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1
"As a famous international journal, World Journal of Radiology has been recognized as one of the best journals in the world, so it ..."
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"As a famous international journal, World Journal of Radiology has been recognized as one of the best journals in the world, so it is my pride to publish an article in the journal. We are very satisfied with the manuscript peer reviewing, editing and publishing process. In addition, the operation of the journal system is also very easy, which is beneficial for authors to process manuscripts and communicate with the editorial office. "
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Mao Q, Zhang P, Zhou MT, Shi Y, Min XL, Xu H, Yang L, Zhang XM. Interpretable radiomics model based on magnetic resonance imaging to predict responses to transarterial chemoembolization for hepatocellular carcinoma. World J Radiol 2026; 18(2): 116486
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"As a famous international journal, World Journal of Radiology has been recognized as one of the best journals in the world, so it ..."
[Read more]
"As a famous international journal, World Journal of Radiology has been recognized as one of the best journals in the world, so it is my pride to publish an article in the journal. We are very satisfied with the manuscript peer reviewing, editing and publishing process.In addition, the operation of the journal system is also very easy, which is beneficial for authors to process manuscripts and communicate with the editorial office. "
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Tao YY, Wang R, Zhang P, Huang XH, Yang L. Functional connectivity alterations in patients with poststroke cognitive impairment: A resting-state functional magnetic resonance imaging study. World J Radiol 2026; 18(2): 116799
3
"Thanks for publishing this important research study that is basis of our daily practices. I hope, every Health-care professionals ..."
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"Thanks for publishing this important research study that is basis of our daily practices. I hope, every Health-care professionals know Pathogen and host dimensions - from nanometer molecules to meter-long structures that govern the strategies of infection, immunity, and survival. More importantly, how time pressure links size driven microbial adaptation, including antimicrobial resistance, into host tolerance and immunity. Hence, we should recognizing size as a central determinant in host-microbe interactions for precision medicine. Thanks again. "
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Pati BK, Panda PK. Body size and infection: An immunological balancing act. World J Immunol 2026; 16(2): 114815
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"Thanks for publishing this important research study that is practice changing. I hope, every clinician and policy makers know the ..."
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"Thanks for publishing this important research study that is practice changing. I hope, every clinician and policy makers know the mortality and morbidity associated with Multidrug-resistant organisms (MDROs), particularly in high-burden settings such as India. We evaluated clinical outcomes associated with MDRO isolation in a tertiary-care hospital and found that while isolation did not significantly reduce mortality among Intensive care unit (ICU) patients, it was associated with significantly longer ICU and hospital length of stay. Thanks again. "
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Pandy P, Singh H, Omar BJ, Kumari D, Panda PK. Clinical outcomes of multidrug-resistant organism infections in a tertiary care hospital in India. World J Clin Cases 2026; 14(5): 117981
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"Thanks for publishing this important research study that is practice changing. I hope, all clinicians or microbiologist who are ..."
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"Thanks for publishing this important research study that is practice changing. I hope, all clinicians or microbiologist who are managing culture positive reports. Right diagnosis is the first step in patient management, then only right treatment can be started and prevent rising AMR. For this, we need wither cultured organism is pathogen or non-pathogen. Thanks again. "
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Yadav B, Pilania J, Kant R, Omar BJ, Saini S, Panwar VK, Bahurupi Y, Panda PK. Stepwise model to differentiate pathogenic from non-pathogenic organisms in urinary isolates: Effectiveness, safety, and feasibility prospective study. World J Exp Med 2025; 15(4): 109134
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"We are truly grateful for the efficient and professional handling of our manuscript throughout the entire review and publication ..."
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"We are truly grateful for the efficient and professional handling of our manuscript throughout the entire review and publication process. The peer review feedback was constructive and significantly improved the quality of our work. The editorial team demonstrated great attention to detail in the final editing and production of the article. Overall, we are very satisfied with the experience and the high quality of the published article. "
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Lin PP, Lv WW, Chen CM. Internet plus-based post-discharge continuity care for mild-to-moderate depression: An exploratory study. World J Psychiatry 2026; 16(2): 112054
7
"Overall, the entire service process was smooth and well-organized, and I am very satisfied with the general experience. The support ..."
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"Overall, the entire service process was smooth and well-organized, and I am very satisfied with the general experience. The support provided via the assistance hotline was helpful in a timely manner. To further enhance the service quality, it would be greatly appreciated if the phone support could become more efficient and effective, so that each inquiry can be addressed more accurately and solutions can be provided more directly. This would help elevate the overall experience to an even higher level. "
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Jing LB, Liu J, Yang ZH, Yang FF, Wang DG, Li YM. Metallic elements and their molecular roles in gastric cancer: Pathogenic mechanisms and therapeutic implications. World J Gastrointest Oncol 2026; 18(2): 114351
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"We sincerely appreciate your esteemed journal for reviewing and publishing our paper. We are delighted to see the work progressing ..."
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"We sincerely appreciate your esteemed journal for reviewing and publishing our paper. We are delighted to see the work progressing smoothly and will continue to maintain high standards in our research. Let us join hands to strive for excellence and further elevate the influence and quality of the journal. May the journal achieve greater accomplishments and academic impact in the new year, and realize its early inclusion in the SCI index. "
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Wen CJ, Cheng JF, Jiang SB, Wang M, Yin XX, Liu R, Shen W, Zhong Y. Comparative analysis of general anesthesia and ultrasound-guided intercostal nerve block in subcutaneous implantable cardioverter-defibrillator perioperative care. World J Cardiol 2025; 17(10): 110900
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"There is one point that puzzles me. After we received the manuscript acceptance letter and paid the page fee, why were the revised ..."
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"There is one point that puzzles me. After we received the manuscript acceptance letter and paid the page fee, why were the revised manuscript still sent for review again?. Certainly, this is a rigorous review process that ensures the quality of the publication of the article. However, it is different from what we usually think, where there is no further revision after receiving the acceptance letter. Overall, we are quite satisfied with the review process as well as the editing and publication process of the article. "
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Li YM, Yasen A, Chen SF, Fan J, Huang XB, Zuo GH, Zheng L. Endoscopic ultrasound-guided transhepatic antegrade stone removal for choledocholithiasis after pancreaticoduodenectomy: A case report and review of literature. World J Gastroenterol 2026; 32(8): 116856
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"The system works very well. one thing to be repaired that sometimes it's not very well documented if the paper is accepted or need ..."
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"The system works very well. one thing to be repaired that sometimes it's not very well documented if the paper is accepted or need revision. At one point i received an email saying the paper is accepted for publication and after 2 or 3 weeks i received an email asking for revision. "
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Khalayleh H, Bader R, Abu Arafeh M, Odeh Q, Rogalsky B, Imam R, Khalaileh A, Imam A. Small bowel lymphatic malformation: Clinical presentation and a comprehensive literature review. World J Clin Oncol 2026; 17(1): 113113
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"We are very satisfied with the overall submission and publication experience at World Journal of Stem Cells. The editorial ..."
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"We are very satisfied with the overall submission and publication experience at World Journal of Stem Cells. The editorial communication was timely and professional, and the peer-review process was fair, constructive, and efficient. The reviewers’ comments were clear and helpful, which greatly improved the quality and clarity of our manuscript. The revision and proofreading stages were well organized, and the production and online publication proceeded smoothly. We also appreciate the language editing and layout quality, as well as the transparent guidance on each step of the workflow. Thank you to the Editorial Office for your support and dedication. We look forward to collaborating with the journal again in the future. "
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Shi ZJ, Ying XM, Liu W. Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles. World J Stem Cells 2026; 18(2): 114303
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"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They ..."
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"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They have significantly improved their submission to the peer process, their response, and their turnaround time. The editorial assistant has been very responsive. Their citation analysis, copy editing, and the process have been refined over the years. Their authors' suite is very transparent, and authors can look at the process and at which stage their publication is, from the reviewer, to the approval process, to copy editing, or in process. This provides the authors with real-time info. I have seen firsthand their responsiveness to comments and process, and their genuine effort to improve to be one of the best in their respective field. Congratulations. "
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Upreti S, Lowe D, Surani S, Patel D. Comparison of older and newer sedation agents in bronchoscopy. World J Methodol 2026; 16(1): 108379
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"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They ..."
[Read more]
"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They have significantly improved their submission to the peer process, their response, and their turnaround time. The editorial assistant has been very responsive. Their citation analysis, copy editing, and the process have been refined over the years. Their authors' suite is very transparent, and authors can look at the process and at which stage their publication is, from the reviewer, to the approval process, to copy editing, or in process. This provides the authors with real-time info. I have seen firsthand their responsiveness to comments and process, and their genuine effort to improve to be one of the best in their respective field. Congratulations. "
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Paudyal V, Thapa R, Itani A, Sharma M, Rayamajhi R, Ratnani I, Surani S. Excessive dynamic airway collapse: A condition behind the veil. World J Methodol 2026; 16(1): 108381
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"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They ..."
[Read more]
"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They have significantly improved their submission to the peer process, their response, and their turnaround time. The editorial assistant has been very responsive. Their citation analysis, copy editing, and the process have been refined over the years. Their authors' suite is very transparent, and authors can look at the process and at which stage their publication is, from the reviewer, to the approval process, to copy editing, or in process. This provides the authors with real-time info. I have seen firsthand their responsiveness to comments and process, and their genuine effort to improve to be one of the best in their respective field. Congratulations. "
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Patel N, Patel V, Murugan Y, Patel K, Varma V, Surani S. Integrating serum ferritin and neutrophil-to-lymphocyte ratio with Sequential Organ Failure Assessment score improves mortality prediction in sepsis. World J Methodol 2026; 16(1): 109733
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"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They ..."
[Read more]
"I have been publishing in different journals managed by Baishideng Publishing. The progress over the years has been apparent. They have significantly improved their submission to the peer process, their response, and their turnaround time. The editorial assistant has been very responsive. Their citation analysis, copy editing, and the process have been refined over the years. Their authors' suite is very transparent, and authors can look at the process and at which stage their publication is, from the reviewer, to the approval process, to copy editing, or in process. This provides the authors with real-time info. I have seen firsthand their responsiveness to comments and process, and their genuine effort to improve to be one of the best in their respective field. Congratulations. "
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Kumari U, Kaka M, Abbas F, Rai A, Kumari S, Wazir HU, Surani S. Comparative efficacy and safety of chlorthalidone vs hydrochlorothiazide in hypertension management: A systematic review and meta-analysis. World J Cardiol 2026; 18(2): 112956
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"I appreciate the structured and transparent peer-review process adopted by the journal. The reviewers’ comments were constructive, ..."
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"I appreciate the structured and transparent peer-review process adopted by the journal. The reviewers’ comments were constructive, detailed, and significantly improved the scientific clarity and quality of the manuscript. The editorial team maintained timely and professional communication throughout the submission and revision stages. The production process was efficient, and the final publication quality was satisfactory. Overall, the experience was smooth, well-organised, and professionally managed. "
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Aher NB, Thothala Prabhakar PK, Thirukonda Govarthanam SK, Krishnamoorthy S. Adolescent varicocele, a Gordian knot: A comprehensive review of clinical perspectives and future directions. World J Methodol 2026; 16(1): 108384
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"We are grateful for the efforts in the review and editing of this study. The feedback was not only timely but constructive as well. ..."
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"We are grateful for the efforts in the review and editing of this study. The feedback was not only timely but constructive as well. All the resources in place to facilitate publication in this journal are quite remarkable. we are looking forward to working together in the near future. Thank you "
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Omullo FP. Risankizumab redefines Crohn’s treatment after ustekinumab failure. World J Gastrointest Pharmacol Ther 2026; 17(1): 114412
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"Baishideng's journals are very friendly to Chinese readers; we've already had several papers accepted, and the word has spread ..."
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"Baishideng's journals are very friendly to Chinese readers; we've already had several papers accepted, and the word has spread throughout the academic community. The submission system is excellent, and the review process is very smooth. I will definitely recommend it to my friends next time. I look forward to our other articles being accepted smoothly again. In short, highly recommended. "
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He M, Qi Y, Zheng ZM, Sha M, Zhao X, Chen YR, Chen ZH, Qian RY, Yao J, Yang ZD. Long noncoding RNA steroid receptor RNA activator 1 inhibits proliferation and glycolysis of esophageal squamous cell carcinoma. World J Gastrointest Oncol 2024; 16(10): 4194-4208
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"Baishideng's journals are very friendly to Chinese readers; we've already had several papers accepted, and the word has spread ..."
[Read more]
"Baishideng's journals are very friendly to Chinese readers; we've already had several papers accepted, and the word has spread throughout the academic community. The submission system is excellent, and the review process is very smooth. I will definitely recommend it to my friends next time. I look forward to our other articles being accepted smoothly again. In short, highly recommended. "
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Zhang TT, Yao J, Zhang HM. Microbiota-metabolite signatures in metastatic colorectal cancer: Promise, pitfalls, and the path forward. World J Gastrointest Oncol 2026; 18(2): 115010
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"We extend our gratitude to the editorial office for their efficient work and to the reviewers for their professional evaluations. ..."
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"We extend our gratitude to the editorial office for their efficient work and to the reviewers for their professional evaluations. The review process for this journal is prompt, and the quality of the papers is high. This journal is a high-level, trustworthy publication, and we will continue to contribute to it in the future. "
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Li JY, Liu SZ, Xu XY, Zhao L. Synergistic potential of combined neural stem cells and mesenchymal stem cells therapy in acute cerebral infarction: A perspective. World J Stem Cells 2026; 18(2): 114433
20793 items Read more >>
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"Re: Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum ..."
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"Re: Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum and its management. World J Clin Urol 2026; 15(1): 114046 [DOI: 10.5410/wjcu.v15.i1.114046]
The authors report on “Practical approach to the review of bladder diverticulum and its management”
The article, which provides a combination of literature review and personal experience, included a detailed discussion of the definition, etiology, pathogenesis, clinical presentation, diagnosis and treatment of bladder diverticulum. The following comments can be of benefit for future considerations:
1.The causes and treatment of bladder diverticulum in children are different from those in adults. So, it would have been better to focus on either of them.
2. The authors stated that “For example, in boys with posterior urethral valves, these diverticula can serve as a pressure relief mechanism to protect the kidneys from damage and maintain bladder function”. In this context, is it possible to treat these diverticula conservatively without active surgical intervention? If the answer is yes, what are the indications.
3. It would have been better to include the pros and cons of the different surgical techniques, namely, extravesical, intravesical, or transdiverticular. Are they comparable? [1,2]
4. Among the active treatment options of bladder diverticulum is transurethral electrovaporization of the diverticular mucosa. It would have been better to include it among the endoscopic treatment procedures [3].
5. Is there a difference in the outcome between staged treatment versus concomitant treatment of the cause and the resulting secondary diverticulum, for example in cases with BOO? [4]
6. In cases of female diverticulum, which are very close to the urethra, what are the recommended tips and tricks [5].
References
[1]. Perri D, Roche JB, Petrut B, Bozzini G. Bladder diverticula management - conservative and surgical outcomes: a narrative review from EAU endourology. Curr Opin Urol. 2026 Jan 1;36(1):79-85. doi: 10.1097/MOU.0000000000001307. Epub 2025 Jun 12. PMID: 40548586.
[2]. Giannarini G, Rossanese M, Macchione L, Mucciardi G, Crestani A, Ficarra V. Robot-assisted Bladder Diverticulectomy Using a Transperitoneal Extravesical Approach. Eur Urol Open Sci. 2022 Sep 8;44:162-168. doi: 10.1016/j.euros.2022.08.016. PMID: 36110902; PMCID: PMC9468349.
[3]. Chandhoke RA, Ghoniem GM. Transurethral Electrovaporization of Bladder Diverticulum: An Alternative to Open or Laparoscopic Bladder Diverticulectomy. J Endourol Case Rep. 2015 Oct 1;1(1):11-3. doi: 10.1089/cren.2015.29002.cha. PMID: 27579375; PMCID: PMC4996560.
[4]. Gazzah W, Ben Taher S, Masmoudi S, Hamza M, Naouar S, Salem B. Management of multiple giant bladder diverticula: a comprehensive approach - a case report. Ann Med Surg (Lond). 2024 May 15;86(7):4187-4190. doi: 10.1097/MS9.0000000000002162. PMID: 38989198; PMCID: PMC11230813.
[5]. Liao C, He Z, Wang X, Guo P, Xiong W. Laparoscopic surgery for female posterior urethral bladder diverticulum with bladder outlet obstruction: A case report. Medicine (Baltimore). 2023 Sep 1;102(35):e34971. doi: 10.1097/MD.0000000000034971. PMID: 37657035; PMCID: PMC10476744.
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Khalid A, Obadele OG, Alabi TO, Nedjim SA, Abdulwahab-Ahmed A, Mungadi IA. Practical approach to the review of bladder diverticulum and its management. World J Clin Urol 2026; 15(1): 114046
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"The paper is an interesting review, concise, comprehensive, complex and well structured. I think this paper is welcome and relevant ..."
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"The paper is an interesting review, concise, comprehensive, complex and well structured. I think this paper is welcome and relevant for medical daily practice even if the pathology debated is rare. Gastrointestinal bleeding is a frequent presentation in clinical practice, therefore is important to known all possible causes of bleeding including secondary to a GI melanoma. There are no grammatical or spelling errors throughtout the text. "
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De Nardi P, Guida S, Damiano G, Rizzo N, Samanes Gajate AM, Riva ST, Paolino G, Colombo M, Tummineri R, Rongioletti F, Mercuri SR, Chiti A, Sileri P, Russo V. Primary melanoma of the gastrointestinal tract. World J Gastroenterol 2026; 32(8): 114571
3
"The dose of ursodeoxycholic acid that was prescribed to the study groups were not matched in this project. The uncontrolled PBC ..."
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"The dose of ursodeoxycholic acid that was prescribed to the study groups were not matched in this project. The uncontrolled PBC patients enface with hypercholesterolemia. This could make bias while diagnosing metabolic criteria for the definition of MASLD. At the same time, the study groups should be matched for the dose of statin consumption. Statins also influence the cholesterol level and should be adjusted as a confounding factor."
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Koky T, Drazilova S, Komarova S, Macej M, Toporcerova D, Janicko M, Spakova I, Rabajdova M, Marekova M, Jarcuska P. Adipokine profiles reflect metabolic dysfunction but not fibrosis in patients with primary biliary cholangitis. World J Hepatol 2026; 18(2): 113685
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Bhati G, Mongardini FM, Bhati K, Singh P, Bansal R, Bansal A, Mahajan S, Docimo L, Caricato M, Capolupo GT, Carannante F. Ruptured primary intrahepatic ectopic pregnancy: A case report and review of literature. World J Clin Cases 2026; 14(6): 118135
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Aby Hadeer R, Ghattas S, Farhat H, Maalouf H, Bitar JE, Ayash D, Mohtar F, Elias B, Wakim R. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for appendiceal mucocele tumors: Five case reports and review of literature. World J Clin Cases 2026; 14(6): 117655
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"Duodenal ischemia in systemic lupus erythematosus (SLE) is a pathological condition of severe lupus enteritis, in which blood flow ..."
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"Duodenal ischemia in systemic lupus erythematosus (SLE) is a pathological condition of severe lupus enteritis, in which blood flow to the intestinal tract is impaired, mainly due to vasculitis and thrombosis. It begins with sudden abdominal pain, vomiting, and fever, and progresses to ulcers, perforation, and necrosis, so early diagnosis by CT and prompt immunosuppressive therapy, such as steroid pulse therapy, are essential. Surgical treatment: If perforation or necrosis is observed, emergency surgery to remove the affected area is required. The authors performed a duodenal anastomosis to avoid PD, and complications such as bile duct stricture were alleviated with a stent after surgery. This is a good paper."
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Kim YK, Jung HI, Kim H, Bae SH. Ischemic duodenal injury due to systemic lupus erythematosus: A case report. World J Gastroenterol 2026; 32(8): 115654
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"1) Ethics - meets requirements («The study was approved by the Ethics Committee of National Cancer Center/Cancer Hospital, Chinese ..."
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"1) Ethics - meets requirements («The study was approved by the Ethics Committee of National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College in accordance with the ethical standards outlined in the 1964 Helsinki Declaration»)
2) Methods - revision required.
Key concerns:
- Subjective criteria for SSA administration
The SSA-treated group includes zero patients with perineural invasion, but the endoscopy-alone group has 1 patient. Lymphovascular invasion was present in both groups (10.5% vs 9.6%), but no clear criteria for SSA initiation are provided. This distribution is clinically illogical and indicates selection bias.
- Deviation from international guidelines (ENETS/NCCN)
73.4% of patients had tumors ≤ 10 mm without muscularis propria invasion. Current guidelines do not recommend adjuvant SSA therapy in this low-risk population. A substantial proportion of SSA-treated patients may have received overtreatment.
Required revisions: Provide an objective, reproducible algorithm for SSA allocation. Perform a subgroup analysis of low-risk patients (≤10 mm, G1, no LVI/PNI).
3) Results - revision required.
• The authors state: «However, endoscopic treatment removes lesions without addressing the underlying pathogenesis, allowing gastrin to continue stimulating neuroendocrine cell growth. Therefore, G-NETs may recur after endoscopic treatment». However, gastrin levels were not measured in this study. As a result: the suppressive effect of SSAs on gastrin was not documented and a direct correlation between gastrin reduction and improved outcomes could not be established.
• Presented descriptively (n = 27, 6 mutations), with no integration into the main prognostic analysis. It is unclear how these data correlate with the risk of progression or response to therapy. This section appears redundant and detracts from the main clinical conclusions.
4) Figures and tables – good, minor issues
Tables 1–4 and Figures 2–4 are clear, well-structured, and properly labeled.
Figure 5: Descriptive genetic data only; not integrated into prognostic analysis. Limited relevance to main findings. Recommend moving to Supplementary Materials.
5) Biostatistics - adequate.
LASSO and Cox regression correctly used, but no sample size calculation, wide CIs, and potential immortal time bias—acknowledge in limitations.
6) References - good
Relevant, up-to-date, no over-citation.
7) Language – good
Clear, concise, grammatically correct.
8) Caveats or drawbacks
• Retrospective single-center design with inherent selection bias: SSA allocation was subjective and no reproducible algorithm provided.
• Deviation from guidelines: 73.4% of patients had low-risk where adjuvant SSAs are not routinely recommended — potential overtreatment.
• No gastrin data: The proposed mechanism (SSAs suppress gastrin) remains unverified; correlation between SSA use and reduced progression is statistical, not mechanistically proven.
• Genetic data (Figure 5): Descriptive only, not integrated into prognostic analysis; limited relevance to main clinical conclusions.
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Yang ZL, Wang HK, Liu Y, Dou LZ, Zhang YM, Ng HI, He S, Chi YB, Wang GQ. Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study. World J Gastroenterol 2026; 32(8): 114268
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"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in ..."
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"Peroxiredoxin 1 (Prdx1) has recently been shown to effectively inhibit the growth of colon cancer in experimental carcinogenesis in mice. The anticancer activity of this substance is based on pyroptosis. Pyroptosis is a key component of cell death. It directly suppresses the tumor by promoting gasdermin D-induced cell lysis and by releasing inflammatory factors that affect the so-called “cell death-anti-tumor immunity”. Peroxiredoxin 1 warrants further investigation for the development of co-expression markers (Prdx1/GSDMD). Furthermore, as the authors note, the efficacy of combination therapies targeting rPrdx1 should be studied promptly to promote personalized treatment of colon cancer."
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Chen ZK, Zhao JW, Meng WY, Wang YG. Peroxiredoxin 1 as a novel pyroptosis inducer in colorectal cancer: Insights and future directions. World J Gastroenterol 2026; 32(8): 116016
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"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic ..."
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"As a systematic review, this paper comprehensively covers the core research content of tumor organoids and provides a systematic collation of knowledge in the field. However, there is room for optimization in terms of data rigor, content depth, and clinical relevance. To enhance its academic value, it is advisable to supplement detailed information on literature screening, strengthen the connection between technical details and clinical applications, enrich the comprehensiveness of discussions on limitations, and optimize the timeliness of case data and references. Other comments:
Figures and tables: I think the paper should have more figures, rather than only tabels."
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Agrawal H, Tanwar H, Gupta N. Tumor organoids in translational cancer research: Models for personalized therapy. World J Transl Med 2026; 12(1): 113050
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Alvarez M, Luna M, Suarez E, Rincon O, Guzman I, Mancera P. Thyroid collision tumor and Graves’ disease: A case report and review of literature. World J Clin Cases 2026; 14(5): 117016
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"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
"The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Bouayad A. Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. World J Clin Cases 2026; 14(5): 115814
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Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors ..."
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Importantly, the authors of this study identified that prolonged disease duration and anxiety are independent high-risk factors for refractory GERD. Anti-anxiety interventions, standardized exercise prescriptions, and lifestyle factors such as sleep and weight management should be explored as a multidimensional risk-targeted intervention.
However, in the real world, we have to distinguish between true refractory GERD and refractory reflux-like symptoms. A systematic evaluation of the patients is essential, as up to 40% of patients with GERD report inadequate symptom control with PPIs, but only a minority have true refractory GERD. Therefore, we should evaluate multiple aspects of the patient's behavior (e.g., optimizing PPI therapy, ensuring correct timing, increasing to twice-daily dosing, or switching to a different PPI) before proceeding with exercise prescriptions and anti-anxiety interventions. Moreover, alternative pharmacologic options, including Histamine-2 receptor antagonists (administered at bedtime for nocturnal symptoms, though tachyphylaxis limits long-term efficacy), potassium-competitive acid blockers, alginates and antacids, prokinetic agents, neuromodulators, bile acid sequestrants, and lifestyle modifications, should be tried in these patients, indicating that individualized, multidisciplinary care is essential.
"
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Zuo XY, Chen QQ. Beyond monotherapy by acid suppression: Reshaping the management of refractory gastroesophageal reflux disease. World J Gastroenterol 2026; 32(7): 116425
13
"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In ..."
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"The paper is interesting and fits well with the body of work addressing nontraditional factors causing myocardial infarction. In particular the discussion is well written. I don't know if I've missed it, but I haven't seen a correlation between myocardial infarction and ethnicity. In Europe ethnicity is an important factor, given that Asian populations have a higher incidence of myocardial infarction at young ages."
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Patel T, Farhan M, Bhatt NK, Fatah HA, Peniel JJ, Kaulgud VV, Mathew T, Bapat AM, Harazeen WS, Alatta AN, Awosika A. Non-traditional risk factors for myocardial infarction in adults under forty: A systematic review of emerging trends. World J Cardiol 2026; 18(2): 116172
14
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
[Read more]
" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Lee H, Han YH, Chung JW, Kim KO, Kwon KA, Kim JH. Upper gastrointestinal bleeding with duodenal varix: A case report. World J Clin Cases 2026; 14(4): 116648
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"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. ..."
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"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. RYDG and OAB are good weight loss surgeries without the risk of GERD. For patients with GERD, the surgical procedure should be selected as suggested by authors."
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Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600
16
"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and ..."
[Read more]
"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and bariatric surgery (MBS) has been considered the most effective treatment for weight loss in obese patients. The most commonly performed surgical procedures are sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and single-anastomotic gastric bypass (OAGB). MBS has different effects on obesity-related GERD depending on the type of procedure performed.
The results suggest that RYGB consistently leads to significant improvement or remission of GERD symptoms, reduced HCl exposure, and reduced need for PPI therapy in obese patients. RYGB and OAGB are more effective than SG for weight loss and GERD control. RYGB is therefore the preferred bariatric procedure for obese patients with clinically evident GERD.
SG is associated with a higher risk of new onset or worsening of GERD, an increased incidence of erosive esophagitis, and an increased risk of Barrett's esophagus. The pathophysiology of these effects is multifactorial and involves changes in gastric anatomy and lower esophageal sphincter function.
Therefore, the choice of the type of surgical procedure that should be performed must be individualized, with RYGB being preferred in obese patients with significant GERD or Barrett's esophagus, while SG can be performed in patients without reflux symptoms but requires careful preoperative assessment of GERD risk.
The aforementioned data should be taken seriously and guide the physician and patient with obesity and GERD towards making the right surgical decisions."
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Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600
17
"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's ..."
[Read more]
"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's disease. In daily medical practice, its treatment is often inadequate since it is usually attributed to side effects of the drugs administered to treat the underlying disease or to psychological causes. The study under review found that indeed, psychological symptoms such as depression, anxiety, stress of any cause, and insomnia are related to its occurrence. In particular, stress is likely to induce the symptom through probable immunological effects. Of interest was the frequent occurrence of fatigue with increased white blood cell count. It therefore seems that fatigue in patients with Crohn's disease has a multifactorial etiology, not exclusively attributable to disease activity or inflammatory markers. As the researchers pointed out, fatigue among IBD patients should receive greater attention in the near future. By conducting additional relevant studies, we will be able to accurately identify the factors that contribute to fatigue, enabling us to develop and implement strategies to effectively identify and support patients experiencing fatigue."
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Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673
18
"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete ..."
[Read more]
"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete intestinal obstruction (CRIO). Given the multifactorial and complex pathophysiology of CRIO, it is inherently challenging to comprehensively describe all clinical conditions. Nevertheless, the authors successfully present a well-structured and comprehensive overview by organizing the discussion into a clear and logical framework."
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Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030
19
"This article provides an interesting topic, with valuable first-hand information.
There were also some notable limitations, as ..."
[Read more]
"This article provides an interesting topic, with valuable first-hand information.
There were also some notable limitations, as addressed in the following:
Of the “Abstract”. The aim does not match well the conclusion.
Some “Keywords” are not adequate. “Metagenomic next-generation sequencing” should be moved from “Keywords”.
There was no “analysis” or associated description in the “Methods” of the “Abstract”, and this is not adequate.
The “Results” in “Abstract” were not consistent with the “Methods” of the “Abstract”.
There was no gold standard (guidelines) and criteria for the diagnosis of pulmonary nocardiosis in the “Materials and Methods”.
The imaging characteristics (Table 4) were not complete, and which should include a complex item comprising two or more imaging characteristics of the lungs .
A total of the pulmonary nocardiosis caused by different species in Table 4 was not 102.
The pulmonary nocardiosis treated by different medications in Table 5 was not clear, some patients treated using more than one medications, and the total number was not 102.
Figure 1 was not necessary, and associated information can be listed in table or presented in text.
Images of pulmonary nocardiosis were not sufficient, and more other representative images had better be added.
The English is not professionalism.
The “Conclusion” that “Nocardia pneumonia commonly coexists with bronchiectasis. Although mNGS has greatly enhanced its detection rate, N. wallacei pneumonia is distinguished on chest CT by its primary presentation of bronchopneumonia, unlike other types.” was not adequate, and it was not well matching the contents of the “Results”."
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Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552
20
"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..."
[Read more]
"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity.
Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter.
"
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Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560
15948 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 36200
- Manuscripts received today
- 0
- Manuscript reviews today
- 4
- Unhandled manuscripts today
- 175
- Active peer-reviewers today
- 1111
- Reviewer acceptance today
- 6
- Reviewer refusals today
- 13
- Total accepted manuscripts
- 40319
- Total rejected manuscripts
- 44728
- Total peer-reviewers
- 4701396
- Total submissions
- 38087
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1
"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. ..."
[Read more]
"The article raises critical issues regarding healthcare expenditure and the anesthesiologist’s responsibility in cost containment. While the narrative is informative, a more quantitative economic comparison and inclusion of updated guidelines or contemporary practice data would strengthen the conclusions. Additionally, deeper exploration of medico-legal concerns and institutional resistance could enhance its practical impact. Nevertheless, the review addresses a clinically meaningful topic. "
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Karim HMR. Healthcare delivery cost and anesthesiologists: Time to have a greater role and responsibility. World J Anesthesiol 2019; 8(3): 19-24
2
"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon ..."
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"I read with great interest the study by Khalifa et al. published in the World Journal of Orthopedics, evaluating the impact of surgeon handedness on radiological and functional outcomes following primary total knee arthroplasty (TKA). The authors should be commended for addressing an underexplored yet clinically relevant surgeon-related variable in arthroplasty practice. The finding that overall limb alignment and functional outcomes were not significantly influenced by operating on the dominant versus non-dominant side is reassuring. However, the increased incidence of tibial component malalignment (MPTA outliers) on the non-dominant side highlights an important technical nuance that may have implications for implant longevity, particularly in mechanically aligned TKA performed with conventional instrumentation. The subgroup analysis comparing intramedullary and extramedullary tibial guides is particularly interesting, suggesting that technique selection may interact with laterality. These findings underscore the potential value of ergonomic optimization and heightened intraoperative vigilance when operating on the non-dominant side. Future prospective studies incorporating sagittal and rotational alignment parameters, inclusion of left-handed surgeons, and long-term survivorship data would further clarify the clinical significance of these observations. Additionally, evaluating whether navigation or robotic assistance mitigates the subtle asymmetries associated with surgeon handedness could provide valuable insights. Overall, this study contributes meaningfully to the ongoing discussion regarding modifiable surgeon-related factors influencing TKA precision and outcomes. "
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Khalifa AA, Abdelaal AM, Moustafa MM. Does surgeon handedness affect the outcomes after primary total knee arthroplasty? A retrospective cohort study. World J Orthop 2026; 17(2): 113696
3
"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from ..."
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"I would like to congratulate the authors on this clinically relevant study. The authors provided a conclusion that differs from previously published results. ETV is generally considered renal-neutral and is commonly used in DCLD due to its renal safety. The statement that ETV is associated with a greater decrease in GFR than TMV is overfitting, as it is a retrospective study. The Difference in decline of approximately 4 mL/min/1.73 m² is very small and may not be clinically meaningful in patients with normal GFR, even though it is statistically significant. The conclusion should be interpreted with caution and requires additional long-term prospective studies to substantiate this claim. Furthermore, the authors did not report any additional adverse events during the study period. "
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Ma SP, Wang L, Zhang YL, Wan X, Liu Q, Tang YL, Malhi LR, Ge SF. Effects of tenofovir amibufenamide and entecavir on estimated glomerular filtration rate in treatment-naïve patients with chronic hepatitis B. World J Hepatol 2026; 18(2): 114346
4
"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver ..."
[Read more]
"I congratulate the authors on this relevant study on this study. As the authors pointed out, Klebsiella is the leading cause of liver abscesses in Asia and is increasingly prevalent in India. It is important to have culture reports at various time points, as they will help us in deciding empirical antibiotics. The authors have shown that the isolated organisms are highly resistant to ampicillin and have low resistance to cephalosporins and carbapenems. With this large amount of data, the authors would have identified the poor prognostic predictors of PLA and treatment outcome. The authors did not present the data on complications of these abscess such as biliary fistula "
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Mai-Phan TA, Thai KP, Le KL, Pham TN, Tran MQ, Pham PC, Duong NNQ, Trinh MT, Le NK. Klebsiella pneumoniae as leading cause of pyogenic liver abscess: Three years study in Southern Vietnam. World J Hepatol 2026; 18(2): 113695
5
"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond ..."
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"Wang and Pan present an editorial that meaningfully extends the discussion of ERAS in elderly gastric cancer patients beyond feasibility toward biologically grounded recovery. Building on prior evidence by Li et al. demonstrating the safety and protocol adherence of ERAS in older adults. The authors appropriately emphasize physiological heterogeneity, frailty, and resilience as key determinants of postoperative outcomes rather than chronological age alone. The proposed multidomain framework integrating nutritional inflammatory balance, circadian regulation, psychological resilience, and digital monitoring, offers an important conceptual advance. However, many of these strategies rely on resource intensive multidisciplinary teams, biomarker surveillance, and wearable technologies, which may limit generalizability outside high-volume or well-resourced centers. Future efforts may benefit from parallel development of simplified, scalable ERAS adaptations for elderly patients. Overall, this editorial provides a valuable roadmap for evolving ERAS from protocol compliance toward patient-centered, biologically informed recovery in an aging surgical population. "
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Wang G, Pan SJ. From feasibility to biological recovery: Reframing enhanced recovery pathways after surgery in elderly gastric cancer patients. World J Gastroenterol 2026; 32(7): 116264
6
"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..."
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"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. "
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He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814
7
"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced ..."
[Read more]
"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced tumor stage, and poor survival in gastric cancer. The combination of clinical data and functional assays strengthens the evidence for the PS-1/β-catenin/p-PTEN axis in promoting invasion and metastasis. These findings highlight a potential therapeutic target for gastric cancer treatment. "
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Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2026; 18(2): 115689
8
"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..."
[Read more]
"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. "
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Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309
9
"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..."
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"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 "
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Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444
10
"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..."
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"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. "
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Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140
11
"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..."
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"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. "
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Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384
12
"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..."
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"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. "
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Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617
13
"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..."
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"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] "
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102
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"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..."
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"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. "
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Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043
15
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
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"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
16
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558
17
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..."
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"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino "
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Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
18
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..."
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"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. "
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Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..."
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. "
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Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "
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Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
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