Baishideng Publishing Group

Singh P, Singh MK, Mishra A. Use of statistical process control to study the patient-specific quality assurance in head and neck cancer. World J Clin Oncol 2026; 17(4): 115851

"I would like to express my concern regarding the journal’s current policy (Section 4) that requires non-native English speakers to ..." [Read more]

"I would like to express my concern regarding the journal’s current policy (Section 4) that requires non-native English speakers to provide a Language Editing Certificate before manuscript acceptance. While I fully support the need for high‑quality academic writing, I believe this policy is unnecessarily discriminatory and outdated. Many non-native English speakers are highly proficient in scientific writing and can produce manuscripts that meet the highest linguistic standards without external editing. Requiring a certificate from a native‑only editing service or a native‑English biomedical scholar implies that non‑native speakers are inherently less capable—a premise that is both inaccurate and unfair. Top‑tier journals such as Cell, Nature, and Science do not impose such a requirement; they evaluate manuscripts based on scientific merit and clarity, regardless of the author’s linguistic background. In fact, some of the most clearly written papers I have encountered come from non‑native English authors. Therefore, I strongly recommend that the journal reconsider and ultimately abolish this mandatory language certification policy. Instead, the editorial office should assess language quality on a case‑by‑case basis during peer review and production, as is standard practice at leading international journals. This change would align the journal with modern, inclusive publishing standards and avoid unnecessary burdens on competent researchers. Overall, my experience with the journal’s editorial process was positive, but this specific language requirement is a significant drawback that I hope will be removed in the future. " [Collapse]

Liu ZY, Zhou Y, Zhao FH, Wang L, Pan TJ, Gao L. New breakthroughs and future trends in renal cell carcinoma therapy: Highlights from the 2025 European Society for Medical Oncology Annual Congress. World J Clin Oncol 2026; 17(4): 118954

"We are highly satisfied with the manuscript editing and publishing process, and we give a positive evaluation of the journal's ..." [Read more]

"We are highly satisfied with the manuscript editing and publishing process, and we give a positive evaluation of the journal's credibility. We are satisfied with the peer review process of the journal, as the reviewers are diligent and responsible, and their professional comments and revision suggestions have helped us improve the scientific rigor and readability of the papers. " [Collapse]

Yuan HF, Kuang DL, Jiao DC, Bi YH. Three kinds of drug-eluting bead transarterial chemoembolisation for treating patients with unresectable non-small cell lung cancer. World J Clin Oncol 2026; 17(4): 118070

"Thank for the substantial contributions of the editorial team and peer reviewers to the final published version of this manuscript. ..." [Read more]

"Thank for the substantial contributions of the editorial team and peer reviewers to the final published version of this manuscript. The editors provided clear guidance throughout the review process, ensuring timely and fair evaluation while maintaining rigorous scholarly standards.We explicitly acknowledge that the final version's rigor and clarity surpass the original submission due to this collaborative scrutiny. This experience reinforces our confidence in the peer-review system as a mechanism for quality assurance. " [Collapse]

He LJ, Meng MY, Huang CK, Liu SY, Wang P, Long W, Gao H, Yang LS, He S, He Y, Guo YF, Zhao YY, Liu Y, Hu LR, Li L, Hou ZL, Wang WJ, Wang XD. Mesenchymal stem cells alleviate renal injury of lupus nephritis mice by reconstructing the immune microenvironment of renal tissue. World J Stem Cells 2026; 18(4): 115446

"The reviewers' comments were constructive and helped improve the manuscript. The suggestions were very relevant in improving the ..." [Read more]

"The reviewers' comments were constructive and helped improve the manuscript. The suggestions were very relevant in improving the quality of the manuscript. The manuscript was reviewed quickly, and the publication time could have been shortened. Maybe once accepted, the online publication could be done immediately. This will be of great help to the authors. " [Collapse]

Agarwal A, Agrawal S, Talukdar D, Kaur M, Biswas S, Swaroop S, Golla R, Kandiyal B, Jana P, Tanwar S, Aggarwal A, Singh HC, Agarwal A, Mahajan M, Tiwari B, Nayak B, Goel A, Das B, Shalimar. Impact of two-session fecal microbiota transplantation on minimal hepatic encephalopathy in cirrhosis. World J Hepatol 2026; 18(4): 116153

"In this review, we aimed to provide a comprehensive and forward-looking overview of precision therapy guided by driver gene mutations ..." [Read more]

"In this review, we aimed to provide a comprehensive and forward-looking overview of precision therapy guided by driver gene mutations in breast cancer, with a particular focus on clinically actionable alterations such as PIK3CA, ESR1, *BRCA1/2*, and AKT1. While targeted therapies—including PI3Kα inhibitors, PARP inhibitors, and oral SERDs—have significantly improved outcomes for specific molecular subtypes, acquired resistance and tumor heterogeneity remain formidable challenges. A key takeaway from our work is the need to move beyond static biomarker testing toward a dynamic, evidence-based decision framework that integrates multi-omics profiling, liquid biopsy, and artificial intelligence. We also emphasize the growing importance of next-generation antibody-drug conjugates and rational combination strategies in overcoming resistance. We hope this review serves as a practical resource for clinicians and researchers, and we are grateful to the editors and peer reviewers for their constructive feedback, which greatly enhanced the quality of our manuscript. " [Collapse]

Liu ZY, Chen R. Precision therapy for driver gene mutations in breast cancer: Current landscape and future perspectives. World J Clin Oncol 2026; 17(4): 117540

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review ..." [Read more]

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review process could be characterized by great satisfaction. Thank you very much for your cooperation. I am looking forward to continuing this scientific activity. I hope to continue with the best impressions. Best regards from Thessaloniki, Greece. " [Collapse]

Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kofinas A, Konstantopoulou I, Pavlidis TE. Current perspectives on diagnosis and management of primary and secondary breast endometriosis and potential risk of breast cancer. World J Clin Oncol 2026; 17(4): 118631

"We sincerely appreciate all the efforts made by the editorial office of this journal. During the whole process of manuscript review, ..." [Read more]

"We sincerely appreciate all the efforts made by the editorial office of this journal. During the whole process of manuscript review, revision, editing and publication, the editors have shown remarkable professionalism, patience and rigorous attitude. Thanks to their hard work and valuable suggestions, our paper has been greatly improved. We would like to express our heartfelt gratitude to the entire editorial team. " [Collapse]

Zhang SH, Yang Y, Zhang Y. Breast cancer and metabolic comorbidities: From epidemiology and molecular mechanisms to precision interventions. World J Clin Oncol 2026; 17(4): 117705

"Thanks to reviewers and editors for their valuable help and support I appreciate the valuable advice and comments of reviewers and ..." [Read more]

"Thanks to reviewers and editors for their valuable help and support I appreciate the valuable advice and comments of reviewers and editors during the while prrocess from submission to publication. Best wishes Nabil Eid, MD &PhD (A. Prof. Osaka Medical and Pharmaceutical University, Osaka, Japan) Department of Human Biology, Anatomy Division, School of Medicine, IMU University, 57000 Kuala Lumpur, Malaysia nabilsaleheid@imu.edu.my nabileidm2@gmail.com nabileidm@yahoo.com https://scholar.google.com.eg/citations?user=r7wimhcAAAAJ&hl=en " [Collapse]

Eid N, Burud IAS, Ogaili RH. Retroperitoneal laparoscopic partial hepatectomy: A novel approach to posterosuperior right-lobe tumors. World J Hepatol 2026; 18(4): 117129

"We sincerely appreciate the editorial team’s professional work and support throughout the review and publication process. Overall, ..." [Read more]

"We sincerely appreciate the editorial team’s professional work and support throughout the review and publication process. Overall, we are satisfied with the journal and would like to express our gratitude for your efforts. However, we were not fully satisfied with the figure processing requirements. We respectfully suggest that authors be allowed to submit figures in more flexible formats, provided that the image resolution and clarity meet the publication standards. In addition, we hope that the publication process can be further accelerated. Thank you again for your assistance and continued support. " [Collapse]

Xie QQ, Zeng MQ, Mao LN, Han SJ, Sun D, Zheng ZG. Multilayered control of retinal stem/progenitor cell fate in the single-cell and organoid era: Developmental blueprints and regenerative opportunities. World J Stem Cells 2026; 18(4): 118621

"Cardiac amyloidosis has long been an underdiagnosed and undertreated condition. In this manuscript, we provide a comprehensive, ..." [Read more]

"Cardiac amyloidosis has long been an underdiagnosed and undertreated condition. In this manuscript, we provide a comprehensive, up-to-date overview. We hope this work will serve as a practical reference for clinicians and help bridge the gap between cutting-edge evidence and everyday patient care. We warmly thank reviewers, and the editorial team for their invaluable contributions. " [Collapse]

Bouziane M, Moufid O, Habbal R. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs. World J Exp Med 2026; 16(1): 112270

"We are fully satisfied with all stages of the publication process. From the initial submission to the final decision, every step was ..." [Read more]

"We are fully satisfied with all stages of the publication process. From the initial submission to the final decision, every step was handled with great professionalism, efficiency, and clarity. Communication was timely and constructive, and the overall experience was smooth and well-organized. We truly appreciate the support and dedication of the editorial team throughout the entire process. " [Collapse]

Bhati G, Capolupo GT, Bhati K, Gupta A, Bansal R, Sai Srinija P, Caricato M, Carannante F. Laparoscopic cholecystectomy in patients with situs inversus totalis: Two case reports and review of literature. World J Clin Cases 2026; 14(12): 118091

"We are fully satisfied with all stages of the publication process. From the initial submission to the final decision, every step was ..." [Read more]

Bhati G, Mongardini FM, Bhati K, Singh P, Bansal R, Bansal A, Mahajan S, Docimo L, Caricato M, Capolupo GT, Carannante F. Ruptured primary intrahepatic ectopic pregnancy: A case report and review of literature. World J Clin Cases 2026; 14(6): 118135

"The authors would like to thank the reviewers and editors who spent time meticulously reviewing our manuscript and for their invaluable ..." [Read more]

"The authors would like to thank the reviewers and editors who spent time meticulously reviewing our manuscript and for their invaluable suggestions that greatly enhanced the quality of this review. The Peer review process was rigorous. They critically analyzed our manuscript and prompted us to improve not only the written text but also the images to best suit the manuscript. The editors have been really helpful and accomodating. " [Collapse]

Habiba UE, Greene DL, Shamim S. Anatomy, function, biomechanics, and regenerative properties of Wharton’s jelly in the umbilical cord. World J Stem Cells 2026; 18(4): 118404

"The peer review was exceptionally thorough, constructive, and fair. The reviewers' comments were insightful and significantly ..." [Read more]

"The peer review was exceptionally thorough, constructive, and fair. The reviewers' comments were insightful and significantly contributed to improving the quality of the final paper. Furthermore, the editorial team was highly professional, communicative, and efficient throughout every stage—from submission to acceptance. Publishing in a journal with such a rigorous yet supportive process has been a very positive experience. Thank you for your excellent work and for maintaining such high standards. " [Collapse]

Xiong JF, He Y, Jiang N, Liu YH, Chen GF, Zhao CQ, Zhang SY, Wu YJ, Xu H. Modulation of the gut-liver axis by oxymatrine alleviates metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; 32(16): 116187

"We would like to express our sincere gratitude to the journal for the efficient and well-organized handling of our manuscript ..." [Read more]

"We would like to express our sincere gratitude to the journal for the efficient and well-organized handling of our manuscript throughout the submission and review process. The timeline from submission to acceptance was remarkably fast, without compromising the thoroughness of the review. We are especially appreciative of the reviewers and the editor, whose comments were constructive, insightful, and highly professional. Their suggestions significantly improved the quality of our paper, helping us clarify key points, strengthen our arguments, and present our findings more rigorously. The entire experience has been both encouraging and academically enriching. " [Collapse]

Huang XY, Zhong QH, Kuang YY, Li ZJ, Huang BJ, He YJ, Zhu MM, Guan Q, Li XY, Qin QY, Ma TH. Thalidomide for refractory hemorrhagic chronic radiation proctitis secondary to pelvic malignancy radiotherapy: A phase II clinical trial. World J Gastroenterol 2026; 32(14): 116529

"I am very satisfied with the overall editorial and publishing process. The online submission system was clear and efficient, the peer ..." [Read more]

"I am very satisfied with the overall editorial and publishing process. The online submission system was clear and efficient, the peer review process was fair and helpful, and the editing and final presentation of the article were of high quality. Communication was professional throughout, and the publication process was completed in a timely manner. Thank you for your support and for maintaining high academic and publishing standards. " [Collapse]

Tsironikos GΙ, Zakynthinos GΕ, Kyprianidou D, Rammou V, Antonogiannis T, Bargiota A, Zakynthinos E, Tsolaki V. Metformin fails to prevent diabetes in non-diabetic cardiovascular patients: Systematic review and meta-analysis. World J Cardiol 2026; 18(4): 115712

"We sincerely express our deep gratitude to the editorial office and anonymous reviewers of the *World Journal of Clinical Cases*. ..." [Read more]

"We sincerely express our deep gratitude to the editorial office and anonymous reviewers of the *World Journal of Clinical Cases*. Your rigorous, professional and meticulous peer review has provided valuable revisions that significantly improved the quality of our manuscript. We highly appreciate the efficient editorial process, thoughtful suggestions and responsible attitude of the whole team. This journal offers an excellent academic platform for sharing clinical experiences and innovative findings. We wish the journal greater influence, wider readership and continuous prosperity in the future. " [Collapse]

Pan HY, Liang JX, Chen WW, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Xu B, Xu TC. Beyond glycemic control: How semaglutide reshapes intestinal neuroception via transforming growth factor-β/brain-derived neurotrophic factor signaling hubs. World J Clin Cases 2026; 14(9): 118295

"The study “Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells ..." [Read more]

"The study “Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis” was published early in the World Journal of Stem Cells in 2026, reflecting its clinical importance. Authored by a multidisciplinary team, it evaluates regenerative strategies using PB-MSCs delivered through different anatomical routes. The paper highlights that combined intra-articular and subchondral injections may offer superior pain relief and functional improvement compared to single-route approaches. Its expedited publication underscores the urgency of advancing biologic therapies in osteoarthritis, providing timely evidence to guide clinicians toward joint-preserving interventions with global relevance. " [Collapse]

Ratna HVK, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis. World J Orthop 2026; 17(4): 116916

"From submission to the first decision, the editorial team responded promptly, and the review process was conducted in a timely manner. ..." [Read more]

"From submission to the first decision, the editorial team responded promptly, and the review process was conducted in a timely manner. The reviewers' comments were constructive and insightful, which significantly improved the quality of our work. Such efficiency is invaluable to researchers and reflects the journal's commitment to high standards. " [Collapse]

Zhang YW, Xu MR, Li MH, Li LX. Product of C-reactive protein and fasting C-peptide indicates cardiovascular risk in type 2 diabetes: A real-world study. World J Diabetes 2026; 17(4): 117063

21195 items Read more >>

Article Quality Tracking-Peer-Review

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria ..." [Read more]

"1 Ethics: Does the ethical approval form provided by the author meet the requirements? The Ethics Committee of the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, waived the need for ethics approval. 2 Methods: Is the experimental method effective? Can it be repeated by fellow researchers (according to adequate textual/citation content presented)? The study is moderately effective as it is retrospective clinical design how ever detailed methodology is missing. furthermore, it is judged on statistical variation not on experimental results variations 3 Results: Are the results true and authentic? Is the theory or hypothesis of universal significance validated or partially validated? The results are appropriately authentic and consistent. Sample size is lower, hence hypothesis is moderately validated. Present study demonstrate the prognosis relevance which is insufficient for application in clinical settings. 4 Figures and tables: Does the author provide perfect tables, line charts and/or graphs? Or, does the author provide figures and tables that are confusing, poorly constructed and/or not well-annotated? Figure and tables are adequately presented 5 Biostatistics: Does the author provide perfect biostatistics data? Or, does the author provide tables and line charts that have mistakes in the data? Standard statistical approach is used in the current study with respect to study design 6 References: Does the author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study? Or, does the author self-cite, omit, mis-cite and/or over-cite references? Appropriate 7 Language: Does the language in article correctly, clearly and concisely express the information? Or, does the article have multiple grammatical and spelling mistakes? Acceptable format, formal and scientifically clear 8 Caveats or drawbacks: What are the caveats or drawbacks for the results? Single center results Lower sample size which might effect on statistical significance Transparency in methodology " [Collapse]

Stawarz K, Gorzelnik A, Klos W, Korzon J, Kissin F, Bienkowska-Pluta K, Stawarz G, Rusetska N, Zwoliński J. Prognostic value of clinicopathological parameters in adenoid cystic carcinoma: A retrospective cohort study. World J Clin Oncol 2026; 17(4): 116329

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer ..." [Read more]

"This review article explores the complex relationship between nutrition, ultra‑processed food consumption, and colorectal cancer development. It highlights how diets rich in additives, refined sugars, and industrial fats contribute to dysbiosis, inflammation, and oxidative stress, thereby increasing cancer risk. Conversely, dietary interventions such as fasting, caloric restriction, and ketogenic regimens show promise in reprogramming tumor metabolism and enhancing therapeutic responses. The authors emphasize that while mechanistic evidence is strong, clinical studies remain limited, heterogeneous, and often small in scale. Overall, the paper underscores the potential of personalized nutrition as a complementary strategy in colorectal cancer prevention and treatment, but stresses the need for well‑designed trials to validate safety, adherence, and long‑term outcomes." [Collapse]

Lima RSP, Sousa JDS, Neres MSO, de Sousa DJM, Martins JA, Pereira IC, da Silva ACA, Severo JS, Torres-Leal FL, da Silva MTB. Colorectal cancer therapy and nutrition: From ultra-processed consumption to metabolic reprogramming. World J Gastrointest Oncol 2026; 18(4): 115511

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing ..." [Read more]

"This article provides valuable insight into the role of CD161⁺CD8⁺ T cells in HBV‑associated hepatocellular carcinoma, emphasizing their contribution to T‑cell exhaustion. The study highlights that PD‑1 inhibitors reduce PD‑1⁺ subsets but fail to affect CD161 expression, suggesting independent regulatory mechanisms. These findings underscore CD161 as a distinct and promising immunotherapeutic target, complementing but not overlapping with PD‑1 blockade strategies. While the evidence is compelling, broader patient cohorts and longitudinal studies will be essential to confirm clinical relevance and therapeutic potential." [Collapse]

Liu CR, Zhang M, Wang MQ, Zhang W, Li J, Shi GZ, Liang FF, Li YP, Huang N. CD161⁺CD8⁺ T cells in patients with hepatitis B virus-associated hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 114547

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates ..." [Read more]

"The study presents a novel synthetic lethality strategy combining atorvastatin and gefitinib for colorectal cancer. It demonstrates strong experimental evidence with both in vitro and in vivo validation, highlighting mechanistic clarity via the AMPK‑SREBP1 pathway. While promising and translational, limitations in sample size and treatment duration suggest further clinical validation is needed." [Collapse]

Huang JH, Ma JQ. HMGCR loss is synthetic lethal with PIK3CD inhibition in colorectal cancer cells. World J Gastrointest Oncol 2026; 18(4): 114220

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes ..." [Read more]

"The work is very interesting. In particular, the discussion is rich and leads to many insights into the relationship between diabetes and coronary heart disease (CAD) and how to address both simultaneously in a prevention strategy. This paper could be a trailblazer for further research investigating the use of other drugs currently used to treat both diabetes and CAD." [Collapse]

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report ..." [Read more]

"The authors deserve praise for coming up with a new and well-thought-out way to solve a difficult clinical problem. This case report beautifully shows how customised three-dimensional printed titanium ribs can be used successfully with bilateral flap coverage to fix a complicated chest wall defect. Combining cutting-edge 3D printing technology with sound reconstructive surgical principles is a forward-thinking approach that works well and looks good. The manuscript is well-organised, clearly written, and backed up by relevant clinical information and images. It gives thoracic and reconstructive surgeons a lot of useful information about planning before surgery, customising implants, and surgical techniques. This report adds important information to the growing field of personalised surgical reconstruction and sets a good example for how it can be used in the future." [Collapse]

Li XA, Chen JY, Bu J, Wu HW. Customized three-dimensional printed titanium ribs combined with bilateral flaps for reconstruction of chest wall defect: A case report. World J Orthop 2026; 17(4): 117533

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral ..." [Read more]

"The manuscript "Management and Prevention of Iatrogenic Ipsilateral Femoral Neck Fracture During Intramedullary Nailing of Femoral Shaft" talks about a clinically important but often overlooked problem in orthopaedic trauma surgery. The authors did a great job of stressing how important it is to be careful during intramedullary nailing. They also talked about both ways to avoid problems and how to handle them when they do happen. The article is well-organised, with a clear progression from identifying the problem to finding solutions that work. The focus on early diagnosis, safety measures during surgery, and imaging protocols adds a lot of clinical value. The section on technical details and surgical tips is especially interesting, making the paper very useful for both new and experienced surgeons. The manuscript adds to the existing body of literature by putting together current evidence and making recommendations that can help lower complication rates and improve patient outcomes. In general, this article is well-written, informative, and useful in a clinical setting, so it should be published." [Collapse]

Nallakumarasamy A, Vetrivel VN, Balaji VP, Yadav R, Jeyaraman N, Muthu S, Jeyaraman M. Management and prevention of iatrogenic ipsilateral femoral neck fracture during intramedullary nailing of femoral shaft. World J Orthop 2026; 17(4): 116107

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Sakurai R, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Perforative peritonitis caused by long-term retention of a rectal foreign body: A case report. World J Clin Cases 2026; 14(11): 119572

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated ..." [Read more]

"Congratulations on the publication of your paper. This is a significant achievement, and I am delighted to see that your dedicated efforts in daily clinical practice and academic work have borne fruit. I read your paper with great interest, particularly because my own specialty is emergency medicine. I also occasionally encounter cases of anorectal foreign bodies in clinical practice, and I believe your paper will serve as a highly valuable reference for the management of such cases in the future. The manuscript is very well organized, clear, and easy to follow. In addition, it incorporates up-to-date information and presents the topic in a balanced and informative manner. Overall, I consider this to be a high-quality paper of substantial clinical value. In recognition of these strengths, I would give this work the highest evaluation. Writing and publishing a paper while maintaining a busy clinical workload is no small accomplishment, and I sincerely hope that you will continue to build on this success and further expand your academic achievements. Congratulations once again on this excellent work." [Collapse]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside ..." [Read more]

"5-FU is the basis of the therapeutic regimens for the pharmacological treatment of gastric cancer (GC). However, the main downside of this treatment is the development of resistance, which, understandably, negatively affects patients’ clinical outcomes. Therefore, innovative therapeutic strategies are needed to overcome 5-FU resistance and improve the prognosis of GC. The authors of the study under review investigated the effects of Xiangshaliujunzi decoction (XSLJZD) on GC cell lines. They found that XSLJZD inhibited cell viability and proliferation, while promoting PANoptosis in 5-FU-resistant cells. Suppression of ZEB1 increased pyroptosis, apoptosis, and the expression of other proteins associated with programmed cell death. The selection of this work for comment was based on two reasons: i) the use of complementary therapy, whether or not based on traditional Chinese Medicine in the treatment of various benign and malignant digestive disorders, should be adopted internationally. The results are no longer empirical but are based on valid clinical and laboratory data, ii) The authors, in designing their study, among other things, investigated the effect of PANoptosis processes (apoptosis, pyroptosis, and necroptosis) which are a very hot topic of research internationally not only in malignant digestive diseases, but also in a host of other benign conditions such as inflammatory bowel disease. Their results, although experimental, reinforce the view that XSLJZD overcomes 5-fluorouracil (5-FU) resistance in GC by inducing PANoptosis." [Collapse]

Gao H, Yin DF, Xing XR, Zhou LJ, Yu R. MiR-200a-3p/ZEB1/IRF1-mediated PANoptosis prompts Xiangshaliujunzi decoction to overcome 5-fluorouracil resistance in gastric cancer. World J Gastroenterol 2026; 32(14): 114331

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication ..." [Read more]

"This draft provides a clear and engaging overview of diabetic retinopathy (DR), presenting it as more than just a vascular complication and highlighting its neurovascular nature. Diabetic retinopathy (DR), and its effective explanation as a complex, multifactorial, and increasingly recognized neurovascular disorder rather than solely a microvascular complication. The paper effectively emphasizes the global burden of the disease and the limitations of current treatments, especially anti-VEGF therapies, while drawing attention to the importance of early retinal changes. One of the main strengths of the review is its broader perspective beyond glucose control. The discussion of inflammation, lipid metabolism, and immune processes is well integrated and reflects current thinking in the field. The discussion of broader perspective as “beyond-glycemia” framework, reinforcing the need for multidimensional therapeutic strategies. The writing flows logically, making complex mechanisms easier to follow. The section on the gut-retina axis is particularly interesting and adds a fresh dimension to the topic. It clearly explains how gut microbiota may influence retinal health through metabolic and immune pathways. The inclusion of microbial metabolites, extracellular vesicles, and immune modulation as mediators of gut-retina communication demonstrates a developed understanding of the current evidence. Overall, the draft is well-organized, informative, and forward-looking, with a strong focus on potential new therapies and future research directions. " [Collapse]

Zeppieri M, Drigo A, Capobianco M, Visalli F, Cappellani F, Musa M, Giglio R, Tognetto D, Khouyyi M, Gagliano C, D’Esposito F, Inferrera L. Beyond glycemia: The influence of systemic inflammation, lipids, and the gut-retina axis in diabetic retinopathy. World J Diabetes 2026; 17(3): 114603

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective ..." [Read more]

"It has been stated that PPI s alone are good effective for aspirin induced gastrointestinal bleeding, but not sufficiently effective for clopidogrel induced gastrointestinal bleeding. However,co-administration with rebamipide provides sufficient hemostatic effect. Please comment the reason why pPI with rebamipide is good effect for the gastrointestinal bleeding with clopidogrel. Please comment the side effect of long term with pPI use." [Collapse]

Kim M, Chi SA, Kim JE, Kim ER, Hong SN, Kim YH, Kim K, Chang DK. Optimal strategies for mitigating gastrointestinal bleeding in patients receiving antiplatelet therapy: Real-world study. World J Gastroenterol 2026; 32(14): 115790

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and ..." [Read more]

"The article explains very well the relevance of the Boruta variables in the clinical-endoscopic model for AIG-associated G-NETs and clearly highlights its strengths and limitations. The text structure is good, and the logical presentation of information facilitates the understanding of the process and the mechanisms involved. In addition, the text is grammatically correct, managing to present new perspectives on how feature selection and the integration of clinical and endoscopic biomarkers can contribute to risk stratification and personalized management of patients with AIG. This approach makes a clear contribution to the specialized literature, opening avenues for future research and practical application of predictive models. " [Collapse]

Yu QQ. Risk stratification of gastric neuroendocrine tumors in autoimmune gastritis: Evaluating the clinical value of an integrated clinical-endoscopic model. World J Gastroenterol 2026; 32(13): 115440

"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was ..." [Read more]

"This is a well-written and presented a rare case report on Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor. Careful questioning of a patient's medical history is crucial for avoiding misdiagnosis and inappropriate treatment. In this case, the failure to carefully question the patient's medical history at the outset is a deficiency. I think that this manuscript is suitable and worth to be published in World Journal of Gastrointestinal Surgery. " [Collapse]

Li ZK, Zhang K, Zhang HL, Lv XL, Guo JQ, Tan W. Splenic tuberculous mass following anti-tuberculosis therapy was misdiagnosed as a splenic tumor: A case report. World J Gastrointest Surg 2026; 18(3): 115137

" The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance ..." [Read more]

" The article meets basic ethical standards with reported approval, though fuller disclosure of consent procedures would enhance transparency. The methodology is appropriate and largely reproducible, but lacks some detail on controls and implementation, limiting full replication. Results are logically presented and consistent with the study design, providing partial support for the hypothesis, though broader generalizability is constrained. Figures and tables are relevant but occasionally insufficiently annotated, reducing clarity. Biostatistical analysis is acceptable, yet could be strengthened through more comprehensive reporting of effect sizes and confidence intervals. References are generally current and relevant, although inclusion of additional recent key studies would improve scholarly depth. The language is clear and mostly concise, with minor grammatical issues. Key limitations include a relatively small and possibly non-representative sample, potential bias, and inadequate discussion of confounding factors, all of which may affect the strength and applicability of the conclusions. " [Collapse]

Chen X, Zhang LL, Zhou Y, Dong DX, Qian XY. Mitochondrial autophagy in diabetes-related cognitive decline and skin ulcers: Mechanistic insights and therapeutic implications. World J Diabetes 2026; 17(3): 112177

"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met ..." [Read more]

"This is a single-center, double-blind, randomized, placebo-controlled trial that enrolled a sufficient number of patients who met the Rome IV diagnostic criteria for FD. Patients were randomized to receive LPZ (30 mg once daily) in combination with FM (flupenthixol 0.5 mg + melitracen 10 mg) or a matching placebo for 2 weeks, followed by a 4-week follow-up. At week 2, the clinical response rate was higher in the LPZ + FM group than in the placebo group. The LPZ + FM group showed greater reductions in PDS, SF-NDI, PHQ-9, Generalized Anxiety Disorders-7, and Pittsburgh Sleep Quality Index scores, with improvements maintained throughout the follow-up. The first comment concerns the usefulness of such studies. These studies are very useful in daily clinical practice precisely because of the magnitude of the problem worldwide. The second comment concerns the study design. In my opinion, another pure group could be included that would receive only the FM combination. The results could separate the percentage contribution of each regimen to the final clinical outcome. In any case, as the authors note, multicenter studies are required to demonstrate the effectiveness of a combination of pharmaceutical agents for the treatment of this frequent and condition with significant functional consequences." [Collapse]

Wang XY, Yin KH, Cheng L, Wang XY, Qiao Y, Tang XR, Wang B, Yan XJ, Chen SL. Efficacy and safety of lansoprazole combined with flupentixol-melitracen for functional dyspepsia: A randomized, double-blinded, placebo-controlled clinical trial. World J Gastroenterol 2026; 32(13): 117115

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while ..." [Read more]

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while guidelines for several incidental findings already exist, consistent and integrated recommendations within radiology reports are lacking. The objectives of this proposal were clearly presented and well defined. The aims were to standardize terminology and decision-making for incidental findings while ensuring a transparent and reproducible link between the findings and their corresponding recommendations. Furthermore, the Incidental-Reporting and Data System (I-RADS) seeks to facilitate data collection and establish an infrastructure for artificial intelligence algorithms to learn from clearly labeled, standardized datasets—enabling machine learning, registries, and big-data research in ways that current fragmented guidelines cannot. Additionally, I-RADS can be integrated into structured reporting platforms, thereby streamlining the diagnostic workflow. I-RADS is not intended to replace existing guidance on incidental findings, such as the ACR recommendations, but rather to complement and consolidate them into a single, simplified cross-sectional system. The proposed I-RADS system features a conceptual framework designed to provide a unified and simplified approach to the classification and communication of incidental findings across imaging modalities and anatomical regions. The reviewer acknowledged that the proposal for the Incidental-Reporting and Data System represents an innovative effort with positive implications. However, unlike other systems, I-RADS must account for a wide range of miscellaneous conditions—such as aortic dissection, occult or chronic splenic rupture, thrombus in the left atrium or main pulmonary artery, retained foreign bodies, and displacement of iatrogenic grafts—which, while not malignant, are life-threatening or hazardous. These should be carefully considered. The methodology for the development of I-RADS requires revision, and the efficacy of the system needs to be validated." [Collapse]

Arkoudis NA, Moschovaki-Zeiger O, Koutserimpas C, Lama N, Velonakis G, Filippiadis D, Spiliopoulos S, Kelekis N. Proposing Incidental-Reporting and Data System: A classification system for incidental findings in radiology. World J Radiol 2026; 18(3): 119025

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and ..." [Read more]

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and causes highout for heart. Some patient after TIPS suffer from Eck and heart failure. Please comment about the diameter of TIPS and preoperative heart. What kinds of parameter for heart is suitable parameter for heart failure after TIPs? " [Collapse]

Zhang TQ, Zhang L, Yong X, Tian C, Chen BJ, Qin JP, Mu D, Tang SH. Transjugular intrahepatic portosystemic shunt for variceal bleeding due to hereditary hemorrhagic telangiectasia with cirrhosis: A case report. World J Gastroenterol 2026; 32(12): 119002

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Siyal M, Tahseen MU, Asim M, Niaz TS, Zakaria N, Leghari A, Niaz SK. Slipped and caught in the cecum: Endoscopic retrieval of a migrated foley feeding jejunostomy tube: A case report. World J Clin Cases 2026; 14(8): 118316

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive ..." [Read more]

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive screening tool for diagnosis and treatment indication. While abdominal ultrasound follow-up is recommended for patients with chronic liver disease, ultrasound elastography may allow for more appropriate screening of patients requiring esophageal varices via endoscopy. This is expected to reduce the need for upper gastrointestinal endoscopy, which is an uncomfortable procedure for patients, and enable more efficient medical care. Further large-scale prospective studies are needed to further validate the usefulness of this non-invasive assessment " [Collapse]

Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; 32(11): 115723

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Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 37068

Manuscripts received today: 1

Manuscript reviews today: 5

Unhandled manuscripts today: 175

Active peer-reviewers today: 898

Reviewer acceptance today: 5

Reviewer refusals today: 6

Total accepted manuscripts: 41164

Total rejected manuscripts: 45344

Total peer-reviewers: 4788960

Total submissions: 38835