Baishideng Publishing Group

Phavichitr N, Tantibhaedhyangkul R, Dumrisilp T, Prachuapthunyachart S, Chanpreecha W, Ratanamongkol P, Chongsrisawat V. Clinical outcomes of two lactose-free formulas in the management of acute childhood diarrhea. World J Clin Pediatr 2026; 15(1): 114953

"Seamless process, submitting an article, which was reviewed in a timely manner with rigorous peer review. The editorial team were ..." [Read more]

"Seamless process, submitting an article, which was reviewed in a timely manner with rigorous peer review. The editorial team were professional and guided the process in a fast and clear manner. Peer reviewers reviewed the article in the pre-specified time with good insight and comments on the article. Publishing with BPG was a very streamlined process. " [Collapse]

Cilia BJ, Haridy J, Raj A, Hannah N. Hepatic hydrothorax as a manifestation of decompensated cirrhosis: An update on current management and future directions. World J Hepatol 2025; 17(10): 110412

"I am very satisfied with the work of the team at the journal. The journal’s workflow is well-structured and rigorous. The PDF ..." [Read more]

"I am very satisfied with the work of the team at the journal. The journal’s workflow is well-structured and rigorous. The PDF preparation stage may take slightly longer than some of the other steps; however, overall, I believe the process is of very high quality. I have no additional suggestions, as the team is already doing an excellent job. " [Collapse]

Kiatvitchukul T, Dokkham P, Jeephet K, Srisingh K. Understanding recurrent wheezing: A parent’s guide. World J Clin Pediatr 2026; 15(1): 113430

"The peer review process was fair and constructive, and the reviewers’ comments were helpful in improving the quality of the manuscript. ..." [Read more]

"The peer review process was fair and constructive, and the reviewers’ comments were helpful in improving the quality of the manuscript. The editorial and publication processes were handled professionally, and communication from the editorial office was clear and supportive. One minor point is that the submission format and workflow differ somewhat from those of many other journals, which may require some time for authors to become familiar with. Overall, however, the publication process was satisfactory. " [Collapse]

Aoki Y, Kawano Y, Ga R, Endo K, Ueda J, Shimizu T, Yoshida H. Vasopressin and fluid retention after liver resection: Comparison with the renin-angiotensin-aldosterone system by surgical extent and liver function. World J Gastroenterol 2026; 32(10): 115167

"The editorial process was efficient and well organized. The peer-review comments were constructive and helpful in improving the quality ..." [Read more]

"The editorial process was efficient and well organized. The peer-review comments were constructive and helpful in improving the quality and clarity of our manuscript. We appreciate the professional support and guidance from the editorial team throughout the review and publication process, which contributed to the successful completion and online publication of our article. " [Collapse]

Chen CY, Hsu YH. Complete resolution of massive chronic subdural hematoma with refined layered middle meningeal artery embolization: A case report. World J Clin Cases 2026; 14(7): 116694

"While the overall experience with the journal was positive, the peer review process and process post acceptance to final publication ..." [Read more]

"While the overall experience with the journal was positive, the peer review process and process post acceptance to final publication felt sluggish. A more nuanced, streamlined post-acceptance workflow with quick responses would have been ideal, but despite the wait, I enjoyed a professional and productive collaboration with the editorial team. " [Collapse]

Mylavarapu M, Chavali SM, Buddharaju AD, Veldurthy S, Cheruvu P, Parikh AG. Vaping during pregnancy and its impact on neonatal outcomes: A systematic review and meta-analysis. World J Clin Pediatr 2026; 15(1): 108069

"Overall, it is a very good experience to publish my article in the World Journal of Pediatrics. The editing and peer-review process ..." [Read more]

"Overall, it is a very good experience to publish my article in the World Journal of Pediatrics. The editing and peer-review process was timley and accurate. The reviewers' comments were fair and objective and helped me improve the quality of the manuscript. The final editing and proofreading process was efficient. I have only a minor commnet regarding the realtively long period from acceptance to publication. For sure, I will consider this journal for my future manuscripts. " [Collapse]

Abdelkreem E, Labeeb YS, Mohamed MA. Efficacy of vitamin D supplementation for children with acute bronchiolitis: A randomized controlled trial. World J Clin Pediatr 2026; 15(1): 114465

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. ..." [Read more]

"Excellent journal and managing team. Very efficient handling and processing. All in all a very smooth and effortlessly process. Hopefully will have many more publications in this reputable and rapidly rising journal. I hope the journal continues to achieve more success, gets WOS indexation and an impact factor soon, and the same be reflected in the ever improving journal metrics. " [Collapse]

Parizad R, Hatwal J, Brar AS, Alizadeh L, Goyal MK, Batta A, Mohan B. Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes. World J Clin Pediatr 2026; 15(1): 111030

"Dear Editors, I am very familiar with the submission and editorial system, as well as with the way your journals operate. The process ..." [Read more]

"Dear Editors, I am very familiar with the submission and editorial system, as well as with the way your journals operate. The process is clearly well established, organized, and efficient. It is truly a pleasure to interact with such a professional editorial team. The platform is user-friendly, intuitive, and facilitates smooth communication throughout the submission and review process. Additionally, the turnaround time for feedback has consistently been fast and effective, which greatly supports authors in improving and advancing their work. Congratulations to the editors and the entire team for maintaining such a high standard of editorial management and author support. " [Collapse]

Ribeiro Junior MAF, Dib Possiedi R, Stefani Pacheco L, de Cesaro Schpchacki N, Nafeesa Hashim S, Monteiro Tavares Pereira B. Direct peritoneal resuscitation in sepsis and intra-abdominal infection: A scoping review. World J Clin Cases 2026; 14(7): 118719

"I am very satisfied with the entire process of publication. The entire procedure was efficient and smooth, and the time from submission ..." [Read more]

"I am very satisfied with the entire process of publication. The entire procedure was efficient and smooth, and the time from submission to receiving the decision may be delayed for quality assurance, which may be be taken care of. The reports from the two anonymous peer reviewers were highly professional and constructive. Their revision suggestions were insightful and to the point, greatly improving the quality and academic rigor of the manuscript. one thing I observered that when the artcle is going to press for final editing, some texts are either missing or replaced by some other e.g., the references. I appreciate the commandable job of the editorial team. This full proof submission experience makes an individual to continue submitting to your journal in future also. " [Collapse]

Keshri S, Goel AK, Garg AK, Anand V, Rathia SK, Yusuf S. Early inotropic support without fluid bolus vs standard resuscitation in pediatric septic shock: A randomized controlled trial. World J Clin Pediatr 2026; 15(1): 109864

"The peer-review process was conducted objectively and efficiently, with constructive comments that helped improve the quality of the ..." [Read more]

"The peer-review process was conducted objectively and efficiently, with constructive comments that helped improve the quality of the manuscript. Editorial communication was clear and timely, and responses to queries were prompt. The editing and production services were professional, well organized, and completed within a reasonable timeframe, contributing to a smooth publication process. " [Collapse]

Bouayad A. Clinical utility of human leukocyte antigen genotyping and immunoglobulin G4 autoantibody testing in autoimmune neurological diseases: A focused minireview. World J Biol Chem 2026; 17(1): 117645

"It was an overall excellent, fast and uneventful reviewing process since the time of article submission. The scientific editor guided ..." [Read more]

"It was an overall excellent, fast and uneventful reviewing process since the time of article submission. The scientific editor guided the whole process very efficiently and was very supportive in terms of article preparation. Moreover, the reviewers' comments helped a lot to improve the scientific quality and appearance of the article. " [Collapse]

Davitis V, Chalidis B. Extra-acetabular resection of a protruding transacetabular screw after total hip arthroplasty for developmental dysplasia: A case report. World J Clin Cases 2026; 14(7): 117757

"I am very satisfied with the submission process and overall efficiency of this journal. The manuscript handling was rigorous and ..." [Read more]

"I am very satisfied with the submission process and overall efficiency of this journal. The manuscript handling was rigorous and well-organized, and the peer-review speed far exceeded my expectations, resulting in a relatively short time from submission to final acceptance. The editorial team was professional and communicated in a timely manner, providing quick responses to any questions I had during the process. This efficient publication pace is very favorable for the timely dissemination of research findings, making it a truly pleasant submission experience. " [Collapse]

Hou L, Chen R, Huang CB, Shi WJ, Wu LL. Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia. World J Psychiatry 2026; 16(3): 114036

"Our overall experience with the evaluation and publication process of the article we sent to this journal is very positive. The online ..." [Read more]

"Our overall experience with the evaluation and publication process of the article we sent to this journal is very positive. The online application system is user-friendly and easy to use, and the application process ran smoothly. The referee evaluation process was carried out in accordance with academic standards and the referee reports were of a quality that would contribute to improving the scientific quality of the study. Constructive and objective feedback from the referees helped improve the article in terms of methodology and content. The editorial process of the journal has been carried out in accordance with academic ethical rules and publication standards, and is at a satisfactory level in terms of editing quality, article format, presentation of tables and figures. In addition, the transparent and systematic progress of the article evaluation and publication process was reassuring for the author. In general, we would like to state that the journal offers a satisfactory experience in terms of editorial management, peer review process and compliance with academic norms. For this reason, we think that the journal offers a reliable and qualified platform for academic publishing. " [Collapse]

Deniz R, Atay ME, Çiftçi B. Electromyographic biofeedback in stroke rehabilitation: A pathway to motor recovery and psychological resilience. World J Psychiatry 2026; 16(3): 115093

"I had a positive experience with the editorial and peer-review process at World Journal of Clinical Pediatrics. Communication with ..." [Read more]

"I had a positive experience with the editorial and peer-review process at World Journal of Clinical Pediatrics. Communication with the editorial office was clear and timely throughout the process. The reviewers provided fair, constructive, and helpful comments that improved the manuscript. I appreciate the professional handling of our submission and the opportunity to publish our work in this journal. " [Collapse]

Khdair Ahmad F, Alkayid MR, Ahmad TM, Hadidi RH, Rahhal RM. Cow’s milk protein allergy in infants: Clinical presentations and outcomes. World J Clin Pediatr 2026; 15(1): 109301

"The journal demonstrates excellent operational efficiency, underpinned by a highly responsive and intuitive website that facilitates ..." [Read more]

"The journal demonstrates excellent operational efficiency, underpinned by a highly responsive and intuitive website that facilitates a seamless submission process. One of its most commendable attributes is the remarkably low overall response time, which is essential for timely academic dissemination. Furthermore, the quality of both the peer reviews and the subsequent editorial oversight is exceptional, providing authors with rigorous, constructive feedback that significantly enhances the manuscript's merit. Based on these strengths—speed, professional rigor, and a user-centric digital infrastructure—I highly recommend this journal as a premier venue for publication. It is an ideal choice for researchers seeking excellence. " [Collapse]

Maurya P, Gupta A, Gupta N. Influence of blood transfusion on outcomes in patients with gastric cancer. World J Gastroenterol 2026; 32(10): 115683

"Dear Editors and Team of WJCP! I would like to express my deepest and most sincere gratitude for the opportunity to publish my work ..." [Read more]

"Dear Editors and Team of WJCP! I would like to express my deepest and most sincere gratitude for the opportunity to publish my work in your esteemed journal. It has been an honor to be a part of such a respected and influential publication, and I am sincerely grateful for the support, guidance, and professionalism shown throughout the process. The submission guidelines were detailed and straightforward, allowing me to navigate the initial stages of the process without any issues. When I had questions or needed clarification, your team responded promptly, paying close attention to the details. This level of responsiveness is not only appreciated, but also essential for maintaining the high standards that your journal is known for. The review process was thorough and constructive. The reviewers provided insightful and well-thought-out comments that truly helped me improve the quality of my work. Instead of feeling discouraged by the criticisms, I realized that they could be an invaluable tool for refining my arguments and strengthening my research position. It is evident that your journal places a strong emphasis on academic excellence, and this commitment to quality is evident in every aspect of your work. In addition, I would like to highlight the professionalism and kindness of the editorial staff. Every email, every request, and every update was handled with attention and respect. You have created an environment that fosters collaboration and intellectual growth, and I am particularly grateful for this. It is rare to find a journal that combines high academic standards with such a supportive and inspiring atmosphere. Publishing in WJCP has been not only a significant milestone in my academic career, but also a valuable learning experience. I have gained a deeper understanding of the importance of clear communication, meticulous editing, and open dialogue in scientific work. Your journal's commitment to disseminating high-quality research has undoubtedly contributed to the advancement of knowledge in our field, and I am proud to have been a part of this mission. On a personal level, I would like to express my gratitude for the way you have treated me as an author. The sense of being valued and respected throughout the publication process has been truly meaningful. It is such positive experiences that inspire researchers to continue contributing to the scientific community and to seek out journals that share these values. In conclusion, I would like to express my deep gratitude for all that your team has done. Your journal is not just a platform for publishing scientific research, but a catalyst for intellectual exchange, a guarantor of academic integrity, and a source of inspiration for scientists around the world. I hope that I will have the opportunity to collaborate with you again in the future, and I will definitely recommend WJCP to my colleagues and peers. Thank you once again for your time, effort, and continued commitment to high standards. With best wishes and deep appreciation, Mikhail Kostik, MD, Professor Saint Petersburg State Pediatric Medical University " [Collapse]

Gabrusskaya T, Ulanova N, Shilova E, Volkova N, Kilina S, Kornienko E, Kostik M. Efficacy and safety of dual-targeted therapy in children with inflammatory bowel disease: Retrospective cohort study. World J Clin Pediatr 2026; 15(1): 111093

"The submission process is very tedious, time-consuming, and requires lots of unnecessary documents. Some of these should be optional, ..." [Read more]

"The submission process is very tedious, time-consuming, and requires lots of unnecessary documents. Some of these should be optional, depending on the type and quality of the manuscripts, e.g., English editing certificate, author checklists. etc. When most journals are trying to make the submission process easy, you are making it more and more difficult. " [Collapse]

Agrawal A, Janjua D, Jadon G. Role of biomarkers in pediatric sepsis: What evidence says? World J Clin Pediatr 2026; 15(1): 111999

"Thank you for editorial team for their continuous support. I found a very helpful organised pathway from the time of submission to ..." [Read more]

"Thank you for editorial team for their continuous support. I found a very helpful organised pathway from the time of submission to the publication tome .every step was smooth and precise. My experience with the journal and publisher is wonderful.. I encourage all my colleagues to consider the world journal if they have a good research " [Collapse]

Fouad Y, Aboelela AS. Lessons from extended induction and practical evidence for improving tofacitinib therapy in ulcerative colitis. World J Gastroenterol 2026; 32(9): 115785

"I am very pleased to have been able to highlight the potential for music therapy as a non-pharmacological treatment to improve the ..." [Read more]

"I am very pleased to have been able to highlight the potential for music therapy as a non-pharmacological treatment to improve the survival rates of ICU patients, and I hope that further neuroscience research in this area will continue. There is growing evidence that music has an effect on the reorganization of brain circuits in the cerebral cortex, but basic clinical research is still lacking, so I would like to conduct further research. " [Collapse]

Nagamine T. Neurobiological rhythms in critical care: A commentary on intensive care unit music therapy efficacy and mechanism. World J Crit Care Med 2026; 15(1): 116487

20891 items Read more >>

Article Quality Tracking-Peer-Review

"This review article summarizes the current knowledge regarding the structure and role of the gut–brain axis, particularly in the ..." [Read more]

"This review article summarizes the current knowledge regarding the structure and role of the gut–brain axis, particularly in the context of acute brain injury. The major components include direct connections between the intestines and the brain through neurological and hormonal systems, as well as indirect communication mediated by intestinal flora and inflammatory cytokines. The structural participants include the autonomic nervous system, comprising both sympathetic and parasympathetic pathways, and the hypothalamic–pituitary–adrenal axis. Within these systems, a vicious cycle may easily develop. Brain inflammation can lead to systemic inflammatory spillover, which may induce increased intestinal permeability (“leaky gut”). This, in turn, can further exacerbate systemic inflammation and subsequently worsen brain inflammation. Potential therapeutic approaches discussed in the manuscript include vagus nerve stimulation, prebiotics and probiotics, fecal microbiota transplantation, and nutritional support. However, the content of the manuscript is largely redundant and does not present novel therapeutic concepts. In addition, the manuscript lacks detailed discussion of the underlying mechanisms and does not provide specific guidance for clinical practice. Overall, the manuscript remains largely descriptive and narrative rather than presenting a rigorous scientific analysis." [Collapse]

Zhao X, Zhang W, Zhang Y, Liu XA. Gastrointestinal dysfunction after brain injury: Mechanisms and the role of the brain-gut axis. World J Gastroenterol 2026; 32(10): 115731

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

"Traditional Chinese Medicine has demonstrated satisfactory preclinical and clinical efficacy in patients with IBD. The data from the ..." [Read more]

"Traditional Chinese Medicine has demonstrated satisfactory preclinical and clinical efficacy in patients with IBD. The data from the review under comment demonstrate that TCM primarily acts through a holistic approach, affecting multiple signaling pathways and other immunological mechanisms, including the composition of the gut microbiota, intestinal barrier integrity, autophagy, and gene expression. TCM treats IBD by synergistically modulating immunity, repairing the intestinal barrier, restoring the gut microbiota, and regulating inflammatory pathways and autophagy. In recent years, a large number of research papers, mainly by Chinese researchers, have sought to identify the therapeutic components of these treatments on the one hand and to investigate their mechanisms of action on the other. Moreover, clinical data and meta-analyses of randomized controlled trials support the effectiveness of PKI. Taken together, these actions will provide PKI with a scientific basis and foundation for its results. It is truly remarkable that both the large pharmaceutical industries and the health providers, as well as the officials of various countries, do not fund large multicenter studies that use PKI or the so-called Alternative Medicine in patients with IBD, at least as a complementary treatment to traditional Western medicine. I believe that the path towards this direction is inevitable in the coming years. Congratulations to the authors of the review." [Collapse]

Zeng SH, Jiang XY, Lin DR, Zhang WJ, Wu YQ, Xu L, Guo SJ. Mechanisms and therapeutic potential of traditional Chinese medicine for inflammatory bowel disease. World J Gastroenterol 2026; 32(10): 115821

"The vascular anatomy of the head and neck is highly complex and variable, and accurately characterizing the spatial relationships ..." [Read more]

"The vascular anatomy of the head and neck is highly complex and variable, and accurately characterizing the spatial relationships between vessels and adjacent bony structures is essential for identifying high-risk patients and guiding surgical planning. In a well-written letter to the editor, Jiang and Li commented on the study by Karangeli et al., a computed tomography angiography-based investigation of the spatial relationship between the hyoid bone and the carotid arteries. That study, which included 224 patients, revealed significant anatomical variability and concluded that carotid–hyoid contact is far more common than previously recognized. These findings carry important implications for radiologists and surgeons, as such contact may predispose patients to dynamic carotid compression, transient ischemic events, or intraoperative vascular injury. Jiang and Li discussed the clinical significance of carotid–hyoid anatomy, its surgical relevance, and age-related considerations. They acknowledged that the study by Karangeli et al. highlights the importance of translating detailed anatomical knowledge into preventive strategies that integrate imaging precision with vascular protection. Their review of the literature also summarized findings from other studies, noting that differences in suprahyoid muscular tension, cervical biomechanical loading, or hormonal influences may alter the course of the carotid arteries and contribute to previously unrecognized, sex-specific vascular risk profiles. Certain anatomical configurations—particularly types VIII and XI—may lead to transient compression, displacement, or repetitive impingement of the internal carotid artery during swallowing, neck rotation, flexion-extension, or physical exertion. Jiang and Li called for comparable longitudinal and multiethnic population-based studies on the hyoid bone and proposed future research directions. They emphasized that the carotid–hyoid relationship is far from an anatomical curiosity; rather, it represents a critical interface with direct implications for cerebrovascular health, surgical safety, and diagnostic accuracy. The authors further noted that radiologists should maintain a heightened awareness of this anatomical relationship in patients with cryptogenic stroke, recurrent focal neurological deficits, or unexplained cervical symptoms. Incorporating carotid–hyoid topographic evaluation into routine CTA reporting not only enhances diagnostic completeness but also facilitates timely risk identification and meaningful prevention, bridging the gap between structural anatomy and clinical protection. The parent study holds substantial clinical significance and relevance, offering valuable insights that can aid clinicians in addressing complex clinical challenges and improving patient outcomes. The article was well written and edited in terms of structure, language and references, and no errors were identified." [Collapse]

Jiang SY, Li R. When anatomy becomes pathology: Rethinking carotid-hyoid contact in cerebrovascular events. World J Radiol 2026; 18(2): 116873

"This study demonstrated that perioperative blood transfusions during gastric cancer surgery are associated with increased postoperative ..." [Read more]

"This study demonstrated that perioperative blood transfusions during gastric cancer surgery are associated with increased postoperative inflammation and stress responses, higher complication rates, and worse long-term outcomes. These results emphasize the importance of reducing unnecessary transfusions during surgery for gastric cancer patients. The immunomodulatory effects and enhanced inflammatory responses of transfusions may adversely affect the prognosis of cancer patients. The researchers concluded that avoiding unnecessary transfusions may facilitate postoperative recovery and improve long-term outcomes in gastric cancer patients. Going forward, it will be important to closely evaluate the need for blood transfusions and develop strategies to minimize transfusions, such as exploring alternative therapies and improving surgical techniques to reduce blood loss." [Collapse]

Maurya P, Gupta A, Gupta N. Influence of blood transfusion on outcomes in patients with gastric cancer. World J Gastroenterol 2026; 32(10): 115683

"We know that Traditional Chinese Medicine is a comprehensive medical system with a history of over 2,000 years, whose offerings focus ..." [Read more]

"We know that Traditional Chinese Medicine is a comprehensive medical system with a history of over 2,000 years, whose offerings focus on restoring balance and harmony between body, mind, and environment. Among its therapeutic methods, herbal medicine holds a leading position through the use of natural recipes based on herbs and minerals, aimed at enhancing self-healing processes. It is particularly effective in treating, among others, autoimmune and inflammatory conditions. Traditional Chinese Medicine is constantly gaining ground as a complementary therapy in the West. The World Health Organization has already officially recognized it by including it in the International Classification of Diseases, which facilitates its integration into national health systems. Currently, its adoption is usually proposed as a parallel to Western medicine rather than a replacement for it. In the study under review, the authors, using complex methods, identified the main bioactive components of Lianhe Xiaozhi ointment and the pathophysiological mechanisms underlying its effective alleviation of metabolic dysfunction-associated steatotic liver disease. In a global system of pharmaceutical treatment of ever-increasing cost, studies such as the one under review are necessary to determine, with adequate scientific methodology, the active ingredients and their precise mode of action in specific pathological conditions. I would like to congratulate the authors on their excellent work. " [Collapse]

Nie LJ, Wang GX, Yang XY, Sun J, Cao YT, Lou Y, Lu YF, Yu JY, Zhou XQ. Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease via peroxisome proliferator-activated receptor alpha pathway activation. World J Gastroenterol 2026; 32(9): 114544

"Thank you for the opportunity to review the quality of the following editorial. Please see my comments below: 1 Ethics: Not applicable ..." [Read more]

"Thank you for the opportunity to review the quality of the following editorial. Please see my comments below: 1 Ethics: Not applicable given manuscript type 2 Methods: Not applicable given manuscript type 3 Results: Not applicable given manuscript type 4 Figures and tables: The included figure adds to the readability of the manuscript 5 Biostatistics: Not applicable given manuscript type 6 References: Appropriate/up-to-date references 7 Language: Concise/well-written editorial 8 Caveats or drawbacks: None " [Collapse]

Huang HY, Tian L. Kill two birds with one stone: Reprogramming tumor microenvironment with growth differentiation factor 11. World J Gastroenterol 2026; 32(9): 115259

"Re: Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum ..." [Read more]

"Re: Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum and its management. World J Clin Urol 2026; 15(1): 114046 [DOI: 10.5410/wjcu.v15.i1.114046] The authors report on “Practical approach to the review of bladder diverticulum and its management” The article, which provides a combination of literature review and personal experience, included a detailed discussion of the definition, etiology, pathogenesis, clinical presentation, diagnosis and treatment of bladder diverticulum. The following comments can be of benefit for future considerations: 1.The causes and treatment of bladder diverticulum in children are different from those in adults. So, it would have been better to focus on either of them. 2. The authors stated that “For example, in boys with posterior urethral valves, these diverticula can serve as a pressure relief mechanism to protect the kidneys from damage and maintain bladder function”. In this context, is it possible to treat these diverticula conservatively without active surgical intervention? If the answer is yes, what are the indications. 3. It would have been better to include the pros and cons of the different surgical techniques, namely, extravesical, intravesical, or transdiverticular. Are they comparable? [1,2] 4. Among the active treatment options of bladder diverticulum is transurethral electrovaporization of the diverticular mucosa. It would have been better to include it among the endoscopic treatment procedures [3]. 5. Is there a difference in the outcome between staged treatment versus concomitant treatment of the cause and the resulting secondary diverticulum, for example in cases with BOO? [4] 6. In cases of female diverticulum, which are very close to the urethra, what are the recommended tips and tricks [5]. References [1]. Perri D, Roche JB, Petrut B, Bozzini G. Bladder diverticula management - conservative and surgical outcomes: a narrative review from EAU endourology. Curr Opin Urol. 2026 Jan 1;36(1):79-85. doi: 10.1097/MOU.0000000000001307. Epub 2025 Jun 12. PMID: 40548586. [2]. Giannarini G, Rossanese M, Macchione L, Mucciardi G, Crestani A, Ficarra V. Robot-assisted Bladder Diverticulectomy Using a Transperitoneal Extravesical Approach. Eur Urol Open Sci. 2022 Sep 8;44:162-168. doi: 10.1016/j.euros.2022.08.016. PMID: 36110902; PMCID: PMC9468349. [3]. Chandhoke RA, Ghoniem GM. Transurethral Electrovaporization of Bladder Diverticulum: An Alternative to Open or Laparoscopic Bladder Diverticulectomy. J Endourol Case Rep. 2015 Oct 1;1(1):11-3. doi: 10.1089/cren.2015.29002.cha. PMID: 27579375; PMCID: PMC4996560. [4]. Gazzah W, Ben Taher S, Masmoudi S, Hamza M, Naouar S, Salem B. Management of multiple giant bladder diverticula: a comprehensive approach - a case report. Ann Med Surg (Lond). 2024 May 15;86(7):4187-4190. doi: 10.1097/MS9.0000000000002162. PMID: 38989198; PMCID: PMC11230813. [5]. Liao C, He Z, Wang X, Guo P, Xiong W. Laparoscopic surgery for female posterior urethral bladder diverticulum with bladder outlet obstruction: A case report. Medicine (Baltimore). 2023 Sep 1;102(35):e34971. doi: 10.1097/MD.0000000000034971. PMID: 37657035; PMCID: PMC10476744. " [Collapse]

Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum and its management. World J Clin Urol 2026; 15(1): 114046

"The paper is an interesting review, concise, comprehensive, complex and well structured. I think this paper is welcome and relevant ..." [Read more]

"The paper is an interesting review, concise, comprehensive, complex and well structured. I think this paper is welcome and relevant for medical daily practice even if the pathology debated is rare. Gastrointestinal bleeding is a frequent presentation in clinical practice, therefore is important to known all possible causes of bleeding including secondary to a GI melanoma. There are no grammatical or spelling errors throughtout the text. " [Collapse]

De Nardi P, Guida S, Damiano G, Rizzo N, Samanes Gajate AM, Riva ST, Paolino G, Colombo M, Tummineri R, Rongioletti F, Mercuri SR, Chiti A, Sileri P, Russo V. Primary melanoma of the gastrointestinal tract. World J Gastroenterol 2026; 32(8): 114571

"The dose of ursodeoxycholic acid that was prescribed to the study groups were not matched in this project. The uncontrolled PBC ..." [Read more]

"The dose of ursodeoxycholic acid that was prescribed to the study groups were not matched in this project. The uncontrolled PBC patients enface with hypercholesterolemia. This could make bias while diagnosing metabolic criteria for the definition of MASLD. At the same time, the study groups should be matched for the dose of statin consumption. Statins also influence the cholesterol level and should be adjusted as a confounding factor." [Collapse]

Koky T, Drazilova S, Komarova S, Macej M, Toporcerova D, Janicko M, Spakova I, Rabajdova M, Marekova M, Jarcuska P. Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis. World J Hepatol 2026; 18(2): 113685

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Bhati G, Mongardini FM, Bhati K, Singh P, Bansal R, Bansal A, Mahajan S, Docimo L, Caricato M, Capolupo GT, Carannante F. Ruptured primary intrahepatic ectopic pregnancy: A case report and review of literature. World J Clin Cases 2026; 14(6): 118135

" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

Aby Hadeer R, Ghattas S, Farhat H, Maalouf H, Bitar JE, Ayash D, Mohtar F, Elias B, Wakim R. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for appendiceal mucocele tumors: Five case reports and review of literature. World J Clin Cases 2026; 14(6): 117655

"Duodenal ischemia in systemic lupus erythematosus (SLE) is a pathological condition of severe lupus enteritis, in which blood flow ..." [Read more]

"Duodenal ischemia in systemic lupus erythematosus (SLE) is a pathological condition of severe lupus enteritis, in which blood flow to the intestinal tract is impaired, mainly due to vasculitis and thrombosis. It begins with sudden abdominal pain, vomiting, and fever, and progresses to ulcers, perforation, and necrosis, so early diagnosis by CT and prompt immunosuppressive therapy, such as steroid pulse therapy, are essential. Surgical treatment: If perforation or necrosis is observed, emergency surgery to remove the affected area is required. The authors performed a duodenal anastomosis to avoid PD, and complications such as bile duct stricture were alleviated with a stent after surgery. This is a good paper." [Collapse]

Kim YK, Jung HI, Kim H, Bae SH. Ischemic duodenal injury due to systemic lupus erythematosus: A case report. World J Gastroenterol 2026; 32(8): 115654

"1) Ethics - meets requirements («The study was approved by the Ethics Committee of National Cancer Center/Cancer Hospital, Chinese ..." [Read more]

"1) Ethics - meets requirements («The study was approved by the Ethics Committee of National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College in accordance with the ethical standards outlined in the 1964 Helsinki Declaration») 2) Methods - revision required. Key concerns: - Subjective criteria for SSA administration The SSA-treated group includes zero patients with perineural invasion, but the endoscopy-alone group has 1 patient. Lymphovascular invasion was present in both groups (10.5% vs 9.6%), but no clear criteria for SSA initiation are provided. This distribution is clinically illogical and indicates selection bias. - Deviation from international guidelines (ENETS/NCCN) 73.4% of patients had tumors ≤ 10 mm without muscularis propria invasion. Current guidelines do not recommend adjuvant SSA therapy in this low-risk population. A substantial proportion of SSA-treated patients may have received overtreatment. Required revisions: Provide an objective, reproducible algorithm for SSA allocation. Perform a subgroup analysis of low-risk patients (≤10 mm, G1, no LVI/PNI). 3) Results - revision required. • The authors state: «However, endoscopic treatment removes lesions without addressing the underlying pathogenesis, allowing gastrin to continue stimulating neuroendocrine cell growth. Therefore, G-NETs may recur after endoscopic treatment». However, gastrin levels were not measured in this study. As a result: the suppressive effect of SSAs on gastrin was not documented and a direct correlation between gastrin reduction and improved outcomes could not be established. • Presented descriptively (n = 27, 6 mutations), with no integration into the main prognostic analysis. It is unclear how these data correlate with the risk of progression or response to therapy. This section appears redundant and detracts from the main clinical conclusions. 4) Figures and tables – good, minor issues Tables 1–4 and Figures 2–4 are clear, well-structured, and properly labeled. Figure 5: Descriptive genetic data only; not integrated into prognostic analysis. Limited relevance to main findings. Recommend moving to Supplementary Materials. 5) Biostatistics - adequate. LASSO and Cox regression correctly used, but no sample size calculation, wide CIs, and potential immortal time bias—acknowledge in limitations. 6) References - good Relevant, up-to-date, no over-citation. 7) Language – good Clear, concise, grammatically correct. 8) Caveats or drawbacks • Retrospective single-center design with inherent selection bias: SSA allocation was subjective and no reproducible algorithm provided. • Deviation from guidelines: 73.4% of patients had low-risk where adjuvant SSAs are not routinely recommended — potential overtreatment. • No gastrin data: The proposed mechanism (SSAs suppress gastrin) remains unverified; correlation between SSA use and reduced progression is statistical, not mechanistically proven. • Genetic data (Figure 5): Descriptive only, not integrated into prognostic analysis; limited relevance to main clinical conclusions. " [Collapse]

Yang ZL, Wang HK, Liu Y, Dou LZ, Zhang YM, Ng HI, He S, Chi YB, Wang GQ. Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study. World J Gastroenterol 2026; 32(8): 114268

"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in ..." [Read more]

"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in mice. The anticancer activity of this substance is based on pyroptosis. Pyroptosis is a key component of cell death. It directly suppresses the tumor by promoting gasdermin D-induced cell lysis and by releasing inflammatory factors that affect the so-called “cell death-anti-tumor immunity”. Peroxiredoxin 1 warrants further investigation for the development of co-expression markers (Prdx1/GSDMD). Furthermore, as the authors note, the efficacy of combination therapies targeting rPrdx1 should be studied promptly to promote personalized treatment of colon cancer." [Collapse]

Chen ZK, Zhao JW, Meng WY, Wang YG. Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions. World J Gastroenterol 2026; 32(8): 116016

"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic ..." [Read more]

"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic collation of knowledge in the field. However, there is room for optimization in terms of data rigor, content depth, and clinical relevance. To enhance its academic value, it is advisable to supplement detailed information on literature screening, strengthen the connection between technical details and clinical applications, enrich the comprehensiveness of discussions on limitations, and optimize the timeliness of case data and references. Other comments: Figures and tables: I think the paper should have more figures, rather than only tabels." [Collapse]

Agrawal H, Tanwar H, Gupta N. Tumor organoids in translational cancer research: Models for personalized therapy. World J Transl Med 2026; 12(1): 113050

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Alvarez M, Luna M, Suarez E, Rincon O, Guzman I, Mancera P. Thyroid collision tumor and Graves’ disease: A case report and review of literature. World J Clin Cases 2026; 14(5): 117016

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..." [Read more]

"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied." [Collapse]

Bouayad A. Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. World J Clin Cases 2026; 14(5): 115814

" Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors ..." [Read more]

" Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors for refractory GERD. Anti-anxiety interventions, standardized exercise prescriptions, and lifestyle factors such as sleep and weight management should be explored as a multidimensional risk-targeted intervention. However, in the real world, we have to distinguish between true refractory GERD and refractory reflux-like symptoms. A systematic evaluation of the patients is essential, as up to 40% of patients with GERD report inadequate symptom control with PPIs, but only a minority have true refractory GERD. Therefore, we should evaluate multiple aspects of the patient's behavior (e.g., optimizing PPI therapy, ensuring correct timing, increasing to twice-daily dosing, or switching to a different PPI) before proceeding with exercise prescriptions and anti-anxiety interventions. Moreover, alternative pharmacologic options, including Histamine-2 receptor antagonists (administered at bedtime for nocturnal symptoms, though tachyphylaxis limits long-term efficacy), potassium-competitive acid blockers, alginates and antacids, prokinetic agents, neuromodulators, bile acid sequestrants, and lifestyle modifications, should be tried in these patients, indicating that individualized, multidisciplinary care is essential. " [Collapse]

Zuo XY, Chen QQ. Beyond monotherapy by acid suppression: Reshaping the management of refractory gastroesophageal reflux disease. World J Gastroenterol 2026; 32(7): 116425

"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In ..." [Read more]

"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In particular the discussion is well written. I don't know if I've missed it, but I haven't seen a correlation between myocardial infarction and ethnicity. In Europe ethnicity is an important factor, given that Asian populations have a higher incidence of myocardial infarction at young ages." [Collapse]

Patel T, Farhan M, Bhatt NK, Fatah HA, Peniel JJ, Kaulgud VV, Mathew T, Bapat AM, Harazeen WS, Alatta AN, Awosika A. Non-traditional risk factors for myocardial infarction in adults under forty: A systematic review of emerging trends. World J Cardiol 2026; 18(2): 116172

15955 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2263

Peer-reviewers: 36378

Manuscripts received today: 3

Manuscript reviews today: 5

Unhandled manuscripts today: 146

Active peer-reviewers today: 863

Reviewer acceptance today: 4

Reviewer refusals today: 7

Total accepted manuscripts: 40591

Total rejected manuscripts: 44884

Total peer-reviewers: 4719217

Total submissions: 38269

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

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BPG E-Books

BPG Blog

All Journal Articles

Lim Y, Lim WB, Bonner T, Wood L, Volpin A. Rethinking meniscal repair in patients over 40: Extending the boundaries of joint preservation. World J Methodol 2026; 16(1): 113664

2026-03-20 | Browse: 454 | Download: 112

Rath S. Advancing chronic low back pain management: Insights from amitriptyline and duloxetine comparison. World J Methodol 2026; 16(1): 113191

2026-03-20 | Browse: 411 | Download: 102

Marneri AG, Pavlidis ET, Stavrati KE, Mouratidou C, Kotoulas SC, Ballas KD, Pavlidis TE. Effects of rosuvastatin treatment and other statins on burn wound healing. World J Methodol 2026; 16(1): 112686

2026-03-20 | Browse: 405 | Download: 116

Nayak B, Mohapatra PR, Chakraborty K, Nanda J, Haripriya S, Mantha SP, Sethy M, Panda BB. Are iris masses in lung carcinoma always a metastasis: Two case reports. World J Methodol 2026; 16(1): 112458

2026-03-20 | Browse: 330 | Download: 128

Mandal D, Pulickal TV, Ahlawat D, Haqbeen W, Kashif I, Alamy H, Prattipati P, Jaladi P, Kabiaru P, Avula A, Kshetri S, Raza I, Shamieh S, Chhetri R. Sirolimus vs paclitaxel-coated balloons in in-stent coronary restenosis: A meta-analysis. World J Methodol 2026; 16(1): 111566

2026-03-20 | Browse: 463 | Download: 129

Aggarwal S, Morya AK, Kaur R, Gurnani B, Kaur K. Role of lifestyle modifications in glaucoma: A systematic review. World J Methodol 2026; 16(1): 110410

2026-03-20 | Browse: 404 | Download: 127

Ayyappan Unnithan AK. Update on hypoxic-ischemic brain injury: Prognosis and management. World J Methodol 2026; 16(1): 110342

2026-03-20 | Browse: 585 | Download: 149

Tariq Z, Faisal A, Basit A, Iftikhar A, Basil AM. Diagnostic dilemmas in hepatoid adenocarcinoma of the stomach: Navigating clinical and pathological loopholes. World J Methodol 2026; 16(1): 110272

2026-03-20 | Browse: 285 | Download: 101

Khan SMI, Waqas M, Khawar M, Batool A, Komel A, Ashraf MA, Saifullah M, Rana I. Temporal trends and disparities in substance use and diabetes mellitus-related mortality in the United States (1999–2022). World J Methodol 2026; 16(1): 110159

2026-03-20 | Browse: 365 | Download: 160

Jeyaraman M, Jeyaraman N, Nallakumarasamy A, Murugan S, Muthu S. Innovative prospects in 3D printed bio-scaffolds for osteochondral tissue engineering: A systematic review. World J Methodol 2026; 16(1): 109784

2026-03-20 | Browse: 420 | Download: 200

Patel N, Patel V, Murugan Y, Patel K, Varma V, Surani S. Integrating serum ferritin and neutrophil-to-lymphocyte ratio with Sequential Organ Failure Assessment score improves mortality prediction in sepsis. World J Methodol 2026; 16(1): 109733

2026-03-20 | Browse: 544 | Download: 173

Okasha HH, Alyouzbaki AZ, Tehami N, Abdellatef A. Fatty pancreas: Current insights and future perspectives. World J Methodol 2026; 16(1): 109580

2026-03-20 | Browse: 480 | Download: 139

Nag DS, Prasad S, Sahu S, Laik JK, Swain A, Anand R, Saroha S, Mahanty PR, Kumar H, Mistari W. Nottingham Hip Fracture Score and Acute Physiology and Chronic Health Evaluation-II: Predicting 30-day mortality in elderly hip fracture. World J Methodol 2026; 16(1): 109473

2026-03-20 | Browse: 388 | Download: 168

Kalluru PKR, Valisekka SS, Katamreddy Y, Cherukuri A, Kuchi D, Siddenthi SM, Mandyam S. Addressing barriers and advancing equitable colorectal cancer screening in the lesbian, gay, bisexual, transgender, and queer/questioning population. World J Methodol 2026; 16(1): 109316

2026-03-20 | Browse: 472 | Download: 104

Karaaytu E, Özdemir Ö. Vitamin D and allergic rhinitis: A mini-review. World J Methodol 2026; 16(1): 109252

2026-03-20 | Browse: 355 | Download: 129

Qiao C, Zhao XH, Jiao YC, Li HW, Guo N, Wei LY, Wang ZR, Li GL, Li DH. Tai Chi for treating cancer-related fatigue: A meta-analysis of randomized controlled trials. World J Methodol 2026; 16(1): 109145

2026-03-20 | Browse: 468 | Download: 197

Mundhra SK, Kochhar R. Methodological insights into fecal microbiota transplantation: Dissecting key approaches for success. World J Methodol 2026; 16(1): 108875

2026-03-20 | Browse: 369 | Download: 104

Mishra A, Juneja D. Decolonizing the gut from multidrug-resistant bacteria: Current strategies and future perspectives. World J Methodol 2026; 16(1): 108646

2026-03-20 | Browse: 360 | Download: 124

Senapati SG, Kothawala A, Ahluwalia V, Desai R. High Red Cell Distribution Width (RDW) as a Prognostic Indicator in Heart Failure. World J Methodol 2026; 16(1): 108611

2026-03-20 | Browse: 351 | Download: 111

Aher NB, Thothala Prabhakar PK, Thirukonda Govarthanam SK, Krishnamoorthy S. Adolescent varicocele, a Gordian knot: A comprehensive review of clinical perspectives and future directions. World J Methodol 2026; 16(1): 108384

2026-03-20 | Browse: 458 | Download: 114

62449 items Read more >>

Featured Articles

Sweety S, Panda S, Das RR. Balanced electrolyte solution vs isotonic saline in the resuscitation of children with diabetic ketoacidosis: A randomized controlled trial. World J Clin Pediatr 2026; 15(1): 111304

2026-03-06 | Browse: 23 | Download: 52

Chatpermporn K, Ngoenmak T, Charoenwat B, Chanpong A, Sriphongphankul H, Hanpitakpong N, Sintusek P. Functional constipation in Thai infants and toddlers: The role of genetic-gut-brain interaction and fiber supplementation. World J Clin Pediatr 2026; 15(1): 111828

2026-03-06 | Browse: 24 | Download: 50

Kiatvitchukul T, Dokkham P, Jeephet K, Srisingh K. Understanding recurrent wheezing: A parent’s guide. World J Clin Pediatr 2026; 15(1): 113430

2026-03-06 | Browse: 25 | Download: 57

Umar TP, Putra AW, Mahendika D, Stella MM, Tandarto K. Screen time in preschool-aged children and attention deficit hyperactivity disorder-related behaviors: A literature review. World J Clin Pediatr 2026; 15(1): 111652

2026-03-06 | Browse: 24 | Download: 39

Schmiliver B, Perera Molligoda Arachchige AS. Imaging of pediatric pulmonary infections: A pictorial review. World J Clin Pediatr 2026; 15(1): 110318

2026-03-06 | Browse: 25 | Download: 38

2026-03-05 | Browse: 29 | Download: 41

Chen CY, Hsu YH. Complete resolution of massive chronic subdural hematoma with refined layered middle meningeal artery embolization: A case report. World J Clin Cases 2026; 14(7): 116694

2026-03-05 | Browse: 22 | Download: 45

2026-03-05 | Browse: 29 | Download: 62

Aggarwal S, Morya AK, Nishant P, Sinha S, Kaur R, Sinha RK, Morya R. Psychiatric disorders like depression and anxiety in age-related macular degeneration. World J Clin Cases 2026; 14(7): 117943

2026-03-05 | Browse: 23 | Download: 39

Thapa R, Paudyal V, Sharma M, Ratnani I, Surani S. Artificial intelligence advancement in addressing cough. World J Clin Cases 2026; 14(7): 118581

2026-03-05 | Browse: 29 | Download: 48

2026-03-05 | Browse: 27 | Download: 43

Chowdhary R, Sheth PD, Rampurawala IM, Kapadia C, Vohra C, Chowdhary R, Arora K, Taranikanti V, Vuthaluru AR, Goyal O, Goyal MK. Multimodal artificial intelligence in capsule endoscopy: Integrating video and sensor data for advanced gastrointestinal diagnostics. Artif Intell Gastrointest Endosc 2026; 7(1): 117988

2026-03-03 | Browse: 40 | Download: 62

Kumar SR, Panigrahi MK, Sasmal PK. Artificial intelligence in upper gastrointestinal bleeding: Can machine learning predict endotherapy requirements? Artif Intell Gastrointest Endosc 2026; 7(1): 114426

2026-03-03 | Browse: 30 | Download: 48

Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L. Integrative study reveals NR1D1 mediates Hedyotis diffusa’s antifibrosis via hypoxia inducible factor-1/ammonia axis. World J Gastroenterol 2026; 32(10): 115334

2026-03-02 | Browse: 59 | Download: 83

Wen JS, Pan ZW, Yao XD, Liu YQ, Zhu YD. Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating Cdkn1c (p57)-mediated glycolytic reprogramming. World J Gastroenterol 2026; 32(10): 113771

2026-03-02 | Browse: 45 | Download: 84

2026-03-02 | Browse: 44 | Download: 93

Salamon D, Krawczyk A, Zapała B, Duplaga M, Kowalska-Duplaga K, Gosiewski T. Gut bacterial and fungal signatures in relation to human leukocyte antigen-DQ2/DQ8 in children with celiac disease and siblings. World J Gastroenterol 2026; 32(10): 116128

2026-03-02 | Browse: 37 | Download: 112

2026-03-02 | Browse: 42 | Download: 72

Li DX, Gu Y, Xia WJ, Sun YF, Hou L, Zhu WX, Wang J. Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis. World J Psychiatry 2026; 16(3): 114446

2026-02-28 | Browse: 62 | Download: 128

Pandey S, Gupta PK, Kar SK. Perceived social support, subjective well-being, coping styles, personality traits, and social media addiction among patients with depression. World J Psychiatry 2026; 16(3): 112604

2026-02-28 | Browse: 63 | Download: 97

10507 items Read more >>

Keyword Search Published Articles Processes

Case report

4758

Hepatocellular carcinoma

1759

Gastric cancer

1284

Colorectal cancer

1265

Prognosis

1094

Inflammatory bowel disease

864

COVID-19

846

Treatment

777

Diagnosis

761

Liver transplantation

746

Ulcerative colitis

691

Meta-analysis

674

Crohn’s disease

628

Endoscopy

623

Cirrhosis

614

Inflammation

602

Helicobacter pylori

595

Magnetic resonance imaging

588

Surgery

562

Pancreatic cancer

519

66998 items Read more >>

Reader Comments

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. ..." [Read more]

"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. While the narrative is informative, a more quantitative economic comparison and inclusion of updated guidelines or contemporary practice data would strengthen the conclusions. Additionally, deeper exploration of medico-legal concerns and institutional resistance could enhance its practical impact. Nevertheless, the review addresses a clinically meaningful topic. " [Collapse]

Karim HMR. Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility. World J Anesthesiol 2019; 8(3): 19-24

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon ..." [Read more]

"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon handedness on radiological and functional outcomes following primary total knee arthroplasty (TKA). The authors should be commended for addressing an underexplored yet clinically relevant surgeon-related variable in arthroplasty practice. The finding that overall limb alignment and functional outcomes were not significantly influenced by operating on the dominant versus non-dominant side is reassuring. However, the increased incidence of tibial component malalignment (MPTA outliers) on the non-dominant side highlights an important technical nuance that may have implications for implant longevity, particularly in mechanically aligned TKA performed with conventional instrumentation. The subgroup analysis comparing intramedullary and extramedullary tibial guides is particularly interesting, suggesting that technique selection may interact with laterality. These findings underscore the potential value of ergonomic optimization and heightened intraoperative vigilance when operating on the non-dominant side. Future prospective studies incorporating sagittal and rotational alignment parameters, inclusion of left-handed surgeons, and long-term survivorship data would further clarify the clinical significance of these observations. Additionally, evaluating whether navigation or robotic assistance mitigates the subtle asymmetries associated with surgeon handedness could provide valuable insights. Overall, this study contributes meaningfully to the ongoing discussion regarding modifiable surgeon-related factors influencing TKA precision and outcomes. " [Collapse]

Khalifa AA, Abdelaal AM, Moustafa MM. Does surgeon handedness affect the outcomes after primary total knee arthroplasty? A retrospective cohort study. World J Orthop 2026; 17(2): 113696

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from ..." [Read more]

"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from previously published results. ETV is generally considered renal-neutral and is commonly used in DCLD due to its renal safety. The statement that ETV is associated with a greater decrease in GFR than TMV is overfitting, as it is a retrospective study. The Difference in decline of approximately 4 mL/min/1.73 m² is very small and may not be clinically meaningful in patients with normal GFR, even though it is statistically significant. The conclusion should be interpreted with caution and requires additional long-term prospective studies to substantiate this claim. Furthermore, the authors did not report any additional adverse events during the study period. " [Collapse]

Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2026; 18(2): 114346

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver ..." [Read more]

"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver abscesses in Asia and is increasingly prevalent in India. It is important to have culture reports at various time points, as they will help us in deciding empirical antibiotics. The authors have shown that the isolated organisms are highly resistant to ampicillin and have low resistance to cephalosporins and carbapenems. With this large amount of data, the authors would have identified the poor prognostic predictors of PLA and treatment outcome. The authors did not present the data on complications of these abscess such as biliary fistula " [Collapse]

Mai-Phan TA, Thai KP, Le KL, Pham TN, Tran MQ, Pham PC, Duong NNQ, Trinh MT, Le NK. Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam. World J Hepatol 2026; 18(2): 113695

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..." [Read more]

"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. " [Collapse]

Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways after surgery in elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..." [Read more]

"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. " [Collapse]

He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced ..." [Read more]

"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced tumor stage, and poor survival in gastric cancer. The combination of clinical data and functional assays strengthens the evidence for the PS-1/β-catenin/p-PTEN axis in promoting invasion and metastasis. These findings highlight a potential therapeutic target for gastric cancer treatment. " [Collapse]

Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2026; 18(2): 115689

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..." [Read more]

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. " [Collapse]

Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..." [Read more]

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 " [Collapse]

Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..." [Read more]

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. " [Collapse]

Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..." [Read more]

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. " [Collapse]

Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..." [Read more]

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. " [Collapse]

Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..." [Read more]

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] " [Collapse]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..." [Read more]

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. " [Collapse]

Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. " [Collapse]

Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..." [Read more]

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino " [Collapse]

Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..." [Read more]

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. " [Collapse]

Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..." [Read more]

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. " [Collapse]

Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..." [Read more]

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. " [Collapse]

Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757

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