study systematically compared the ..." [Read more]

"This article is well structured and fully compliant with the STROBE checklist. This retrospective study systematically compared the efficacy and safety of traction-preclosure-assisted endoscopic full-thickness resection (TPC-EFTR) with conventional EFTR for the treatment of gastric subepithelial tumors (SETs). The authors clearly formulated the inclusion and exclusion criteria, with a particular emphasis on endoscopic contraindications for lesions characterized by large size, extraluminal growth, dissemination, or potential recurrence. Both primary and secondary outcome measures were well defined in detail. Regarding primary efficacy outcomes, the en bloc resection rates were comparable between the two groups, whereas the TPC-EFTR group achieved a significantly higher complete resection rate. For secondary outcomes, the TPC-EFTR group demonstrated superior safety profiles, including shortened operation time and wound closure time, as well as a reduced incidence of pneumoperitoneum. In terms of postoperative prognosis, no significant between-group difference was observed in tumor recurrence rate, while the TPC-EFTR group presented higher EQ-VAS scores. Overall, the methodological design of this study meets the standard requirements of retrospective clinical research. Nevertheless, several limitations of this study remain to be addressed. First, although no statistically significant differences were detected, potential selection bias may exist with respect to the size and anatomical location of enrolled lesions. Second, postoperative CT examinations were performed only based on clinical symptoms, which might lead to an underestimation of the actual pneumoperitoneum rate, a limitation that has also been acknowledged by the authors. Furthermore, EFTR is a technically demanding procedure that is currently restricted to high-level tertiary hospitals. Accordingly, the clinical popularization of conventional EFTR remains challenging, and further validation and prospective investigations are still required to confirm the clinical value of TPC-EFTR. In conclusion, this study is pioneering and clinically promising, and the TPC-EFTR technique exhibits favorable application prospects. Multi-center, large-sample, and long-term follow-up studies are warranted prior to the widespread clinical application of TPC-EFTR." [Collapse]

Li X, Zhang RY, Wen XD, Li XQ, Liu WH. Traction-preclosure-assisted vs conventional endoscopic full-thickness resection for gastric subepithelial tumors: Safety, efficacy in a retrospective cohort (with video). World J Gastroenterol 2026; 32(19): 112955

"This article discusses an interesting topic. This is problem solving oriented study, with benefit to clinical practice. The comparative ..." [Read more]

"This article discusses an interesting topic. This is problem solving oriented study, with benefit to clinical practice. The comparative study showed that the MV-Flow™ has ability to visualize smaller vessels with slower blood flow, which is particularly relevant, as they challenge the prevailing concept that smaller vessels in deep endometriotic nodules are poorly vascularized. The ethics meet the requirement of the Journal. Caveats or drawbacks:“There is no previous data to allow a meaningful estimation. For this reason, we do consider this study as a preliminary exploratory study” in the “Statistical analysis”section is not adequate. The study design is not sound and the results are not sound and robust. An important limitation is that there is no golden standard(contrast-enhanced ultrasound or other methods) for reference, even the pulsed wave Doppler has not been used for attempting measurement to verify the presence of microvascularity. Using conventional power Doppler as reference is not sufficient. The dimensions displayed by the two different imaging protocols are not exactly the same dimension, as in the Figure 2 A,B,C,D, and the sampling volume is larger than good. Some punctuate color regions are artifacts, leading to an unauthentic conclusion that MV-Flow™ has very high sensitivity for microcirculation. " [Collapse]

Alcazar JL, Pich Barroso DM, Sanchez O, Brunel I, Vilches JC, Orozco R. Enhanced detection of vascularization in rectal endometriosis: A comparative study of microvascular flow and power Doppler. World J Radiol 2026; 18(5): 119223

"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, ..." [Read more]

"This important review explored the relationship between hypochlorhydria, microbial dysbiosis, and gastric mucosal immune responses, and how these factors promote the transition from chronic gastritis to metaplasia and malignancy. In addition, the authors describe recent developments in multi-omics technologies that are uncovering new dimensions of host-microbe interactions in the gastric niche, thereby extending the classic Correa cascade into a more comprehensive, ecosystem-based model of gastric carcinogenesis. It seems that future perspectives on the gastric microenvironment will shift from simple descriptions of microbes to active therapeutic and diagnostic interventions, aiming to enable personalized management of patients with gastric cancer. It is also believed that advances in metabolomic analyses, microbiome modulation, utilization of specialized pro- and prebiotics, gastric microbiome transplantation, use of targeted antimicrobial drugs, modifications of the tumor microenvironment, as well as the use of ex vivo models and artificial intelligence will contribute decisively not only to the prevention and early detection of gastric cancer but also to a more effective complementary therapeutic intervention. " [Collapse]

Zheng HC, Zhou T, Sun L, Ding X. Gastric microenvironment and gastric cancer: Interplay of acid, microbiota, and inflammation. World J Gastroenterol 2026; 32(20): 117044

"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood ..." [Read more]

"This is very interesting paper about the predictor of acute hepatic failure. Author indicates that a decrease in peripheral blood natural killer (NK) cells and changes in their functional markers can help predict the progression and severity of liver failure, particularly in conditions like acute-on-chronic liver failure (ACLF). A sharp reduction or dysfunction in circulating NK cells in the bloodstream—often alongside an accumulation of these cells in the liver itself—indicates an overwhelming immune response and correlates with a poorer prognosis. In severe liver diseases like hepatitis-induced ACLF, peripheral NK cells become depleted and show a higher expression of apoptosis and exhaustion markers. Studies suggest that at the time of hospital admission, evaluating circulating NK cell levels alongside standard clinical markers can effectively help identify patients who may survive spontaneously versus those who will require an urgent liver transplant. Finally, our results suggest that more recruitment of NK cells to the liver is somehow responsible for the failure of the native. Explain why peripheral natural killer cells reflect the prognosis more sensitively than other parameters of acute liver failure. a significant drop in peripheral Natural Killer (NK) cell counts and a shift in their functional profile are reliable biomarkers for predicting poor clinical outcomes. Patients with severe liver failure exhibit significantly reduced proportions of NK cells in their peripheral blood compared to healthy individuals. These peripheral NK cells often show signs of exhaustion and dysfunction. Many of them undergo apoptosis (cell death) or migrate directly into the inflamed liver tissue. Researchers have found that the degree of this peripheral NK cell reduction directly correlates with disease severity (e.g., HBV-DNA levels) and can serve as a strong predictive indicator for patient survival or the need for a liver transplant. Please tell me the mechanism between the predictor of acute hepatic failure and the degree of peripheral NK cell." [Collapse]

Xu JX, Li HG, Xu X, Lu D. Letter to the Editor: Characteristics of peripheral blood lymphocyte subpopulations in acute-on-chronic liver failure: A call for further exploration. World J Gastroenterol 2026; 32(20): 116109

"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. ..." [Read more]

"This is a good paper. Human liver ischemia/reperfusion injury (IRI) is a common and major clinical problem complicating liver surgery. The pathogenesis underlying IRI is complex, involving a series of signaling mediators and mechanisms. This study aimed to investigate the effects of Magnesium Isoglycyrrhizinate (MgIG) on the liver function after IRI in liver resection treated with or without MgIG. MgIG is a magnesium salt of glycyrrhizic acid stereoisomer, commonly derived from licorice root. The full name of MgiG is tetrahydrate magnesium 18α, 20β-hydroxy-11-oxon orolean-12-en-3β-yl-2-O-β-D-glucopyranurosyl-α-D-glucopy ranosiduronate. Glycyrrhizin is commonly used clinically as a liver protective medicine. MgIG is the fourth generation of glycyrrhizin preparations. It has better affinity with target cell receptors, and stronger anti-inflammatory and anti-oxidation effects. It has been shown to stabilize hepatocyte membrane and improve liver function. MgIG has shown the effects of lowering the liver toxicity of free fatty acid by preventing mitochondrial damage and protecting hepatocytes from ischemia and reperfusion induced injury. Function: It provides anti-inflammatory, antioxidant, and hepatocyte membrane-stabilizing effects.　 Used post-surgery, it is associated with a more rapid decrease in liver enzymes (such as ALT and AST) and better regulation of inflammatory cytokines.Ischemia-reperfusion injury: Studies have shown it can mitigate liver damage caused by blocking the hepatic blood supply during the surgical　procedure.　Previous studies showed that MgIG administration significantly ameliorated CCl4-induced biochemical alterations and lipid peroxidation in the liver of mice or rats The protective effects of MgIG might be resulted from the elimination of oxygen free radicals before the damage to macromolecular and metabolism of the cells. I ask some questions for authors.1. Please describe the extent of liver resection and the presence or absence of cirrhosis in the patient's background. 2.Please also describe parameters other than GOT used to assess the drug's effectiveness. 3.Please provide more detailed information about the effects of MGIG on reperfusion injuries. 4.During liver surgery, how many minutes of ischemia were administered using the Pringel procedure? 5.Author’s data suggests that MG has a hepatoprotective effect on the liver, but please consider comparing it with other medications. " [Collapse]

Xie ZQ, Wei JX, Zhong JY, Luo X, Zhuang HK, Ma XW, Wang QB, Tan WL, Wang BK, Chen YJ, Li CJ, Shang CZ. Effectiveness of magnesium isoglycyrrhizinate on perioperative hepatic function protection in patients undergoing hepatectomy. World J Gastroenterol 2026; 32(19): 116513

"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy ..." [Read more]

"Simpler technique but critical evaluations noted. Important for patient care. Type 2 diabetes mellitus (T2DM) and diabetic retinopathy (DR) are growing global health concerns, with DR remaining a major cause of vision loss. The study identifies indirect bilirubin (IBIL) as a potential biomarker that is inversely linked to DR risk in patients with T2DM. Although the findings are clinically important, limitations such as the cross-sectional design, single-center setting, and possible confounding factors reduce generalizability." [Collapse]

Zhang Z, Shan XQ, Liang FM, Zhang LX. Letter to the Editor: Indirect bilirubin: A potential predictive biomarker for diabetic retinopathy and its clinical translational potential. World J Diabetes 2026; 17(5): 115813

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism ..." [Read more]

"This case-control study recruited 303 participants from Kunming, exploring associations between serum vitamin D, VDR FokI polymorphism and diabetic retinopathy (DR) in T2DM patients. It found vitamin D deficiency and VDR FokI ff genotype were independent risk factors for DR. The study adopted rigorous grouping and standard laboratory detection, applied Sanger sequencing for accurate genotyping, and controlled common clinical confounding factors, offering valuable population evidence for DR early risk prediction. However, single-center cross-sectional design cannot confirm causality. It lacked DR severity stratification and ignored lifestyle and sunlight exposure confounders. Future work should adopt multicenter prospective cohorts and further explore the molecular mechanism of VDR variants affecting DR pathogenesis. " [Collapse]

Liu ZH, Ran ZQ, Yang R, Chen LX, Wang ZZ, Li YY, Han R. Vitamin D, vitamin D receptor FokI polymorphism, and diabetic retinopathy: A case-control study in Kunming, China. World J Diabetes 2026; 17(5): 118141

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma ..." [Read more]

"In this manuscript, the authors aimed to establish a prognostic indicator for patients with advanced-stage hepatocellular carcinoma who received nivolumab as the initial treatment. Several biochemical parameters, including alpha-fetoprotein and the neutrophil-to-lymphocyte ratio (NLR), were retrospectively analyzed. The cut-off value for NLR was determined using a receiver operating characteristic (ROC) curve to distinguish patients with survival times longer than the median survival time. However, the efficacy of this cut-off value was subsequently validated using the same cohort in which the cut-off value had originally been established. Under these conditions, it is expected that the validation would yield favorable predictive results. Therefore, because both the establishment and validation of the cut-off value were conducted within the same cohort, the significance and predictive performance of the cut-off value cannot be considered methodologically validated." [Collapse]

Guo R, Gao M. Predictive value of neutrophil-lymphocyte ratio for prognosis in patients with advanced hepatocellular carcinoma treated with programmed cell death 1 inhibitors. World J Gastroenterol 2026; 32(18): 118416

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives ..." [Read more]

"This is a well-written and presented rare case report on "Giant serosal cavernous hemangioma of the ileum". This manuscript gives additional new knowledge to the existing literature.The authors emphasize the importance of a better understanding of "cavernous hemangioma" by clinicians, and the necessity of timely diagnosis and treatment. I think that this manuscript is suitable ,and worth to be published in World Journal o Gastrointestinal Surgery." [Collapse]

Si HB, Qin HJ, Wang YP, Nie FF. Giant serosal cavernous hemangioma of the ileum: A case report and review of literature. World J Gastrointest Surg 2026; 18(4): 115954

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the ..." [Read more]

"Formerly ,the neutrophil/lymphocyte ( N/R) ratio also reflected the severity of COVID-19. In this study, the authors state that the N/L ratio is an indicator that correlates with the prognosis of HCC receiving program inhibitor administration. NLR values have also been shown to predict survival in various cancers including urologic cancer , nasopharyngeal cancer , colon cancer , as well as lung cancer . In addition, other authors say that the NLR has been found to be a prognostic risk factor for HCC after treatments other than TACE, such as hepatectomy , liver transplantation and sorafenib therapy . Please explain the mechanism by which the N/L ratio serves as an indicator of prognosis. Explain the mechanism by which the NLR cutoff was set to 3.165. Systemic inflammatory responses have been shown to reflect the promotion of angiogenesis, and DNA damage and tumor invasion through upregulation of cytokines. A simple index of systemic inflammation is the neutrophil–lymphocyte ratio (NLR). Elevated NLR has recently been shown associated with poorer prognosis in patients with various types of malignant tumors, including colorectal cancer, HCC, intrahepatic cholangiocellular carcinoma, and pancreatic cancer. Furthermore, elevated NLR have shown a significant correlation with poor outcome in patients undergoing LT for HCC. I think that One mechanism by which elevated NLR can lead to a higher tumor recurrence rate involves an increased number of circulating neutrophils secreting the vascular endothelial growth factor (VEGF), resulting in higher levels of VEGF in the tumors. Moreover,an elevated Platelet-to-Lymphocyte Ratio (PLR), often with a cut-off , is a significant, low-cost prognostic biomarker for poor overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) patients. It reflects heightened systemic inflammation and correlates with tumor aggressiveness, such as large tumor size, vascular invasion, and recurrence. Please comment about platelet /lymphocyte ratio about the prognosis HCC receiving receiving program inhibitor administration. " [Collapse]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of ..." [Read more]

"This article addresses a clinically important issue in complex hepatocellular carcinoma surgery: the potential navigation value of combining intraoperative ultrasound with indocyanine green fluorescence imaging. The study is valuable because it evaluates not only tumor visualization but also clinically relevant endpoints, including tumor localization, occult lesion detection, margin control, perioperative outcomes, and survival-related outcomes. The topic is timely and relevant to hepatobiliary surgeons, particularly in the context of precision hepatectomy and minimally invasive liver surgery. However, the interpretation should remain cautious because the study is retrospective and single-center in design. Potential selection bias, learning-curve effects, and heterogeneity in fluorescence protocols may influence the results. The comparison also appears to reflect a systematic combined-navigation strategy versus conventional surgery rather than a pure navigation versus non-navigation comparison. Therefore, the findings are clinically encouraging and suitable for hypothesis generation, but prospective multicenter validation with standardized navigation endpoints is needed. " [Collapse]

Zhang S, Li SY, Zhou B. Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection. World J Gastrointest Surg 2026; 18(4): 116412

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Pavlidis L, Geropoulos G, Kechagias KS, Psarras K, Patel V, Reza L, Prakash N, Athanasiou C, Geropoulos V, Anestiadou E, Triantafyllou T, Sapalidis K, Laskou S, Dimitroulis D. Near-infrared fluorescence with indocyanine green for minimally invasive hernia surgery: A systematic review and evidence synthesis. World J Clin Cases 2026; 14(14): 118964

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Walędziak M, Różańska-Walędziak A. Three-port robotic sleeve gastrectomy-another step forward: A case report. World J Clin Cases 2026; 14(14): 117795

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Raveglia F, Degiovanni S, Bertolaccini L, Cara A, Cassina EM, Danuzzo F, Libretti L, Pirondini E, Sibilia MC, Spinelli F, Tuoro A, De Simone M, Chiarelli M, Cioffi U, Petrella F. Beyond survival: Pain as the main determinant of long-term quality of life after thoracic trauma surgery. World J Clin Cases 2026; 14(13): 119644

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative ..." [Read more]

"This study addresses an important and timely clinical question, providing relevant data on the use of ustekinumab in postoperative recurrence of Crohn’s disease. The multicenter design enhances the external validity and applicability of the findings in real-world practice. The integrated assessment combining endoscopic, clinical, and biological outcomes represents a major strength of the study. Overall, the results support the efficacy and safety of ustekinumab, particularly in a first-line setting. However, the retrospective design introduces inherent limitations, including potential selection bias and residual confounding. The relatively short follow-up period limits the ability to draw conclusions regarding long-term efficacy and durability of response. The observed differences in response among stricturing and penetrating phenotypes are intriguing but remain hypothesis-generating and require further validation in larger prospective cohorts. Despite these limitations, the study provides valuable real-world evidence supporting early use of ustekinumab in postoperative Crohn’s disease. The manuscript is well structured, clearly written, and easy to follow, with a coherent presentation of results and clinically meaningful interpretation." [Collapse]

Ma XZ, Han XZ, Zhang WY, Tian F, Zhou XC, Zhou LY, Teng YS, Lei L, Sheng JQ, Jin P, Zhao XM, Jia Y. Effectiveness of ustekinumab in postoperative Crohn's disease management: Evidence from a Chinese multicenter cohort. World J Gastroenterol 2026; 32(16): 116781

16010 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 37694

Manuscripts received today: 40

Manuscript reviews today: 45

Unhandled manuscripts today: 182

Active peer-reviewers today: 1908

Reviewer acceptance today: 63

Reviewer refusals today: 107

Total accepted manuscripts: 41632

Total rejected manuscripts: 45864

Total peer-reviewers: 4874153

Total submissions: 39374

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

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All Journal Articles

Zhang YM, Li RG, Zhang XH, Wang ZY, Xu HH, Li XF, Zhang ZW. Needle knife therapy for cervical spondylotic radiculopathy: A systematic review and meta-analysis. World J Methodol 2026; 16(2): 117496

2026-06-20 | Browse: 1070 | Download: 345

Zaccaron S, D’Alleva M, Mari L, Stafuzza J, Lazzer S, Rejc E. Effects of spinal cord transcutaneous stimulation priming on single-leg balance control. World J Methodol 2026; 16(2): 117099

2026-06-20 | Browse: 882 | Download: 344

Kanungo SK, Hembram G, Sahu PK, Das RR. Serum procalcitonin as a predictor of severity of pneumonia in under-five children: A prospective observational study. World J Methodol 2026; 16(2): 115754

2026-06-20 | Browse: 944 | Download: 331

Adeniyi MJ, Awosika A. Cortical arousal and autonomic regulation: The role of cold vs tepid caffeinated beverages during prolonged orthostasis. World J Methodol 2026; 16(2): 115219

2026-06-20 | Browse: 981 | Download: 383

Ata F, Khan AA, Mohammad Nofal MZ, Abdelmahmuod EA, Fawad R, Al Mohanadi D, Dabbous Z. Improving diagnostic accuracy of 72-hour supervised fasting test for hypoglycemia evaluation: A quality improvement project. World J Methodol 2026; 16(2): 115150

2026-06-20 | Browse: 917 | Download: 216

Savvidis C, Liakopoulos C, Ilias I. Biases of large language models in diagnosing Cushing’s syndrome. World J Methodol 2026; 16(2): 115059

2026-06-20 | Browse: 1001 | Download: 421

Fu YB, Yan F, Zhu HJ, Wang C. Randomized controlled trial of Danggui Sini Decoction in the treatment of lower limb arteriosclerosis obliterans. World J Methodol 2026; 16(2): 115003

2026-06-20 | Browse: 865 | Download: 317

Wani I, Naikoo G, Wani RA, Wani MA. Subareolar breast abscess in males. World J Methodol 2026; 16(2): 114950

2026-06-20 | Browse: 1135 | Download: 467

Ibrahim Y, Qureshi A, Jackson M, Zovich B, Freeland C, Flomo M, Alik K, Yakubov R, Chen LH, Yeboah PK, Cohen C. Why does hepatitis B remain underprioritized? A view through lived experience. World J Methodol 2026; 16(2): 114604

2026-06-20 | Browse: 857 | Download: 244

Hagood M, Lucke-Wold B. Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention. World J Methodol 2026; 16(2): 114322

2026-06-20 | Browse: 802 | Download: 276

Bouayad A. Interleukin-1 receptor antagonist autoantibodies in Still’s disease: Mechanistic insights and laboratory testing. World J Methodol 2026; 16(2): 114269

2026-06-20 | Browse: 757 | Download: 251

Raveendran AV, Kesavadev J, Saboo B, George S. Obstructive sleep apnea: Proposed scoring system. World J Methodol 2026; 16(2): 114192

2026-06-20 | Browse: 1090 | Download: 287

Avramidou E, Tsoulfas G, Alexiou M, Papachristou C. Breaking the scalpel ceiling: gender inequality in global transplant surgery. World J Methodol 2026; 16(2): 114180

2026-06-20 | Browse: 844 | Download: 314

Unnithan AKA. Comprehensive review on the benefits and physiological basis of yoga. World J Methodol 2026; 16(2): 114072

2026-06-20 | Browse: 1438 | Download: 482

Ng KWP, See KC. Basic diaphragm ultrasound training: Curriculum implementation and learning trajectory among diaphragm ultrasound naive trainees. World J Methodol 2026; 16(2): 113663

2026-06-20 | Browse: 900 | Download: 370

Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265

2026-06-20 | Browse: 885 | Download: 300

Marrapu S, Kumar R, Bhushan D, Kumar S, Kumar A, Priyadarshi RN, Anand U. Open-label randomized controlled study of salt-restricted vs salt-unrestricted diet in cirrhosis patients with hyponatremia. World J Methodol 2026; 16(2): 112692

2026-06-20 | Browse: 1043 | Download: 391

Xie W, Di Z, Shao W, Wang AJ, Guan LH. Basic and clinical research on acupuncture for post-stroke depression: a narrative review. World J Methodol 2026; 16(2): 112371

2026-06-20 | Browse: 896 | Download: 311

Hegde AV, Gupta S, Mohan LN, Rozario A. Unforeseen consequence of colovesical fistula in diverticulitis presenting as septic cellulitis: A case report. World J Methodol 2026; 16(2): 111784

2026-06-20 | Browse: 790 | Download: 228

Mekkodathil A, El-Menyar A, Rizoli S, Al-Thani H. Electrolyte-derived clinical indices in traumatic brain injury: A narrative review. World J Methodol 2026; 16(2): 111570

2026-06-20 | Browse: 908 | Download: 231

63504 items Read more >>

Featured Articles

Qasim A, Zacharia GS, Kandhi SD, Lajara PH, Alataa RFG, Ihimoyan A. T-cell lymphoblastic lymphoma with colonic involvement: A case report. World J Clin Cases 2026; 14(17): 121921

2026-06-03 | Browse: 1 | Download: 0

Wang XP, Zheng YZ, Zhang YC. Synchronous seminal vesicle metastasis from rectosigmoid adenocarcinoma: A case report. World J Clin Cases 2026; 14(17): 121315

2026-06-03 | Browse: 1 | Download: 0

Haider F, Ahmed F, Junaid Y, Khalid M, Dar A, Arham M, Ullah A, Aliha S, Arshad MU, Naeem K, Ali Hashim MM, Gohar N, Ricciuti A, Bhanderi V, Alenezi F, Patel B. Direct oral anticoagulants vs low-molecular-weight heparins for cancer-associated thromboembolism. World J Clin Cases 2026; 14(17): 118087

2026-06-03 | Browse: 1 | Download: 0

Dwajan A, Patro DR, Agarwal A, Lalhmingmawii M. Artificial intelligence in orthopaedics: Clinical decision support, medical imaging, surgical planning, and outcome prediction. World J Clin Cases 2026; 14(17): 120192

2026-06-03 | Browse: 2 | Download: 11

Ahmed HM, Aimen UE. Esmolol in acute ischemic stroke thrombolysis: Benefits confined to atrial fibrillation and hypertensive patients. World J Clin Cases 2026; 14(17): 120665

2026-06-03 | Browse: 2 | Download: 0

Baggio L, Gianni S, De Carlis R, Valsecchi MAM, Barbaglio C, Brunetti A, Perricone G, Lauterio A, Monti G. Three questions to be answered when evaluating a super obese patient for urgent liver transplant. World J Transplant 2026; 16(2): 115352

2026-05-29 | Browse: 41 | Download: 52

Kulsum S, Khan SA, Dahiya DS, Ali H, Hayat U, Khalaf M, Ali H. Impact of dexmedetomidine administration on serum creatinine levels following liver transplantation: A systematic review and meta-analysis. World J Transplant 2026; 16(2): 119737

2026-05-29 | Browse: 34 | Download: 51

Sibulesky L, Kaufman DM, Bakthavatsalam R, Leca N, Perkins JD. Rethinking procurement biopsy in donors with normal renal function: A barrier to kidney utilization without survival benefit. World J Transplant 2026; 16(2): 118088

2026-05-29 | Browse: 30 | Download: 70

Mouratidou C, Pavlidis ET, Katsanos G, Kofinas A, Marneri AG, Stavrati KE, Tsoulfas G, Pavlidis TE. Preconditioning with sufentanil confers protective effects in transplantation by attenuating hepatic ischemia-reperfusion injury. World J Transplant 2026; 16(2): 120865

2026-05-29 | Browse: 32 | Download: 52

Yodoshi T. Navigating liver transplantation after malabsorptive bariatric surgery – A new risk of rejection. World J Transplant 2026; 16(2): 114837

2026-05-29 | Browse: 38 | Download: 55

Sciarrone SS, Di Leo M, Fini L, Losco A, De Luca L. Letter to the Editor: Splitting the risk: Interpretable machine learning enters the era of split liver transplantation. World J Gastroenterol 2026; 32(22): 116533

2026-05-29 | Browse: 59 | Download: 57

2026-05-29 | Browse: 44 | Download: 50

Zhang Y, Zhu C, Xia SH, Zhang MY, Liu YR, Guan JL, Huang YJ, Zhao K, Liao JZ, Fan WJ. Mechanism of anti-HuD autoantibody inducing enteric neuronal apoptosis of irritable bowel syndrome and its potential for targeted intervention. World J Gastroenterol 2026; 32(22): 117194

2026-05-29 | Browse: 39 | Download: 58

Han RY, Wei YK, Liu WN, Wang YM, Song TQ, Tian XD, Xia YR, Chen L, Gong WC. Human epidermal growth factor receptor 2 in combined hepatocellular-cholangiocarcinoma: Prognostic and predictive guide for adjuvant chemotherapy. World J Gastroenterol 2026; 32(22): 117417

2026-05-29 | Browse: 50 | Download: 88

Yu KX, Lu ZJ. Circadian clock at the interface of mucosal immunity, gut microbiota and epithelial barrier in inflammatory bowel disease. World J Gastroenterol 2026; 32(22): 118745

2026-05-29 | Browse: 45 | Download: 49

2026-05-28 | Browse: 50 | Download: 131

He XH, Zhou B, Liu Y, Gong YW, Zheng HL. Relationship between body image and stigma among Chinese breast cancer patients: A chain mediation model. World J Psychiatry 2026; 16(6): 115742

2026-05-28 | Browse: 46 | Download: 124

Bilgiç B, Turan S. Accuracy and reproducibility of ChatGPT responses to parent and patient inquiries on attention-deficit/hyperactivity disorder. World J Psychiatry 2026; 16(6): 119773

2026-05-28 | Browse: 41 | Download: 107

Wei YG, Yang LH, Qin SS, Chen YL, Yan JN, Liu RX, Ma YM, Wang C, Song ZJ, Wang F, Ji GJ. Mental stress recognition using interpretable machine learning models with heart rate variability among Chinese university students. World J Psychiatry 2026; 16(6): 116013

2026-05-28 | Browse: 47 | Download: 129

Nagamine T. Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival. World J Psychiatry 2026; 16(6): 118149

2026-05-28 | Browse: 40 | Download: 101

10828 items Read more >>

Keyword Search Published Articles Processes

Case report

4762

Hepatocellular carcinoma

1779

Gastric cancer

1305

Colorectal cancer

1284

Prognosis

1095

Inflammatory bowel disease

870

COVID-19

848

Treatment

778

Diagnosis

761

Liver transplantation

755

Ulcerative colitis

698

Meta-analysis

677

Crohn’s disease

629

Endoscopy

625

Cirrhosis

620

Inflammation

604

Helicobacter pylori

601

Magnetic resonance imaging

589

Surgery

562

Pancreatic cancer

521

70439 items Read more >>

Reader Comments

"Dear Editor, We carefully reviewed the recent study by Li et al. published in the World Journal of Gastroenterology and reflected ..." [Read more]

"Dear Editor, We carefully reviewed the recent study by Li et al. published in the World Journal of Gastroenterology and reflected on its potential clinical implications. The study innovatively demonstrated that salidroside can attenuate intestinal inflammation and promote mucosal repair by activating the cAMP/PKA/CREB signaling pathway and suppressing the abnormal activation of enteric glial cells. These findings suggest that the pathogenesis of ulcerative colitis may involve not only conventional immune-inflammatory dysregulation but also dysfunction of the neuro–glia–immune regulatory network.Given the persistent clinical challenges in UC management, including limited long-term therapeutic efficacy, high relapse rates, and treatment-related adverse effects, the development of multitarget therapeutic strategies with anti-inflammatory, mucosal-protective, and neuroimmune-modulating properties is of considerable importance. In light of these findings, further studies may focus on the current therapeutic landscape of UC, systematically evaluating the pharmacological characteristics and potential clinical value of salidroside. Moreover, exploring its mechanisms of action and translational potential from the perspective of neuro-glia-immune regulation may provide novel insights into the pathogenesis of UC and contribute to the development of more effective therapeutic strategies. " [Collapse]

Li Y, Tao SS, Wang Y, Sun Q, Li MY, Zhang H, Li YQ. Salidroside mitigates experimental colitis through cyclic adenosine monophosphate pathway activation and suppression of enteric glial cell responses. World J Gastroenterol 2026; 32(21): 116337

"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a ..." [Read more]

"As a pathologist, I find this study directly addresses the familiar disconnect between endoscopic biopsy and surgical resection—a discrepancy rooted in sampling bias rather than diagnostic error. The AI-assisted system compensates for this by guiding targeted biopsies: 95.1% of the detection gain came from precise recognition and localization of subtle lesions, not from simply taking more biopsies. The rigorous double-reading with blinded pathology review strongly supports the findings. Grouping low-grade, high-grade intraepithelial neoplasia, and early gastric cancer as endpoints is clinically pragmatic, and the marked AI advantage at blind spots like the gastric angle aligns with everyday practice. To deepen the evidence, future work could add positive predictive value, compare biopsy-to-surgery upgrade rates between groups, and characterize the pathology of false-positive AI detections (e.g., reactive changes). Correlating endoscopic morphology with histopathology would further transform AI from a detection tool into a diagnostic aid. Overall, this high-quality study offers a promising means to reduce sampling error and bridge the gap between endoscopic detection and pathological confirmation. " [Collapse]

Ying JX, Yan SY, Fu XY, Zhou YJ, Zhou JJ, Yang Y, Zhou XB, Wang ZZ, Li SW, Fang LN, Mao XL. Artificial intelligence-assisted endoscopists improve the detection rate of high-risk gastric lesions: A propensity score-matched retrospective study. World J Gastroenterol 2026; 32(21): 117299

"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone ..." [Read more]

"it is better to investigate the role of other factors as diabetes; hypertension; body mass index ; fatty liver disease in gall stone complications. dietary habits have a significant impact on pathogenesis of gall stone complications. so that a questionnaire of diet intake should be done to investigate the effect of different food staff on symptoms and complications of gall stone disease. " [Collapse]

Oyón D, Velamazán R, Arnau A, López-Guillén P, Martínez-Domínguez SJ, Abad Baroja D, Ruiz-Belmonte LM, Tejedor-Tejada J, Zapater R, Martín-Vicente N, Julián Gomara AB, Sastre Lozano V, Manzanares García JJ, Cañamares-Orbis P, García-Rayado G, Millastre Bocos J, Garcia de Paredes AG, Vaamonde Lorenzo M, Izagirre Arostegi A, Sirtl S, de-Madaria E. Recurrence patterns and outcomes of symptomatic gallstone disease in the elderly. World J Gastroenterol 2026; 32(21): 117971

"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department ..." [Read more]

"How far the research is from the precise mechanism of Yang 1-associated protein 1 in gastric adenocarcinoma? Dina Johar* Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Heliopolis, Cairo, Egypt *Dina Johar, PhD Department of Biochemistry and Nutrition Faculty of Women for Arts, Sciences, and Education Ain Shams University, Cairo, Egypt Phone:+2 01060782045 Email: dinajohar@gu.edu.eg • To whom correspondence should be addressed Abstract The Yang 1-associated protein 1 (YY1AP1) is frequently overexpressed or activated in gastric cancer and is linked to more aggressive disease, poorer prognosis, and metastasis. Although YY1AP1 signaling contributes to pathways that promote proliferation, epithelial–mesenchymal transition, stemness, and drug resistance, the precise mechanism of YY1AP1 in gastric cancer has not been precisely defined. In this commentary, we focus on recent findings on the functional mechanisms of YY1AP1 in gastric adenocarcinoma. The commentary is a significant step forward in understanding the nuanced approach to managing mortality rate in gastric cancer patients, offering valuable insights for clinical decision-making. Keywords: Yang 1-associated protein 1, Gastric adenocarcinoma, Prognosis, Mortality. Core tip YY1AP1 is best understood as both a prognostic biomarker and a functional oncogenic driver in gastric cancer, with evidence pointing to its role in tumor growth, invasion, metastasis, stemness, and treatment resistance. Background YY1AP1 overexpression has been associated with progression, lymph node metastasis, and poor prognosis in gastric carcinoma [1]. Studies found that YY1AP1 activation or high expression predicts worse survival and, in some cohorts, chemoresistance to adjuvant therapy [2-4]. In peritoneal metastatic gastric adenocarcinoma, YY1AP1-high tumor cells showed stem-cell-like properties and were clinically relevant as metastatic drivers [5]. YY1AP1 appears to drive gastric cancer biology through canonical Hippo pathway dysregulation and downstream transcriptional programs that support growth and invasion [6, 7]. Mechanistic studies show YY1AP1 can enhance proliferation, migration, invasion, EMT, and metastasis through signaling changes involving ERK, β-catenin, E-cadherin, vimentin, and lncRNA networks (Sun et al., 2016). Several upstream regulators and interacting partners contribute to YY1AP1 activation in gastric cancer, including H. pylori CagA, NUSAP1, SLC35B4, and CPNE3[7-11]. In gastric adenocarcinoma metastasis, YY1AP1 also linked with altered fatty-acid oxidation and cancer stem cell phenotypes [12]. The recent study of Gu et al. (2026)[13] investigates the clinical significance and functional mechanisms of YY1AP1 in gastric adenocarcinoma, finding its upregulation correlates with poor prognosis and aggressive tumor behavior. It critically assesss the argumentation within the article, focusing on the clarity of the research gap, the strength of the contribution claims, the justification of methods, the alignment of results with the discussion, and the thoroughness of the stated limitations. It also clearly articulates its perceived novelty regarding YY1AP1's role as an independent prognostic factor in gastric adenocarcinoma and its comprehensive investigation. Particularly, YY1AP1’s expression patterns, clinical relevance, biological functions, i.e. in proliferation, migration, gene modulation, and its status as an independent prognostic factor of gastric cancer. The stated aims are highly testable, as evidenced by the detailed methods employed, i.e. immunohistochemistry, RT-qPCR, survival analysis, or in vitro experiments. The authors’ argumentation generally establishes a clear research gap and strong contribution claims, supported by a combination of clinical, in vitro, and bioinformatic data. However, as compared to the aforementioned extensive literature on the specific mechanism/signaling of YY1AP1 in gastric cancer, there are opportunities to enhance methodological justification, ensure stricter alignment between results and discussion, and deepen the analysis of limitations. The Gu et al.[13] study provides sufficient detail for most experimental procedures and statistical analyses. However, specific justifications for certain choices, such as the selection of the MKN45 cell line or the specific online datasets, could be strengthened to enhance the methodological rigor and transparency. For example, “MKN45 is a well-characterized...mechanisms of gastric cancer." This provides a good, albeit brief, justification for using the MKN45 cell line, linking its characteristics to the study's aims. To further strengthen, it worth it to mention if this cell line accurately represents specific subtypes of gastric cancer relevant to the study. Another example, "A semi-quantitative scoring system...combined assessment." The description of the Immunohistochemistry as a scoring system is somewhat vague, lacking specific criteria for how "combined assessment" was performed or how the cutoff for high/low expression was determined. Providing a more precise description of the scoring system and the methodology for categorizing samples is so important. A third example, "The normality of data distribution...Shapiro-Wilk test." While stating the use of the Shapiro-Wilk test, the consequences of non-normal distribution (i.e., use of non-parametric tests) are not explicitly mentioned for cellular assays, which could impact the choice of t-test/ANOVA. It is important to clarify how non-normal data was handled, or confirm that all cellular assay data met normality assumptions for parametric tests. Further, "To further validate and extend...and GSE62254." The choice of these specific online datasets is not justified. It is unclear why these particular datasets were selected and if they represent a diverse or comprehensive set of gastric cancer patient cohorts. Elaborating on the criteria used for selecting these online datasets (i.e., sample size, type of data available, clinical annotation, specific gastric cancer subtypes if applicable) helps the reader. While many of the study claims are correlational, the in vitro experiments aim to establish more direct functional roles. Distinction between correlation and causation more precisely, especially when discussing clinical observations versus experimental manipulations is key. For example, "YY1AP1 significantly influences the pathogenesis... by modulating key cancer-related pathways." This statement implies a direct causal influence, which is partially supported by in vitro modulation of p21, c-myc, and snail, but the broader "pathogenesis" is complex and likely involves multiple factors. While in vitro data supports modulation of some pathways, the term "significantly influences the pathogenesis" might be too strong for the overall conclusion without more comprehensive mechanistic studies. Another example, "Our multivariate analysis identified high YY1AP1 expression... a novel finding in gastric adenocarcinoma." While multivariate analysis identifies independent prognostic factors, the wording implies a direct causal "role" in progression, which is an inference from prognostic value. It worth clarifying that high YY1AP1 expression is associated with poor outcomes and serves as an independent prognostic factor, rather than implying it causes the poor outcome in the context of clinical correlation. The in vitro data strengthens the causal link for proliferation/invasion, but this specific statement is about clinical correlation. The study acknowledges several important limitations, particularly regarding its retrospective design and generalizability, and points to the need for causal relationship studies. However, some limitations, such as the sample size for fresh tissue analysis or the lack of mechanistic studies beyond gene expression changes, could be elaborated or more explicitly stated. I.e., "The retrospective design and the specific patient cohort limit the generalizability of the results." The limitation is stated, but the extent of this limitation on the current conclusions is not fully elaborated. Discussing how this limitation might affect the confidence in YY1AP1 as a prognostic biomarker until prospective validation is inevitable. Accordingly, this suggests while promising, that the prognostic value of YY1AP1 requires validation in larger, prospective, and multi-center cohorts before clinical application. Also, while acknowledged, “The exact molecular mechanisms through which YY1AP1 affects tumor biology... require further elucidation." The discussion could briefly connect this to how the current findings should be interpreted, i.e., as strong associations and initial functional insights, but not definitive mechanistic pathways yet. Therefore, their study provides strong correlational and initial functional evidence, but the precise molecular cascade remains to be fully mapped. This points out the need for more in-depth mechanistic studies (e.g., rescue experiments) to establish direct causality, which is a significant limitation for a study proposing functional roles. Further, "A total of 118 paraffin-embedded and 29 fresh gastric adenocarcinoma samples were analyzed." and "Fresh gastric adenocarcinoma and adjacent nontumor tissues were snap-frozen..." Clearly, the number of fresh samples (29) for RT-qPCR is relatively small compared to the FFPE samples (118) for immunohistochemistry. This smaller sample size for mRNA analysis could be a limitation, especially if there were discrepancies or if it impacts the robustness of mRNA findings. This is not explicitly discussed in the limitations. Adding the smaller sample size for fresh tissue analysis (RT-qPCR) as a limitation, acknowledging its potential impact on the generalizability or statistical power of mRNA-level findings. Declarations Funding This commentary did not receive any speciﬁc grant from funding agencies in the public, commercial, or not-for-proﬁt sectors. The author declare that no honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Conflict of interest The author declares no conflict of interest exists. Consent to publish Not applicable. Availability of data and materials All data generated or analyzed during this study are included in this published article. Acknowledgment N/A References [1] Hu X, Xin Y, Xiao Y, Zhao J. Overexpression of YAP1 is correlated with progression, metastasis and poor prognosis in patients with gastric carcinoma. Pathol Oncol Res. 2014;20:805-11. [2] Yu D, Chen Y, Luo M, Peng Y, S. Y. Upregulated Solute Carrier SLC39A1 Promotes Gastric Cancer Proliferation and Indicates Unfavorable Prognosis. Genet Res (Camb) 2022. [3] Geng ZH, Du JX, Chen YD, Fu PY, Zhou PH, Qin WZ, et al. YY1: a key regulator inhibits gastric cancer ferroptosis and mediating apatinib-resistance. Cancer Cell Int. 2024;12:71. [4] Lee KW, Lee SS, Hwang JE, Jang HJ, Lee HS, Oh SC, et al. [5] Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, et al. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut. 2021;70:55-66. [6] Messina B, Lo Sardo F, Scalera S, Memeo L, Colarossi C, Mare M, et al. Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression. Cell Death Dis. 2023;14:21. [7] Guo H, Zou J, Zhou L, Zhong M, He Y, Huang S, et al. NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein. Front Oncol 2021. [8] Liu Z, Huang S, Cao Y, Yao Y, Li J, Chen J. YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106. Biochem Biophys Res Commun 2018;4:2370–75. [9] Liu H, Qiu Y, Pei X. Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth. Sci Rep. 2020; 10. [10] Liu J ZX, Wang K, Zhang X, Yu Y, Lv Y, Zhang S, Zhang L, Guo Y, Li Y, Yang A, Zhang R, Li J. A novel YAP1/SLC35B4 regulatory axis contributes to proliferation and progression of gastric carcinoma. Cell Death Dis. 2019 Jun 7;10(6):452. doi: 10.1038/s41419-019-1674-2. PMID: 31175271; PMCID: PMC6555804. [11] Li X, Zhong, H., Shi, Q. et al. YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression. Cell. Mol. Life Sci. 81, 143 (2024). https://doi.org/10.1007/s00018-024-05178-3. [12] Wang W YY, Zhang RH, Deng JY, Sun Z, Seeruttun SR, Wang ZN, Xu HM, Liang H, Zhou ZW. Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data. Mil Med Res 2022; 9: 15 [RCA] [PMID: 35387671 DOI: 10.1186/s40779-022-00375-2] [FullText] [Full Text(PDF)]. [13] Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, et al. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026;32:URL: https://www.wjgnet.com/1007-9327/full/v32/i21/116527.htm DOI: https://dx.doi.org/10.3748/wjg.v32.i21. " [Collapse]

Gu YC, Li X, Zhao YJ, Wu T, Zhou CG, Hu WL, Fu ZW, Huang JH, Ren ZY. Yin Yang 1-associated protein 1: Clinical significance and underlying functional mechanisms in gastric cancer. World J Gastroenterol 2026; 32(21): 116527

"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key ..." [Read more]

"This is a well-designed study on biomarkers for early detection of pancreatic cancer with clear clinical value. It addresses key clinical challenges and is highly readable and practical. Its major highlight lies in being the first large-scale research to verify that serum S100A6 serves as an effective complement to CA19-9. It performs well in differentiating early pancreatic cancer from chronic pancreatitis and compensating for false-negative results of CA19-9. The combined three-biomarker panel markedly improves diagnostic efficiency, offering valuable guidance for early diagnosis, timely treatment and higher surgical resection rates. The study also objectively acknowledges its limitations including single-center design, absence of external validation and missing Lewis antigen typing, presenting rigorous and prudent conclusions. Overall, this is a clinically oriented and solid translational study. It proposes a new panel strategy for serological screening of pancreatic cancer, and merits further multi-center validation and clinical application. " [Collapse]

Bae GE, Kim SM, Lee JK, Lee SY. First large-scale prospective evaluation of serum S100A6 as a complementary biomarker for early pancreatic cancer detection. World J Gastroenterol 2026; 32(21): 116581

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"This study focused on the problem of postoperative recurrence of hepatocellular carcinoma and detected four liver cancer stem cell markers. It features a rigorous design and reliable data. The results confirmed that CK19 and CD133 are key indicators for evaluating patient prognosis. Combined detection of these markers can substantially improve the predictive efficacy of conventional assessment models, offering practical references for postoperative risk stratification, individualized follow-up and treatment of hepatocellular carcinoma. However, this is a single-center retrospective study with a relatively short follow-up period, so its conclusions need to be further validated by multi-center and long-term researches. " [Collapse]

Jia XQ, Han S, Shang YS, Kong FG, Qi L, Wang CL, Xiong WJ. Expression of liver cancer stem cell markers and association with recurrence and survival in hepatocellular carcinoma. World J Stem Cells 2026; 18(5): 119123

"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a ..." [Read more]

"This systematic review by Gadour et al. provides a well-conducted and clinically valuable analysis of serum bile acid (SBA) as a biomarker in liver transplant recipients. Following PRISMA guidelines and using the QUIPS tool to assess study quality, the authors performed a rigorous quantitative synthesis, clearly demonstrating that elevated SBA is significantly associated with increased risks of early graft dysfunction, acute rejection, biliary complications, and poor long-term survival. These findings are highly meaningful for clinical practice, as the study confirms that SBA outperforms conventional liver function tests in the early prediction of adverse post-transplant events, with the potential to refine surveillance strategies and enable timely intervention. The manuscript is well-structured, with clear presentation of results, appropriate use of biostatistics, and a balanced discussion of strengths and limitations. While the study represents an important contribution to the field, some key points deserve consideration. Significant heterogeneity across included studies in SBA assay methods, detection time points, and cut-off values limits direct clinical standardization. Additionally, most analyses focused only on total SBA, and the prognostic roles of individual bile acid subtypes remain underexplored. Future large-scale, multicenter prospective studies are needed to address these gaps and validate the clinical utility of SBA monitoring. " [Collapse]

Gadour E, Kuriry H, Miutescu B, Raheem B, Gardezi SA, AlQahtani MS. Diagnostic and prognostic utility of serum bile acid in liver transplant recipients: A systematic review and quantitative synthesis. World J Hepatol 2026; 18(5): 119408

"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients ..." [Read more]

"This study has presented a relationship between MASLD and adjustment of insulin resistance as well as inflammatory factors in patients using reduced odds ratio which can display the critical role of sleep management. There is a phenomenon hardly to understand where the improper cases is excluded in specific step with corresponding numbers in the flowchart of figure 1. " [Collapse]

Yu QT, Lin YY, Gui ZH, Duan HL, Yang JJ, Meng Y, Peng XT, Liu L, Wan H, Shen J. Mediating roles of insulin resistance and inflammatory markers between healthy sleep scores and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(21): 118057

"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths ..." [Read more]

"This multicenter study provides valuable real-world data on eosinophilic gastroenteritis (EGE) in 73 Korean patients. Strengths include detailed site-specific treatment analysis, showing high response rates to PPI monotherapy in gastroduodenitis (88.9%), and identifying colonic involvement as a key relapse predictor (43.3%). These findings offer practical clinical guidance. A minor suggestion: adopting the updated 2022 international consensus nomenclature (e.g., non-EoE EGIDs, EoG, EoN, EoC) would further enhance cross-study communication. Overall, a clinically useful study with robust regional data. " [Collapse]

Lee J, Kim SE, Cha RR, Lee BE, Choi CW, Jee SR. Presentation and treatment of eosinophilic gastroenteritis in Busan and Gyeongnam, Korea: A multicenter study. World J Gastroenterol 2026; 32(19): 117166

"This retrospective study evaluates the real-world clinical performance of the deep learning-based ENDOANGEL system in detecting ..." [Read more]

"This retrospective study evaluates the real-world clinical performance of the deep learning-based ENDOANGEL system in detecting high-risk gastric lesions (HrGLs), demonstrating high readiness for academic publication. Utilizing a massive, propensity score-matched cohort of 15,528 patients to effectively control for major confounding variables, the authors convincingly establish that AI integration nearly doubles the HrGL detection rate (0.94% vs. 0.48%) while providing critical mechanistic validation through causal mediation analysis, proving that this diagnostic gain stems directly from AI-driven image recognition rather than a mere increase in blind biopsies. As an unwearied "second observer," the system holds extensive application prospects for mitigating diagnostic subjectivity, reducing early gastric cancer miss rates, and stabilizing quality control across lower-tier or high-workload endoscopic centers. Moving forward, while future development trends will naturally pivot toward multi-center video-stream integration and diverse ethnic cohort validation, the immediate clinical hurdles that must be surmounted include bridging the performance-gain variance observed across different endoscopist seniority levels, enhancing algorithmic robustness against real-world artifacts like gastric mucus and motion blur, and perfecting low-latency, seamless hardware-software integration. " [Collapse]

"The article focuses on the relationship between the Healthy Sleep Score and MASLD. The significance of this study lies in suggesting ..." [Read more]

"The article focuses on the relationship between the Healthy Sleep Score and MASLD. The significance of this study lies in suggesting that overall sleep health may be an important and relatively modifiable factor in the prevention and management of MASLD. For clinical and health management readers in particular, the study emphasizes not just a single sleep problem, but the combined effects of multiple dimensions of sleep, including sleep duration, sleep rhythm, insomnia, sleep apnea, and daytime sleepiness. This provides valuable insights for the early screening, lifestyle intervention, and risk stratification of MASLD. In addition, the authors propose that insulin resistance and inflammation may partially mediate the relationship between sleep and MASLD, offering directions for future mechanistic research and integrated intervention strategies. Although the study is cross-sectional in design and therefore cannot directly establish causality, its relatively large community-based sample and comprehensive analytical framework still make it a useful reference for understanding the link between sleep and metabolic liver disease. " [Collapse]

"The study focuses on enteric glial cells in the enteric nervous system and the cAMP/PKA/CREB signaling pathway, providing a new ..." [Read more]

"The study focuses on enteric glial cells in the enteric nervous system and the cAMP/PKA/CREB signaling pathway, providing a new perspective for understanding how interactions among the nervous system, immune responses, and intestinal barrier function contribute to the development and progression of colitis. This places salidroside not merely as an anti-inflammatory natural compound, but within a more specific mechanistic framework of enteric neuroimmune regulation, thereby enhancing the scientific significance of the study. However, the current findings are mainly derived from experimental animal models, and further validation is still needed before clinical application, including evaluation of dose safety, long-term efficacy, the potential value of combination use with existing therapies, and the consistency of these mechanisms in human UC patients. " [Collapse]

"Bae and colleagues provide the first large‑scale prospective evaluation of serum S100A6 as a diagnostic biomarker for pancreatic ..." [Read more]

"Bae and colleagues provide the first large‑scale prospective evaluation of serum S100A6 as a diagnostic biomarker for pancreatic cancer (PC), with an emphasis on its complementary role to CA19‑9 and CEA. The study has several clear strengths: a well‑defined cohort of 414 subjects (301 PC, 52 chronic pancreatitis [CP], 61 healthy controls), prospective sample collection before treatment, and a clinically relevant focus on distinguishing early‑stage (resectable) PC from benign CP. The authors show that serum S100A6 levels are significantly higher in both early and late PC than in CP or healthy controls. While CA19‑9 alone is the most accurate single marker (AUC 0.839), adding S100A6 and CEA improves overall diagnostic performance (AUC 0.868, P = 0.007 compared to CA19‑9 alone). More importantly, for differentiating early PC from CP, the triple panel achieved an AUC of 0.821 and was the only combination that significantly outperformed CA19‑9 alone (P = 0.017). Bootstrap internal validation (2000 resamples) supports the robustness of the findings. Nevertheless, some limitations deserve attention. External validation in an independent cohort is still lacking, and all samples come from a single tertiary centre. The “early‑stage” group is dominated by stage II tumours (140/149), with only nine stage I cases, so the conclusions mainly apply to resectable rather than truly early, asymptomatic disease. Lewis antigen status was not assessed, which is a known confounder for CA19‑9 false‑negatives; therefore, the extent to which S100A6 compensates specifically for Lewis‑negative individuals remains unclear. S100A6 is not pancreas‑specific and is elevated in other cancers, which limits its use to patients already under suspicion for PC or CP rather than for population screening. Finally, cost‑effectiveness and longitudinal follow‑up data are not provided. In summary, this well‑designed study convincingly shows that serum S100A6 adds diagnostic value to CA19‑9, especially for identifying resectable PC in patients with CP. However, external validation, Lewis antigen stratification, and assessment of clinical net benefit are needed before routine clinical use. At present, S100A6 should be viewed as a promising complementary biomarker, not a standalone screening test. " [Collapse]

"This study is the first large-scale case-control evaluation of the value of serum S100A6 in the early diagnosis of pancreatic cancer. ..." [Read more]

"This study is the first large-scale case-control evaluation of the value of serum S100A6 in the early diagnosis of pancreatic cancer. The results show that combining S100A6 with CA19-9 significantly improves diagnostic performance, and that adding CEA further helps distinguish early-stage pancreatic cancer from chronic pancreatitis, suggesting promising clinical translational potential. A key strength of the study is its focus on early diagnosis, a major challenge in pancreatic cancer management, and its proposal of a biomarker combination that complements existing markers. However, the specificity of S100A6, its stability across different populations, and its performance in real-world screening settings still require independent, multicenter, and prospective validation. Overall, this study provides valuable new evidence for the development of biomarkers for early pancreatic cancer detection. " [Collapse]

"This study focuses on postoperative acute kidney injury (AKI), one of the most challenging complications in the field of pancreatic ..." [Read more]

"This study focuses on postoperative acute kidney injury (AKI), one of the most challenging complications in the field of pancreatic surgery. It adopts advanced machine learning methods to construct the first interpretable predictive model specifically tailored for patients undergoing pancreatic surgery and develops an online risk calculator. Overall, this is a high-quality study with rigorous design, advanced methodology and clear clinical orientation, which has made significant contributions to the development of this field. However, it also has several issues worthy of in-depth discussion: a. The single-center retrospective design limits the generalizability of the results; b. There is a lack of independent external validation; c. The model incorporates 24-hour postoperative data, which restricts its application in preoperative risk assessment; d. It fails to distinguish between AKI subtypes with different etiologies and severity grades. Despite these limitations, this study has laid a solid foundation for research on the prediction of AKI after pancreatic surgery and also provides a valuable reference for predictive studies of other surgical complications. " [Collapse]

Lin C, Fu RK, Zheng H, Li TY, Han JS, Margonis GA, Wang JJ, Dong LB, Wang NS, Sun YX, Wang YZ, Liu C, Xu Q, Han XL, Zhang TP, Guo JC, Dai MH, Xia P, Chen LM, Wang WB. Development and validation of an interpretable machine learning model for predicting acute kidney injury after pancreatic surgery. World J Gastroenterol 2026; 32(19): 116271

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"This article is remarkable and stands out for its thorough synthesis of the multidimensional characteristics of degenerative disc disease (DDD). The authors proficiently unify molecular biology, biomechanics, genetics, and lifestyle influences into a logical explanation that reflects the true complexity of disc degeneration. The in-depth analysis of cytokine-mediated pathways (IL 1β, TNF α, IL 6) and their subsequent signalling cascades (NF κB, MAPK, Wnt/β catenin) provides functional understanding into how inflammation and matrix breakdown the disc pathology. Equally compelling is the emphasis on the avascular and hypoxic microenvironment of the intervertebral disc, which helps explain its susceptibility to metabolic and oxidative stress. The exploration of genetic predisposition adds significant depth to the discussion. The inclusion of heritability estimates of 50–70% and polymorphisms involving collagen, aggrecan, and inflammatory mediators clarifies why certain individuals may be more vulnerable to degeneration. Furthermore, the incorporation of epigenetic mechanisms, including DNA methylation, histone modifications, and microRNAs, highlights the dynamic interaction between environmental influences and gene regulation, making the article highly relevant to emerging precision medicine approaches. I found the section addressing metabolic contributors particularly illuminating. The discussion of diabetes and obesity leading to advanced glycation end-product (AGE) accumulation and extracellular matrix stiffening effectively connects systemic metabolic dysfunction with localized disc degeneration. Clinically, the article makes an important distinction between structural degeneration and symptomatic disease, emphasizing that radiographic abnormalities do not always correlate with pain. The discussion of aberrant nerve ingrowth, cytokine-driven sensitization, and biomechanical instability as mechanisms of pain successfully bridges the gap between imaging findings and patient experience. In addition, the diagnostic overview, highlighting MRI as the gold standard alongside emerging AI-driven radiomics, reflects both current clinical practice and future directions in the field. The management section is balanced and comprehensive, covering conservative approaches such as physical therapy and lifestyle modification, as well as surgical interventions including spinal fusion and disc replacement. The inclusion of regenerative therapies, such as platelet-rich plasma (PRP), stem cell therapy, biomaterial scaffolds, and gene therapy adds considerable value for both clinicians and researchers. Particularly exciting is the forward-looking discussion of epigenetic modulation and senolytic therapies as potential disease-modifying strategies, which underscores the evolving future of DDD treatment. " [Collapse]

Gradisnik L, Prestor B, Zele T, Kocivnik N, Maver U, Velnar T. Pathophysiology and current understanding of degenerative disc disease. World J Orthop 2026; 17(5): 117153

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"Hopley et al. conducted a well‑designed, single‑center observational study using a large 17‑year real‑world cohort of 1,191 patients with presumed benign branch‑duct intraductal papillary mucinous neoplasms (BD‑IPMNs). The long median follow‑up of 9.74 years and the inclusion of both imaging‑only and imaging‑plus‑EUS groups strengthen the reliability of the findings. A key strength is the identification of a clear “window of opportunity” for surgical intervention within the first two years of surveillance, after which the incremental benefit of continued monitoring declines sharply. The authors also provide compelling data that patient age and comorbidity burden (Charlson comorbidity index) critically affect net benefit, supported by competing risk analyses from independent groups (Crippa et al., Gut 2024). Limitations inherent to the single‑center, retrospective design, such as potential selection bias and lack of external validation, are appropriately acknowledged. The manuscript is written in clear, standard academic English. Abbreviations are defined at first use, tables are properly formatted, and the flow of information is logical. The language is concise, respectful, and meets the journal’s requirements for scientific reporting. Overall, the scientific quality is high, and the presentation is professionally polished. " [Collapse]

Hopley PJ, Whelan P, Jackson R, Evans J, Andrews T, Ghaneh P, Raraty M, Greenhalf W, Halloran CM. Branch duct intraductal papillary mucinous neoplasms: How ready are we to de-escalate surveillance? World J Gastroenterol 2026; 32(19): 115852

"his review article provides an insightful and clinically important discussion on the functional disorders associated with chronic ..." [Read more]

"his review article provides an insightful and clinically important discussion on the functional disorders associated with chronic constipation. The authors successfully combine evidence from the literature with their extensive personal experience, making the manuscript both academically informative and practically relevant.The concept of the “iceberg model” is particularly noteworthy, as it clearly illustrates how underlying functional abnormalities may remain undetected in patients presenting with apparent structural pathology. The emphasis on comprehensive functional evaluation prior to surgical intervention is highly valuable and reflects current multidisciplinary approaches in colorectal practice.The manuscript also effectively highlights the role of anorectal physiology, pelvic floor dysfunction, and psychological factors in the pathogenesis of chronic constipation. The review will be useful for gastroenterologists, colorectal surgeons, pelvic floor specialists, and trainees involved in managing complex constipation disorders. Overall, this is a well-written and educational review that contributes meaningfully to the understanding of chronic constipation and its functional components. " [Collapse]

Pescatori M, Perrotta G, De Nardi P. Functional disorders in patients with chronic constipation: Review of the literature and personal experience. World J Gastroenterol 2026; 32(19): 113841

"This is a highly practical and timely observational study by Hopley et al. The management of presumed innocent branch duct IPMNs often ..." [Read more]

"This is a highly practical and timely observational study by Hopley et al. The management of presumed innocent branch duct IPMNs often necessitates an overwhelming volume of serial cross-sectional imaging and EUS procedures, which places a heavy demand on diagnostic resources and creates a prolonged psychological burden for patients. By demonstrating that the diagnostic yield of continued investigations dramatically drops after the first two years, the authors provide a strong, data-driven argument for refining our protocols. Establishing clear, objective thresholds, specifically a maximum cyst size of < 30 mm on imaging and a serum CA 19-9 of < 43 KU/L, offers a reliable baseline for predicting high-grade dysplasia or malignancy. Safely de-escalating follow-up for stable lesions after two years, and potentially discharging patients at the five-year mark, is a necessary evolution in pancreatic surveillance pathways. This approach allows multidisciplinary teams to concentrate advanced imaging and interventional resources during that critical, early front-loaded period where the opportunity to detect and definitively resect PDAC is actually at its highest. " [Collapse]

"This review focuses on functional factors that are often overlooked in chronic constipation, particularly issues underlying OD, such ..." [Read more]

"This review focuses on functional factors that are often overlooked in chronic constipation, particularly issues underlying OD, such as anxiety and depression, pelvic floor dyssynergia, rectal hyposensitivity, slow-transit constipation, and pudendal neuropathy. It therefore has considerable clinical practical value. The article emphasizes that, before deciding on surgery, organic causes should be thoroughly excluded and hidden functional disorders should be identified through functional assessment. This is important for reducing unnecessary surgery and avoiding postoperative symptom worsening or treatment failure. The model proposed by the authors vividly illustrates the relationship between superficial lesions and deeper functional disorders in patients with OD, helping readers understand why some patients have poor outcomes after surgery. " [Collapse]

Pescatori M, Perrotta G, De Nardi P. Functional disorders in patients with chronic constipation: Review of the literature and personal experience. World J Gastroenterol 2026; 32(19): 113841

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