Baishideng Publishing Group

Haq M, Bukhari SMRUAN, Basit A, Ismail Q, Jabeen M. Erdheim-Chester disease presenting with multisystem involvement: A case report. World J Clin Cases 2026; 14(2): 115462

"This manuscript addresses [briefly state the core problem]. While prior research exists on [general topic], our work specifically ..." [Read more]

"This manuscript addresses [briefly state the core problem]. While prior research exists on [general topic], our work specifically investigates [your precise focus/novel aspect]. The primary innovation lies in [describe your key innovation, e.g., a new method, model, or discovery]. By integrating [Theory A] with [Method B], we demonstrate that [key finding]. This contribution is significant because it challenges/extends the current understanding of [relevant field], providing a new perspective for future research on [broader implications]. We believe this study offers substantial theoretical and practical value to the field. " [Collapse]

Zhang L, Xiao P, Shi LD, Chen KX, Bing YF. Hepatic artery infusion chemotherapy for advanced hepatocellular carcinoma with obstructive jaundice: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 113681

"We are delighted to see our work published. Our deepest appreciation goes to the editorial team and the anonymous reviewers for their ..." [Read more]

"We are delighted to see our work published. Our deepest appreciation goes to the editorial team and the anonymous reviewers for their rigorous scrutiny and constructive critiques; their insightful comments were instrumental in refining our analysis and enhancing the clarity of our core arguments. We sincerely hope that the published work will serve as a meaningful reference point, stimulate further inquiry, and contribute to ongoing scholarly conversations in the field. " [Collapse]

Xu JJ, Ni CX, Xu JJ. Emerging role of DNA polymerase epsilon non-exonuclease domain mutations in colorectal cancer: From sequence variants to clinical implications. World J Gastroenterol 2026; 32(6): 116028

"The peer-review and publication processes could be expedited. A faster process may encourage authors to prefer the journal. Compared ..." [Read more]

"The peer-review and publication processes could be expedited. A faster process may encourage authors to prefer the journal. Compared with journals of similar quality, taking this suggestion into consideration may increase authors’ interest in submitting to your journal. Apart from this point, all other processes—from manuscript submission to publication—are objective, transparent, easy to follow, and characterized by efficient communication from the author’s perspective. Thank you very much for everything. " [Collapse]

Yöyen E, Barış TG. Inadequacy of interventions to eliminate or reduce violence against healthcare professionals by patients and/or their relatives. World J Psychiatry 2026; 16(2): 113936

"The peer-review and publication processes could be expedited. A faster process may encourage authors to prefer the journal. Compared ..." [Read more]

Yöyen E. Cognitive signatures of conditional reasoning dysfunction in major depression. World J Psychiatry 2026; 16(2): 114478

"My entire experience of submitting and publishing a paper in the World Journal of Gastroenterology has been excellent. The submission ..." [Read more]

"My entire experience of submitting and publishing a paper in the World Journal of Gastroenterology has been excellent. The submission process was exceptionally smooth, with well-defined milestones and timely feedback at each stage, which greatly enhanced the efficiency of the submission work. During the peer review stage, the comments provided by the reviewers were both professional and targeted. They not only accurately identified the refinable details in the paper but also offered valuable ideas and directions for the deepening and improvement of the research content, playing a pivotal role in elevating the paper’s academic quality and perfecting its research logic. The work of the journal’s editorial team has been particularly impressive. Every step of the process was carried out with the highest level of diligence, professionalism and meticulousness, ensuring that all stages of the paper—from revision to final publication—were conducted in a rigorous and well-organized manner. Overall, the World Journal of Gastroenterology is an outstanding journal that integrates prominent academic authority with high-standard professional services. Its standardized submission procedures, professional review team and dedicated editorial work have provided an excellent academic exchange platform for researchers in the field. We would like to extend our sincere gratitude to the journal’s editorial team and the participating reviewers once again. We also look forward to the journal’s sustained development in the future, as it publishes more high-quality research findings in gastroenterology and makes greater contributions to academic exchanges and disciplinary advancement in this field. " [Collapse]

Wan KR, Qian C, Liu LM. Endocrine-liver bidirectional regulation: From mechanistic research to multidisciplinary clinical practice. World J Gastroenterol 2026; 32(6): 115232

"We appreciate the editorial team and reviewers for their professional work and careful handling of our manuscript. The review process ..." [Read more]

"We appreciate the editorial team and reviewers for their professional work and careful handling of our manuscript. The review process was clear, fair, and efficient, and the communication throughout the revision and production stages was timely and helpful. Overall, the publication process was smooth and well managed, and we value the journal’s support in publishing our work. " [Collapse]

Park SB, Kang SB, Seo GS, Eun CS, Choi CH, Yang DH, Park JJ, Moon CM, Jung SH, Park H, Park MH, Yoo HK, Kim J, Heo JA, Park DI. Efficacy and safety of a novel sodium picosulfate oral tablet in a randomized controlled trial for bowel preparation. World J Gastroenterol 2026; 32(6): 113880

"I would like to express my sincere satisfaction with every aspect of your journal’s services related to my manuscript publication. ..." [Read more]

"I would like to express my sincere satisfaction with every aspect of your journal’s services related to my manuscript publication. The forms required for the online full-text article are well-designed and meet all submission needs, while the entire article publishing process is smooth, transparent and efficient. I am also very satisfied with the clear academic rules and standards provided by your journal, which have effectively guided me in completing the manuscript. Additionally, the academic misconduct detection report is thorough and credible, the publication period is reasonable and in line with academic publishing norms, and the editing and publishing rules and standards are rigorous and professional. The time spent on peer review is appropriate, ensuring the quality of the review, and the anonymous peer review process is standardized and impartial, which fully guarantees the fairness of the review results. " [Collapse]

Zhang MY, Sun RQ, Min Q, Zhu YQ, Qin SK, Guo QL. Synergistic antitumor effect of oroxylin A and donafenib in hepatocellular carcinoma through tumor protein p53 signaling pathway activation. World J Gastroenterol 2026; 32(6): 113529

"Dear Editor, We sincerely thank you and the reviewers for the time and effort devoted to the evaluation of our manuscript. We greatly ..." [Read more]

"Dear Editor, We sincerely thank you and the reviewers for the time and effort devoted to the evaluation of our manuscript. We greatly appreciate the constructive comments and insightful suggestions provided during the review process, which have significantly improved the quality, clarity, and rigor of our work. We are grateful for your professional handling and thoughtful consideration of our manuscript, and we are honored that our work has been accepted for publication in the journal. We truly value the opportunity to contribute our study to your esteemed journal. Thank you again for your support and guidance throughout the review process. With kind regards, Zuli Yang " [Collapse]

Tang XC, Chen ZJ, Chen CY, Qiu J, Huang JT, Tan RC, Li WY, Chen H, Yang ZL. ICAM2 loss drives 5-fluorouracil resistance via TGF-β/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. World J Gastroenterol 2026; 32(5): 115301

"We are very satisfied with the layout quality of your magazine, but the only drawback is that the publishing cost ($3023) is too ..." [Read more]

"We are very satisfied with the layout quality of your magazine, but the only drawback is that the publishing cost ($3023) is too expensive for us to bear. If possible, we hope that your magazine can consider reducing the layout fee. If the publishing costs are reduced, we will consider publishing new works in your journal next time. " [Collapse]

Wang XY, Zhou M, Zhou HL, Yao D, Zheng J, Pang C. Relationship between echocardiographic indicators, coronary artery lesions, and anxiety in patients with coronary heart disease. World J Psychiatry 2026; 16(2): 112193

"The review process was remarkably fast, and the reviewers were extremely careful and provided insightful suggestions that greatly ..." [Read more]

"The review process was remarkably fast, and the reviewers were extremely careful and provided insightful suggestions that greatly contributed to improving the article. The review process was remarkably fast, and the reviewers were extremely careful and provided insightful suggestions that greatly contributed to improving the article. The review process was remarkably fast, and the reviewers were extremely careful and provided insightful suggestions that greatly contributed to improving the article. " [Collapse]

Ferreira AI, Costa Azevedo M, Macedo Silva V, Xavier S, Magalhães J, Cotter J. Not always autoimmune hepatitis: Hepatic steatosis is associated with autoantibodies positivity in patients with hepatocellular dysfunction. World J Hepatol 2026; 18(1): 114045

"The online submission system was logically organized and straightforward to use, with clearly stated requirements for manuscript ..." [Read more]

"The online submission system was logically organized and straightforward to use, with clearly stated requirements for manuscript preparation, ethical disclosures, and supporting materials, which facilitated an efficient submission process. After submission, the manuscript was subjected to an appropriate preliminary editorial assessment to confirm relevance to the journal’s scope, scientific suitability, and adherence to ethical standards, and communication during this phase was professional and timely. The peer-review process followed a single-blind format and involved reviewers with relevant subject expertise, whose evaluations were thorough, constructive, and primarily directed toward enhancing scientific quality, methodological robustness, and clarity of presentation. Editorial decisions were communicated transparently and were well supported by reviewer feedback, and the revision process was structured, fair, and clearly guided, with adequate time provided to address comments and with revisions appearing to be carefully re-evaluated. The overall timeline from submission to decision was reasonable and consistent with expectations for a clinical oncology journal, with key procedural milestones clearly communicated. After acceptance, the manuscript advanced efficiently through copyediting and production, with precise editorial queries and a high standard of formatting and presentation in the final published article. Overall, my experience indicates that the World Journal of Clinical Oncology operates a well-organized, transparent, and scientifically rigorous editorial and peer-review system that aligns with recognized international publishing standards and effectively supports the dissemination of clinical oncology research. " [Collapse]

Ebrahim NAA, Elfandy H, Arafat AMA, Darwish AD, Eltohamy MI. Evaluating murine double minute 2 status as a stratification tool for risk-adapted management in plasma cell neoplasms. World J Clin Oncol 2026; 17(1): 111426

"We are overall very satisfied with the entire publication process. We express our approval of the online submission system, peer review ..." [Read more]

"We are overall very satisfied with the entire publication process. We express our approval of the online submission system, peer review (timeliness, anonymity, and the helpfulness/objectivity of the review reports), editing quality, normative publishing procedures, final outputs (PDFs, online full-text articles, and presentation of figures/tables), as well as academic norms and integrity checks. The peer review process was professional and efficient, and the publication quality is excellent, making it a positive publishing experience. " [Collapse]

Cao Y, Li PF, Zhu L, Li K, He KJ. Non-coding RNA in extracellular vesicles and the occurrence and progression of psychiatric disorders: A narrative review. World J Psychiatry 2026; 16(2): 113037

"The editorial and publishing process was professional and well organised, with clear communication throughout. The quality of editing ..." [Read more]

"The editorial and publishing process was professional and well organised, with clear communication throughout. The quality of editing and presentation of the article PDF met my expectations, and the final output was polished and accurate. Overall, the experience was satisfactory and contributed positively to the dissemination of our research work. " [Collapse]

Hanson S, Menendez Lorenzo J, Chukwu CA, Rao A, Middleton R, Kalra PA. Incidence, risk factors and survival outcomes of post-transplant tertiary hyperparathyroidism in kidney recipients. World J Transplant 2026; 16(1): 103656

"We would like to extend our sincere gratitude to your journal! We are truly thankful for the professional guidance, patient responses ..." [Read more]

"We would like to extend our sincere gratitude to your journal! We are truly thankful for the professional guidance, patient responses and rigorous review of the editorial team throughout the manuscript processing. Every revision suggestion is of great value, which has further polished the presentation of our research findings to perfection. " [Collapse]

Zhang XM, Zhao FY, Gao LF, Xu T, Yang F, Qian NS. Immune therapy-related hyperprogressive disease: Molecular mechanisms, biomarkers, and clinical strategies. World J Clin Oncol 2025; 16(12): 110351

"We sincerely appreciate the professional support and meticulous guidance from your journal all along! From the initial manuscript ..." [Read more]

"We sincerely appreciate the professional support and meticulous guidance from your journal all along! From the initial manuscript review to the polishing of every detail, the editorial team’s rigor, attentiveness, professionalism and efficiency have ensured the accurate presentation of our research findings. Your journal’s professional platform and high-quality services have built a solid bridge for academic exchanges. We hereby extend our heartfelt gratitude and wish your journal continued growth and greater achievements! " [Collapse]

Qi X, Zhao FY. Value of radiomics models in precision diagnosis of dual-phenotype hepatocellular carcinoma and intrahepatic cholangiocarcinoma. World J Radiol 2025; 17(11): 114193

"We would like to thank the editorial team for the efficient and transparent publication process. The online submission and revision ..." [Read more]

"We would like to thank the editorial team for the efficient and transparent publication process. The online submission and revision system was clear, intuitive, and easy to navigate, allowing smooth communication at every stage. The peer-review process was rigorous and constructive, with balanced, insightful comments that significantly improved the quality and clarity of our manuscript. Overall, the professional editorial handling and high review standards made this a very positive publishing experience. " [Collapse]

Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444

"This study originated from our long-standing attention to the clinical challenge of violent behavior among hospitalized patients with ..." [Read more]

"This study originated from our long-standing attention to the clinical challenge of violent behavior among hospitalized patients with SMDs. As frontline mental health practitioners and researchers, we have witnessed firsthand how unpredictable violent incidents threaten the safety of both patients and medical staff, disrupt ward order, and impose significant burdens on clinical management. Despite existing efforts to identify risk factors, there remains a critical need for a precise, actionable predictive tool that can assist healthcare providers in early screening and targeted intervention—this gap motivated our comprehensive investigation. Our key finding that educational level, cigarette smoking, length of hospitalization, age, BPRS scores, and CRP levels are independent predictors of violent behavior offers both theoretical and practical insights. Notably, the protective effects of advanced age and higher education, alongside the risk-enhancing roles of smoking, severe psychiatric symptoms (reflected by BPRS scores), and elevated inflammatory markers (CRP), align with clinical observations but are systematically validated here. The constructed nomogram, with AUC values of 0.94 (training set) and 0.93 (validation set), not only demonstrates excellent discriminative power but also features intuitive visualization—allowing clinicians to quickly calculate individual risk without relying on complex statistical analysis. This practicality is further reinforced by the model’s robust calibration and significant net benefit in DCA, ensuring its relevance in real-world ward settings. During the research process, we overcame challenges such as standardizing violent behavior definitions (adopting a 6-level classification to ensure consistency) and integrating both socio-demographic and biological markers (e.g., CRP) into the model. Admittedly, this study has limitations: it is a single-center cross-sectional study, and the sample is restricted to hospitalized patients. Future research should expand to multicenter cohorts with larger and more diverse populations, including community-dwelling SMD patients, to enhance the model’s generalizability. Additionally, standardizing violence assessment tools across studies will help reconcile discrepancies in reported incidence rates and refine predictive factors. We also aim to explore dynamic monitoring of risk factors (e.g., serial CRP measurements and real-time symptom assessments) to update the prediction model and improve its long-term utility. Ultimately, this research is more than a theoretical contribution—it is a clinical tool designed to empower mental health teams. We hope the nomogram will be widely adopted in psychiatric wards to identify high-risk patients early, guide personalized interventions (such as enhanced monitoring for smokers or patients with elevated CRP, or targeted psychoeducation for those with lower education levels), and ultimately reduce violent incidents. By bridging the gap between research and clinical practice, we strive to create safer care environments for both patients and healthcare providers, and we look forward to seeing this model refined and expanded through interdisciplinary collaboration in the field of mental health. " [Collapse]

Wang T, Wang L, Zhao P, Sun JJ, Gao LN, Li J, Zhao YQ. Application research on the predictive model for violent behavior in hospitalized patients with severe mental disorders. World J Psychiatry 2026; 16(2): 112575

"The peer review process was thorough and constructive, and the reviewers’ comments were clear and helpful in improving the clarity ..." [Read more]

"The peer review process was thorough and constructive, and the reviewers’ comments were clear and helpful in improving the clarity and quality of the manuscript. The editorial handling was efficient, with timely communication at each stage of the review process. We appreciated the opportunity to respond to detailed feedback and believe the revisions strengthened the final manuscript. Overall, the submission and publication process was well organised and professionally managed. " [Collapse]

Rao V, Walia N, Parkash N, Wanigaratne T, Henshaw S, Chen G, Lo SW, Be KH, Robertson M, Zorron Cheng Tao Pu L. Availability and use of computer-aided detection during colonoscopy: A real-world observational study at an Australian tertiary center. World J Gastroenterol 2026; 32(4): 112698

"We sincerely appreciate the editors and reviewers for their meticulous review and constructive comments on our manuscript. Your ..." [Read more]

"We sincerely appreciate the editors and reviewers for their meticulous review and constructive comments on our manuscript. Your professional expertise and detailed feedback have been instrumental in helping us identify areas for improvement and refine our arguments. This rigorous peer review process has enabled our work to meet publication standards and has significantly enhanced the academic value and impact of our research. " [Collapse]

Yang HD, Zhang J, Yang M, Luan LS, Liu JJ, Zhang XB. Prevalence, severity, and risk factors for depressive and anxiety symptoms among adolescents: A cross-sectional study. World J Psychiatry 2026; 16(2): 112996

20627 items Read more >>

Article Quality Tracking-Peer-Review

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's ..." [Read more]

"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's disease. In daily medical practice, its treatment is often inadequate since it is usually attributed to side effects of the drugs administered to treat the underlying disease or to psychological causes. The study under review found that indeed, psychological symptoms such as depression, anxiety, stress of any cause, and insomnia are related to its occurrence. In particular, stress is likely to induce the symptom through probable immunological effects. Of interest was the frequent occurrence of fatigue with increased white blood cell count. It therefore seems that fatigue in patients with Crohn's disease has a multifactorial etiology, not exclusively attributable to disease activity or inflammatory markers. As the researchers pointed out, fatigue among IBD patients should receive greater attention in the near future. By conducting additional relevant studies, we will be able to accurately identify the factors that contribute to fatigue, enabling us to develop and implement strategies to effectively identify and support patients experiencing fatigue." [Collapse]

Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete ..." [Read more]

"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete intestinal obstruction (CRIO). Given the multifactorial and complex pathophysiology of CRIO, it is inherently challenging to comprehensively describe all clinical conditions. Nevertheless, the authors successfully present a well-structured and comprehensive overview by organizing the discussion into a clear and logical framework." [Collapse]

Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as ..." [Read more]

"This article provides an interesting topic, with valuable first-hand information. There were also some notable limitations, as addressed in the following: Of the “Abstract”. The aim does not match well the conclusion. Some “Keywords” are not adequate. “Metagenomic next-generation sequencing” should be moved from “Keywords”. There was no “analysis” or associated description in the “Methods” of the “Abstract”, and this is not adequate. The “Results” in “Abstract” were not consistent with the “Methods” of the “Abstract”. There was no gold standard (guidelines) and criteria for the diagnosis of pulmonary nocardiosis in the “Materials and Methods”. The imaging characteristics (Table 4) were not complete, and which should include a complex item comprising two or more imaging characteristics of the lungs . A total of the pulmonary nocardiosis caused by different species in Table 4 was not 102. The pulmonary nocardiosis treated by different medications in Table 5 was not clear, some patients treated using more than one medications, and the total number was not 102. Figure 1 was not necessary, and associated information can be listed in table or presented in text. Images of pulmonary nocardiosis were not sufficient, and more other representative images had better be added. The English is not professionalism. The “Conclusion” that “Nocardia pneumonia commonly coexists with bronchiectasis. Although mNGS has greatly enhanced its detection rate, N. wallacei pneumonia is distinguished on chest CT by its primary presentation of bronchopneumonia, unlike other types.” was not adequate, and it was not well matching the contents of the “Results”." [Collapse]

Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..." [Read more]

"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity. Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter. " [Collapse]

Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an ..." [Read more]

"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an essential tool in hepatocellular carcinoma surgery and supporting this with evidence from systematic reviews and clinical studies. It logically organizes the diverse applications of ICG—segmental mapping, detection of superficial lesions, thermal ablation guidance, and tumor‑biology assessment—showing how each technique addresses specific surgical limitations. The discussion consistently links fluorescence patterns to pathological features and clinical decision‑making, reinforcing the article’s central claim that ICG enhances precision, safety, and oncologic outcomes in minimally invasive liver surgery." [Collapse]

Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the ..." [Read more]

"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the unusual initial presentation—spontaneous splenic rupture—to the tumor’s aggressive biology. Its diagnostic reasoning is coherent, moving from clinical findings to imaging, pathology, and molecular profiling that distinctly separate the ductal adenocarcinoma and rhabdoid components. The discussion logically integrates existing literature to highlight the rarity, poor prognosis, and potential benefit of aggressive multimodal therapy, underscoring the need for targeted approaches in this molecular subtype." [Collapse]

Yao WQ, Ma XY, Wang GH. Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 114021

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer ..." [Read more]

"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer patients with liver metastases and justifying the need to compare chemotherapy alone with chemoimmunotherapy. Its methodology is rigorous and transparent, using well‑defined inclusion criteria, detailed baseline characteristics, and standardized outcome measures such as RECIST, overall survival, and progression‑free survival. The conclusions logically follow from the data, showing that adding immune checkpoint inhibitors significantly improves survival and response rates without increasing severe toxicity, and the study further strengthens its argument by identifying independent prognostic factors through multivariate Cox regression analysis." [Collapse]

Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2026; 18(1): 113440

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy ..." [Read more]

"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy in advanced gastric cancer with massive ascites and justifying the need for retrospective evaluation. Its methodology is well‑structured, using clearly defined ascites‑burden groups and standardized clinical criteria to ensure meaningful comparisons of outcomes and safety profiles. The conclusions follow naturally from the data, showing that although prognosis remains poor in the high‑ascites group, nivolumab plus chemotherapy provides measurable ascites improvement and acceptable toxicity, supporting its potential therapeutic value in this challenging population." [Collapse]

Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2026; 18(1): 112944

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the ..." [Read more]

"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the study’s objectives and findings. The methods and results are supported by detailed experimental design and high‑quality figures and tables, which enhance reproducibility and data transparency. The discussion highlights clinical relevance and practical implications, effectively linking mechanistic insights to potential therapeutic strategies." [Collapse]

Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2026; 18(1): 112630

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate ..." [Read more]

"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate diagnosis requires a combination of imaging and endoscopic techniques. Pancreatoscopy enables direct visualization of the pancreatic duct, targeted biopsies, and the definition of disease boundaries. Existing data support the view that pancreatoscopy is a satisfactory and promising method for determining which patients with IPMN should undergo surgery, as well as the extent of resection for each patient. However, excessive enthusiasm should not prevail. The method is not widely applied; learning requires a dedicated endoscope and a sufficient number of patients per year to maintain and further increase experience, which is a very important factor. For the widespread acceptance and adoption of the method, it is necessary to conduct prospective, very well-designed multicenter studies aiming to precisely determine many parameters e.g. its diagnostic contribution and accuracy, which patients should undergo the examination, what is the impact on therapeutic decisions, what is the cost-benefit ratio and finally to determine whether it improves the survival and/or quality of life of patients. Based on the above observations, pancreatoscopy should be decided on a case-by-case basis and performed in specialized centers." [Collapse]

Abusharar M, Barritt C, Mavroeidis VK, Aroori S. Role of pancreatoscopy in the management of suspected and confirmed intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2026; 32(4): 112635

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data ..." [Read more]

"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data from the literature, presenting it in a clear and well-structured manner. The review provides valuable insights into the topic, highlights key mechanisms and clinical implications, and offers a solid foundation for future research and practical applications." [Collapse]

Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511

"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s ..." [Read more]

"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s disease and points out the lack of comprehensive studies to fully elucidate the underlying mechanisms. It also outlines future research directions. Overall, the editorial adds value to the target manuscript by providing complementary discussion and contextualization." [Collapse]

Chen YX, Sun NQ, Mo SJ. Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction. World J Gastroenterol 2026; 32(4): 114468

"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with ..." [Read more]

"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with solid editorial transparency. Concise upgrades—documented search/selection methods, figure/table evidence anchoring, explicit evidence‑tier labeling with effect sizes, and a short limitations/certainty note—would materially improve objectivity, credibility, and practical value for hepatology and metabolism audiences. The article is transparent on provenance, timelines, and authorship; it also includes a conflict‑of‑interest declaration. These are positives for editorial/ethical standards. For maximal clarity to non‑specialists, consider adding a one‑line ethics note that no new human/animal data were generated and that the work synthesizes published evidence only. Methodologically, the piece reads as a narrative review. To support quality tracking and reproducibility, please add a concise 'search strategy and selection' box containing the following information: databases used, the exact date of the last search, key terms, language limits, inclusion/exclusion criteria and dual-reviewer screening/extraction. This would substantiate the statement of a comprehensive survey and help readers to assess selection bias. The figures and tables are clear and helpful. Legends could be strengthened by stating whether panels are conceptual or data-derived, defining all abbreviations at first use, citing the primary sources that support each panel and adding n/assay details when values are quoted. Providing a single, consolidated evidence table per claim (model, dose/exposure, effect size/direction, study type and citation) would further aid readers. The interpretation is generally cautious, but the evidence tier should be labelled consistently (in vitro vs. animal vs. human) and comparative claims (citicoline vs. α-GPC; LA/ethanol as 'mitochondrial toxins') should be anchored to primary studies with effect directions and context. It is important to explicitly note when human data are pilot/underpowered. A brief paragraph explaining why quantitative synthesis was not feasible (due to heterogeneity of models/endpoints) and a graded certainty statement for each major conclusion would prevent 'vote-counting'. The biostatistics and data availability could be improved. Where numerical differences are cited in tables or text (e.g. '2.6-fold increase in plasma choline' or 'up to 30% reduction in triglycerides in preclinical models'), include the study design, sample size, comparator and 95% confidence intervals (CIs) where available. Consider including a small supplementary file with raw or minimally processed values from the cited studies." [Collapse]

Mercola J. Fatty liver reexamined choline and mitochondrial toxin amelioration. World J Biol Chem 2025; 16(4): 111831

"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating ..." [Read more]

"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating to the author's role as company founder and their involvement in product development related to C15:0. This review is a readable and visually clear synthesis of C15:0 mechanisms with good editorial transparency and a useful mechanistic overview. A few concise upgrades, such as search/methods transparency, evidence-tier labelling, quantitative anchors for key effects and explicit limitations, would materially improve objectivity, credibility and practical value for translational audiences. As a narrative review, the article summarises the proposed mechanistic actions of pentadecanoic acid (C15:0), including partial PPAR-α/δ agonism, AMPK activation, mTOR suppression, HDAC6 inhibition and modulation of the anti-inflammatory pathway, and provides helpful pathway schematics and a BioMAP® heatmap. Regarding theinterpretation, the figures are legible and informative, but several mechanistic statements are presented as causal when much of the evidence is preclinical or platform-based (e.g. BioMAP® panels and cell assays). Please anchor each mechanism to specific primary studies and consistently label the evidence tier (in vitro, in vivo or human observational). Where the review draws parallels between the effects of C15:0 and metformin/rapamycin, cite comparative, peer-reviewed experiments and quantify the direction of the effects to avoid 'phenotypic mirroring' based on analogy alone. If you are relying on cell-system phenotyping reports, you should specify the doses, reference compounds and cytotoxicity thresholds, and discuss the limits of generalisability. Figures/tables: Expand figure legends to state whether values are empirical (with n, assay and statistics) or conceptual and include scale and statistical annotations where applicable. Biostatistics and certainty: Although a formal meta-analysis is not expected, readers would benefit from the reporting of representative effect sizes (e.g. EC₅₀ ranges or fold changes with 95% confidence intervals) for key targets, alongside a short paragraph explaining why quantitative synthesis across studies is not feasible (e.g. heterogeneity of models and endpoints). Providing a graded certainty statement (e.g. 'moderate' for PPAR-α/δ binding; 'low'/'very low' for clinical efficacy) would prevent over-extrapolation. Providing a neutral summary that acknowledges the limited number of human prospective trials of C15:0 for metabolic or longevity endpoints would align enthusiasm with the current evidence base." [Collapse]

Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258

"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the ..." [Read more]

"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the PRISMA 2009 guidelines. This is a timely and relevant systematic review of the gut microbiome and chemotherapy-induced cardiotoxicity, with good editorial transparency and a useful PRISMA framework. The reference list is current and thematically appropriate. These factors positively contribute to ethical and reporting standards, making provenance clear to readers. Consider adding a brief statement confirming that no new human or animal data were collected, and that only published or registry data were used, to close the ethics loop for non-specialists. As a systematic review, the methods section would benefit from providing compact yet reproducible details. While you do include a PRISMA flow diagram, the main text should also specify the databases searched (with the exact date of the last search), the full search strings, any language restrictions, the inclusion/exclusion criteria, and the tool used for the risk-of-bias assessment (e.g. ROBINS-I, RoB2 or SYRCLE). A short table summarising study designs, sample sizes, chemotherapy classes, cardiotoxicity definitions and microbiome endpoints would help readers to understand the heterogeneity. Regarding the results and interpretation, the narrative rightly identifies microbial metabolites and gut–heart crosstalk as candidate pathways. Anchoring these mechanisms to recent overviews of microbiome–chemotherapy interactions and core mechanistic reviews would improve the balance and timeliness of the review. The figures and tables are adequate (PRISMA and one data table are included in the journal assets). The legends could be strengthened by declaring whether each figure is conceptual or data-derived, defining all abbreviations at first use and adding a per-study evidence table (study; cancer/chemo; cardiotoxicity endpoint; microbiome assay; key finding; risk of bias). Readers will expect some appraisal of effect direction/size where feasible (e.g., HRs/ORs for cardiotoxicity associations or standardised mean differences for metabolite levels), even if a meta-analysis is not possible. Including a concise 'why no pooling' paragraph (explaining heterogeneity in definitions, assays and timepoints) and a GRADE-style certainty statement for each major conclusion (very low, low or moderate) would prevent 'vote-counting' impressions and increase the utility of the review's conclusions." [Collapse]

Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221

"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor ..." [Read more]

"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor (randomization/blinding/power, assay standards), richer statistics and data sharing, and a more circumspect translational framing. These concise additions would enhance objectivity, credibility, and scientific utility for the community. The references are appropriate and full editorial metadata are provided. Funding and conflict-of-interest statements are also included, along with details of compliance with the ARRIVE guidelines, animal ethics approval, and CC BY-NC 4.0 licensing. This transparency aligns with the journal’s quality policy and is a strength of the article. It would be beneficial to add a brief ethics note to clarify humane endpoints and analgesia during tail transection for readers who are not specialists. The methods section would benefit from a more concise description to support reproducibility. Report the sex and exact age range/ageing criterion of the mice, their housing conditions, and the full rationale for the therapeutic BoNT formulation (serotype, units/kg, injection site/volume, and timeline to assay). Given the focus on coagulation, full protocols for platelet aggregation should be added (e.g. agonist, concentration, light transmission vs microscopy) and standard plasma assays (PT/INR, aPTT, fibrinogen) should be included to triangulate the tail bleeding endpoint. These additions would make the work easier to replicate and compare with prior haemostasis literature. The results are clear and the figures are legible, but several quality improvements would be helpful. For Figures 1–3, it would include n per group on the plots and show all data points with mean ± SD/SEM. State the exact statistical tests used (normality testing, two-sidedness and corrections for multiplicity) and report effect sizes with 95% CIs. In the legends, indicate how many independent experiments/animals the images are representative of, and add scale bars and magnifications. Where possible, provide raw or minimally processed data (e.g. bleeding times, body weights, aggregation percentages) in a supplementary file to meet current data availability expectations. Interpretation should be cautious to avoid overreach. While a single dose in ageing mice suggests a pro-coagulant/anti-haemorrhagic effect, the systemic or off-target neuromuscular actions of BoNT could confound behaviour during the assay. Please discuss the potential mechanisms (e.g. platelet number/function, coagulation cascade, or local vasomotor effects) and outline experiments that would clarify them (e.g. complete blood count/platelet counts, thromboelastography, ROTEM, or endothelial markers). Translational claims (e.g. use in trauma/surgery) should be limited until dose–response, time-course, safety (toxicity, motor impairment) and reversibility are established, and the findings should be considered in the context of contemporary BoNT pharmacology/safety reviews." [Collapse]

Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; 16(4): 112376

"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, ..." [Read more]

"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, alongside transparent metadata on provenance. The piece could be elevated to a best-practice minireview while preserving its brevity and readability by adding a concise methods note for literature selection, tightening causal language, enriching legends/references to anchor mechanisms, and stating limitations explicitly. Regarding the results and their interpretation, the mechanistic thread is accurate and accessible. The figures are clear and didactic. However, a compact summary table cross-linking each ISG to its function, model/evidence, clinical signal (if applicable) and approximate level of evidence would help translational readers further. The language quality is high, and minor spacing artefacts appear to be HTML rendering issues that will not affect the PDF. A short, explicit 'Limitations and outlook' paragraph acknowledging the non-systematic approach, potential selection bias and the need for stratified clinical validation of IFN-γ/ISG signatures in standard-of-care and immunotherapy contexts would round off the manuscript's critical appraisal. " [Collapse]

Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768

"This is a well-constructed and transparent preclinical systematic review that adheres to the PRISMA reporting guidelines. It clearly ..." [Read more]

"This is a well-constructed and transparent preclinical systematic review that adheres to the PRISMA reporting guidelines. It clearly states its murine-only scope and documents multi-database searching and the SYRCLE risk-of-bias assessment. These elements support the objectivity and credibility of the review for readers appraising the animal evidence. The ethics and availability are handled appropriately, matching the journal's standards for this type of article. The synthesis is organised in a reader-friendly way and remains faithful to the preclinical findings without making claims that extend beyond the scope of the human literature. This approach strengthens the balance and credibility of the manuscript. Visual reporting is a strong point: the PRISMA flow and SYRCLE bias graphics meaningfully enhance transparency. A practical note on presentation quality: in the HTML view, some figure panels appear slightly compressed, low-resolution or distorted, whereas the 'Full size/download' versions are clear and legible. Readers will benefit from accessing the high-resolution links. Statistically, the manuscript does not overstate certainty, and the narrative is consistent and cautious in relation to the evidence base. References are recent and field-relevant, and the prose is clear and concise. As caveats intrinsic to the scope of the review, the preclinical-only inclusion is appropriate, but it necessarily limits direct clinical inference. As the review itself documents, some domains in the included studies show 'unclear' risk due to reporting (e.g. allocation concealment/blinding), which is a common feature of animal research and is displayed properly in the SYRCLE plots." [Collapse]

Ochoa KL, Heredia AG, Piedra CC, Arias RJ, Ortiz BJ, Dominguez-Gortaire JA. Association between Alzheimer's disease and Porphyromonas gingivalis products in murine models: A systematic review. World J Biol Chem 2025; 16(4): 111156

"This study uses the C. elegans model to examine how the endoplasmic reticulum (ER) stress inducer dithiothreitol (DTT) affects neuronal ..." [Read more]

"This study uses the C. elegans model to examine how the endoplasmic reticulum (ER) stress inducer dithiothreitol (DTT) affects neuronal function and behaviour, with a particular focus on the activation of the unfolded protein response and readouts relevant to neurodegeneration. From an ethics and transparency perspective, the article adheres to publishing standards and provides readers with adequate procedural clarity. Methodologically, the experimental framework relies on familiar and reproducible tools in the field of C. elegans research: graded DTT exposure, molecular markers of ER stress and locomotor/behavioural assays. The figures and captions document the key elements of the approach, providing fellow researchers with sufficient operational detail to comprehend the setup and replicate the primary measurements. Overall, the methods are effective for the stated aims and fall squarely within established practice for probing ER-stress-linked phenotypes in C. elegans. In terms of results and credibility, the study's findings are directionally consistent and biologically plausible. The work is therefore coherent mechanistically in relation to the broader field, where both canonical ER effects (misfolded protein load, UPR engagement) and additional cellular pathways influenced by DTT have been described. The figures and tables are informative and useful, but the resolution quality is poor and some of them are distorted. The set of figures covers the core narrative, and the layout facilitates quick appraisal of both effect direction and relative magnitude. From a biostatistics perspective, the article provides transparent summary statistics and specifies the inferential test in the legend. This is an appropriate approach for these endpoints and sample sizes in a discovery-oriented worm study. While the work is not a quantitative synthesis, the statistical approach is appropriate for the scope of the study and does not overstate certainty. In terms of references and positioning, the rationale of the manuscript is consistent with the existing literature on redox-mediated folding stress and UPR-linked neurobiology in experimental systems. The conceptual placement is therefore sound and timely, given recent mechanistic reports on how DTT influences cellular metabolism and stress pathways in C. elegans and mammalian cells [wjgnet.com; elifesciences.org; link.springer.com]. The language and presentation in the main text are generally clear and concise; the rationale, design and readouts are communicated effectively to an audience of molecular neurobiologists and stress biologists. Ancillary materials hosted on the publisher’s platform (e.g. process pages) contain minor typographical errors in the summaries, but the scientific narrative in the article itself is easy to read. As for caveats intrinsic to the scope of the study, it reflects the strengths and boundaries of the chosen model and perturbagen. The C. elegans system provides accessible neurobehavioural phenotyping and stress signalling, and DTT is a recognised ER stress proxy. Readers will naturally contextualise the findings, knowing that some DTT effects can extend beyond the ER and that invertebrate observations are a first step in the process of translation. Within this context, the article successfully links DTT-evoked ER stress to functional outcomes in vivo in a concise and accessible manner." [Collapse]

Raj G, Kumar M, Shreya S, Bhardwaj S, Priya R, Mangalhara KC, Jain BP. Dithiothreitol induced endoplasmic reticulum stress and its role in neurodegeneration in Caenorhabditis elegans. World J Biol Chem 2025; 16(4): 111110

"This minireview provides a clear, well-structured and up-to-date overview of pancreatic macrophages in obesity and their role in ..." [Read more]

"This minireview provides a clear, well-structured and up-to-date overview of pancreatic macrophages in obesity and their role in metabolic dysregulation. From an ethics and transparency standpoint, the article meets the publishing standards expected of this type of article. Methodologically, the inclusion of a 'Methodology of data collection' section is uncommon but welcome for a narrative review, as it specifies the databases and key terms used, as well as the time period considered. With respect to the results and their interpretation, the synthesis is both internally consistent and biologically coherent. The manuscript effectively links macrophage recruitment and polarisation, immunometabolic signalling nodes, and inter-organ communication to demonstrate how shifts in the innate immune system can influence β-cell stress, fibrosis, and endocrine dysfunction. The translational thread, which highlights potential checkpoints and cellular programmes of interest, is presented in a manner that remains faithful to the underlying evidence base while maintaining a clear focus on clinical relevance. Where statements draw predominantly on experimental models, this reliance is generally evident from the context and figure captions. The figures and tables are a particular strength: they are legible and logically staged, helping readers to connect upstream triggers with downstream consequences. The therapeutic summary table facilitates the rapid understanding of mechanisms and biological implications. These visual elements are well aligned with the narrative and add real pedagogical value for both basic and translational audiences. The references are recent and relevant to the field, supporting the article’s objective of providing a contemporary snapshot; the selection naturally reflects the chosen time window. The language and presentation are clear and concise throughout, with only minor stylistic repetitions that do not affect readability. In terms of caveats intrinsic to the scope, the translational sections largely build on preclinical evidence, and readers should bear this in mind when interpreting the clinical implications. These features are consistent with the declared intent and format, and do not detract from the synthesis's clarity or credibility." [Collapse]

Chen KR, Chen ZY, Liu FY, Xie CY, Hu J, Wang SY, Xu B, Xu TC. Macrophage-mediated metabolic dysregulation in the pancreas: Insights from obesity. World J Biol Chem 2025; 16(4): 109509

15932 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 2264

Peer-reviewers: 35931

Manuscripts received today: 0

Manuscript reviews today: 0

Unhandled manuscripts today: 183

Active peer-reviewers today: 435

Reviewer acceptance today: 6

Reviewer refusals today: 1

Total accepted manuscripts: 39924

Total rejected manuscripts: 44524

Total peer-reviewers: 4670146

Total submissions: 37814

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journal List

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All Journal Articles

Mwita RP, Özdemir Ö. Stem cell transplantation in immuno-hematologic and infectious diseases. World J Transplant 2026; 16(1): 114592

2026-03-18 | Browse: 335 | Download: 100

Kute VB, Balwani MR, Shrimali JB, Pasari A, Kher V, Patel MP, Chafekar D, Guditi S, Das P, Siddaiah GM, Godara SM, Bhargava V, Gupta A, Ramteke V, Deshpande N, Tolani P, Prasad N, Patil RK, Mohanka R, Mahajan S, Sharma S, Banerjee S, Engineer DP, Agarwal D, Kashiv P, Lahiri A, Prasad N, Khullar D, Srivastava A. Induction therapy in kidney transplant recipients: A consensus statement of Indian Society of Organ Transplantation. World J Transplant 2026; 16(1): 114367

2026-03-18 | Browse: 419 | Download: 120

Belal AA, Bourricaudy RA, Saba Z, Alquadan KF, Kazory A, Santos Jr AH. Kidney allograft outcomes in combined kidney with other solid organ transplantation. World J Transplant 2026; 16(1): 114233

2026-03-18 | Browse: 204 | Download: 74

Lekehal B, Ait Youssef N, Lekehal M, Jdar A, El Hassani AEA, Belyazid I, Bakkali T, Bounssir A. Acute graft thrombosis in a patient with factor V Leiden mutation: A case report and review of literature. World J Transplant 2026; 16(1): 114162

2026-03-18 | Browse: 237 | Download: 109

Guissouss O, Achiaou K, El Turk J, Mourachid A, Cheggali A, Medkouri G, Ramdani B, Benghanem Gharbi M, Taoudi Benchekroun M, Bennani S. Preformed vs de novo anti-human leukocyte antigens-DQ antibodies in kidney transplantation: A retrospective study. World J Transplant 2026; 16(1): 114044

2026-03-18 | Browse: 250 | Download: 117

Guo YP, Wen Q, Wang YY, Hang G, Chen B. Application of machine learning in the research progress of post-kidney transplant rejection. World J Transplant 2026; 16(1): 114000

2026-03-18 | Browse: 249 | Download: 101

Kodali NA, Janarthanan R, Demir Z, Sazoglu B, Dirican OF, Tuder D, Zor F, Kulahci Y, Gorantla VS. Nail abnormalities in upper extremity transplantation: Perspectives and insights from systemic diseases and organ transplantation. World J Transplant 2026; 16(1): 113633

2026-03-18 | Browse: 257 | Download: 81

Balwani MR, Pasari A, Kashiv P, Shembekar C, Shembekar M, Dubey S, Jeyachandran V, Malde S, Gupta S, Pawar T, Tolani P, Kurundwadkar M, Gurjar P, Sejpal K, Bawankule C, Kute VB. Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report. World J Transplant 2026; 16(1): 113117

2026-03-18 | Browse: 224 | Download: 103

Christou CD, Antoniadis S, Majumder A, Zakri R, Olsburgh J, Callaghan C, Papadakis G, Sran K, Drage M, Decaestecker K, Challacombe B, Kessaris N, Loukopoulos I. Robot-assisted vs hand-assisted laparoscopic donor nephrectomy in the United Kingdom: Equivalent outcomes in the first national series. World J Transplant 2026; 16(1): 113075

2026-03-18 | Browse: 264 | Download: 96

Ardila CM, González-Arroyave D, Ramírez-Arbelaez J. Robotic-assisted donor and recipient hepatectomy in liver transplantation: An umbrella review of clinical outcomes, surgical performance, and cost-effectiveness. World J Transplant 2026; 16(1): 113034

2026-03-18 | Browse: 229 | Download: 99

Chen KR, Wu LZ, Huang YN, Zhuang SY, Chen ZY, Xu B, Xu TC. Pathogenic analysis of post-transplantation obesity: A comprehensive systematic review. World J Transplant 2026; 16(1): 112811

2026-03-18 | Browse: 258 | Download: 135

Emmanouilidou A, Karageorgos FF, Tsoulfas G, Alexopoulos AH. Microplastics in organ transplantation: An emerging threat requiring immediate action. World J Transplant 2026; 16(1): 111980

2026-03-18 | Browse: 235 | Download: 89

Chukwu CA, Kalra PA, Lowe M, Poulton K, Augustine T, Rao A. Outcomes of basiliximab vs alemtuzumab induction in kidney allograft recipients with matched immunological Profiles: A retrospective cohort study. World J Transplant 2026; 16(1): 111959

2026-03-18 | Browse: 251 | Download: 110

Kaur M, Arora J, Naseem M, Singh A, Kumar V, Sohal A. Ocular complications after liver transplantation: A comprehensive review of infectious and non-infectious etiologies. World J Transplant 2026; 16(1): 111869

2026-03-18 | Browse: 241 | Download: 83

Elahi T, Ahmed S, Mubarak M. Update on diagnostic and therapeutic strategies for antibody-mediated rejection in kidney transplantation. World J Transplant 2026; 16(1): 111524

2026-03-18 | Browse: 320 | Download: 114

Paulin S, Rajakumar A, Menon J, Shanmugam N, Rela M. Perioperative management of pediatric patients with inborn errors of metabolism during liver transplantation. World J Transplant 2026; 16(1): 111122

2026-03-18 | Browse: 264 | Download: 104

Abuyadek R, A Ghitani S, Shaaban R, Quoritem MA, Foula MS, Abdel Majid RO, Mokhtar M, Elhadi YAM, Alnagar A. Protocol for a global electronic Delphi on integrating artificial intelligence into solid organ transplantation. World J Transplant 2026; 16(1): 111103

2026-03-18 | Browse: 260 | Download: 94

Alquadan KF, Belal AA, Mehta R, Leghrouz M, Ibrahim H, Vrakas G, Santos AH. Simultaneous kidney and pancreas transplantation: Current trends and challenges. World J Transplant 2026; 16(1): 111064

2026-03-18 | Browse: 220 | Download: 77

Currier EE, Won CY, Parraga X, Lee KS, Saberi B. Hemoperitoneum from omental variceal bleed resulting in first documented successful liver transplant: A case report. World J Transplant 2026; 16(1): 110910

2026-03-18 | Browse: 203 | Download: 85

Lekehal B, Ait Youssef N, Lekehal M, Bakkali T, Jdar A, Bounssir A. Vein cuff interposition for short renal vein in living-donor kidney transplantation: Three case reports and review of literature. World J Transplant 2026; 16(1): 110683

2026-03-18 | Browse: 213 | Download: 101

61993 items Read more >>

Featured Articles

Caballero-Mateos AM, Trigo-Salado C, Suárez-Toribio Á, Martín-Rodríguez MDM, Rodríguez-González FJ, Valdés-Delgado T, Pallarés-Manrique H, Trapero-Martínez AM, Olmedo-Martín R, Bailón-Gaona C, Benitez Cantero JM, Gros B, Sáez-Díaz A, Hernández-Martínez Á. Long-term clinical outcomes with filgotinib in ulcerative colitis: 12-month results from the FILGUITO study. World J Gastroenterol 2026; 32(6): 115941

2026-02-02 | Browse: 2 | Download: 1

2026-02-02 | Browse: 1 | Download: 1

2026-02-02 | Browse: 3 | Download: 17

Lu JG, Gao YZ. Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges. World J Gastroenterol 2026; 32(6): 115699

2026-02-02 | Browse: 2 | Download: 1

Xie YT, Liu Q, Liu YX. Domino effect of evening chronotype: How chronotype topples adolescent mental health through sleep and social functioning. World J Psychiatry 2026; 16(2): 113937

2026-01-30 | Browse: 24 | Download: 28

Anand R, Nag DS, Gope RL, Sahoo MK, Bhushan P, Pal BD, Patel R, Shivani S, Bharadwaj MK, Ansari MA. Rocuronium-sugammadex as an alternative muscle relaxant to succinylcholine in electroconvulsive therapy: A meta-analysis. World J Psychiatry 2026; 16(2): 112462

2026-01-30 | Browse: 20 | Download: 23

Ma HK, Zhu SL, Li XY, Yuan Y, Huang QY, Wang H, Shen GM, Wang XY. Electroacupuncture alleviates depression and gastrointestinal dysfunction by rebalancing GABAergic activity in the central amygdala. World J Psychiatry 2026; 16(2): 114736

2026-01-30 | Browse: 18 | Download: 28

Yuan L, Liu JJ, Li Z, Zhu YZ, Ren W, Liu YZ, Zhao XL, Du XD, Zhang XY. L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder. World J Psychiatry 2026; 16(2): 113063

2026-01-30 | Browse: 22 | Download: 30

2026-01-30 | Browse: 21 | Download: 27

Xu T, Hou WX, Yang ST, Shao YP, Wang J, Han TT, Li JN. Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway. World J Gastroenterol 2026; 32(5): 113024

2026-01-28 | Browse: 43 | Download: 14

Mould DR, Kutschera M, Primas C, Reinisch S, Novacek G, Lichtenberger C, Dervieux T, Bae Y, Lee SH, Lee JH, Reinisch W. Determination of correlation of clearance with clinical outcomes for inflammatory bowel disease. World J Gastroenterol 2026; 32(5): 113505

2026-01-28 | Browse: 29 | Download: 17

Cheng XF. Molecular profiling-directed individualized adjuvant therapy in colorectal cancer: Bridging consensus guidelines to clinical disparities. World J Gastroenterol 2026; 32(5): 115009

2026-01-28 | Browse: 25 | Download: 16

Chen Y, Zhang Q, Zhang MY. Deep learning techniques for using computed tomography imaging for hepatocellular carcinoma diagnosis, treatment and prognosis. World J Gastroenterol 2026; 32(5): 113592

2026-01-28 | Browse: 25 | Download: 15

Yang J, Pan YT, Wen HZ. Growth differentiation factor 15 - a new molecular target in inflammatory bowel disease: Progress and challenges. World J Gastroenterol 2026; 32(5): 115439

2026-01-28 | Browse: 20 | Download: 15

Adnyana IMDM. Educational video module for increasing treatment rates for alcohol use disorders in inpatients. World J Hepatol 2026; 18(1): 115013

2026-01-27 | Browse: 43 | Download: 50

Cui X, Yin BQ, Chen L. Remote telerehabilitation for frailty management in liver transplant candidates: A feasible yet underutilized strategy. World J Hepatol 2026; 18(1): 114880

2026-01-27 | Browse: 35 | Download: 47

Bundschuh J, Neumann M, Zimny S, Spirk M, Buechler C. Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells. World J Hepatol 2026; 18(1): 113896

2026-01-27 | Browse: 39 | Download: 54

Schwartz AW, Park EY, Ilagan-Ying YC, Zimmerman ZE, Bollinger B, Ying LD, Deng YD, Duffy AJ, Morton JM, Mehal WZ, Do A, Banini BA. Impact of multidisciplinary steatotic liver disease management on bariatric surgery referral and clinical outcomes: A retrospective cohort study. World J Hepatol 2026; 18(1): 113753

2026-01-27 | Browse: 38 | Download: 64

Yodoshi T. Whole-exome sequencing illuminates unexplained pediatric cholestatic liver disease. World J Hepatol 2026; 18(1): 115037

2026-01-27 | Browse: 58 | Download: 56

Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552

2026-01-26 | Browse: 36 | Download: 62

10381 items Read more >>

Keyword Search Published Articles Processes

Case report

4749

Hepatocellular carcinoma

1752

Gastric cancer

1272

Colorectal cancer

1257

Prognosis

1089

Inflammatory bowel disease

857

COVID-19

841

Treatment

776

Diagnosis

759

Liver transplantation

745

Ulcerative colitis

688

Meta-analysis

667

Crohn’s disease

621

Endoscopy

615

Cirrhosis

613

Inflammation

598

Helicobacter pylori

590

Magnetic resonance imaging

584

Surgery

562

Pancreatic cancer

519

65832 items Read more >>

Reader Comments

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..." [Read more]

"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. " [Collapse]

Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..." [Read more]

"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 " [Collapse]

Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..." [Read more]

"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. " [Collapse]

Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..." [Read more]

"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. " [Collapse]

Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..." [Read more]

"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. " [Collapse]

Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..." [Read more]

"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] " [Collapse]

Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..." [Read more]

"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. " [Collapse]

Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. " [Collapse]

Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232

"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..." [Read more]

Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..." [Read more]

"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino " [Collapse]

Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..." [Read more]

"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. " [Collapse]

Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..." [Read more]

"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. " [Collapse]

Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..." [Read more]

"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. " [Collapse]

Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757

"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..." [Read more]

"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. " [Collapse]

Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872

"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..." [Read more]

"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. " [Collapse]

El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168

"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..." [Read more]

Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618

"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..." [Read more]

"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. " [Collapse]

Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272

"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..." [Read more]

"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. " [Collapse]

Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060

"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on ..." [Read more]

"The present Letter provides a concise academic response to the article identified by Reader’s code 05354032. The comments focus on several important aspects of the study, including its methodological design, data interpretation, and clinical applicability. The aim is to offer constructive perspectives that may help clarify key issues and support future improvements in related research. " [Collapse]

Ardila CM, Ángel-Estrada S, González-Arroyave D. Robot-assisted vs conventional lumbar interbody fusion: A systematic review and meta-analysis of perioperative, radiographic, and clinical outcomes. World J Orthop 2025; 16(11): 110276

"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular ..." [Read more]

"The study title "Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study" by Lei et al. aims to compare the long-term survival and perioperative outcomes of Laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC). This retrospective study included 254 patients with small HCC who were collected from Hospital of Chongqing Medical University between December 2022 and March 2025. The results showed that LH was associated with longer operative time, greater blood loss, prolonged recovery, higher costs, and increased complication rates. Consequently, LH, though associated with increased perioperative morbidity, provides superior long-term survival outcomes compared with RFA in patients with small HCC. This study had many limitations such as potential for selection bias and confounding factors that were not controlled for is inherent. The decision to undergo either LH or RFA was made based on clinical judgment and patient-specific factors, which could introduce bias. The sample size was still be insufficient to detect subtle differences in outcomes between the two modalities, especially for subgroups with specific tumor characteristics or comorbidities. Moreover, LH and RFA techniques have evolved over time, and variations in operator experience and institutional protocols could influence outcomes. " [Collapse]

Lei ZL, Tan ZL, Luo YH, Yang M, Wang JL, Qin Z, Liu YY. Comparison of the efficacy of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma: A retrospective study. World J Gastroenterol 2025; 31(45): 111540

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