Baishideng Publishing Group

Othman AAA, Elsharkawy L, Saleh MW, Mohamed MM, Elsayed FMA. Multimarker model for non-invasive assessment of variceal bleeding in chronic hepatitis C cirrhotic patients. World J Hepatol 2026; 18(3): 117040

"We would like to thank you and the editorial team for all the time and effort devoted to our manuscript. We are very pleased to see ..." [Read more]

"We would like to thank you and the editorial team for all the time and effort devoted to our manuscript. We are very pleased to see the article published online. We also greatly appreciate the careful handling of the paper throughout the review and production process. Thank you again for your professionalism, efficiency, and support in bringing our work to publication. " [Collapse]

Ying ZK, Xu XY, Hu JW, Cui Y, Jiang DW. Single-cell transcriptomics reveals a spermatogonial stem cell-centered spermatogenic microenvironment: Pathophysiological mechanisms and therapeutic targets in male infertility. World J Stem Cells 2026; 18(3): 118401

"I am pleased to share my feedback on the three evaluation surveys regarding my experience with this journal. First, concerning the ..." [Read more]

"I am pleased to share my feedback on the three evaluation surveys regarding my experience with this journal. First, concerning the journal's credibility, I found it to be highly reputable with transparent policies and strong ethical standards, which inspired confidence in submitting our work. Second, the peer review process was exceptionally professional and constructive; the reviewers provided insightful and detailed comments that significantly improved the quality of our manuscript, and the review timeline was reasonable. Overall, I am thoroughly satisfied with the entire publishing system. The editorial team was responsive, supportive, and maintained clear communication throughout, making this a smooth and positive experience. I commend the journal for maintaining high standards and fostering an author-friendly environment. This has been one of the best publishing experiences I have had, and I would gladly consider this journal for future submissions. " [Collapse]

Zhou ZX, Xiao JJ, Ning ZX. Advances in artificial intelligence for imaging-based diagnosis of hepatocellular carcinoma. World J Hepatol 2026; 18(3): 116233

"The publication reflects a highly professional and efficient editorial and peer-review process, where constructive and insightful ..." [Read more]

"The publication reflects a highly professional and efficient editorial and peer-review process, where constructive and insightful feedback significantly contributes to improving the clarity, rigor, and overall quality of the manuscript. The smooth communication, transparency, and meticulous handling at each stage demonstrate the journal’s strong commitment to maintaining high academic standards and supporting authors throughout the publication journey. " [Collapse]

Halphen J Jr, Ahmadzade M, Mankidy B, Berenji A, Ghasemi-Rad M. Letter to the Editor: Evidence for a two-step species-level pulmonary nocardiosis diagnostic approach. World J Radiol 2026; 18(3): 118126

"First of all, I would like to thank all the editors involved in publishing our manuscript this time. They are very professional, ..." [Read more]

"First of all, I would like to thank all the editors involved in publishing our manuscript this time. They are very professional, responsible, meticulous, and patient. I think this is also the fundamental reason why the World Journal of Stem Cells has been improving and becoming more and more successful. Second, the peer reviewers' comments are professional and keep pace with the forefront of development, which greatly helped us improve the quality of the manuscript and perfect the research logic. Finally, I would like to thank everyone's hard work again and look forward to continuing cooperation with the World Journal of Stem Cells in the future. " [Collapse]

Li YJ, Chen X, Luo YY, Chang J, Liu SZ, Shan XQ, Song JJ, Hao N, Yan XH, Gao WL, Liu JW, Zhao L. Acupuncture improves transplanted neural stem cells in dementia mice by modulating hippocampal microenvironment via microRNA-124 mediated Notch and Wnt pathways. World J Stem Cells 2026; 18(3): 114929

"We are highly satisfied with the editorial process, which has been consistently rigorous and thorough. The peer-review phase was ..." [Read more]

"We are highly satisfied with the editorial process, which has been consistently rigorous and thorough. The peer-review phase was excellent, providing insightful and timely feedback that significantly enhanced the overall quality of our manuscript. We would like to express our sincere gratitude to the editorial staff for their professionalism throughout the publication process. At this time, we have no further concerns or negative observations to report " [Collapse]

Hernández-Almonacid PG, Espejo-Amado JS, Marín-Quintero X. Autoimmune liver diseases in older adults: Clinical challenges and management considerations. World J Hepatol 2026; 18(3): 117367

"I would like to sincerely thank the editorial team for providing such a wonderful and enriching experience throughout the publication ..." [Read more]

"I would like to sincerely thank the editorial team for providing such a wonderful and enriching experience throughout the publication of this article. Every stage of the process was handled with remarkable transparency and efficiency, ensuring that timelines were respected and communication remained clear. The team’s dedication went beyond routine editorial work; they actively engaged in refining and curating the manuscript to enhance its overall quality, clarity, and readability. Their thoughtful guidance and constructive feedback not only improved the scientific rigor of the paper but also ensured that the final version would be more impactful and accessible to readers. " [Collapse]

Muthu S, Natarajan KP, Viswanathan VK, Kolarpatti Ponnusamy DV, Satish Kumar RC, Sharun K, Jang HJ. Infrared thermography as adjunctive imaging in spine surgery: Evaluating thermal asymmetry for predicting symptomatic level and recovery. World J Radiol 2026; 18(3): 116736

"The submission system functions well and is easy to operate. The peer review process is efficient and well-organized, with comments ..." [Read more]

"The submission system functions well and is easy to operate. The peer review process is efficient and well-organized, with comments that are objective, professional, and helpful for revising and improving the manuscript. The editorial work is careful and standardized, and the publication arrangement is reasonable. The whole publishing service is satisfactory. " [Collapse]

Tang P, Nong QH, Xiong KH, Tang HH, Huang BB, Huang GL, Li Q, He SP, Chen G, Feng ZB, Li JD. Overexpression and clinicopathological significance of cullin-2 in hepatocellular carcinoma progression. World J Hepatol 2026; 18(3): 117134

"Thank you very much for publishing our manuscript in your esteemed journal. The review process was fair and rigorous, characterized ..." [Read more]

"Thank you very much for publishing our manuscript in your esteemed journal. The review process was fair and rigorous, characterized by thoughtful and constructive feedback that significantly improved the scientific quality and clarity of our work. We especially appreciate the dedication of the reviewers and the editorial team, whose efforts helped strengthen the methodology, refine the discussion, and enhance the presentation of our results. This has been a highly valuable experience, and we look forward to the opportunity to collaborate with your prestigious journal again in the future. Best Regards Professor Marcio Concepción-Zavaleta " [Collapse]

Fuentes-Mendoza JM, Concepción-Zavaleta MJ, Mendoza-Godoy JJ, Concepción-Urteaga LA, Martínez-Gutiérrez CO, Paz-Ibarra J. Dyslipidemia in liver cirrhosis: Pathophysiology and emerging therapeutic approaches. World J Hepatol 2026; 18(3): 115539

"I am grateful to everyone involved in the process of publishing our manuscript for their very professional and friendly attitude. ..." [Read more]

"I am grateful to everyone involved in the process of publishing our manuscript for their very professional and friendly attitude. The journal's editors were very understanding of the technical difficulties the authors encountered and did everything possible to ensure their prompt and successful resolution. The reviewers' comments were highly professional and contributed to the manuscript's improved quality. " [Collapse]

Plakida A, Iushkovska O, Sierpińska LE. Metabolically associated fatty liver disease: What hepatologists need to know about this systemic disease. World J Hepatol 2026; 18(3): 113284

"The peer review process was remarkably efficient and highly constructive. The reviewers provided detailed, insightful, and valuable ..." [Read more]

"The peer review process was remarkably efficient and highly constructive. The reviewers provided detailed, insightful, and valuable comments that not only greatly improved the quality and clarity of our manuscript but also helped us refine our research logic and strengthen our conclusions. We are extremely satisfied with the professional, meticulous editorial work and the seamless publication experience with the journal. The entire team demonstrated great patience and expertise, making the publication journey smooth and rewarding. We sincerely appreciate their efforts and look forward to potential future collaborations. " [Collapse]

Zhang XY, Li YK, Tian ZB, Guo QY, Liu JN, Liu RQ, Ren KY. Predictive model for vedolizumab efficacy in moderate-to-severe ulcerative colitis based on computed tomography-derived body compositions and nutritional inflammatory markers. World J Radiol 2026; 18(3): 117599

"My experience with publishing in the World Journal of Radiology has been consistently positive. The publication process has always ..." [Read more]

"My experience with publishing in the World Journal of Radiology has been consistently positive. The publication process has always been smooth and up to standard. The peer review comments are generally constructive and helpful. The helpdesk and editorial office respond quickly to any issues or questions. I would recommend publishing with WJR, as I have continued to do. " [Collapse]

Arkoudis NA, Moschovaki-Zeiger O, Koutserimpas C, Lama N, Velonakis G, Filippiadis D, Spiliopoulos S, Kelekis N. Proposing Incidental-Reporting and Data System: A classification system for incidental findings in radiology. World J Radiol 2026; 18(3): 119025

"I would like to express my satisfaction with the overall editorial and publication process of the journal. The online submission system ..." [Read more]

"I would like to express my satisfaction with the overall editorial and publication process of the journal. The online submission system was user-friendly and efficient. The peer review process was well-organized, and the reviewers provided constructive and valuable feedback that improved the quality of our manuscript. The editing and formatting of the article, including figures and tables, were handled professionally. The final published version, both in PDF and online full-text format, met high academic standards. Overall, the journal maintains a rigorous and transparent publication process, and I appreciate the efforts of the editorial team and reviewers. Thank you for your contribution to the dissemination of high-quality scientific research. " [Collapse]

Tahtabasi M, Kaya E, Yalcin M, Kaya V. Percutaneous vs surgical management of World Health Organization cystic echinococcosis 1 and 3a liver hydatid cysts. World J Gastroenterol 2026; 32(3): 114226

"Thank you to the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company ..." [Read more]

"Thank you to the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor, and the entire World Journal of Clinical Oncology team for their efforts throughout the publication process of our manuscript. My colleagues and I are honored to be published in this high-quality, high-impact journal! The journal's consideration of manuscripts was fast, the peer review process was open and transparent, and the review results were professional. The entire team of World Journal of Clinical Oncology is very hard-working, friendly, and professional. I look forward to the opportunity for me and my colleagues to submit another manuscript to World Journal of Clinical Oncology. " [Collapse]

He YF, Wang HZ, Bian N, Hu XD, He QT, Liu JQ, Li HM, Lu SF, Wu N. Correlation between bariatric surgery and breast cancer risk in women: A systematic review and meta-analysis. World J Clin Oncol 2026; 17(3): 114774

"The submission process for World Journal of Clinical Oncology was smooth and efficient. The editorial team was highly responsible, ..." [Read more]

"The submission process for World Journal of Clinical Oncology was smooth and efficient. The editorial team was highly responsible, providing timely and constructive guidance. Each step of the workflow was transparent, compliant, and professionally handled. I greatly appreciate the journal’s rigorous standards and supportive communication throughout the review and publication process. " [Collapse]

Li SH, Liu ZS, Chen YJ, Li JD, Wei L, Chen YY, Zhang W, Huang ZG, Chen ZD, Chen G, Wei DM, Mo ZN, Deng LL. PIGU overexpression and regulation of cellular biological functions in bladder cancer. World J Clin Oncol 2026; 17(3): 117055

"Overall, this was a challenging publication experience. We were initially invited to submit this review to World Journal of ..." [Read more]

"Overall, this was a challenging publication experience. We were initially invited to submit this review to World Journal of Gastroenterology, and after completing two rounds of revisions, we were informed that the manuscript would instead be considered for a sister journal. While we understand that editorial priorities can change, this transition at a late stage was somewhat unexpected and difficult from an author perspective. In addition, the peer review and revision process could benefit from improved clarity and usability. The instructions from the editorial office were at times unclear, and the submission platform was not particularly intuitive, which led to avoidable inefficiencies and additional time spent on formatting and administrative steps. A more streamlined and transparent process would significantly enhance the overall experience for authors. Given these considerations, we would carefully weigh future submissions to this publisher. " [Collapse]

Pham HT, Dong ZY, De Alba M, Cottle C, Zhang MY, Parker JB, Morecroft-Phillipps R, Chaludiya K, Ingram D, Ahmad AN, Zeng Z, Mohseni MM, Zhang ZZ, Rueda Prada L, Ali M, Yang V. Immunotherapy in liver metastases: Challenges, emerging evidence, and future directions. World J Clin Oncol 2026; 17(3): 116093

"I would like to thank the editorial team, staff, and reviewers for their time and consideration. Over the years, the submission and ..." [Read more]

"I would like to thank the editorial team, staff, and reviewers for their time and consideration. Over the years, the submission and review process has evolved significantly. The submission process has been streamlined. The author's area has a live update of the process, and any discussion/decision can be viewed and tracked through the portal. Over the years, not only has the reviewers' response time improved, but the quality has also improved, which has helped enhance the manuscript's quality. The communication and site stability have significantly improved. The editing and production department has been very thorough. Once again thanks for allowing us to contribute our work in the journal " [Collapse]

Faheem MSB, Hassan ST, Feroze F, Khan A, Munir SU, Khaliq A, Fatima ST, Mendonca R, Surani S. Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation. World J Clin Cases 2026; 14(8): 118582

"I was highly satisfied with both the submission and peer review process. The system was clear, efficient, and user-friendly, allowing ..." [Read more]

"I was highly satisfied with both the submission and peer review process. The system was clear, efficient, and user-friendly, allowing for smooth communication and timely updates. The reviewers provided constructive and insightful feedback, which significantly improved the quality of the manuscript and contributed positively to the overall publication experience. Thank you " [Collapse]

Kalamara TV, Dodos K, Georgakopoulou VE. Immunoglobulin replacement therapy and infection risk in chronic lymphocytic leukemia: A systematic review and meta-analysis. World J Clin Cases 2026; 14(9): 118210

"One of the reviewer's was very abrasive and should not be a reviewer. He even accused us of not being Native English speakers. When ..." [Read more]

"One of the reviewer's was very abrasive and should not be a reviewer. He even accused us of not being Native English speakers. When asked for a new reviewer, the journal did not supply a new reviewer but instead just altered their comments to make it seem that they did not make any derogatory comments. " [Collapse]

Kakooza J, Akankwasa P, Mugabe S, Kiadii BK, Lewis CR. Blunt esophageal injury in a pediatric patient: A case report. World J Clin Cases 2026; 14(9): 118553

"I am very satisfied with the entire review and publication process. From the initial submission to the final stages, everything was ..." [Read more]

"I am very satisfied with the entire review and publication process. From the initial submission to the final stages, everything was handled in a highly professional and well-organized manner. The communication throughout the process was clear, timely, and helpful, which made it easy to follow each step and understand what was expected at every stage. I especially appreciate the professionalism of the team and their quick and effective responses whenever any issues or questions arose. Their willingness to address concerns and provide guidance contributed significantly to a smooth and positive overall experience. It is evident that a great deal of care is put into maintaining high standards in both the review and publication procedures. The only aspect that I believe could be improved is the length of time between submission and final publication. While I understand that thorough reviews require time and attention, a shorter turnaround period would make the process even more efficient and beneficial for authors. " [Collapse]

Corovic IF, Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, Radosavljevic GD, Simovic Markovic BJ. ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death. World J Gastroenterol 2026; 32(12): 114576

21034 items Read more >>

Article Quality Tracking-Peer-Review

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while ..." [Read more]

"This is a compelling topic with significant clinical relevance. The development of this system stems from a key gap: while guidelines for several incidental findings already exist, consistent and integrated recommendations within radiology reports are lacking. The objectives of this proposal were clearly presented and well defined. The aims were to standardize terminology and decision-making for incidental findings while ensuring a transparent and reproducible link between the findings and their corresponding recommendations. Furthermore, the Incidental-Reporting and Data System (I-RADS) seeks to facilitate data collection and establish an infrastructure for artificial intelligence algorithms to learn from clearly labeled, standardized datasets—enabling machine learning, registries, and big-data research in ways that current fragmented guidelines cannot. Additionally, I-RADS can be integrated into structured reporting platforms, thereby streamlining the diagnostic workflow. I-RADS is not intended to replace existing guidance on incidental findings, such as the ACR recommendations, but rather to complement and consolidate them into a single, simplified cross-sectional system. The proposed I-RADS system features a conceptual framework designed to provide a unified and simplified approach to the classification and communication of incidental findings across imaging modalities and anatomical regions. The reviewer acknowledged that the proposal for the Incidental-Reporting and Data System represents an innovative effort with positive implications. However, unlike other systems, I-RADS must account for a wide range of miscellaneous conditions—such as aortic dissection, occult or chronic splenic rupture, thrombus in the left atrium or main pulmonary artery, retained foreign bodies, and displacement of iatrogenic grafts—which, while not malignant, are life-threatening or hazardous. These should be carefully considered. The methodology for the development of I-RADS requires revision, and the efficacy of the system needs to be validated." [Collapse]

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and ..." [Read more]

"TIPS is good procedure for esophageal varix. This procedure is portal vein -hepatic vein shunt. TIPS decrease portal pressure and causes highout for heart. Some patient after TIPS suffer from Eck and heart failure. Please comment about the diameter of TIPS and preoperative heart. What kinds of parameter for heart is suitable parameter for heart failure after TIPs? " [Collapse]

Zhang TQ, Zhang L, Yong X, Tian C, Chen BJ, Qin JP, Mu D, Tang SH. Transjugular intrahepatic portosystemic shunt for variceal bleeding due to hereditary hemorrhagic telangiectasia with cirrhosis: A case report. World J Gastroenterol 2026; 32(12): 119002

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied" [Collapse]

Siyal M, Tahseen MU, Asim M, Niaz TS, Zakaria N, Leghari A, Niaz SK. Slipped and caught in the cecum: Endoscopic retrieval of a migrated foley feeding jejunostomy tube: A case report. World J Clin Cases 2026; 14(8): 118316

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive ..." [Read more]

"Researchers have concluded that elastography can provide an objective assessment of esophageal varices and may serve as a non-invasive screening tool for diagnosis and treatment indication. While abdominal ultrasound follow-up is recommended for patients with chronic liver disease, ultrasound elastography may allow for more appropriate screening of patients requiring esophageal varices via endoscopy. This is expected to reduce the need for upper gastrointestinal endoscopy, which is an uncomfortable procedure for patients, and enable more efficient medical care. Further large-scale prospective studies are needed to further validate the usefulness of this non-invasive assessment " [Collapse]

Martínez-Díaz FM, Jiménez-Cuevas EA, Morales-Galicia AE, Ramírez-Mejía MM, Qi XS, Poo JL, Méndez-Sánchez N. Toward noninvasive prediction of treatment outcomes in patients with variceal bleeding. World J Gastroenterol 2026; 32(11): 115723

"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares ..." [Read more]

"It has long been established that respiratory and digestive diseases coexist in a proportion of patients. This coexistence shares significant pathogenetic mechanisms, including microbial, immunological, and metabolic pathways. The combined clinical manifestations of two different systems often require complex therapeutic interventions. Thus, in recent years, the lung-gut axis has emerged as equally important, underscoring the complex bidirectional regulatory network between gastrointestinal and respiratory diseases. The clinical coexistence of digestive and respiratory system diseases in the same patient poses both diagnostic and therapeutic challenges, and their management should be rational and effective, aiming to reduce the risk of worsening the underlying diseases. The treatment of these coexisting pathological conditions requires a deep knowledge of their pathophysiology and significant experience in treating them. The need for cooperation between the gastroenterologist and the pulmonologist for the most rational treatment of patients is self-evident. This cooperation for the treatment of combined digestive diseases with diseases of other systems, in my opinion, will be increasingly required in the coming years, as the common pathogenetic mechanisms are clarified and the therapeutic quiver is enriched with new pharmaceutical agents." [Collapse]

Huang HJ, Liu PP, Dong DF. Research progress on comorbidity between gastrointestinal and pulmonary diseases from the perspective of the gut-lung axis. World J Gastroenterol 2026; 32(11): 115846

"Review summary and Recommendations 1. Clinical Context: Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. ..." [Read more]

"Review summary and Recommendations 1. Clinical Context: Walled-off pancreatic necrosis (WON) is heterogeneous in clinical course. While some patients resolve with transmural drainage alone, others deteriorate and require direct endoscopic necrosectomy (DEN). Chronological criteria, such as the 4-week cutoff in the revised Atlanta classification, do not reliably predict clinical trajectory. 2. Key Findings: o Persistent sepsis, systemic inflammatory response syndrome (SIRS), hypoalbuminemia, anemia, extensive necrosis (>30–40%), and unfavorable anatomical patterns predict drainage failure and DEN requirement. o Lone et al’s predictive model (AUC 0.892) demonstrates strong discriminative ability, supporting early identification of patients unlikely to respond to drainage alone. o The concept of “passive drainage failure” captures patients at high risk, characterized by large solid debris, compartmentalized collections, and persistent systemic inflammation. 3. Step-Up vs Upfront DEN: o Timing should not be guided solely by predefined intervals but by individualized risk assessment. o Step-up strategies minimize unnecessary interventions but may delay care in high-risk patients. o Upfront DEN can prevent deterioration in selected patients but carries higher procedural risk if overused. o Guidelines support necrosectomy in cases of persistent sepsis, cavity compartmentalization, or failure of cavity collapse despite adequate drainage. 4. Safety Considerations: o DEN is effective but carries 15–30% complication rates, including bleeding, perforation, stent occlusion, and infection exacerbation. o Deferring DEN in patients with ongoing infection or high necrotic burden may worsen outcomes and complicate later intervention. o Risk stratification is essential to balance procedural risk against the risk of inaction. 5. Future Directions: o Integration of multivariate risk models, incorporating clinical, biochemical, and imaging variables, may individualize timing decisions. o AI and machine learning could enhance predictive accuracy, using longitudinal data and quantitative necrosis assessment. o The paradigm shift is toward intervention guided by patient-specific risk rather than temporal thresholds. Recommendations 1. Clinical Practice: o Implement early risk stratification in all WON cases to identify patients at high risk of drainage failure. o Reserve step-up strategies for low-to-moderate risk patients and consider early DEN for high-risk phenotypes. o Monitor clinical, laboratory, and imaging markers closely to guide escalation decisions. 2. Research: o Validate predictive models like Lone et al’s across larger, multi-center cohorts. o Investigate AI-driven, real-time risk scoring systems integrating necrosis quantification and host response metrics. o Explore the interplay of nutritional status, necrosis morphology, and systemic inflammation as modifiers of intervention timing. 3. Guideline Implications: o Guidelines should emphasize risk-based rather than time-based criteria for DEN. o Step-up and upfront strategies should be framed as complementary, with risk stratification as the central decision-making tool. Bottom Line: Timing of DEN should transition from protocol-driven intervals to personalized, risk-guided decisions. Intervention becomes appropriate when waiting poses greater risk than acting. " [Collapse]

Singeap AM, Chiriac S, Minea H, Trifan A. Between step-up and upfront intervention: Risk stratification as the missing link in timing endoscopic necrosectomy. World J Gastrointest Endosc 2026; 18(3): 116865

"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, ..." [Read more]

"This is a high-level evaluation of a study or meta-analysis that summarizes its overall quality, reliability, strengths, limitations, and clinical relevance without going into excessive technical detail. It’s the type of assessment a clinician, journal reviewer, or guideline committee might write to quickly judge how much weight to give the study’s findings. Overall Quality: The meta-analysis includes 17 randomized controlled trials with 1,689 patients, representing a moderate-to-high-quality evidence base. The search strategy was comprehensive, covering multiple international and Chinese databases, which minimizes publication bias. Strengths: • Large, pooled sample size with randomized controlled trial design. • Direct comparison between minimally invasive ES and standard TS. • Evaluates both efficacy and safety, including recovery time and costs. • Clinically relevant outcomes such as bleeding, prolapse, complications, and hospital stay. Limitations: • Variation in ES and TS techniques across studies may introduce heterogeneity. • Follow-up durations were not consistently reported, limiting assessment of long-term outcomes and recurrence. • Most studies had relatively small individual sample sizes, which may affect statistical power for less common complications. Clinical Relevance: • Provides strong evidence that ES is a safe, effective, and cost-efficient alternative to TS. • Supports adoption of ES as a first line minimally invasive option for internal hemorrhoid treatment, especially for patients seeking faster recovery. Conclusion: The meta-analysis is methodologically sound and clinically meaningful. While some heterogeneity exists, the findings are consistent and indicate that ES offers meaningful advantages over TS in terms of safety, recovery, and cost. Further large-scale, multicenter studies with standardized protocols would strengthen the evidence base. " [Collapse]

Wu SY, Chen YS, Li XH, Yu TJ, Xie F, Jiang QF, Lan Y, He P, Li SC, Li WS, Chen WD. Efficacy and safety of endoscopic sclerotherapy vs traditional surgery in the treatment of internal hemorrhoids: A meta-analysis. World J Gastrointest Endosc 2026; 18(3): 116697

"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during ..." [Read more]

"Summary: This study presents an exploratory analysis of bilateral upper limb sEMG activity in an experienced endoscopist during simulated colonoscopy, focusing on different bowel loop configurations. Key findings include: • Muscle activation and fatigue: Complex loops significantly increase muscle load and fatigue, particularly in the left extensor digitorum and stabilizing muscles like the left flexor carpi radialis and right middle deltoid. • Bilateral asymmetry: The left arm consistently sustains high activation, while the right arm shows task-specific activation, suggesting differential biomechanical demands for gross stabilization versus fine manipulation. • Correlation with procedure duration: Longer insertion times are associated with more rapid fatigue in stabilizer muscles. • Implications: These results objectively demonstrate increased biomechanical demand during challenging colonoscopy maneuvers, supporting the need for ergonomic interventions, workload management, and device design optimization. Strengths: • Comprehensive sEMG analysis across 14 bilateral muscles with high temporal resolution (1500 Hz). • Clear differentiation of muscle load and fatigue patterns across loop types. • Quantitative correlation between loop complexity, insertion time, and fatigue metrics. • Direct applicability to ergonomic and occupational health improvements in endoscopy. Limitations: • Single-operator study limits generalizability. • Simulation model may not fully capture anatomical variability and real-world procedural stress. • Small sample size; statistical power and inter-operator variability not addressed. Recommendations: 1. Manuscript refinement: Emphasize novelty and clinical relevance, particularly the practical applications for ergonomic device design and occupational safety protocols. 2. Future research: Recommend multi-operator studies to validate muscle activation patterns across experience levels and real-world procedures. 3. Ergonomic integration: Suggest incorporating findings into colonoscopy training programs and device evaluation to reduce repetitive strain injuries. 4. Data visualization: Consider additional heatmaps or muscle activation timelines to highlight asymmetry and fatigue progression, enhancing interpretability for clinicians. Overall Assessment: The study provides valuable, objective biomechanical data supporting ergonomic improvements in colonoscopy. With minor clarifications and broader context regarding clinical translation, this manuscript is suitable for publication in this journal focusing on endoscopy, and also journals directing occupational health, or medical ergonomics. " [Collapse]

Wang RG, Wang YQ, Cao H. Bilateral upper limb surface electromyography analysis during single-operator colonoscopy: Implications for ergonomics and occupational health. World J Gastrointest Endosc 2026; 18(3): 116646

"Summary: This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing ..." [Read more]

"Summary: This retrospective cross-sectional study evaluated 801 patients with inoperable esophageal malignancies undergoing self-expandable metallic stent (SEMS) placement using the vertebral column and diaphragm as fluoroscopic landmarks. Patients ranged from 18–95 years (mean 50 ± 15), with 50.9% female. Dysphagia was the presenting symptom (mean duration 3.84 months), and squamous cell carcinoma was the predominant histology (74.16%). Tumors most commonly involved the middle third of the esophagus, and inoperability was primarily due to distant metastases (52.81%). Tracheoesophageal fistula was present in 6%, and the mean stricture length was 8.4 cm. Pre-stent dilatation was required in 17.4% of patients. SEMS lengths ranged from 8–18 cm. The landmark-based technique achieved 100% technical success without major immediate adverse events. Repeat interventions were minimal (1.87% re-stenting for tumor overgrowth; 1.37% dilatation for tumor ingrowth). Reviewer Comments: Strengths: *Large patient cohort with comprehensive demographic and tumor characteristics. *Clear demonstration of technical feasibility and safety of landmark-based SEMS placement. *Low rates of immediate complications and repeat interventions indicate procedural reliability. Limitations: *Retrospective design limits causal inference and generalizability. *Lack of comparative data with conventional SEMS placement techniques. *No formal assessment of patient-reported outcomes (e.g., dysphagia relief scores, quality of life). *Long-term stent patency and survival data are not reported. Recommendations: *Consider prospective, comparative studies to validate the landmark-based approach against standard techniques. *Include standardized patient-centered outcomes (dysphagia scoring, nutritional status, and quality of life). *Explore the applicability of this technique in anatomically complex or upper esophageal tumors. *Discussion could be strengthened by addressing limitations related to stent type, tumor morphology, and fluoroscopic variability. Overall Assessment: The study presents a practical, reproducible technique for SEMS placement using vertebral and diaphragmatic landmarks with excellent technical success. The findings are clinically relevant, particularly for high-volume centers performing palliative esophageal stenting. Future prospective studies are warranted to assess long-term outcomes and patient-centered benefits." [Collapse]

Siyal M, Asim M, Qureshi S, Ghazanfar S, Siddiqui AR, Ahmed N, Altaf A, Zakaria N, Yaseen A, Kakar F, Kadir S, Hasan MK, Niaz SK. Navigating self-expandable metallic stent placement in inoperable esophageal malignancies: A landmark-based technique using the vertebral column and diaphragm. World J Gastrointest Endosc 2026; 18(3): 116060

"This study underscores the importance of considering systemic immune modulation in H. pylori infection, particularly in DU patients, ..." [Read more]

"This study underscores the importance of considering systemic immune modulation in H. pylori infection, particularly in DU patients, and may inform future research on cytokine-mediated disease mechanisms and potential therapeutic strategies. Further, the study bridges gap between gastroenterology and systemic immunology, showing that H. pylori eradication can have meaningful systemic effects, which is clinically relevant for patient care, risk assessment, and possibly long-term outcomes. Furthermore, the findings suggest that H. pylori eradication confers systemic immunological benefits beyond the resolution of gastric pathology, including a distinct anti-inflammatory shift in duodenal ulcer patients. Incorporating disease-specific immune responses into clinical practice could support more personalized post-eradication monitoring and management. Future guidelines might consider systemic inflammation outcomes as an additional rationale for timely eradication, particularly in patients at risk for inflammation-related comorbidities." [Collapse]

de Melo FF, Lemos FFB, Leal RAOS, Rocha GA, de Magalhães Queiroz DM. Helicobacter pylori eradication is associated with systemic anti-inflammatory shift in duodenal ulcer patients compared to those with gastritis. World J Gastrointest Endosc 2026; 18(3): 116958

"Review Summary Report Review Notes: • The study addresses an important clinical question and provides practical guidance for ..." [Read more]

"Review Summary Report Review Notes: • The study addresses an important clinical question and provides practical guidance for treatment selection. • Retrospective design and relatively small sample size, especially in the stent group, limit the strength of conclusions. • Cost-effectiveness data are valuable but could be strengthened with more detailed breakdowns (e.g., procedural vs. post-procedural costs). • Future prospective studies or randomized trials could validate these findings and refine patient selection criteria for SEMS use. " [Collapse]

Yuan HF, Liu P, Guo CQ, Bi YH. Comparative study of self-expandable stent placement, bougie dilation, and balloon dilation for post-inflammatory oesophageal strictures. World J Gastrointest Endosc 2026; 18(3): 117303

"The manuscript addresses a highly relevant and timely topic in medical education. The focus on VR-based endoscopy training is ..." [Read more]

"The manuscript addresses a highly relevant and timely topic in medical education. The focus on VR-based endoscopy training is well-motivated given patient safety concerns and the growing adoption of simulation-based methods. The systematic review methodology is appropriate, and the results are clearly summarized. Overall, the manuscript is of interest to readers in gastroenterology, medical education, and simulation-based training. • Significance: Addresses a highly relevant topic in endoscopy training and patient safety; VR-based training is of growing interest. • Strengths: o Clear focus on multiple endoscopic procedures (EGD, colonoscopy, ERCP, EUS). o Adherence to PRISMA 2020 guidelines is noted. o Quantitative outcomes (odds ratios, P-values, competency scores) enhance rigor. o Balanced conclusion emphasizes VR as an adjunct to conventional training. • Major Points for Revision: o Provide detailed search strategy (databases, terms, date range) and inclusion/exclusion criteria; consider adding a PRISMA flow diagram. o Clarify study selection and screening process; report if independent reviewers were used. o Include risk-of-bias assessment for included studies using standard tools (e.g., Cochrane RoB 2, ROBINS-I). o Discuss heterogeneity across studies (simulator type, trainee experience, training duration) and its impact on results. o Address clinical relevance beyond skill metrics (e.g., patient outcomes, procedural complications, skill retention). o Standardize outcome reporting for clarity (odds ratios, mean ± SD, pass rates). • Minor Points: o Ensure consistent abbreviation usage (GIE vs GI endoscopy). o Simplify complex sentences for readability. o Include review registration information if available (e.g., PROSPERO). • Recommendation: Minor to moderate revision; manuscript is strong but would benefit from enhanced methodological transparency and discussion of heterogeneity and clinical impact. " [Collapse]

Gadour E, Miutescu B, Nica C, Taheri E, Al Saeed Z, Raheem B, Facciorusso A, AlQahtani MS. Virtual reality training for gastrointestinal endoscopy: A systematic review of efficacy and outcomes. World J Gastrointest Endosc 2026; 18(3): 117820

"Overall Assessment: This manuscript addresses a highly relevant and timely topic, evaluating the diagnostic performance of AI-assisted ..." [Read more]

"Overall Assessment: This manuscript addresses a highly relevant and timely topic, evaluating the diagnostic performance of AI-assisted colonoscopy for real-time colorectal polyp histology. The study is well-structured, with rigorous methodology and clear presentation of results. The findings, demonstrating that AI outperforms human endoscopists—particularly in less experienced operators—are clinically important. However, several aspects require clarification and elaboration to strengthen the manuscript’s impact and reproducibility. Major Comments: Search Strategy & Study Selection: Please provide full details of the literature search, including databases, search terms, date range, and inclusion/exclusion criteria. A PRISMA flow diagram would enhance transparency. Quality Assessment: Include a table summarizing QUADAS-2 risk of bias assessments for all studies. Clarify how studies with high risk of bias were considered in analyses. Heterogeneity: Substantial heterogeneity (I² = 74.3%) is reported. Consider subgroup or meta-regression analyses based on AI type, polyp characteristics, or endoscopist experience to explore sources of variability. Statistical Analysis: Clarify whether hierarchical or bivariate models were considered, as these are often preferred in diagnostic accuracy meta-analyses. Clinical Interpretation: Discuss the practical significance of AI’s improved accuracy, including potential impact on management decisions, optical biopsy strategies, and clinical workflows. Limitations: Explicitly address publication bias, spectrum bias, and generalizability of AI algorithms across centers. Also, note that AI technology is rapidly evolving, which may limit applicability of current findings. Minor Comments: Clarify the definition of “human experts” (experience, certification). *Specify polyp types included in the analysis. *Consider tables summarizing AI algorithms, training/validation datasets, and imaging modalities. *Streamline some sentences for readability and consistency in terminology. *Briefly mention future considerations such as cost-effectiveness, regulatory, and ethical implications of AI deployment. Recommendation: The manuscript is important and of high interest, but minor to moderate revisions are required to clarify methodology, address heterogeneity, and strengthen discussion of clinical applicability and limitations." [Collapse]

Curlej P, Soldera J. Artificial intelligence in predicting colorectal polyp histology: Systematic review and meta-analysis of diagnostic accuracy in real-time procedures. World J Gastrointest Endosc 2026; 18(3): 116381

"Post-ERCP pancreatitis (PEP) is comprehensive and clearly outlined both epidemiology and pathophysiology. The discussion appropriately ..." [Read more]

"Post-ERCP pancreatitis (PEP) is comprehensive and clearly outlined both epidemiology and pathophysiology. The discussion appropriately highlights the multifactorial nature of PEP and effectively integrates patient- and procedure-related risk factors. The emphasis on individualized risk assessment and evidence-based preventive strategies is well-placed. To further strengthen the manuscript for a critical audience, consider the following suggestions: 1. Clarify incidence ranges: You report an incidence of 3–15% in general populations and up to 40% in high-risk patients. Providing references for these ranges and defining “high-risk” explicitly (e.g., presence of multiple risk factors, prior pancreatitis, or sphincter of Oddi dysfunction) would enhance clarity. 2. Risk factor hierarchy: While multiple risk factors are listed, it may be helpful to indicate which factors carry the strongest evidence or highest odds ratios, perhaps in a table or figure. This helps readers quickly gauge clinical impact. 3. Preventive strategies: The paragraph mentions rectal NSAIDs, pancreatic stenting, hydration, and precut sphincterotomy. It could be strengthened by briefly noting the level of evidence or guideline recommendation for each (e.g., ESGE or ASGE guidelines), distinguishing strategies supported by strong randomized trials versus observational data. 4. Pharmacologic agents: The statement that agents like somatostatin, gabexate, and nafamostat have inconsistent efficacy is accurate, but citing meta-analyses or systematic reviews would make this more authoritative. 5. Emerging tools: Mentioning AI and risk prediction models is forward-looking. Consider briefly highlighting specific models that have shown promise or limitations, to give readers a sense of current clinical applicability. 6. Future directions: The call for standardization and validation is important. You might also suggest exploring combination preventive strategies and personalized approaches based on risk stratification, which would align with precision medicine trends. Overall, the paragraph is well-structured and readable, with a clear progression from epidemiology to pathogenesis, risk factors, prevention, and future directions. Addressing the points above would enhance rigor and utility for a specialist audience. " [Collapse]

Xu PW, Xu QQ, Yu Y, Jiao Y, Liu YH, Yang L. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2026; 18(3): 115736

"Clinically, the report is worthy. It clearly frames the problem, current solutions, and future directions. Cholangiocarcinoma is an ..." [Read more]

"Clinically, the report is worthy. It clearly frames the problem, current solutions, and future directions. Cholangiocarcinoma is an aggressive malignancy often diagnosed at an advanced stage due to nonspecific symptoms. Conventional imaging and ERCP-based sampling have limited sensitivity, with reported diagnostic yields of 50–70% for tissue acquisition. Digital single-operator cholangioscopy improves diagnostic accuracy to 85–95% through direct visualization and targeted biopsies and facilitates therapeutic interventions, including biliary drainage, stenting, photodynamic therapy, and radiofrequency ablation, with procedural complication rates typically <5%. Despite these advances, interobserver variability, operator expertise, and limited long-term outcome data remain challenges. Integration of artificial intelligence shows preliminary promise in real-time lesion characterization but requires prospective validation. Future studies should define comparative effectiveness, patient-centered outcomes, and standardized protocols to optimize cholangioscopy in multidisciplinary CCA management." [Collapse]

Musalia JG, Alzayyat S, Aljahdli ES, Al-Lehibi A, Lara LF, Gabr M. Cholangioscopy in the diagnosis and management of cholangiocarcinoma. World J Gastrointest Endosc 2026; 18(3): 115412

"The paper presents a clear and well-structured case report describing delayed intramural hematoma following Endoscopic submucosal ..." [Read more]

"The paper presents a clear and well-structured case report describing delayed intramural hematoma following Endoscopic submucosal dissection for a laterally spreading tumor. The case narrative is logical, clinically relevant, and supported by follow-up demonstrating complete resolution and a well-healed scar, which strengthens the clinical outcome. However, the scientific contribution is limited by several factors. The conclusion overgeneralizes from a single case, suggesting that conservative therapy is effective without acknowledging that broader evidence is required. The article also does not clearly define the novelty of the case relative to previously reported intramural hematomas after ESD. In addition, important clinical and procedural details such as lesion size, risk factors, hematoma characteristics, and rationale for management are lacking. The discussion of mechanisms and alternative treatment approaches is also minimal. Overall, the report is clinically informative but primarily descriptive, and it would be strengthened by clarifying its novelty, providing more procedural detail, and moderating the conclusion to reflect the limitations of a single-case observation. " [Collapse]

Xu YL, Zhang ML, Zhou HJ, Gao PJ, Zhang XN, Rao M. Giant rectal intramural hematoma following endoscopic submucosal dissection successfully treated with conservative therapy: A case report. World J Gastrointest Endosc 2026; 18(3): 115257

"This article interprets the 5% plateau time model for colonoscopy in colonic diverticular bleeding and emphasizes that a 40-minute ..." [Read more]

"This article interprets the 5% plateau time model for colonoscopy in colonic diverticular bleeding and emphasizes that a 40-minute observation period should be treated as a flexible minimum floor rather than a rigid rule. By framing observation time as a “time-to-yield” curve, we propose practical strategies for computed tomography-stratified targets, a 20-25-minutes quality checkpoint, individualized shortening in high-risk patients and structured documentation. These suggestions aim to improve time efficiency and operational quality in the management of acute lower gastrointestinal bleeding." [Collapse]

Li C, Liu YQ, Wang HX. Feasibility of a forty-minute post-colonoscopy observation period for diverticular bleeding: Assessing the five per cent plateau model. World J Gastrointest Endosc 2026; 18(3): 115049

"This article addresses an important and clinically relevant issue in the management of acute caustic ingestion: the optimal role of ..." [Read more]

"This article addresses an important and clinically relevant issue in the management of acute caustic ingestion: the optimal role of esophagogastroduodenoscopy versus computed tomography in early triage and risk stratification. The authors clearly describe the strengths of early endoscopic evaluation, particularly its role as the gold standard for grading mucosal injury when performed within 12–24 hours. The manuscript also appropriately highlights the growing role of cross-sectional imaging, emphasizing how computed tomography can detect transmural injury and extra-luminal complications such as necrosis, perforation, mediastinitis, and peritonitis findings that may not be fully appreciated endoscopically. The paper effectively frames these modalities as complementary rather than competing diagnostic tools. This balanced perspective reflects current clinical thinking and has practical relevance for emergency and gastroenterology teams managing caustic ingestion. However, several areas could be strengthened to enhance the manuscript’s impact. First, the discussion of CT would benefit from greater attention to the heterogeneity of imaging protocols and the lack of universally accepted CT grading systems for caustic injury. Second, a more structured comparison of diagnostic accuracy, predictive value for complications, and influence on clinical decision-making (e.g., surgical referral) would improve the clinical utility of the review. Third, incorporation of a proposed triage algorithm integrating both modalities could provide readers with clearer practical guidance. Overall, this is a timely and useful review that synthesizes the evolving literature on diagnostic strategies in caustic ingestion. With additional clarification of imaging criteria, standardization challenges, and clinical decision pathways, the manuscript would provide even stronger guidance for clinicians managing this high-risk emergency. " [Collapse]

Singh AK, Birda CL, Kochhar R. Optimizing triage in acute caustic ingestion: Choosing between endoscopy and computed tomography. World J Gastrointest Endosc 2026; 18(3): 114327

"This is a valuable case report illustrating the diagnostic challenges of abdominal presentations of hereditary angioedema. With modest ..." [Read more]

"This is a valuable case report illustrating the diagnostic challenges of abdominal presentations of hereditary angioedema. With modest revisions—particularly expanding the clinical description and strengthening the discussion of the genetic findings—the manuscript would make a useful contribution to the literature. The manuscript would benefit from expanded clinical detail, stronger discussion of the mutation, and clearer differentiation between hereditary and acquired angioedema. Addressing these issues will significantly improve the clarity and impact of the case report." [Collapse]

Matsuura K, Ueda C, Hashimura C, Yakushiji H, Horiuchi T. Hereditary angioedema with recurrent abdominal pain in a patient with a novel SERPING1 gene mutation: A case report. World J Gastrointest Endosc 2026; 18(3): 113096

"This review article summarizes the current knowledge regarding the structure and role of the gut–brain axis, particularly in the ..." [Read more]

"This review article summarizes the current knowledge regarding the structure and role of the gut–brain axis, particularly in the context of acute brain injury. The major components include direct connections between the intestines and the brain through neurological and hormonal systems, as well as indirect communication mediated by intestinal flora and inflammatory cytokines. The structural participants include the autonomic nervous system, comprising both sympathetic and parasympathetic pathways, and the hypothalamic–pituitary–adrenal axis. Within these systems, a vicious cycle may easily develop. Brain inflammation can lead to systemic inflammatory spillover, which may induce increased intestinal permeability (“leaky gut”). This, in turn, can further exacerbate systemic inflammation and subsequently worsen brain inflammation. Potential therapeutic approaches discussed in the manuscript include vagus nerve stimulation, prebiotics and probiotics, fecal microbiota transplantation, and nutritional support. However, the content of the manuscript is largely redundant and does not present novel therapeutic concepts. In addition, the manuscript lacks detailed discussion of the underlying mechanisms and does not provide specific guidance for clinical practice. Overall, the manuscript remains largely descriptive and narrative rather than presenting a rigorous scientific analysis." [Collapse]

Zhao X, Zhang W, Zhang Y, Liu XA. Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis. World J Gastroenterol 2026; 32(10): 115731

15974 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 36657

Manuscripts received today: 44

Manuscript reviews today: 63

Unhandled manuscripts today: 182

Active peer-reviewers today: 2314

Reviewer acceptance today: 77

Reviewer refusals today: 79

Total accepted manuscripts: 40844

Total rejected manuscripts: 45088

Total peer-reviewers: 4745831

Total submissions: 38525

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

Reference Citation Analysis

BPG E-Books

BPG Blog

All Journal Articles

2026-03-28 | Browse: 93 | Download: 37

2026-03-28 | Browse: 273 | Download: 90

Kumar I, Kumari S, Ojha R, Kumari R, Kushwaha K, Singh PK, Verma A. Characterization of endometriosis in patients with Mullerian anomalies using the Enzian classification: A retrospective cohort study. World J Radiol 2026; 18(3): 118143

2026-03-28 | Browse: 61 | Download: 34

Halphen Jr J, Ahmadzade M, Mankidy B, Berenji A, Ghasemi-Rad M. Evidence for a two-step species-level pulmonary nocardiosis diagnostic approach. World J Radiol 2026; 18(3): 118126

2026-03-28 | Browse: 63 | Download: 34

Mounir AM, Elmokadem AH, Saleh GAH, El-Morsy A, Abd El-Raouf GH. Role of metal artifact reduction software in computed tomography angiography of lower limb metallic prosthesis: A retrospective study. World J Radiol 2026; 18(3): 118119

2026-03-28 | Browse: 56 | Download: 27

2026-03-28 | Browse: 76 | Download: 42

Jamil J, Ali S, Ahmad A, Al-Zakwani M, Gul A, Shah PA, Haq S, Lawitz E. Metabolic profiles and hepatic steatosis assessed by controlled attenuation parameter and elastography during Ramadan fasting in San Antonio, United States. World J Radiol 2026; 18(3): 117162

2026-03-28 | Browse: 70 | Download: 38

Chen Q, Li KN, Liu TQ. From clinical efficacy to population health: Implementing vonoprazan-amoxicillin dual therapy for Helicobacter pylori control. World J Gastroenterol 2026; 32(12): 116953

2026-03-28 | Browse: 285 | Download: 93

Zhong SY, Deng XR, Han BC, Yang LQ, Ye ST, Niu XK. Diagnostic performance of magnetic resonance imaging-based radiomics for detecting prostate cancer: A systematic review and meta-analysis. World J Radiol 2026; 18(3): 116826

2026-03-28 | Browse: 60 | Download: 30

2026-03-28 | Browse: 69 | Download: 40

Yan F, Xue XL, Guo Y, Zhang QR, You RR, Shang J, Wu XP, Geng JW, Gao XH, Ye Q, Liang J, Wang XY, Zeng JY, Chen J, Lin YC, Chen XY, Du Q, Yin WL, Liu L, Wang F, Xu BG, Zhang WH, Xiang HL. Baseline hepatitis B surface antigen and cirrhosis predict extended interferon therapy in chronic hepatitis B: A retrospective study. World J Gastroenterol 2026; 32(12): 116287

2026-03-28 | Browse: 328 | Download: 110

Yang YH, Li Y. Reconsidering early-life bile acid amidation defect in environmental enteric dysfunction. World J Gastroenterol 2026; 32(12): 116258

2026-03-28 | Browse: 242 | Download: 73

Ning ZX, Xiao JJ, Zhou ZX. Artificial intelligence-assisted endoscopy in the detection of early gastrointestinal cancer: Progress, challenges, and future directions. World J Gastroenterol 2026; 32(12): 115990

2026-03-28 | Browse: 254 | Download: 65

Kiseleva Y, Maslennikov R, Poluektova E, Zolnikova O, Sigidaev A, Zharikov Y, Shirokova E, Ivashkin V. Microbiome-immune interactions in autoimmune liver diseases. World J Gastroenterol 2026; 32(12): 115853

2026-03-28 | Browse: 294 | Download: 79

Corovic IF, Pantic JM, Stanisavljevic IA, Pavlovic SM, Jovanovic IP, Radosavljevic GD, Simovic Markovic BJ. ST2 gene deficiency alleviates acute gastric injury in mice by modulating inflammation and epithelial cell death. World J Gastroenterol 2026; 32(12): 114576

2026-03-28 | Browse: 252 | Download: 81

Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; 32(12): 113939

2026-03-28 | Browse: 293 | Download: 95

Dupuis O, Mavromatis S, Mavromatis A, Compas CN, Sabbagh C, Oliveira L, Hassard P. Endocuff Vision-enhanced colonoscopy: Does it improve polyp detection? World J Gastroenterol 2026; 32(12): 113927

2026-03-28 | Browse: 266 | Download: 110

Deng QX, Yang K, He J, Li JF, Li XQ, Zou L, Li YM, Xu SM, Jiang Z, Wu LJ. Autophagy related RHEB-CSF1R complex promotes tumor metastasis via advancing phosphorylation levels of PI3K, AKT, mTOR in pancreatic cancer. World J Gastroenterol 2026; 32(12): 112725

2026-03-28 | Browse: 314 | Download: 115

Bashir A, Arora R, Mehrotra D, Bala M, Parry AH, Iqball A, Bhat SA, Wani ZA. Non-invasive prediction of significant hepatic fibrosis in individuals with chronic hepatitis C infection using fibrosis risk score and machine learning models. World J Hepatol 2026; 18(3): 117465

2026-03-27 | Browse: 85 | Download: 54

Hernández-Almonacid PG, Espejo-Amado JS, Marín-Quintero X. Autoimmune liver diseases in older adults: Clinical challenges and management considerations. World J Hepatol 2026; 18(3): 117367

2026-03-27 | Browse: 112 | Download: 53

62687 items Read more >>

Featured Articles

2026-03-26 | Browse: 5 | Download: 1

Johnston HE, Mayr HE, Andelkovic ME, Takefala TG, Chen Y, Thrift AP, Hickman IJ, Macdonald GA. Clinical burden of physical frailty in patients evaluated for liver transplantation: A retrospective cohort study. World J Hepatol 2026; 18(3): 114279

2026-03-26 | Browse: 3 | Download: 1

Hafez MM, Nasseem M, Boukhechem I, ElSheikh R, Tawheed A. Optimizing nutritional interventions in chronic liver disease: Etiology-specific strategies for enhanced clinical management. World J Hepatol 2026; 18(3): 114435

2026-03-26 | Browse: 4 | Download: 1

Plakida A, Iushkovska O, Sierpińska LE. Metabolically associated fatty liver disease: What hepatologists need to know about this systemic disease. World J Hepatol 2026; 18(3): 113284

2026-03-26 | Browse: 3 | Download: 1

Hernández-Almonacid PG, Espejo-Amado JS, Marín-Quintero X. Autoimmune liver diseases in older adults: Clinical challenges and management considerations. World J Hepatol 2026; 18(3): 117367

2026-03-26 | Browse: 5 | Download: 1

Halphen Jr J, Ahmadzade M, Mankidy B, Berenji A, Ghasemi-Rad M. Evidence for a two-step species-level pulmonary nocardiosis diagnostic approach. World J Radiol 2026; 18(3): 118126

2026-03-26 | Browse: 5 | Download: 6

2026-03-26 | Browse: 6 | Download: 16

2026-03-26 | Browse: 4 | Download: 15

2026-03-26 | Browse: 3 | Download: 14

2026-03-26 | Browse: 3 | Download: 15

Mushtaq A, Choudhery MS, Arif T, Niaz A, Pervaiz A. Maximizing pediatric stem cell harvest: A novel two-step digestion approach for adipose tissue. World J Stem Cells 2026; 18(3): 116388

2026-03-25 | Browse: 13 | Download: 13

Wang AR, Zhang YY, Liu YJ, Ren LN, Yan QH, Wang KF, Wang Y. Exosomes of adipose-derived mesenchymal stem cells loaded with globular adiponectin improve islet function for type 2 diabetes. World J Stem Cells 2026; 18(3): 115363

2026-03-25 | Browse: 5 | Download: 18

Zhou HF, Xu JM, Li J, Xu F, Li JF, Yu Y, Yuan H, Bian YF, Wang YL, Du YF. Human amniotic mesenchymal stem cell-derived small extracellular vesicles repair of jaw osteoradionecrosis. World J Stem Cells 2026; 18(3): 114746

2026-03-25 | Browse: 7 | Download: 20

Enjoji T, Kobayashi S, Miyamoto D, Ogawa S, Tetsuo H, Soyama A, Adachi T, Eguchi S, Kanetaka K. Allogeneic myoblast cell sheet transplantation for esophageal wall reinforcement. World J Stem Cells 2026; 18(3): 113900

2026-03-25 | Browse: 2 | Download: 17

2026-03-25 | Browse: 2 | Download: 12

Kakooza J, Akankwasa P, Mugabe S, Kiadii BK, Lewis CR. Blunt esophageal injury in a pediatric patient: A case report. World J Clin Cases 2026; 14(9): 118553

2026-03-24 | Browse: 11 | Download: 32

Loor CS, Macias Fernandez PK, Blasco Arriaga EE, Custodio LE, Bombón Caizaluisa MF, Ross Rodriguez EA, Pozo Albán MI, Grochowska A, Gagliardo Cadena EA. Hidden giant - atypical pediatric anterior mediastinal teratoma: A case report. World J Clin Cases 2026; 14(9): 118016

2026-03-24 | Browse: 5 | Download: 32

2026-03-24 | Browse: 6 | Download: 30

Chapra A, Ata F, Abdellatif A, Nofal M, Daniyal A, Mohammad Younus A, Shah JZ, Rasul K. Incidence and clinical course of immune checkpoint inhibitor-related cardiac adverse events: A descriptive study from the Middle East. World J Clin Cases 2026; 14(9): 118187

2026-03-24 | Browse: 8 | Download: 31

Pan HY, Liang JX, Chen WW, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Xu B, Xu TC. Beyond glycemic control: How semaglutide reshapes intestinal neuroception via transforming growth factor-β/brain-derived neurotrophic factor signaling hubs. World J Clin Cases 2026; 14(9): 118295

2026-03-24 | Browse: 6 | Download: 32

10597 items Read more >>

Keyword Search Published Articles Processes

Case report

4759

Hepatocellular carcinoma

1762

Gastric cancer

1288

Colorectal cancer

1270

Prognosis

1095

Inflammatory bowel disease

864

COVID-19

847

Treatment

778

Diagnosis

761

Liver transplantation

748

Ulcerative colitis

692

Meta-analysis

676

Crohn’s disease

628

Endoscopy

624

Cirrhosis

615

Inflammation

602

Helicobacter pylori

597

Magnetic resonance imaging

588

Surgery

562

Pancreatic cancer

520

67887 items Read more >>

Reader Comments

"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in ..." [Read more]

"I thank Khan et al for conducting this meta-analysis and finding out that hypoalbuminemia is a risk factor for mortality in cholangitis. I have a few comments that have to be taken into account while interpreting this study. First, this meta-analysis includes only retrospective studies. Second, there is no subgroup analysis by benign versus malignant aetiology of acute cholangitis. The outcomes of cholangitis depend on aetiology, which is not studied. This indicates whether hypoalbuminemia is due to cholangitis as an acute-phase reactant, or whether any underlying aetiology needs to be identified. Whether any intervention in acute cholangitis with hypoalbuminemia has any role in the outcome has not been studied. However, this meta-analysis provides meaningful research questions for future prospective studies. " [Collapse]

Khan RTY, Ahsam S, Kumar SK, Khan K, Kakar MT, Hyder A, Malik W, Mubarak M, Luck NH. Hypoalbuminemia as a predictor of mortality in patients with acute cholangitis: A systematic review and meta-analysis. World J Gastrointest Pathophysiol 2026; 17(1): 113373

"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), ..." [Read more]

"Sheriefet al. [1]demonstrated dual parametric evaluation to assess diagnostic performance for Hepatocellular carcinoma (HCC), discriminating from Hepatitis C-related liver Cirrhosis and Healthy control cohorts via plasma in a single centred Egyptian population.This study [1] revealed two leading biomarkers with exceptional accuracy (AUC >0.99); hsa-miR-21-5p (Sensitivity and Specificity of 98.6% and 96.7%, respectively) and Leukocyte-associated immunoglobulin-like receptor-1(LAIR-1) mean fluorescence intensity (MFI) (Sensitivity and Specificity of 100 % and 98.3%, respectively). Sherief et al. [1]aims to address one of the clinically challenging issues i.e. lack of sensitive, specific circulatory biomarker/s for early diagnosis of Hepatocellular Carcinoma (HCC).Commentary noted several strengths of the study by Sherief et al. [1],such as; looks technicallymoderatein study design, methodology and innovation level i.e. prospective study, minimally invasive sample collection, exploration of dual parameters: tumour derived circulatory micro-RNA and immune related marker. Additionally, study employed rigorous statistical analysis for diagnostic performance assessment including ROC curve analysis, comparative Sensitivity/Specificity,revealed promising findings that may pave for future research towards biomarkers validation and discovery. However,present commentary observed several concerns for the study by Sherief et al. [1]; (i) Lack of mechanistic cascade exploration including causal pathway/s.(ii) Median age of HCC cohort is significantly higher than Hepatitis C-related liver Cirrhosis and Healthy control, may be a biasing factor in expression pattern. (iii) Since study did not include follow up subjects that limits for probing of prognostic markers. (iv) Paucity of multi-centric involvement for diversified population, may limit the findings for generalized conception. (v) Validation of findings through blinded samples may demonstrate a better decision regarding applicability. (vi) Authors used word ‘noninvasive’, for plasma-based markers investigation(vii) Global Cancer statistics 2022,wasalready published in 2024[2], still authors used GLOBOCON 2020 [3] reference in epidemiological outline in the manuscript [1], latest reference can provide contemporary status. The article by Sherief et al. [1], demonstrated balanced and structured scientific contents along with logical explanations. However, addition of graphical abstract to present the study in nutshell may improve the visibility for readers. A large sample sized, multi-centered,longitudinal study, involving diversified geographical and ethnic population of HCC, Hepatitis C-related liver Cirrhosis, Healthy control cohorts, and mechanistically relevant subgroups, using common protocol, validation through blinded samples, may provide potential edge for HCCdiagnosticsto achieve common consensus and identification of prognostic biomarkers. Integrated nomogram ofhsa-miR-21-5p with LAIR-1 MFI, may be explored for possible better diagnosticsetup. Application of Artificial Intelligence (AI) may be explored for diagnostic performance as well as high throughput outcomes. References: 1. Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026 March 15a; 18(3): 116567. 2. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for36 cancers in185 countries. CA Cancer J Clin. 2024; 74:229–263 3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021; 71: 209-249 " [Collapse]

Sherief DE, Shehata HH, Nosair N, Othman AAA, Sadaka E, Elgamal R. Dual-parameter liquid biopsy using plasma miR-21-5p and T cell LAIR-1 mean fluorescence intensity for hepatocellular carcinoma diagnosis in a high-risk Egyptian cohort. World J Gastrointest Oncol 2026; 18(3): 116567

"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, ..." [Read more]

"I read with ken interest about the following article. As a reader I have few comments/ suggestions also. Alok Bharadwaj, Manas Taneja, Sneha Dubey, Aditya Saxena. Very low-density lipoprotein and the human health. World J Exp Med 2026;16(1): 117024 [DOI: 10.5493/wjem.v16.i1.117024] Abstract Apo B100, TGL and cholesterol are present in LDL in addition to VLDL. But the ratio of TGL: cholesterol may vary. PATHOLOGICAL ROLE OF VLDL: Metabolism-associated fatty liver disease and liver disease: Distinction between NAFLD, MAFLD and MASLD may be provided Following the classification of metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic fatty liver disease (NAFLD) has recently been redefined again as metabolic dysfunction-associated steatotic liver disease (MASLD). Both MASLD and MALFD were linked to higher all-cause mortality risk, but MASLD identified a greater number of individuals compared to MAFLD. (Song R, Li Z, Zhang Y, Tan J, Chen Z. Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults. Liver Int. 2024;44:1051-1060. doi:10.1111/liv.15856) Metabolic-associated fatty liver disease (MAFLD) exhibits a raised VLDL secretion rate attributed to increased intrahepatic TGs hydrolysis. They apparent the absence of immediate VLDL secretion reduction yet maintained a consistent apo B100 secretion rate, as informed by previous studies/ I would like to reframe this sentence: in the presence of elevated counter-regulatory hormones, lipolysis takes place in the adipose tissue releasing free fatty acids into circulation. Majority of these fatty acids are take up liver and converted into triglycerides. If VLDL secretion from liver is not proportionate to the level of fatty acid entry into liver, fatty acids may get accumulated in the liver causing different forms of fatty liver. In individuals with insulin resistance and higher body weight, there is an elevation in apo C-III levels within VLDL. Apo CIII is an inhibitor of lipoprotein lipase, thus inhibiting lipolysis of TGL in VLDL, thus increasing VLDL concentration in blood. Insulin resistance and MetS Insulin-hampered VLDL production, along with insulin resistance, leads to increased and decreased production of VLDL, often associated with hypertriglyceridemia Does VLDL increase or decrease with insulin resistance Hepatic VLDL production is decreased by glucagon Mechanism behind this Alterations of VLDL in various disorders have been explained well. All the mechanistic pathways have been adequately addressed " [Collapse]

Bharadwaj A, Taneja M, Dubey S, Saxena A. Very low-density lipoprotein and the human health. World J Exp Med 2026; 16(1): 117024

"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous ..." [Read more]

"This letter to the Editor notes the potential significance of clinical situation in patients who suffer from emphysematous pyelonephritis. This is very important. Clinical findings and symptoms must be the cornestone in these conditions in order to avoid the worse outcomes of patients. In addition, the Modified National Early Warning Score 2 based on physiological situation of patient shoud be very helpfull, as well as computed tomography findings. " [Collapse]

Sevik C, Erbin A, Canat HL. Integrating Modified National Early Warning Score 2, computed tomography staging, and laboratory markers for enhanced prognostic stratification in emphysematous pyelonephritis. World J Nephrol 2026; 15(1): 113952

"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy ..." [Read more]

"This manuscript defined as Editorial is generally good, but it mildly offers new lights in concept of diabetic nephropathy complications and its progression in death. Pathophysiology paragragh is better than the other parts of manuscript. Addiotionally, inequalities and differences between racial and ethic groups were noted, which is not usual in other published manuscripts. " [Collapse]

Gembillo G, Ricca MF, Santoro D. Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality. World J Nephrol 2026; 15(1): 108432

"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver ..." [Read more]

"Reader’s code: 00106360 Commentary on the Article Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer The study by Chon HY et al. examines the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on liver metastasis and survival in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors assessed hepatic steatosis primarily through the hepatic steatosis index (HSI) and additionally validated findings using CT-based measurements of liver fat. The study found no significant association between MASLD and the presence of liver metastasis at diagnosis or during follow-up, suggesting that hepatic steatosis may not be a key determinant of metastatic spread in pancreatic cancer (Chon et al., 2026). The findings contrast with previous research in other malignancies, such as colorectal and breast cancers, where hepatic steatosis has been reported to influence liver metastasis risk or metastasis-free survival (van Saane et al., 2019; Wu et al., 2020). In the present study, tumor size and elevated CA19-9 levels were the main predictors of liver metastasis, while diabetes mellitus was associated with improved survival outcomes, possibly reflecting earlier detection among diabetic patients (Chon et al., 2026). Critical Appraisal of the Study The study by Chon HY and colleagues evaluates the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and liver metastasis in patients with Pancreatic Ductal Adenocarcinoma. Using a large retrospective cohort of 2123 patients, the authors investigated whether hepatic steatosis, measured by the hepatic steatosis index (HSI), influences the development of liver metastasis and overall survival. Strengths One of the major strengths of this study is its large sample size and long study period (2006–2021), which enhances the statistical power and reliability of the findings. The authors used robust statistical methods, including logistic regression and Cox proportional hazards models, to analyze risk factors for both baseline and newly developed liver metastases. Another notable strength is the additional CT-based validation in a subgroup of patients, which helps corroborate the HSI-based assessment of hepatic steatosis. The study also carefully adjusted for multiple potential confounders such as age, BMI, diabetes, lipid profile, tumor size, and CA19-9 levels. Limitations Despite these strengths, several limitations should be considered. First, the retrospective design limits the ability to establish causal relationships. Second, the primary assessment of hepatic steatosis relied on the HSI, an indirect surrogate marker derived from BMI and liver enzyme ratios, which may be influenced by cancer-related factors such as cachexia, inflammation, or biliary obstruction. Third, important pathological variables (e.g., lymph node status, lymphovascular invasion, and perineural invasion) were not consistently available and therefore could not be included in the multivariate models. Additionally, the CT-based validation was limited to a subset of patients, which may introduce selection bias. Clinical Implications Clinically, the findings suggest that MASLD may not be a significant determinant of liver metastasis in pancreatic cancer, contrasting with observations in other malignancies. Instead, established markers such as tumor size and elevated CA19-9 levels appear to remain more reliable predictors of metastatic risk and mortality. These results highlight the aggressive biological behavior of pancreatic cancer, where tumor-driven mechanisms may outweigh the influence of underlying hepatic metabolic conditions. Future prospective studies incorporating advanced imaging, histologic confirmation, and molecular analysis of the tumor–liver microenvironment are needed to further clarify the role of MASLD in pancreatic cancer progression. Despite its strengths, including a large sample size and robust statistical modeling, the retrospective design and reliance on HSI rather than histologic confirmation limit the ability to establish causality. Nevertheless, this study contributes important evidence suggesting that the relationship between MASLD and metastasis may be cancer-specific and biologically complex. Reference Chon HY, Rhee H, Kim J, et al. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World Journal of Gastroenterology. 2026;32(11):115488. van Saane AM, et al. Non-alcoholic fatty liver disease and colorectal liver metastasis risk. Liver International. 2019. Wu W, et al. Hepatic steatosis and liver metastasis-free survival in breast cancer. Cancer Medicine. 2020. " [Collapse]

Chon HY, Rhee H, Kim J, Leem G, Jo JH, Chung MJ, Park JY, Bang S, Park SW, Kim SU, Lee HS. Impact of metabolic dysfunction-associated steatotic liver disease on liver metastasis and survival in pancreatic cancer. World J Gastroenterol 2026; 32(11): 115488

"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates ..." [Read more]

"Esophageal variceal bleeding is one of the most severe complications of cirrhotic portal hypertension, associated with high rates of rebleeding and mortality. Although endoscopic variceal band ligation (EVBL) is currently the standard treatment, its reliance on repeated endoscopic follow-up presents challenges, including invasiveness, high resource consumption, and poor patient tolerance. This study focuses on the potential application of multiparametric ultrasound (MP-US) in predicting outcomes following EVBL, proposing a novel follow-up strategy that is noninvasive, individualized, and reproducible, with significant promise for clinical translation. The article begins with the clinical burden of EVB, progressively introduces the limitations of current diagnostic and therapeutic approaches, and naturally transitions to the technical advantages and research evidence supporting MP-US, culminating in future research directions. The structure is well-organized, and the logic is rigorous. The critical analysis of existing technologies is insightful. The article objectively highlights the limitations of HVPG and repeated endoscopy, particularly their inaccessibility in resource-limited settings. It also provides a reasonable evaluation of the shortcomings of noninvasive tools such as the Baveno criteria and elastography in predicting postprocedural outcomes, reflecting the authors' deep understanding of clinical realities. The analysis of MP-US's clinical application is thorough. By integrating measurements of liver stiffness, spleen stiffness, and perfusion imaging, MP-US enables a comprehensive assessment of portal hypertension from both structural and hemodynamic perspectives, overcoming the limitations of traditional single-parameter prediction models. Citing data from Ainora et al, the study demonstrates the potential of MP-US in predicting variceal eradication and guiding individualized follow-up. The outlook on future research directions is instructive. The article notes that current studies are mostly small-sample, single-center designs lacking standardized operating and interpretation protocols, and calls for multicenter, prospective studies to validate the clinical value of MP-US—a recommendation with practical significance. Figure 1 is highly informative, clearly illustrating the evolutionary pathway from invasive to noninvasive diagnostic tools, facilitating readers' understanding of technological advancements. Areas for improvement and suggestions: The issue of MP-US technical standardization requires further clarification. Although the article mentions that MP-US is influenced by factors such as operator experience and equipment variability, it does not delve deeply into how to achieve standardized operation and interpretation; future research should focus on this aspect. A cost-effectiveness analysis is lacking. While MP-US has the potential to reduce the frequency of endoscopic examinations, its high equipment costs and reliance on contrast agents may limit its widespread adoption in certain regions. Future studies should incorporate health economic evaluations. The integration of AI with MP-US warrants further exploration. The article mentions the application of AI in endoscopic measurement but does not explore the possibility of combining AI with MP-US. Future research could investigate AI-based automated analysis of MP-US images and risk prediction models. This study, with its clear logic, solid literature support, and forward-looking perspective, systematically elaborates on the potential application of MP-US in post-EVBL follow-up. It not only provides clinicians with new diagnostic and therapeutic insights but also points future researchers toward promising directions. If further advancements are made in MP-US standardization, multicenter validation, and AI integration, it holds the potential to achieve truly noninvasive, precise, and individualized management of portal hypertension in patients with cirrhosis. " [Collapse]

"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic ..." [Read more]

"This systematic review of 8 randomized trials (1758 participants) rigorously evaluates adjunctive pharmacotherapies for diuretic resistance in acute decompensated heart failure (ADHF), adhering to PRISMA guidelines and using Cochrane’s RoB 2.0 for bias assessment. Key findings show proximal nephron-targeted agents (acetazolamide, SGLT2 inhibitors) and distal thiazide diuretics effectively boost decongestion: acetazolamide raises successful decongestion rates (42.2% vs 30.5%), SGLT2 inhibitors enhance urine output and reduce worsening HF, while thiazides prompt greater weight loss but increase renal dysfunction risk. Notably, older agents (high-dose spironolactone, low-dose dopamine/nesiritide) yield no meaningful clinical benefits. The review’s strength lies in its exclusive focus on randomized trials, but heterogeneity in endpoints and short follow-up limit generalizability. It provides a mechanistically guided, stepwise clinical framework for ADHF management, emphasizing personalized adjunct selection, and identifies the need for large head-to-head trials and long-term outcome research to address existing evidence gaps. " [Collapse]

Patel V, Zameer R, Kumar B, Das M. Adjunctive pharmacologic therapies for diuretic resistance in acute decompensated heart failure: Systematic review of randomized trials. World J Meta-Anal 2026; 14(1): 118496

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. ..." [Read more]

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. While the narrative is informative, a more quantitative economic comparison and inclusion of updated guidelines or contemporary practice data would strengthen the conclusions. Additionally, deeper exploration of medico-legal concerns and institutional resistance could enhance its practical impact. Nevertheless, the review addresses a clinically meaningful topic. " [Collapse]

Karim HMR. Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility. World J Anesthesiol 2019; 8(3): 19-24

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon ..." [Read more]

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon handedness on radiological and functional outcomes following primary total knee arthroplasty (TKA). The authors should be commended for addressing an underexplored yet clinically relevant surgeon-related variable in arthroplasty practice. The finding that overall limb alignment and functional outcomes were not significantly influenced by operating on the dominant versus non-dominant side is reassuring. However, the increased incidence of tibial component malalignment (MPTA outliers) on the non-dominant side highlights an important technical nuance that may have implications for implant longevity, particularly in mechanically aligned TKA performed with conventional instrumentation. The subgroup analysis comparing intramedullary and extramedullary tibial guides is particularly interesting, suggesting that technique selection may interact with laterality. These findings underscore the potential value of ergonomic optimization and heightened intraoperative vigilance when operating on the non-dominant side. Future prospective studies incorporating sagittal and rotational alignment parameters, inclusion of left-handed surgeons, and long-term survivorship data would further clarify the clinical significance of these observations. Additionally, evaluating whether navigation or robotic assistance mitigates the subtle asymmetries associated with surgeon handedness could provide valuable insights. Overall, this study contributes meaningfully to the ongoing discussion regarding modifiable surgeon-related factors influencing TKA precision and outcomes. " [Collapse]

Khalifa AA, Abdelaal AM, Moustafa MM. Does surgeon handedness affect the outcomes after primary total knee arthroplasty? A retrospective cohort study. World J Orthop 2026; 17(2): 113696

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from ..." [Read more]

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from previously published results. ETV is generally considered renal-neutral and is commonly used in DCLD due to its renal safety. The statement that ETV is associated with a greater decrease in GFR than TMV is overfitting, as it is a retrospective study. The Difference in decline of approximately 4 mL/min/1.73 m² is very small and may not be clinically meaningful in patients with normal GFR, even though it is statistically significant. The conclusion should be interpreted with caution and requires additional long-term prospective studies to substantiate this claim. Furthermore, the authors did not report any additional adverse events during the study period. " [Collapse]

Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2026; 18(2): 114346

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver ..." [Read more]

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver abscesses in Asia and is increasingly prevalent in India. It is important to have culture reports at various time points, as they will help us in deciding empirical antibiotics. The authors have shown that the isolated organisms are highly resistant to ampicillin and have low resistance to cephalosporins and carbapenems. With this large amount of data, the authors would have identified the poor prognostic predictors of PLA and treatment outcome. The authors did not present the data on complications of these abscess such as biliary fistula " [Collapse]

Mai-Phan TA, Thai KP, Le KL, Pham TN, Tran MQ, Pham PC, Duong NNQ, Trinh MT, Le NK. Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam. World J Hepatol 2026; 18(2): 113695

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..." [Read more]

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. " [Collapse]

Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways after surgery in elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..." [Read more]

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. " [Collapse]

He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced ..." [Read more]

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced tumor stage, and poor survival in gastric cancer. The combination of clinical data and functional assays strengthens the evidence for the PS-1/β-catenin/p-PTEN axis in promoting invasion and metastasis. These findings highlight a potential therapeutic target for gastric cancer treatment. " [Collapse]

Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2026; 18(2): 115689

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..." [Read more]

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. " [Collapse]

Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..." [Read more]

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 " [Collapse]

Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..." [Read more]

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. " [Collapse]

Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..." [Read more]

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. " [Collapse]

Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..." [Read more]

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. " [Collapse]

Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617

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