Baishideng Publishing Group

Fan MW, Tian JL, Zhang SH, Zhao ZJ, Liu XR, Liu CX, Chen Y. Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis. World J Diabetes 2026; 17(2): 114252

"The submission and review process was satisfactory. The reviews were fair and helped improve the manuscript. The time from submission ..." [Read more]

"The submission and review process was satisfactory. The reviews were fair and helped improve the manuscript. The time from submission to publication was not very long. Authors who submit unfunded articles cannot afford the services of a professional editor. They require some consideration. Otherwise, the whole process was quite user-friendly. " [Collapse]

Chakrabarti S, Kathiravan S, Sarah N. Videoconferencing-delivered psychotherapy for obsessive-compulsive disorder in low-resource settings: A pilot study from India. World J Psychiatry 2026; 16(2): 111577

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. ..." [Read more]

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. Hopefully will have many more publications in this very reputable journal. I hope the journal continues to achieve more success and the same be reflected in the ever improving journal metrics. Hope to contribute in all ways possible and also gets indexed in Scopus soon to further expand its reach. " [Collapse]

Suresh MG, Mohamed S, Geetha HS, Prabhu S, Trivedi N, Ng ZC, Mehta PD, Brar AS, Sohal A, Goyal MK, Hatwal J, Batta A. Metabolic dysfunction-associated steatotic liver disease and type 2 diabetes: Pathophysiology, diagnosis, and emerging therapeutic strategies. World J Diabetes 2026; 17(2): 113149

"This systematic review and meta-analysis deals with the effect of teriparatide on improving fracture union in osteoporotic ..." [Read more]

"This systematic review and meta-analysis deals with the effect of teriparatide on improving fracture union in osteoporotic intertrochanteric fractures. The article submission process was easy and straightforward. Given the journal's high standards for language quality, we had to take professional help for language editing services. The peer-review process was quick and comprehensive, providing valuable feedback that substantially improved the manuscript's quality. The final submission process and the published paper were quite satisfying. " [Collapse]

Keshav K, Kaustubh K, Mishra P. Effect of teriparatide on improving fracture union in osteoporotic intertrochanteric fractures: A systematic review and meta-analysis. World J Orthop 2026; 17(2): 113659

"We appreciate the professional and efficient editorial process provided by World Journal of Diabetes. The manuscript underwent a ..." [Read more]

"We appreciate the professional and efficient editorial process provided by World Journal of Diabetes. The manuscript underwent a rigorous and constructive peer-review process, and the reviewers’ comments were insightful and helpful in improving the scientific clarity and overall quality of our work. The editorial office maintained timely and clear communication throughout submission, revision, and production stages, which greatly facilitated the publication process. We also acknowledge the language and production editors for their careful and thorough work. Overall, our experience with the journal was positive, and we believe World Journal of Diabetes provides a valuable platform for the dissemination of clinically relevant and translational research. " [Collapse]

Huang XL, Wang Y, Chen DF, Duan JN, Michael N, Jiang R, Ge YS, Wang B. Decapping scavenger enzyme as a promising biomarker in diabetic foot ulcers: A need for cautious interpretation. World J Diabetes 2026; 17(2): 116056

"First of all, I would like to thank all the reviewers for their comments and suggestions, which allowed remarkable improvements in ..." [Read more]

"First of all, I would like to thank all the reviewers for their comments and suggestions, which allowed remarkable improvements in the quality of the paper. Due to the prompt cooperation of the Responsible Production Editor, the proofreading process was simple and quick. However, the Auto-edited version of the manuscript included some references with words starting with the capital letters, which had to be modified manually. " [Collapse]

Regis D, Borgese R, Bagnis F, Magnan B, Samaila EM. Early dislocation in primary total hip arthroplasty: Evaluation of treatment options following closed reduction. World J Orthop 2026; 17(2): 113367

"We are delighted that our article "Relationship between the appendix and ulcerative colitis: A new discovery" has been successfully ..." [Read more]

"We are delighted that our article "Relationship between the appendix and ulcerative colitis: A new discovery" has been successfully published in your journal. We would like to express our sincere gratitude to the editorial team and peer reviewers of the World Journal of Gastrointestinal Endoscopy for their constructive feedback and professional support throughout the review process. We suggest that your journal could shorten the review time and simplify the review process. Overall, We are satisfied with the entire publication process. If we have suitable articles in the future, We look forward to continuing our cooperation. " [Collapse]

Wu XJ, Xiang RY, Gong P, Chen Q, Li XF. Relationship between the appendix and ulcerative colitis: A new discovery. World J Gastrointest Endosc 2026; 18(2): 113439

"This journal provides a generally smooth submission and review experience. The editorial communication is clear and professional, ..." [Read more]

"This journal provides a generally smooth submission and review experience. The editorial communication is clear and professional, and the process follows standard academic practices. Reviewer comments are constructive and helpful for improving the manuscript. The online system is easy to use, and the publication workflow is transparent. Overall, I am satisfied with the quality of handling and the final outcome. " [Collapse]

Zeng RX, Wang CQ, Yang H, Sun P, Liu PP, Wei LC, Chen TT, Wang Z, Huang H, Li ZM, Tian XP, Wang Y. Anatomical laterality of primary intestinal diffuse large B-cell lymphoma independently stratifies survival: New prognostic nomogram incorporating tumor location. World J Gastroenterol 2026; 32(7): 115406

"Our study demonstrates that formononetin significantly delays cellular senescence in renal cells and ameliorates diabetic kidney ..." [Read more]

"Our study demonstrates that formononetin significantly delays cellular senescence in renal cells and ameliorates diabetic kidney disease (DKD) pathology, primarily through inhibiting the p53 signaling pathway. These findings not only reveal a novel protective mechanism of formononetin but also position the p53-mediated senescence pathway as a promising therapeutic target for DKD. We believe this work provides a valuable foundation for developing new senotherapeutic strategies against chronic kidney diseases. " [Collapse]

Ji Y, Liu RX, He PY, Zhou YM, Li YC, Guo J, Nie B, Liu YN, Liu WJ. Formononetin inhibits p53 signaling pathway activation to delay cellular senescence and ameliorates diabetic kidney disease. World J Diabetes 2026; 17(2): 112500

"I am glad to publish my research results in WJSC. Reviewers' comments were helpful for advanced manuscript. However, manuscript ..." [Read more]

"I am glad to publish my research results in WJSC. Reviewers' comments were helpful for advanced manuscript. However, manuscript submission system is so complex, especially submitting sectioned loading after acceptance. It is recommended that the manuscript should be submitted in one file. Manuscript template may be helpful for authors to conveniently prepare a manuscript. Thank you very much! " [Collapse]

Shin K, Cha Y, Ban YH, Seo DW, Choi EK, Park D, Kang SK, Ra JC, Kim YB. Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits. World J Stem Cells 2019; 11(12): 1115-1129

"Great support for manuscript improvement. All the authors would like to express their gratefulness for such a supporting journal team, ..." [Read more]

"Great support for manuscript improvement. All the authors would like to express their gratefulness for such a supporting journal team, in terms of quick and accurate communication. I would like also to express one more thought regarding the time needed for paper production and the total time needed to be published after the final acceptance decision, which I feel it can be shorter. " [Collapse]

Chatzivasiliadis M, Konstantinou P, Koulalis D, Kostretzis L, Gkantsinikoudis N, Chaniotakis C, Gkoumousian K, Kapetanakis S. Laminectomy alone vs laminectomy with posterior fusion in lumbar spinal stenosis: The role of instability. World J Orthop 2026; 17(2): 113932

"We are very honored to have our manuscript published in the World Journal of Gastrointestinal Endoscopy. The entire submission and ..." [Read more]

"We are very honored to have our manuscript published in the World Journal of Gastrointestinal Endoscopy. The entire submission and review process was highly efficient and professional. The peer review was rigorous, fair, and constructive, with reviewers providing insightful and detailed comments that significantly improved the quality of our work. The editorial team was responsive, supportive, and maintained clear communication throughout every stage. We deeply appreciate the journal’s commitment to academic integrity, high standards, and timely publication. This experience has been excellent, and we would confidently recommend this journal to colleagues in the field of gastrointestinal endoscopy. " [Collapse]

Dai HY, Liang X, Zhu YQ, Li Z. Pretraction-assisted endoscopic submucosal dissection for rectal neuroendocrine tumors: Efficacy and future directions. World J Gastrointest Endosc 2026; 18(2): 115174

"The publication process was efficient, and the peer review report was clear, constructive, and timely. The review workflow was well ..." [Read more]

"The publication process was efficient, and the peer review report was clear, constructive, and timely. The review workflow was well organized, allowing for a smooth and transparent revision process. We sincerely appreciate the reviewers’ valuable comments and the editorial team’s prompt handling of our manuscript. Thank you for your time, effort, and professionalism. " [Collapse]

Selçuk E, Erem M, Yıldırım S. Critical appraisal of bone graft meta-analysis in tibial plateau fractures. World J Orthop 2026; 17(2): 114188

"The submission and peer-review process was well organized and efficient. The reviewers’ comments were constructive and helpful in ..." [Read more]

"The submission and peer-review process was well organized and efficient. The reviewers’ comments were constructive and helpful in improving the quality of the manuscript. Communication with the editorial office was professional and timely. Overall, we had a positive experience with the journal and appreciate the efforts of the editors and reviewers. " [Collapse]

Qian YR, Liu P, Xu H, Lv Y, Zhang XF, Xiang JX. Microenvironment plays a critical role in modulating tumor cell dormancy: Current perspectives and potential treatment options. World J Clin Oncol 2026; 17(2): 114298

"I am pleased to express my complete satisfaction with the timeline and efficiency of the entire procedure. From submission to final ..." [Read more]

"I am pleased to express my complete satisfaction with the timeline and efficiency of the entire procedure. From submission to final acceptance, every stage was handled smoothly and professionally. The editorial team maintained prompt and clear communication, and the reviewers provided thorough, constructive feedback, reflecting the journal’s commitment to academic rigor and operational excellence. This experience has been highly positive, and I would gladly recommend your journal to colleagues in my field. I look forward to the possibility of contributing again in the future. " [Collapse]

Cai C, Chen JM, Qiu ZX, Ren SQ. Role of claudin-6 in high-grade endometrial carcinoma: Implications for risk stratification and personalized treatment strategies. World J Clin Oncol 2026; 17(2): 116390

"I am very satisfied with my publication experience with the BPG group, which allows me to publish while enhancing the quality of my ..." [Read more]

"I am very satisfied with my publication experience with the BPG group, which allows me to publish while enhancing the quality of my articles. The journal is of high quality, and the reviewers and experts are highly qualified. I particularly appreciated the editing process, which enabled me to correct errors and improve the overall quality of my work " [Collapse]

Ismaili N. Shifting paradigm in locally advanced resectable gastric and gastroesophageal junction cancers. World J Gastrointest Oncol 2026; 18(2): 113150

"The system's strict format requirements for submitting references make the submission process quite challenging, especially considering ..." [Read more]

"The system's strict format requirements for submitting references make the submission process quite challenging, especially considering that some references may not meet the standards and requirements. In such cases, it is actually feasible for editors to make necessary modifications and adjustments later on. This approach will expedite the submission process of the paper. " [Collapse]

Liu YC, Xiao J, Chen L. RRM2 attenuates renal tubular ferroptosis in diabetic kidney disease via the PI3K/Akt/Nrf2 pathway: Strengths, limitations, and future research directions. World J Diabetes 2026; 17(2): 115021

"The article “Orthopedic Trinity: Arthroscopy, Sports Medicine, and Regenerative Orthopedics” was published in the World Journal of ..." [Read more]

"The article “Orthopedic Trinity: Arthroscopy, Sports Medicine, and Regenerative Orthopedics” was published in the World Journal of Orthopaedics on February 18, 2026, as a minireview. Authored by Madhan Jeyaraman and colleagues, the paper highlights the convergence of three pivotal domains shaping modern orthopaedic practice: minimally invasive arthroscopy, evidence-driven sports medicine, and cutting-edge regenerative orthopedics. The publication emphasizes how these fields collectively advance patient care by integrating precision diagnostics, functional rehabilitation, and biologically enhanced healing strategies. It underscores the synergy between clinical innovation and translational research, offering a roadmap for orthopaedic surgeons to adopt holistic approaches in musculoskeletal care. By situating these disciplines within a unified framework, the article contributes to global discourse on orthopaedic education, practice, and future directions. Its appearance in a high-visibility international journal reflects the growing importance of interdisciplinary collaboration in redefining orthopaedic standards worldwide. " [Collapse]

Jeyaraman M, Saketh ASPVS, Jeyaraman N, Ramasubramanian S, Nallakumarasamy A, Muthu S. Orthopedic trinity: Arthroscopy, sports medicine, and regenerative orthopedics. World J Orthop 2026; 17(2): 113197

"The authors dont have any comment. The editorial process for our study was excellent. Thank you for the great job. Authors: Josue ..." [Read more]

"The authors dont have any comment. The editorial process for our study was excellent. Thank you for the great job. Authors: Josue Aliaga Ramos and Vitor Nunes Arantes. Thank you for your time. World Journal of Gastrointestinal Endoscopy. (Mastering gastric endoscopic submucosal dissection: A learning curve analysis of over 100 consecutive cases performed by Wenstern endoscopist ) " [Collapse]

Aliaga Ramos J, Nunes Arantes V. Mastering gastric endoscopic submucosal dissection: A learning curve analysis of over 100 consecutive cases performed by Western endoscopist. World J Gastrointest Endosc 2026; 18(2): 113502

"We wish to express our profound gratitude to each and every expert and editor involved in this project. The outstanding outcome we ..." [Read more]

"We wish to express our profound gratitude to each and every expert and editor involved in this project. The outstanding outcome we have achieved is a direct result of your exceptional professionalism, meticulous efforts, and truly collaborative spirit. We are deeply appreciative of the insightful guidance and dedicated work that elevated the quality of our work. This successful experience serves as a significant inspiration and solid foundation for our team. Moving forward, we are fully committed to building upon this achievement with even greater dedication. We will diligently integrate the valuable lessons learned and strive for continuous improvement in our processes, aiming to consistently produce and deliver content of the highest possible standard in all our future endeavors. " [Collapse]

Yang RR, Yan YR, Li YF. Recent advances in spasmolytic polypeptide expressing metaplasia research. World J Gastrointest Oncol 2026; 18(2): 113995

20690 items Read more >>

Article Quality Tracking-Peer-Review

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Lee H, Han YH, Chung JW, Kim KO, Kwon KA, Kim JH. Upper gastrointestinal bleeding with duodenal varix: A case report. World J Clin Cases 2026; 14(4): 116648

"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. ..." [Read more]

"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. RYDG and OAB are good weight loss surgeries without the risk of GERD. For patients with GERD, the surgical procedure should be selected as suggested by authors." [Collapse]

Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600

"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and ..." [Read more]

"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and bariatric surgery (MBS) has been considered the most effective treatment for weight loss in obese patients. The most commonly performed surgical procedures are sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and single-anastomotic gastric bypass (OAGB). MBS has different effects on obesity-related GERD depending on the type of procedure performed. The results suggest that RYGB consistently leads to significant improvement or remission of GERD symptoms, reduced HCl exposure, and reduced need for PPI therapy in obese patients. RYGB and OAGB are more effective than SG for weight loss and GERD control. RYGB is therefore the preferred bariatric procedure for obese patients with clinically evident GERD. SG is associated with a higher risk of new onset or worsening of GERD, an increased incidence of erosive esophagitis, and an increased risk of Barrett's esophagus. The pathophysiology of these effects is multifactorial and involves changes in gastric anatomy and lower esophageal sphincter function. Therefore, the choice of the type of surgical procedure that should be performed must be individualized, with RYGB being preferred in obese patients with significant GERD or Barrett's esophagus, while SG can be performed in patients without reflux symptoms but requires careful preoperative assessment of GERD risk. The aforementioned data should be taken seriously and guide the physician and patient with obesity and GERD towards making the right surgical decisions." [Collapse]

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's ..." [Read more]

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's disease. In daily medical practice, its treatment is often inadequate since it is usually attributed to side effects of the drugs administered to treat the underlying disease or to psychological causes. The study under review found that indeed, psychological symptoms such as depression, anxiety, stress of any cause, and insomnia are related to its occurrence. In particular, stress is likely to induce the symptom through probable immunological effects. Of interest was the frequent occurrence of fatigue with increased white blood cell count. It therefore seems that fatigue in patients with Crohn's disease has a multifactorial etiology, not exclusively attributable to disease activity or inflammatory markers. As the researchers pointed out, fatigue among IBD patients should receive greater attention in the near future. By conducting additional relevant studies, we will be able to accurately identify the factors that contribute to fatigue, enabling us to develop and implement strategies to effectively identify and support patients experiencing fatigue." [Collapse]

Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete ..." [Read more]

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete intestinal obstruction (CRIO). Given the multifactorial and complex pathophysiology of CRIO, it is inherently challenging to comprehensively describe all clinical conditions. Nevertheless, the authors successfully present a well-structured and comprehensive overview by organizing the discussion into a clear and logical framework." [Collapse]

Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as ..." [Read more]

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as addressed in the following: Of the “Abstract”. The aim does not match well the conclusion. Some “Keywords” are not adequate. “Metagenomic next-generation sequencing” should be moved from “Keywords”. There was no “analysis” or associated description in the “Methods” of the “Abstract”, and this is not adequate. The “Results” in “Abstract” were not consistent with the “Methods” of the “Abstract”. There was no gold standard (guidelines) and criteria for the diagnosis of pulmonary nocardiosis in the “Materials and Methods”. The imaging characteristics (Table 4) were not complete, and which should include a complex item comprising two or more imaging characteristics of the lungs . A total of the pulmonary nocardiosis caused by different species in Table 4 was not 102. The pulmonary nocardiosis treated by different medications in Table 5 was not clear, some patients treated using more than one medications, and the total number was not 102. Figure 1 was not necessary, and associated information can be listed in table or presented in text. Images of pulmonary nocardiosis were not sufficient, and more other representative images had better be added. The English is not professionalism. The “Conclusion” that “Nocardia pneumonia commonly coexists with bronchiectasis. Although mNGS has greatly enhanced its detection rate, N. wallacei pneumonia is distinguished on chest CT by its primary presentation of bronchopneumonia, unlike other types.” was not adequate, and it was not well matching the contents of the “Results”." [Collapse]

Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..." [Read more]

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity. Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter. " [Collapse]

Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an ..." [Read more]

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an essential tool in hepatocellular carcinoma surgery and supporting this with evidence from systematic reviews and clinical studies. It logically organizes the diverse applications of ICG—segmental mapping, detection of superficial lesions, thermal ablation guidance, and tumor‑biology assessment—showing how each technique addresses specific surgical limitations. The discussion consistently links fluorescence patterns to pathological features and clinical decision‑making, reinforcing the article’s central claim that ICG enhances precision, safety, and oncologic outcomes in minimally invasive liver surgery." [Collapse]

Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the ..." [Read more]

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the unusual initial presentation—spontaneous splenic rupture—to the tumor’s aggressive biology. Its diagnostic reasoning is coherent, moving from clinical findings to imaging, pathology, and molecular profiling that distinctly separate the ductal adenocarcinoma and rhabdoid components. The discussion logically integrates existing literature to highlight the rarity, poor prognosis, and potential benefit of aggressive multimodal therapy, underscoring the need for targeted approaches in this molecular subtype." [Collapse]

Yao WQ, Ma XY, Wang GH. Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 114021

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer ..." [Read more]

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer patients with liver metastases and justifying the need to compare chemotherapy alone with chemoimmunotherapy. Its methodology is rigorous and transparent, using well‑defined inclusion criteria, detailed baseline characteristics, and standardized outcome measures such as RECIST, overall survival, and progression‑free survival. The conclusions logically follow from the data, showing that adding immune checkpoint inhibitors significantly improves survival and response rates without increasing severe toxicity, and the study further strengthens its argument by identifying independent prognostic factors through multivariate Cox regression analysis." [Collapse]

Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2026; 18(1): 113440

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy ..." [Read more]

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy in advanced gastric cancer with massive ascites and justifying the need for retrospective evaluation. Its methodology is well‑structured, using clearly defined ascites‑burden groups and standardized clinical criteria to ensure meaningful comparisons of outcomes and safety profiles. The conclusions follow naturally from the data, showing that although prognosis remains poor in the high‑ascites group, nivolumab plus chemotherapy provides measurable ascites improvement and acceptable toxicity, supporting its potential therapeutic value in this challenging population." [Collapse]

Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2026; 18(1): 112944

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the ..." [Read more]

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the study’s objectives and findings. The methods and results are supported by detailed experimental design and high‑quality figures and tables, which enhance reproducibility and data transparency. The discussion highlights clinical relevance and practical implications, effectively linking mechanistic insights to potential therapeutic strategies." [Collapse]

Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2026; 18(1): 112630

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate ..." [Read more]

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate diagnosis requires a combination of imaging and endoscopic techniques. Pancreatoscopy enables direct visualization of the pancreatic duct, targeted biopsies, and the definition of disease boundaries. Existing data support the view that pancreatoscopy is a satisfactory and promising method for determining which patients with IPMN should undergo surgery, as well as the extent of resection for each patient. However, excessive enthusiasm should not prevail. The method is not widely applied; learning requires a dedicated endoscope and a sufficient number of patients per year to maintain and further increase experience, which is a very important factor. For the widespread acceptance and adoption of the method, it is necessary to conduct prospective, very well-designed multicenter studies aiming to precisely determine many parameters e.g. its diagnostic contribution and accuracy, which patients should undergo the examination, what is the impact on therapeutic decisions, what is the cost-benefit ratio and finally to determine whether it improves the survival and/or quality of life of patients. Based on the above observations, pancreatoscopy should be decided on a case-by-case basis and performed in specialized centers." [Collapse]

Abusharar M, Barritt C, Mavroeidis VK, Aroori S. Role of pancreatoscopy in the management of suspected and confirmed intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2026; 32(4): 112635

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data ..." [Read more]

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data from the literature, presenting it in a clear and well-structured manner. The review provides valuable insights into the topic, highlights key mechanisms and clinical implications, and offers a solid foundation for future research and practical applications." [Collapse]

Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511

"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s ..." [Read more]

"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s disease and points out the lack of comprehensive studies to fully elucidate the underlying mechanisms. It also outlines future research directions. Overall, the editorial adds value to the target manuscript by providing complementary discussion and contextualization." [Collapse]

Chen YX, Sun NQ, Mo SJ. Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction. World J Gastroenterol 2026; 32(4): 114468

"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with ..." [Read more]

"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with solid editorial transparency. Concise upgrades—documented search/selection methods, figure/table evidence anchoring, explicit evidence‑tier labeling with effect sizes, and a short limitations/certainty note—would materially improve objectivity, credibility, and practical value for hepatology and metabolism audiences. The article is transparent on provenance, timelines, and authorship; it also includes a conflict‑of‑interest declaration. These are positives for editorial/ethical standards. For maximal clarity to non‑specialists, consider adding a one‑line ethics note that no new human/animal data were generated and that the work synthesizes published evidence only. Methodologically, the piece reads as a narrative review. To support quality tracking and reproducibility, please add a concise 'search strategy and selection' box containing the following information: databases used, the exact date of the last search, key terms, language limits, inclusion/exclusion criteria and dual-reviewer screening/extraction. This would substantiate the statement of a comprehensive survey and help readers to assess selection bias. The figures and tables are clear and helpful. Legends could be strengthened by stating whether panels are conceptual or data-derived, defining all abbreviations at first use, citing the primary sources that support each panel and adding n/assay details when values are quoted. Providing a single, consolidated evidence table per claim (model, dose/exposure, effect size/direction, study type and citation) would further aid readers. The interpretation is generally cautious, but the evidence tier should be labelled consistently (in vitro vs. animal vs. human) and comparative claims (citicoline vs. α-GPC; LA/ethanol as 'mitochondrial toxins') should be anchored to primary studies with effect directions and context. It is important to explicitly note when human data are pilot/underpowered. A brief paragraph explaining why quantitative synthesis was not feasible (due to heterogeneity of models/endpoints) and a graded certainty statement for each major conclusion would prevent 'vote-counting'. The biostatistics and data availability could be improved. Where numerical differences are cited in tables or text (e.g. '2.6-fold increase in plasma choline' or 'up to 30% reduction in triglycerides in preclinical models'), include the study design, sample size, comparator and 95% confidence intervals (CIs) where available. Consider including a small supplementary file with raw or minimally processed values from the cited studies." [Collapse]

Mercola J. Fatty liver reexamined choline and mitochondrial toxin amelioration. World J Biol Chem 2025; 16(4): 111831

"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating ..." [Read more]

"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating to the author's role as company founder and their involvement in product development related to C15:0. This review is a readable and visually clear synthesis of C15:0 mechanisms with good editorial transparency and a useful mechanistic overview. A few concise upgrades, such as search/methods transparency, evidence-tier labelling, quantitative anchors for key effects and explicit limitations, would materially improve objectivity, credibility and practical value for translational audiences. As a narrative review, the article summarises the proposed mechanistic actions of pentadecanoic acid (C15:0), including partial PPAR-α/δ agonism, AMPK activation, mTOR suppression, HDAC6 inhibition and modulation of the anti-inflammatory pathway, and provides helpful pathway schematics and a BioMAP® heatmap. Regarding theinterpretation, the figures are legible and informative, but several mechanistic statements are presented as causal when much of the evidence is preclinical or platform-based (e.g. BioMAP® panels and cell assays). Please anchor each mechanism to specific primary studies and consistently label the evidence tier (in vitro, in vivo or human observational). Where the review draws parallels between the effects of C15:0 and metformin/rapamycin, cite comparative, peer-reviewed experiments and quantify the direction of the effects to avoid 'phenotypic mirroring' based on analogy alone. If you are relying on cell-system phenotyping reports, you should specify the doses, reference compounds and cytotoxicity thresholds, and discuss the limits of generalisability. Figures/tables: Expand figure legends to state whether values are empirical (with n, assay and statistics) or conceptual and include scale and statistical annotations where applicable. Biostatistics and certainty: Although a formal meta-analysis is not expected, readers would benefit from the reporting of representative effect sizes (e.g. EC₅₀ ranges or fold changes with 95% confidence intervals) for key targets, alongside a short paragraph explaining why quantitative synthesis across studies is not feasible (e.g. heterogeneity of models and endpoints). Providing a graded certainty statement (e.g. 'moderate' for PPAR-α/δ binding; 'low'/'very low' for clinical efficacy) would prevent over-extrapolation. Providing a neutral summary that acknowledges the limited number of human prospective trials of C15:0 for metabolic or longevity endpoints would align enthusiasm with the current evidence base." [Collapse]

Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258

"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the ..." [Read more]

"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the PRISMA 2009 guidelines. This is a timely and relevant systematic review of the gut microbiome and chemotherapy-induced cardiotoxicity, with good editorial transparency and a useful PRISMA framework. The reference list is current and thematically appropriate. These factors positively contribute to ethical and reporting standards, making provenance clear to readers. Consider adding a brief statement confirming that no new human or animal data were collected, and that only published or registry data were used, to close the ethics loop for non-specialists. As a systematic review, the methods section would benefit from providing compact yet reproducible details. While you do include a PRISMA flow diagram, the main text should also specify the databases searched (with the exact date of the last search), the full search strings, any language restrictions, the inclusion/exclusion criteria, and the tool used for the risk-of-bias assessment (e.g. ROBINS-I, RoB2 or SYRCLE). A short table summarising study designs, sample sizes, chemotherapy classes, cardiotoxicity definitions and microbiome endpoints would help readers to understand the heterogeneity. Regarding the results and interpretation, the narrative rightly identifies microbial metabolites and gut–heart crosstalk as candidate pathways. Anchoring these mechanisms to recent overviews of microbiome–chemotherapy interactions and core mechanistic reviews would improve the balance and timeliness of the review. The figures and tables are adequate (PRISMA and one data table are included in the journal assets). The legends could be strengthened by declaring whether each figure is conceptual or data-derived, defining all abbreviations at first use and adding a per-study evidence table (study; cancer/chemo; cardiotoxicity endpoint; microbiome assay; key finding; risk of bias). Readers will expect some appraisal of effect direction/size where feasible (e.g., HRs/ORs for cardiotoxicity associations or standardised mean differences for metabolite levels), even if a meta-analysis is not possible. Including a concise 'why no pooling' paragraph (explaining heterogeneity in definitions, assays and timepoints) and a GRADE-style certainty statement for each major conclusion (very low, low or moderate) would prevent 'vote-counting' impressions and increase the utility of the review's conclusions." [Collapse]

Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221

"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor ..." [Read more]

"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor (randomization/blinding/power, assay standards), richer statistics and data sharing, and a more circumspect translational framing. These concise additions would enhance objectivity, credibility, and scientific utility for the community. The references are appropriate and full editorial metadata are provided. Funding and conflict-of-interest statements are also included, along with details of compliance with the ARRIVE guidelines, animal ethics approval, and CC BY-NC 4.0 licensing. This transparency aligns with the journal’s quality policy and is a strength of the article. It would be beneficial to add a brief ethics note to clarify humane endpoints and analgesia during tail transection for readers who are not specialists. The methods section would benefit from a more concise description to support reproducibility. Report the sex and exact age range/ageing criterion of the mice, their housing conditions, and the full rationale for the therapeutic BoNT formulation (serotype, units/kg, injection site/volume, and timeline to assay). Given the focus on coagulation, full protocols for platelet aggregation should be added (e.g. agonist, concentration, light transmission vs microscopy) and standard plasma assays (PT/INR, aPTT, fibrinogen) should be included to triangulate the tail bleeding endpoint. These additions would make the work easier to replicate and compare with prior haemostasis literature. The results are clear and the figures are legible, but several quality improvements would be helpful. For Figures 1–3, it would include n per group on the plots and show all data points with mean ± SD/SEM. State the exact statistical tests used (normality testing, two-sidedness and corrections for multiplicity) and report effect sizes with 95% CIs. In the legends, indicate how many independent experiments/animals the images are representative of, and add scale bars and magnifications. Where possible, provide raw or minimally processed data (e.g. bleeding times, body weights, aggregation percentages) in a supplementary file to meet current data availability expectations. Interpretation should be cautious to avoid overreach. While a single dose in ageing mice suggests a pro-coagulant/anti-haemorrhagic effect, the systemic or off-target neuromuscular actions of BoNT could confound behaviour during the assay. Please discuss the potential mechanisms (e.g. platelet number/function, coagulation cascade, or local vasomotor effects) and outline experiments that would clarify them (e.g. complete blood count/platelet counts, thromboelastography, ROTEM, or endothelial markers). Translational claims (e.g. use in trauma/surgery) should be limited until dose–response, time-course, safety (toxicity, motor impairment) and reversibility are established, and the findings should be considered in the context of contemporary BoNT pharmacology/safety reviews." [Collapse]

Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; 16(4): 112376

"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, ..." [Read more]

"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, alongside transparent metadata on provenance. The piece could be elevated to a best-practice minireview while preserving its brevity and readability by adding a concise methods note for literature selection, tightening causal language, enriching legends/references to anchor mechanisms, and stating limitations explicitly. Regarding the results and their interpretation, the mechanistic thread is accurate and accessible. The figures are clear and didactic. However, a compact summary table cross-linking each ISG to its function, model/evidence, clinical signal (if applicable) and approximate level of evidence would help translational readers further. The language quality is high, and minor spacing artefacts appear to be HTML rendering issues that will not affect the PDF. A short, explicit 'Limitations and outlook' paragraph acknowledging the non-systematic approach, potential selection bias and the need for stratified clinical validation of IFN-γ/ISG signatures in standard-of-care and immunotherapy contexts would round off the manuscript's critical appraisal. " [Collapse]

Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768

15935 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2264

Peer-reviewers: 36008

Manuscripts received today: 0

Manuscript reviews today: 1

Unhandled manuscripts today: 171

Active peer-reviewers today: 236

Reviewer acceptance today: 1

Reviewer refusals today: 1

Total accepted manuscripts: 40089

Total rejected manuscripts: 44574

Total peer-reviewers: 4680960

Total submissions: 37938

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

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All Journal Articles

Mwita RP, Özdemir Ö. Stem cell transplantation in immuno-hematologic and infectious diseases. World J Transplant 2026; 16(1): 114592

2026-03-18 | Browse: 431 | Download: 120

Kute VB, Balwani MR, Shrimali JB, Pasari A, Kher V, Patel MP, Chafekar D, Guditi S, Das P, Siddaiah GM, Godara SM, Bhargava V, Gupta A, Ramteke V, Deshpande N, Tolani P, Prasad N, Patil RK, Mohanka R, Mahajan S, Sharma S, Banerjee S, Engineer DP, Agarwal D, Kashiv P, Lahiri A, Prasad N, Khullar D, Srivastava A. Induction therapy in kidney transplant recipients: A consensus statement of Indian Society of Organ Transplantation. World J Transplant 2026; 16(1): 114367

2026-03-18 | Browse: 561 | Download: 147

Belal AA, Bourricaudy RA, Saba Z, Alquadan KF, Kazory A, Santos Jr AH. Kidney allograft outcomes in combined kidney with other solid organ transplantation. World J Transplant 2026; 16(1): 114233

2026-03-18 | Browse: 269 | Download: 90

Lekehal B, Ait Youssef N, Lekehal M, Jdar A, El Hassani AEA, Belyazid I, Bakkali T, Bounssir A. Acute graft thrombosis in a patient with factor V Leiden mutation: A case report and review of literature. World J Transplant 2026; 16(1): 114162

2026-03-18 | Browse: 329 | Download: 131

Guissouss O, Achiaou K, El Turk J, Mourachid A, Cheggali A, Medkouri G, Ramdani B, Benghanem Gharbi M, Taoudi Benchekroun M, Bennani S. Preformed vs de novo anti-human leukocyte antigens-DQ antibodies in kidney transplantation: A retrospective study. World J Transplant 2026; 16(1): 114044

2026-03-18 | Browse: 331 | Download: 141

Guo YP, Wen Q, Wang YY, Hang G, Chen B. Application of machine learning in the research progress of post-kidney transplant rejection. World J Transplant 2026; 16(1): 114000

2026-03-18 | Browse: 321 | Download: 118

Kodali NA, Janarthanan R, Demir Z, Sazoglu B, Dirican OF, Tuder D, Zor F, Kulahci Y, Gorantla VS. Nail abnormalities in upper extremity transplantation: Perspectives and insights from systemic diseases and organ transplantation. World J Transplant 2026; 16(1): 113633

2026-03-18 | Browse: 332 | Download: 96

Balwani MR, Pasari A, Kashiv P, Shembekar C, Shembekar M, Dubey S, Jeyachandran V, Malde S, Gupta S, Pawar T, Tolani P, Kurundwadkar M, Gurjar P, Sejpal K, Bawankule C, Kute VB. Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report. World J Transplant 2026; 16(1): 113117

2026-03-18 | Browse: 443 | Download: 158

Christou CD, Antoniadis S, Majumder A, Zakri R, Olsburgh J, Callaghan C, Papadakis G, Sran K, Drage M, Decaestecker K, Challacombe B, Kessaris N, Loukopoulos I. Robot-assisted vs hand-assisted laparoscopic donor nephrectomy in the United Kingdom: Equivalent outcomes in the first national series. World J Transplant 2026; 16(1): 113075

2026-03-18 | Browse: 343 | Download: 120

Ardila CM, González-Arroyave D, Ramírez-Arbelaez J. Robotic-assisted donor and recipient hepatectomy in liver transplantation: An umbrella review of clinical outcomes, surgical performance, and cost-effectiveness. World J Transplant 2026; 16(1): 113034

2026-03-18 | Browse: 326 | Download: 122

Chen KR, Wu LZ, Huang YN, Zhuang SY, Chen ZY, Xu B, Xu TC. Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review. World J Transplant 2026; 16(1): 112811

2026-03-18 | Browse: 332 | Download: 157

Emmanouilidou A, Karageorgos FF, Tsoulfas G, Alexopoulos AH. Microplastics in organ transplantation: An emerging threat requiring immediate action. World J Transplant 2026; 16(1): 111980

2026-03-18 | Browse: 331 | Download: 107

Chukwu CA, Kalra PA, Lowe M, Poulton K, Augustine T, Rao A. Outcomes of basiliximab vs alemtuzumab induction in kidney allograft recipients with matched immunological Profiles: A retrospective cohort study. World J Transplant 2026; 16(1): 111959

2026-03-18 | Browse: 344 | Download: 132

Kaur M, Arora J, Naseem M, Singh A, Kumar V, Sohal A. Ocular complications after liver transplantation: A comprehensive review of infectious and non-infectious etiologies. World J Transplant 2026; 16(1): 111869

2026-03-18 | Browse: 345 | Download: 99

Elahi T, Ahmed S, Mubarak M. Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation. World J Transplant 2026; 16(1): 111524

2026-03-18 | Browse: 463 | Download: 140

Paulin S, Rajakumar A, Menon J, Shanmugam N, Rela M. Perioperative management of pediatric patients with inborn errors of metabolism during liver transplantation. World J Transplant 2026; 16(1): 111122

2026-03-18 | Browse: 361 | Download: 124

Abuyadek R, A Ghitani S, Shaaban R, Quoritem MA, Foula MS, Abdel Majid RO, Mokhtar M, Elhadi YAM, Alnagar A. Protocol for a global electronic Delphi on integrating artificial intelligence into solid organ transplantation. World J Transplant 2026; 16(1): 111103

2026-03-18 | Browse: 333 | Download: 109

Alquadan KF, Belal AA, Mehta R, Leghrouz M, Ibrahim H, Vrakas G, Santos AH. Simultaneous kidney and pancreas transplantation: Current trends and challenges. World J Transplant 2026; 16(1): 111064

2026-03-18 | Browse: 325 | Download: 106

Currier EE, Won CY, Parraga X, Lee KS, Saberi B. Hemoperitoneum from omental variceal bleed resulting in first documented successful liver transplant: A case report. World J Transplant 2026; 16(1): 110910

2026-03-18 | Browse: 274 | Download: 102

Lekehal B, Ait Youssef N, Lekehal M, Bakkali T, Jdar A, Bounssir A. Vein cuff interposition for short renal vein in living-donor kidney transplantation: Three case reports and review of literature. World J Transplant 2026; 16(1): 110683

2026-03-18 | Browse: 285 | Download: 120

62115 items Read more >>

Featured Articles

Wan KR, Qian C, Liu LM. Study on the mechanism of hepatitis C virus-mediated development and progression of liver cirrhosis and hepatocellular carcinoma. World J Gastroenterol 2026; 32(7): 115234

2026-02-06 | Browse: 18 | Download: 29

Prakash HS, Sehrawat A, Swamy AM, Sundriyal D. Refining early detection of hepatocellular carcinoma: The promise of the GALAD score. World J Gastroenterol 2026; 32(7): 115044

2026-02-06 | Browse: 7 | Download: 24

Wu AK, Li JY, Zhang K, Meng M, Wang X, Liu Y, Xie P, Rong WQ, Wu F, Wang HG, Meng X, Wu JX. Lactate metabolism-driven tumor heterogeneity and molecular signatures in intrahepatic cholangiocarcinoma. World J Gastroenterol 2026; 32(7): 113973

2026-02-06 | Browse: 8 | Download: 38

Duan M, Kong QZ, Zuo XL, Yang XY, Li YY. Optimizing Helicobacter pylori therapy through gastroenterologist education: A prospective interventional study. World J Gastroenterol 2026; 32(7): 115876

2026-02-06 | Browse: 5 | Download: 37

Qiao XY, Li ZH, Lin SY, Wen G. Endoscopic ultrasound in early gastric cancer: Diagnostic accuracy and Tis/T1a lesion over staging risks. World J Gastroenterol 2026; 32(7): 116463

2026-02-06 | Browse: 5 | Download: 30

Yang WP, Zeng JH, Wu BL, Zhou WT, Luo JZ, Dai YY, Yang SX, Huang ZS, Huang YQ. Pathological effects of diabetic mice with Helicobacter pylori infection. World J Diabetes 2026; 17(2): 112534

2026-02-06 | Browse: 6 | Download: 35

Li YJ, Ge HY, Zhang GG, Chen HY, Xi YJ, Wang K, Huang YL, Zhang C, Fan X, Yan XQ. Fibroblast growth factor 1 alleviates diabetic nephropathy by reducing renal lipid accumulation in diabetic kidney. World J Diabetes 2026; 17(2): 112475

2026-02-06 | Browse: 5 | Download: 25

Tian JX, Zhang YJ, Zhang YX, Wei JH, Fang XY, Miao RY, Ma KL, Guan HF, Wang XM, Wu HR. Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder. World J Diabetes 2026; 17(2): 111453

2026-02-06 | Browse: 5 | Download: 32

Rana NS, Vishvakarma NK, Sonkar SC, Beg MMA. Diabetes: A comprehensive review of the Indian landscape in contrast with global trends. World J Diabetes 2026; 17(2): 110701

2026-02-06 | Browse: 12 | Download: 27

Donate-Correa J, Martínez-Alberto CE. Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart. World J Diabetes 2026; 17(2): 113221

2026-02-06 | Browse: 5 | Download: 23

He BM, Sun XL, Huang XY, Zhang SS, Hong QX. Effects of electroacupuncture combined with flurbiprofen axetil on postoperative pain and early functional recovery after breast cancer surgery. World J Clin Oncol 2026; 17(2): 114431

2026-02-06 | Browse: 7 | Download: 32

Zweig V, Goel S, Maitra R. Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration. World J Clin Oncol 2026; 17(2): 113428

2026-02-06 | Browse: 8 | Download: 33

Li ZY, Peng SY, Li FL, Cai HQ. Immunosuppressive tumor microenvironment shape pancreatic cancer unresponsive to current immunotherapies. World J Clin Oncol 2026; 17(2): 114423

2026-02-06 | Browse: 6 | Download: 31

Wang C, Zhang J, Chen ZK, Wang YG, Shi M. Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies. World J Clin Oncol 2026; 17(2): 114107

2026-02-06 | Browse: 6 | Download: 24

Zuo DB, Chen ZH, Jin YM, Sang M, Sun XD, Guo A, Li XY, Wu JX, Ji KK, Zhou H. Common gamma chain cytokines-driven optimization of chimeric antigen receptor T cells: Mechanistic insights and future directions. World J Clin Oncol 2026; 17(2): 115451

2026-02-06 | Browse: 5 | Download: 24

2026-02-06 | Browse: 4 | Download: 12

2026-02-06 | Browse: 4 | Download: 13

Russo A, Patanè V, Pezzella MC, Troiani T, Argenziano G, Reginelli A. Ultra-high-frequency ultrasound in the detection of recurrent conjunctival melanoma: A case report. World J Clin Cases 2026; 14(4): 117226

2026-02-05 | Browse: 26 | Download: 42

Segawa A, Kakinuma T, Miyazawa C, Takeuchi J, Tamura M, Morita A, Takae S, Suzuki N, Ariizumi Y. Successful perioperative management for a giant ovarian tumor in older adults: A case report. World J Clin Cases 2026; 14(4): 116737

2026-02-05 | Browse: 19 | Download: 41

Capobianco M, Zeppieri M, Nicolosi SG, Faro GD, Salanitro D, Khouyyi M, D’Esposito F, Gagliano C. When eye disease affects the mind: Psychological burden and functioning in autoimmune ophthalmology. World J Clin Cases 2026; 14(4): 117692

2026-02-05 | Browse: 19 | Download: 31

10419 items Read more >>

Keyword Search Published Articles Processes

Case report

4753

Hepatocellular carcinoma

1757

Gastric cancer

1281

Colorectal cancer

1261

Prognosis

1092

Inflammatory bowel disease

859

COVID-19

843

Treatment

777

Diagnosis

759

Liver transplantation

745

Ulcerative colitis

691

Meta-analysis

671

Crohn’s disease

624

Endoscopy

621

Cirrhosis

613

Inflammation

600

Helicobacter pylori

595

Magnetic resonance imaging

585

Surgery

562

Pancreatic cancer

519

66064 items Read more >>

Reader Comments

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..." [Read more]

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. " [Collapse]

Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways for elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..." [Read more]

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. " [Collapse]

He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced ..." [Read more]

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced tumor stage, and poor survival in gastric cancer. The combination of clinical data and functional assays strengthens the evidence for the PS-1/β-catenin/p-PTEN axis in promoting invasion and metastasis. These findings highlight a potential therapeutic target for gastric cancer treatment. " [Collapse]

Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2026; 18(2): 115689

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..." [Read more]

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. " [Collapse]

Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..." [Read more]

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 " [Collapse]

Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..." [Read more]

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. " [Collapse]

Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..." [Read more]

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. " [Collapse]

Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..." [Read more]

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. " [Collapse]

Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..." [Read more]

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] " [Collapse]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..." [Read more]

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. " [Collapse]

Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. " [Collapse]

Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..." [Read more]

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino " [Collapse]

Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..." [Read more]

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. " [Collapse]

Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..." [Read more]

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. " [Collapse]

Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..." [Read more]

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. " [Collapse]

Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757

"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..." [Read more]

"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. " [Collapse]

Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872

"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..." [Read more]

"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. " [Collapse]

El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168

"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..." [Read more]

Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618

"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..." [Read more]

"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. " [Collapse]

Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272

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