Baishideng Publishing Group

Xu S, Zhu Z, Zhang HM, Xu YT, Shi PH, Zheng Y, Chen YT, Lu GR, Zheng BJ. Targeting Dialister-driven succinate accumulation: A novel strategy for Crohn’s disease activity control and recurrence prevention. World J Gastroenterol 2026; 32(8): 116173

"The editors and reviewers offered insightful and constructive feedback throughout the entire submission process, which significantly ..." [Read more]

"The editors and reviewers offered insightful and constructive feedback throughout the entire submission process, which significantly improved the clarity and rigor of the manuscript. Their thorough evaluations and detailed suggestions not only enhanced the overall quality of the work but also demonstrated their exceptional expertise and dedication. We are truly grateful for their time, effort, and professional guidance. " [Collapse]

Li WJ, Li LZ. Artificial intelligence in mobile health applications: A comprehensive review of its role in diabetes care. World J Methodol 2026; 16(1): 107488

"The manuscript submission system is user-friendly. Each step is clearly described. The files, including images, are easy to upload. ..." [Read more]

"The manuscript submission system is user-friendly. Each step is clearly described. The files, including images, are easy to upload. The peer review process is quick and hence the authors get a decision without delay. The review process is very smooth. Overall, the journal executes the entire process well. Thank you for the opportunity to write this feedback. " [Collapse]

Dutta AK, Rao NV, Bharadwaj PK, Benny S. Frequency and characteristics of synchronous gastric cancers: Need for improved awareness and better detection. World J Gastrointest Oncol 2026; 18(2): 113508

"The entire editorial and production team managed our manuscript with notable efficiency and professionalism. We especially appreciate ..." [Read more]

"The entire editorial and production team managed our manuscript with notable efficiency and professionalism. We especially appreciate the constructive and insightful feedback provided by the reviewers, which greatly enhanced the quality of our paper. Communication at every stage was clear and timely, and the editors proved to be highly accessible and supportive via email. We are very satisfied with the remarkably smooth and well-organized publication experience. " [Collapse]

Zhu KY, Wang SJ, Li J, Ma PP, Feng SS, Guo L, Lu YB, Dong L, Ding DF. Association of serum bile acid profiles with the risk of gastrointestinal autonomic neuropathy in patients with type 2 diabetes mellitus. World J Diabetes 2026; 17(2): 112859

"Thank you to the editors of the magazine for their hard work, and it is your recognition that makes this article a success. Thanks ..." [Read more]

"Thank you to the editors of the magazine for their hard work, and it is your recognition that makes this article a success. Thanks to the reviewers' comments, they gave us a lot of pertinent revisions and provided good guidance for our paper revisions. Thank you to all members of our research team for their cooperation and joint efforts. In addition, We appreciate the great help/technical support/experimental support from the Medical Research Center, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University. " [Collapse]

Huang NF, Ling P, Xu YJ, Feng XF, Zheng Y, Sun T. Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence. World J Gastroenterol 2026; 32(8): 115077

"I would like to thank you for allowing me to write a letter about your paper. I am pleased to have been able to write this paper ..." [Read more]

"I would like to thank you for allowing me to write a letter about your paper. I am pleased to have been able to write this paper because I was able to point out that although orthopedic surgery, including devices, has advanced, in order for this technology to successfully lead to an improvement in quality of life, it is necessary to take into consideration the psychological aspects of patients undergoing surgery. " [Collapse]

Nagamine T. Considering mental function for successful total knee arthroplasty in older people. World J Methodol 2026; 16(1): 107921

"Iam indebted to the journal for their fair peerreview process, which improved the quality of my article. The editorial team was of ..." [Read more]

"Iam indebted to the journal for their fair peerreview process, which improved the quality of my article. The editorial team was of great help and always approachable through email. I sincerely thank the whole editorial team for their cooperation; it was great to be associated with you all. Looking forward to other such associations in the future. " [Collapse]

Pathania J, Pathania V. Real-world effectiveness and safety of teduglutide in patients with short bowel syndrome. World J Gastrointest Pharmacol Ther 2026; 17(1): 117071

"Everything has gone smoothly, except for the publication timeline. Overall, I’m extremely happy with the process. The final article ..." [Read more]

"Everything has gone smoothly, except for the publication timeline. Overall, I’m extremely happy with the process. The final article PDF looks excellent, and the supplementary / accessory details are well done. The quality of the work and presentation is truly satisfying. No other issues noted by me or other authors who were involved in making this manuscript. " [Collapse]

Kalluru PKR, Valisekka SS, Katamreddy Y, Cherukuri A, Kuchi D, Siddenthi SM, Mandyam S. Addressing barriers and advancing equitable colorectal cancer screening in the lesbian, gay, bisexual, transgender, and queer/questioning population. World J Methodol 2026; 16(1): 109316

"It was a great experience to publish this manuscript in a well-established journal in the field of cardiology. The time to the decision ..." [Read more]

"It was a great experience to publish this manuscript in a well-established journal in the field of cardiology. The time to the decision is amazing, aligning with the relevant reviewers' comments and a smooth revision process. Communication with the help desk and the editorial team was very good. Moreover, the proofreading and final production were of a high standard. " [Collapse]

Elmenyar E, Abbara MA, Al-Ghoul Z, Al Mahmeed W, Cander B, Abdelrahman AS, Al-Thani H, El-Menyar A. Phenomenon of “de Winter” pattern, sign, or syndrome: A systematic scoping review and data analysis. World J Cardiol 2026; 18(2): 114561

"The peer-review process was conducted objectively and efficiently, with constructive comments that helped improve the quality of the ..." [Read more]

"The peer-review process was conducted objectively and efficiently, with constructive comments that helped improve the quality of the manuscript. Editorial communication was clear and timely, and responses to queries were prompt. The editing and production services were professional, well organized, and completed within a reasonable timeframe, contributing to a smooth publication process. " [Collapse]

Bouayad A. Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. World J Clin Cases 2026; 14(5): 115814

"The peer review process was thorough, rigorous, and highly constructive. The reviewers provided insightful and well-substantiated ..." [Read more]

"The peer review process was thorough, rigorous, and highly constructive. The reviewers provided insightful and well-substantiated comments that helped refine the methodology, improve clarity, and strengthen the scientific message of the manuscript. Their feedback encouraged critical reflection and led to meaningful revisions that enhanced the overall quality and robustness of the study. This process exemplifies the value of transparent and objective peer review in advancing reliable and impactful scientific research. " [Collapse]

Karavidas N, Tzatzaliaris D. Tele-scoliosis-screening and treat protocol: A hybrid in-person and online approach for scoliosis treatment in remote patients. World J Methodol 2026; 16(1): 107307

"The publication process was exceptionally smooth and efficient from initial submission through final publication. The peer-review ..." [Read more]

"The publication process was exceptionally smooth and efficient from initial submission through final publication. The peer-review stage was handled in a timely manner, with clear communication and constructive feedback that helped improve the manuscript without unnecessary delays. Editorial decisions were prompt, and the overall workflow felt well organized and transparent. After acceptance, the production phase was equally fast, including copyediting, proof preparation, and final online release. Overall, the journal demonstrated a professional, responsive, and streamlined process with a genuinely speedy transition from review to production. " [Collapse]

Karmakar R, Kandalkar A, Mukundan A. Total neoadjuvant therapy in rectal cancer: Challenging traditions without compromising surgical safety. World J Gastrointest Oncol 2026; 18(2): 115507

"I would like to express my sincere gratitude to the entire editorial and production team for the outstanding support throughout the ..." [Read more]

"I would like to express my sincere gratitude to the entire editorial and production team for the outstanding support throughout the publication process. From submission to final online release, the experience was smooth, professional, and remarkably well coordinated. Communication from the editorial office was clear, timely, and always courteous, which made each stage of revision and production straightforward and efficient. I was particularly impressed by the quality and constructiveness of the peer-review process. The reviewers’ comments were thoughtful, relevant, and clearly aimed at strengthening the scientific rigor and clarity of the manuscript. Their feedback helped refine both the structure and presentation of the work, ultimately improving the overall quality of the final publication. It is evident that the journal maintains a high standard in selecting knowledgeable and engaged reviewers. The editorial guidance provided during revisions was also excellent. Instructions were precise and practical, allowing us to address all requirements without confusion or unnecessary delays. The production stage was equally efficient, with careful attention to formatting, language quality, and presentation. The final published version reflects a high level of editorial care and professionalism. Overall, this has been a very positive and rewarding publishing experience. I deeply appreciate the dedication of everyone involved — from assistant editors and reviewers to language editors and production staff — whose collective efforts ensure the high quality and integrity of the journal. I look forward to future collaborations and would gladly recommend this journal to colleagues seeking a reliable, rigorous, and author-supportive publication venue. " [Collapse]

Prodan R, Soldera J. Mirtazapine for the treatment of irritable bowel syndrome: A systematic review. World J Methodol 2026; 16(1): 107908

"I would like to express my sincere gratitude to the entire editorial and production team for the outstanding support throughout the ..." [Read more]

Shah Q, Soldera J. Exploring effectiveness of Metronidazole, Bismuth, and Rifaximin in treating small intestinal bacterial overgrowth and irritable bowel syndrome: A systematic review. World J Methodol 2026; 16(1): 107169

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review ..." [Read more]

"Everything was excellent. The editorial office services and prompt response to requests were enthusiastic. Also, the peer review process could be characterized by great satisfaction. Thank you very much for your cooperation. I am looking forward to continuing this scientific activity. I hope to continue with the best impressions. Best regards from Thessaloniki, Greece. " [Collapse]

Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kotoulas SC, Ballas KD, Pavlidis TE. Effects of rosuvastatin treatment and other statins on burn wound healing. World J Methodol 2026; 16(1): 112686

"Very good quality of peer review. The process was very easy and with a lot of efforts from all the parts. The only thing I would like ..." [Read more]

"Very good quality of peer review. The process was very easy and with a lot of efforts from all the parts. The only thing I would like to suggest is a modification: for the first time submitting the paper, the website could be set just as the same as the pattern of when the paper was accepted with the tables and main topics already in order and you just set the data inside the tables. " [Collapse]

Nunes BCM, Rocha RSP, Berzin TM, Franco MC, Kum AST. Staged multimodal endoscopic vacuum therapy for a complex gastro-pleuro-broncho-cutaneous fistula: A case report. World J Clin Cases 2026; 14(5): 117850

"The journal’s review process was thorough, constructive, and highly professional, providing clear and insightful feedback that ..." [Read more]

"The journal’s review process was thorough, constructive, and highly professional, providing clear and insightful feedback that significantly improved the quality of the manuscript. The timely communication and balanced, expert evaluation reflected a strong commitment to academic rigor and author support. We thank the editors for the chanche to publish in this esteemed journal. " [Collapse]

Deligiannis P, Katsimperis S, Kyriazis I, Angelopoulos P, Neofytou P, Kapsalos-Dedes SG, Triantafyllou P, Arseniou P, Katelani S, Papatsoris A. Fluoroscopy-guided transurethral resection with antegrade guidewire assistance for retrieval of a buried double-J stent: A case report. World J Clin Cases 2026; 14(5): 117384

"We would like to express our sincere gratitude to the editorial team and the reviewers for their exceptional support. Working on this ..." [Read more]

"We would like to express our sincere gratitude to the editorial team and the reviewers for their exceptional support. Working on this manuscript has been a genuine pleasure. We are deeply appreciative of the board's invaluable assistance, which included meticulous feedback and constructive suggestions at every stage—from initial submission to final revisions—in preparing the manuscript for publication. " [Collapse]

Pereverzeva KG, Glenza A, Yakushin SS. Oral anticoagulant therapy and outcomes in new-onset atrial fibrillation during acute myocardial infarction: A systematic review and meta-analysis. World J Cardiol 2026; 18(2): 114265

"WJGO is a very good magazine. It actively seeks peer-reviewers and has clear requirements for the manuscripts. All the editors are ..." [Read more]

"WJGO is a very good magazine. It actively seeks peer-reviewers and has clear requirements for the manuscripts. All the editors are very friendly and work highly efficiently. The editors and I had a series of discussions about the details in the manuscript. I will continue to submit my articles to WJGO in the future. " [Collapse]

Zhang Y, Li ZX, Ma DY, Liu F. Solitary esophageal metastasis ten years after curative resection of stage I rectal adenocarcinoma: A case report. World J Gastrointest Oncol 2026; 18(2): 113494

"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid ..." [Read more]

"Enjoyed the peer review process, which was efficient and effective. I think the submission system is user friendly, allow for rapid communication between the journal and authors. Additionally enjoyed the clear and concise peer review report. Would do this all over again, if given another chance. Congratulations to the F6 publishing systems. Keep up the good work. Kevan English, MD Internal Medicine University of Nebraska Medical Center " [Collapse]

Garcia R, English K. Mixed hepatocellular-cholestatic liver injury from cefepime: A case report. World J Clin Cases 2026; 14(4): 117573

20715 items Read more >>

Article Quality Tracking-Peer-Review

"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in ..." [Read more]

"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in mice. The anticancer activity of this substance is based on pyroptosis. Pyroptosis is a key component of cell death. It directly suppresses the tumor by promoting gasdermin D-induced cell lysis and by releasing inflammatory factors that affect the so-called “cell death-anti-tumor immunity”. Peroxiredoxin 1 warrants further investigation for the development of co-expression markers (Prdx1/GSDMD). Furthermore, as the authors note, the efficacy of combination therapies targeting rPrdx1 should be studied promptly to promote personalized treatment of colon cancer." [Collapse]

Chen ZK, Zhao JW, Meng WY, Wang YG. Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions. World J Gastroenterol 2026; 32(8): 116016

"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic ..." [Read more]

"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic collation of knowledge in the field. However, there is room for optimization in terms of data rigor, content depth, and clinical relevance. To enhance its academic value, it is advisable to supplement detailed information on literature screening, strengthen the connection between technical details and clinical applications, enrich the comprehensiveness of discussions on limitations, and optimize the timeliness of case data and references. Other comments: Figures and tables: I think the paper should have more figures, rather than only tabels." [Collapse]

Agrawal H, Tanwar H, Gupta N. Tumor organoids in translational cancer research: Models for personalized therapy. World J Transl Med 2026; 12(1): 113050

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Alvarez M, Luna M, Suarez E, Rincon O, Guzman I, Mancera P. Thyroid collision tumor and Graves’ disease: A case report and review of literature. World J Clin Cases 2026; 14(5): 117016

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Bouayad A. Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. World J Clin Cases 2026; 14(5): 115814

" Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors ..." [Read more]

" Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors for refractory GERD. Anti-anxiety interventions, standardized exercise prescriptions, and lifestyle factors such as sleep and weight management should be explored as a multidimensional risk-targeted intervention. However, in the real world, we have to distinguish between true refractory GERD and refractory reflux-like symptoms. A systematic evaluation of the patients is essential, as up to 40% of patients with GERD report inadequate symptom control with PPIs, but only a minority have true refractory GERD. Therefore, we should evaluate multiple aspects of the patient's behavior (e.g., optimizing PPI therapy, ensuring correct timing, increasing to twice-daily dosing, or switching to a different PPI) before proceeding with exercise prescriptions and anti-anxiety interventions. Moreover, alternative pharmacologic options, including Histamine-2 receptor antagonists (administered at bedtime for nocturnal symptoms, though tachyphylaxis limits long-term efficacy), potassium-competitive acid blockers, alginates and antacids, prokinetic agents, neuromodulators, bile acid sequestrants, and lifestyle modifications, should be tried in these patients, indicating that individualized, multidisciplinary care is essential. " [Collapse]

Zuo XY, Chen QQ. Beyond monotherapy by acid suppression: Reshaping the management of refractory gastroesophageal reflux disease. World J Gastroenterol 2026; 32(7): 116425

"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In ..." [Read more]

"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In particular the discussion is well written. I don't know if I've missed it, but I haven't seen a correlation between myocardial infarction and ethnicity. In Europe ethnicity is an important factor, given that Asian populations have a higher incidence of myocardial infarction at young ages." [Collapse]

Patel T, Farhan M, Bhatt NK, Fatah HA, Peniel JJ, Kaulgud VV, Mathew T, Bapat AM, Harazeen WS, Alatta AN, Awosika A. Non-traditional risk factors for myocardial infarction in adults under forty: A systematic review of emerging trends. World J Cardiol 2026; 18(2): 116172

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Lee H, Han YH, Chung JW, Kim KO, Kwon KA, Kim JH. Upper gastrointestinal bleeding with duodenal varix: A case report. World J Clin Cases 2026; 14(4): 116648

"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. ..." [Read more]

"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. RYDG and OAB are good weight loss surgeries without the risk of GERD. For patients with GERD, the surgical procedure should be selected as suggested by authors." [Collapse]

Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600

"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and ..." [Read more]

"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and bariatric surgery (MBS) has been considered the most effective treatment for weight loss in obese patients. The most commonly performed surgical procedures are sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and single-anastomotic gastric bypass (OAGB). MBS has different effects on obesity-related GERD depending on the type of procedure performed. The results suggest that RYGB consistently leads to significant improvement or remission of GERD symptoms, reduced HCl exposure, and reduced need for PPI therapy in obese patients. RYGB and OAGB are more effective than SG for weight loss and GERD control. RYGB is therefore the preferred bariatric procedure for obese patients with clinically evident GERD. SG is associated with a higher risk of new onset or worsening of GERD, an increased incidence of erosive esophagitis, and an increased risk of Barrett's esophagus. The pathophysiology of these effects is multifactorial and involves changes in gastric anatomy and lower esophageal sphincter function. Therefore, the choice of the type of surgical procedure that should be performed must be individualized, with RYGB being preferred in obese patients with significant GERD or Barrett's esophagus, while SG can be performed in patients without reflux symptoms but requires careful preoperative assessment of GERD risk. The aforementioned data should be taken seriously and guide the physician and patient with obesity and GERD towards making the right surgical decisions." [Collapse]

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's ..." [Read more]

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's disease. In daily medical practice, its treatment is often inadequate since it is usually attributed to side effects of the drugs administered to treat the underlying disease or to psychological causes. The study under review found that indeed, psychological symptoms such as depression, anxiety, stress of any cause, and insomnia are related to its occurrence. In particular, stress is likely to induce the symptom through probable immunological effects. Of interest was the frequent occurrence of fatigue with increased white blood cell count. It therefore seems that fatigue in patients with Crohn's disease has a multifactorial etiology, not exclusively attributable to disease activity or inflammatory markers. As the researchers pointed out, fatigue among IBD patients should receive greater attention in the near future. By conducting additional relevant studies, we will be able to accurately identify the factors that contribute to fatigue, enabling us to develop and implement strategies to effectively identify and support patients experiencing fatigue." [Collapse]

Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete ..." [Read more]

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete intestinal obstruction (CRIO). Given the multifactorial and complex pathophysiology of CRIO, it is inherently challenging to comprehensively describe all clinical conditions. Nevertheless, the authors successfully present a well-structured and comprehensive overview by organizing the discussion into a clear and logical framework." [Collapse]

Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as ..." [Read more]

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as addressed in the following: Of the “Abstract”. The aim does not match well the conclusion. Some “Keywords” are not adequate. “Metagenomic next-generation sequencing” should be moved from “Keywords”. There was no “analysis” or associated description in the “Methods” of the “Abstract”, and this is not adequate. The “Results” in “Abstract” were not consistent with the “Methods” of the “Abstract”. There was no gold standard (guidelines) and criteria for the diagnosis of pulmonary nocardiosis in the “Materials and Methods”. The imaging characteristics (Table 4) were not complete, and which should include a complex item comprising two or more imaging characteristics of the lungs . A total of the pulmonary nocardiosis caused by different species in Table 4 was not 102. The pulmonary nocardiosis treated by different medications in Table 5 was not clear, some patients treated using more than one medications, and the total number was not 102. Figure 1 was not necessary, and associated information can be listed in table or presented in text. Images of pulmonary nocardiosis were not sufficient, and more other representative images had better be added. The English is not professionalism. The “Conclusion” that “Nocardia pneumonia commonly coexists with bronchiectasis. Although mNGS has greatly enhanced its detection rate, N. wallacei pneumonia is distinguished on chest CT by its primary presentation of bronchopneumonia, unlike other types.” was not adequate, and it was not well matching the contents of the “Results”." [Collapse]

Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..." [Read more]

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity. Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter. " [Collapse]

Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an ..." [Read more]

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an essential tool in hepatocellular carcinoma surgery and supporting this with evidence from systematic reviews and clinical studies. It logically organizes the diverse applications of ICG—segmental mapping, detection of superficial lesions, thermal ablation guidance, and tumor‑biology assessment—showing how each technique addresses specific surgical limitations. The discussion consistently links fluorescence patterns to pathological features and clinical decision‑making, reinforcing the article’s central claim that ICG enhances precision, safety, and oncologic outcomes in minimally invasive liver surgery." [Collapse]

Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the ..." [Read more]

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the unusual initial presentation—spontaneous splenic rupture—to the tumor’s aggressive biology. Its diagnostic reasoning is coherent, moving from clinical findings to imaging, pathology, and molecular profiling that distinctly separate the ductal adenocarcinoma and rhabdoid components. The discussion logically integrates existing literature to highlight the rarity, poor prognosis, and potential benefit of aggressive multimodal therapy, underscoring the need for targeted approaches in this molecular subtype." [Collapse]

Yao WQ, Ma XY, Wang GH. Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 114021

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer ..." [Read more]

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer patients with liver metastases and justifying the need to compare chemotherapy alone with chemoimmunotherapy. Its methodology is rigorous and transparent, using well‑defined inclusion criteria, detailed baseline characteristics, and standardized outcome measures such as RECIST, overall survival, and progression‑free survival. The conclusions logically follow from the data, showing that adding immune checkpoint inhibitors significantly improves survival and response rates without increasing severe toxicity, and the study further strengthens its argument by identifying independent prognostic factors through multivariate Cox regression analysis." [Collapse]

Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2026; 18(1): 113440

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy ..." [Read more]

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy in advanced gastric cancer with massive ascites and justifying the need for retrospective evaluation. Its methodology is well‑structured, using clearly defined ascites‑burden groups and standardized clinical criteria to ensure meaningful comparisons of outcomes and safety profiles. The conclusions follow naturally from the data, showing that although prognosis remains poor in the high‑ascites group, nivolumab plus chemotherapy provides measurable ascites improvement and acceptable toxicity, supporting its potential therapeutic value in this challenging population." [Collapse]

Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2026; 18(1): 112944

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the ..." [Read more]

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the study’s objectives and findings. The methods and results are supported by detailed experimental design and high‑quality figures and tables, which enhance reproducibility and data transparency. The discussion highlights clinical relevance and practical implications, effectively linking mechanistic insights to potential therapeutic strategies." [Collapse]

Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2026; 18(1): 112630

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate ..." [Read more]

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate diagnosis requires a combination of imaging and endoscopic techniques. Pancreatoscopy enables direct visualization of the pancreatic duct, targeted biopsies, and the definition of disease boundaries. Existing data support the view that pancreatoscopy is a satisfactory and promising method for determining which patients with IPMN should undergo surgery, as well as the extent of resection for each patient. However, excessive enthusiasm should not prevail. The method is not widely applied; learning requires a dedicated endoscope and a sufficient number of patients per year to maintain and further increase experience, which is a very important factor. For the widespread acceptance and adoption of the method, it is necessary to conduct prospective, very well-designed multicenter studies aiming to precisely determine many parameters e.g. its diagnostic contribution and accuracy, which patients should undergo the examination, what is the impact on therapeutic decisions, what is the cost-benefit ratio and finally to determine whether it improves the survival and/or quality of life of patients. Based on the above observations, pancreatoscopy should be decided on a case-by-case basis and performed in specialized centers." [Collapse]

Abusharar M, Barritt C, Mavroeidis VK, Aroori S. Role of pancreatoscopy in the management of suspected and confirmed intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2026; 32(4): 112635

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data ..." [Read more]

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data from the literature, presenting it in a clear and well-structured manner. The review provides valuable insights into the topic, highlights key mechanisms and clinical implications, and offers a solid foundation for future research and practical applications." [Collapse]

Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511

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