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"I'm satisfied about the peer review process. "The author's comments should be no less than 50 words." I'm very very satisfied about ..."
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"I'm satisfied about the peer review process. "The author's comments should be no less than 50 words." I'm very very satisfied about the peer review process~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~the editor invited a lot of reviewers. There are some reviewers who are highly professional and have a constructive impact on the manuscript. I am honored to have published an editorial in the World Journal of Gastroenterology. I am willing to submit more manuscripts in the future if there are any suitable ones. "
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Lu JG, Gao YZ. Dyspepsia following Helicobacter pylori eradication: Shifts in etiology and clinical challenges. World J Gastroenterol 2026; 32(6): 115699
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"We are truly grateful for the exceptional support received throughout the publication process. The constructive comments from the ..."
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"We are truly grateful for the exceptional support received throughout the publication process. The constructive comments from the peer reviewers and the rigorous guidance from the Editor-in-Chief and Editorial Director have significantly enhanced the quality of our manuscript. Furthermore, we would like to extend our special thanks to the Assistant Editor, Language Editor, and Production Editor for their efficiency and attention to detail. It has been a distinct pleasure working with such a professional team, and we look forward to future collaborations. "
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Wang YN, Jiang JX, Pang CX, Sun L, Sun R, Wang FM, Jiang HJ. Phosphatidylinositol-3-kinase/protein kinase B signaling dysregulation in steroid-induced osteonecrosis of the femoral head: A minireview of therapeutic implications. World J Orthop 2026; 17(2): 110517
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"This journal demonstrates exceptional efficiency and rigor throughout its manuscript handling workflow, making it a highly recommended ..."
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"This journal demonstrates exceptional efficiency and rigor throughout its manuscript handling workflow, making it a highly recommended publication venue for researchers. First, its manuscript processing speed is impressively fast upon receiving submissions. The editorial team conducts careful and thorough preliminary checks, showing strict responsibility in ensuring submissions align with the journal’s scope and basic formatting requirements. Manuscripts are promptly sent to peer reviewers without unnecessary delays, which significantly shortens the overall review cycle. Second, the peer review process is both constructive and efficient. Reviewers provide fair, insightful comments and practical suggestions—these inputs are not only targeted but also highly beneficial for authors to refine their manuscripts, directly enhancing the quality of the final published work. Notably, the feedback turnaround time is relatively quick compared to many peer journals in the same field, reducing authors’ waiting time. Finally, the journal maintains high standards of rigor in post-acceptance proofreading after notifying authors of manuscript acceptance. The proofreading work ensures minimal errors in the final published version, reflecting the team’s commitment to publication quality. In summary, this journal’s streamlined, responsible, and high-quality manuscript handling process greatly supports researchers and upholds the academic integrity of its publications. "
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Liu RB, Xin JY, Huang Z, Li KY. Sonazoid-contrast-enhanced ultrasound for the histological diagnosis of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 111144
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"Respected Chief Editor and Esteemed Reviewers, Greetings of the day. Thank you so very much for publishing our manuscript in your ..."
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"Respected Chief Editor and Esteemed Reviewers, Greetings of the day. Thank you so very much for publishing our manuscript in your prestigious PubMed Journal. We are very much obliged for the great efforts done by the reviewers, editors and the publication team. Their actions had greatly improved the overall scientific and academic quality of our manuscript upto highest international standards. Hopefully this unique manuscript will garner lots of citation in the scientific community. Thanks for the opportunity. Best Regards, Dr . Arvind Kumar Morya MS(Gold Medalist) MNAMS Additional Professor & Unit-I Head Cataract, Glaucoma, Refractive, Squint Paediatric Ophthalmology and Medical Retina Services Associate Editor UKJOS, National Advisor IJO,GJCSRO Editorial Board Member IJOVS, WJCC, EC-Ophthalmology, DOS Times, Journal of HOS. Reviewer Elsevier, AIMDR and IJO Clinical Trial Expert Panel - CDSCO & Ministry of Health and Family Welfare Convenor - AIOS Adverse Event Committee Department of Ophthalmology All India Institute of Medical Sciences, Bibinagar Hyderabad, Telangana -508126 INDIA +91-8003996598 "
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Behera RK, Gupta PC, Morya AK, Khullar S. Safety and efficacy of keratorefractive surgery in diabetes mellitus: A clinical review. World J Clin Cases 2026; 14(4): 118154
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"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working ..."
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"We are happy with the submission. I hope that y the editor can provide us with additional invited papers. We look forward to working with BPG. The reviewing process needs work. It takes numerous months before reviewers are found. The system could be improved by slimlining the entire submission process. Other journals take 1-2 for complete publication. "
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Capobianco M, Zeppieri M, Nicolosi SG, Faro GD, Salanitro D, Khouyyi M, D’Esposito F, Gagliano C. When eye disease affects the mind: Psychological burden and functioning in autoimmune ophthalmology. World J Clin Cases 2026; 14(4): 117692
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"I am very satisfied with the entire editorial and peer-review process. The communication with the editorial office was clear, timely, ..."
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"I am very satisfied with the entire editorial and peer-review process. The communication with the editorial office was clear, timely, and professional throughout all stages. The reviewers’ comments were constructive, insightful, and helped improve the quality and clarity of the manuscript. I especially appreciate the fairness and efficiency of the review process, as well as the helpful guidance provided by the editors. Thank you for your thorough and well-organized work. "
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Popovic DD, Dragovic M, Panic N, Marjanovic-Haljilji M, Glisic T, Lukic S, Mijac D, Bogdanovic J, Bogdanović L, Djokovic A, Starcevic A, Filipovic B. Harnessing artificial intelligence in gastrointestinal endoscopy for early detection of dysplastic lesions in inflammatory bowel disease. World J Gastrointest Endosc 2026; 18(2): 113912
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"We are totally satisfied with all the submission process. We are very grateful to the reviewers and the Editor for their insightful ..."
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"We are totally satisfied with all the submission process. We are very grateful to the reviewers and the Editor for their insightful comments and constructive suggestions during the peer-review process. Finally, we are thankful to the Editor for giving us the opportunity to publish our manuscript. It has been an honor to have published our manuscript in the World Journal of Gastrointestinal Endoscopy. "
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Martino A, Granata A, Zito FP, Fiorentino R, Bennato R, Saviano S, de Leone A, Graceffa P, Ricchiuti M, Orsini L, Crolla E, Sarnelli G, Cartabellotta F, Lombardi G. Endoscopic ultrasound-guided gallbladder drainage for bilirubin normalization in distal malignant biliary obstruction: A focused review. World J Gastrointest Endosc 2026; 18(2): 114771
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"We extend our sincere gratitude to the editors and reviewers for their insightful feedback and constructive suggestions during the ..."
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"We extend our sincere gratitude to the editors and reviewers for their insightful feedback and constructive suggestions during the peer-review process. Their meticulous review and valuable comments have significantly strengthened the manuscript. We also deeply appreciate the journal for providing this valuable opportunity to share our findings with the academic community. "
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Li JL, Cheng C, Zhang P, Fan J, Zhang L, Zhu LR, Tao KX, Cai M. Rectal follicular thyroid-like carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(2): 115179
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"I would like to express my sincere gratitude to the editorial team and peer reviewers of the World Journal of Gastrointestinal ..."
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"I would like to express my sincere gratitude to the editorial team and peer reviewers of the World Journal of Gastrointestinal Endoscopy for their constructive feedback and professional support throughout the review process. I am particularly appreciative of the timely responses and the thoroughness of the peer review, which greatly contributed to improving the quality of my manuscript. The overall experience with the journal has been very positive. The submission system is user-friendly, and the communication from the editorial office has been clear and efficient. The journal's focus on gastrointestinal endoscopy aligns well with my research, and I am pleased to have my work published in such a reputable journal. I believe the World Journal of Gastrointestinal Endoscopy is an excellent platform for advancing research in this field, and I look forward to seeing the journal continue to grow in both quality and impact. If I may offer a suggestion for future improvements, it would be to consider speeding up the peer review process, as this could further enhance the overall experience for authors. "
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Tu HS, Chen ML, Hong J, He L. Beyond weight loss: Quality of life and internalized weight bias in endoscopic bariatric revision. World J Gastrointest Endosc 2026; 18(2): 115986
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"Dear Editor, Thank you for giving us the opportunity to provide feedback on our experience publishing our manuscript. We appreciate ..."
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"Dear Editor, Thank you for giving us the opportunity to provide feedback on our experience publishing our manuscript. We appreciate the journal’s commitment to quality and continuous improvement. We were very satisfied with the professional and efficient handling of our manuscript. The peer-review process was rigorous, and the editorial decisions were communicated clearly and in a timely manner.The online submission system was intuitive and easy to use.The peer-review was remarkably fast, which we greatly appreciated.The proofreading and typesetting quality of the final proof were excellent.Thank you again for your excellent work and for fostering such an open dialogue with authors. We look forward to submitting our future work to World Journal of Psychiatry. Sincerely, Yaozhou Tian "
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Wang W, Li H, Liu YP, Chen Y, Zhang XR, Wang YZ, Tian YZ. Clinical efficacy of Xifeng Huashi and its effect on mental status in patients with diarrheal irritable bowel. World J Psychiatry 2026; 16(2): 113123
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"On behalf of all authors, we thank the editorial team of World Journal of Gastroenterology for the professional and efficient handling ..."
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"On behalf of all authors, we thank the editorial team of World Journal of Gastroenterology for the professional and efficient handling of our manuscript (ID: 115556). The process was excellent. We particularly appreciated the constructive peer review comments, which strengthened our paper, and the clear communication throughout. The final production quality is also commendable. Thank you for your dedicated work. "
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Lian WL, Cai LS, Lian MQ, Lian MJ, Sun YQ, Lv CB, Huang GP, Huang RJ, Zhang YB, Zeng WM, Xu QH, Zhu QJ, Chen QX. Efficacy and safety of sequential hyperthermic intraperitoneal chemotherapy following surgery for pathological T staging 4 gastric cancer. World J Gastroenterol 2026; 32(6): 115556
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"The peer review process was prompt and appropriate. The editing of the main manuscript and reference was appropriate. The final editing ..."
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"The peer review process was prompt and appropriate. The editing of the main manuscript and reference was appropriate. The final editing of the tables was also helpful. There were many documents to submit. We believe it would be better if the time from acceptance to publication could be shortened. Overall, it was a highly transparent process. Thank you. "
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Terashi S, Ozaka S, Kagoshima Y, Shimomori Y, Takahashi H, Minezaki D, Tsutsumi K, Fukuda M, Hirashita Y, Fukuda K, Ogawa R, Kodama M, Murakami K, Mizukami K. Bowel preparation for small bowel capsule endoscopy in patients with suspected or established Crohn’s disease. World J Gastrointest Endosc 2026; 18(2): 113762
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"The publication process is efficient and transparent. The editors communicate clearly and keep authors updated at every stage of the ..."
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"The publication process is efficient and transparent. The editors communicate clearly and keep authors updated at every stage of the review and publication process. The online submission and tracking platform is easy to use and user-friendly, making it simple to follow the manuscript’s progress, submit revisions, and respond to editorial requests without difficulty. "
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Aguila EJT, Lau LHS, Li JW, Berzin TM. Endoscopic clip systems for hemostasis and defect closure in gastrointestinal endoscopy. World J Gastrointest Endosc 2026; 18(2): 116000
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"Dear Editors and Team of World Journal of Orthopedics I would like to express my deepest and most sincere gratitude for the opportunity ..."
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"Dear Editors and Team of World Journal of Orthopedics I would like to express my deepest and most sincere gratitude for the opportunity to be part of your esteemed publication. Having my work featured in World Journal of Ortopedics has been an extraordinary honour, and I am truly thankful for the professionalism, dedication, and thoughtful guidance demonstrated by your entire team throughout the publication process. From the very first interaction, I was impressed by the clarity of your submission guidelines and the responsiveness of your editorial staff. Your meticulous attention to detail, constructive feedback, and willingness to engage in meaningful dialogue significantly enhanced the quality of my contribution. It is evident that every member of your team approaches their work with a genuine commitment to academic rigour and intellectual integrity. What truly sets World Journal of Orthopedics apart is not only its reputation as a leading platform for scholarly discourse but also the respectful and supportive manner in which authors are treated. The peer‑review process was both rigorous and fair, providing valuable insights that helped refine my arguments and strengthen my research. I appreciate how you balance high standards with empathy for the authors’s journey—a rare and admirable combination in academic publishing. Moreover, I am grateful for the transparency and timeliness of your communications. Knowing exactly where my manuscript stood at each stage of the process alleviated much of the uncertainty that often accompanies publication efforts. Your organisational efficiency and clear workflows made what can sometimes be a stressful experience feel collaborative and rewarding. Beyond the technical aspects, I want to acknowledge the broader impact of your journal. World Journal of Orthopedics serves as a vital conduit for knowledge exchange, fostering interdisciplinary conversations and advancing our collective understanding in World Journal of Orthopedics. Being included among such distinguished company is both humbling and inspiring, and I hope that my work contributes meaningfully to the ongoing dialogue you facilitate. I also wish to extend my appreciation to the anonymous reviewers whose thoughtful comments and challenging questions pushed me to think more deeply about my subject. Their expertise and generosity with time are invaluable to the academic community, and I am grateful for their role in shaping this final publication. Finally, I would like to thank you for maintaining a journal that is not only respected for its content but also for its ethical standards, accessibility efforts, and commitment to diversity in scholarship. These qualities reflect a vision of academia at its best—inclusive, rigorous, and forward‑looking. Please accept this letter as a heartfelt expression of my gratitude. I feel privileged to have been published in World Journal of Orthopedics and look forward to continuing to read, learn from, and contribute to your outstanding publication in the future. With deepest appreciation, Mikhail Kostik, MD, PhD, Professor "
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Yakovlev AA, Gaidar EV, Suspitsin EN, Korzun PR, Kostik MM. Osteopathia striata with cranial sclerosis, associated with juvenile idiopathic arthritis: A case report and review of literature. World J Orthop 2026; 17(2): 113473
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"This study offers a focused comparative assessment of graft-augmented versus graftless fixation in the management of scaphoid nonunion, ..."
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"This study offers a focused comparative assessment of graft-augmented versus graftless fixation in the management of scaphoid nonunion, addressing a persistent area of clinical uncertainty. By correlating radiological union with functional outcomes, the findings support a more individualized approach to graft utilization rather than routine application. they inform surgical decision-making while encouraging further prospective investigations. "
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Elshahhat A, Ahmed M, Saleh A, Abed Y, Elashmawy H, Nour K. Necessity of grafting in scaphoid nonunion fixation: A comparative outcome analysis. World J Orthop 2026; 17(2): 112889
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Abushal MH, Embaby OM, Mersal M, Badghish E, Elalfy M. Cemented vs uncemented femoral fixation in total hip arthroplasty: A systematic review and meta-analysis of periprosthetic fracture risk. World J Orthop 2026; 17(2): 115615
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"This work is dedicated to exploring fundamental scientific questions and refining experimental methodologies. We anticipate that these ..."
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"This work is dedicated to exploring fundamental scientific questions and refining experimental methodologies. We anticipate that these findings will contribute to the advancement of the field, while also acknowledging that they may reveal new complexities. We sincerely welcome constructive critiques and collaborative opportunities from peers worldwide to jointly address more significant challenges and drive the progress of science. "
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Yang PC, Xiao CY, Wang J, Yan CH, Li QY, Li SY, Li J, Zhang LJ, Dai CB. Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages. World J Gastroenterol 2026; 32(6): 113010
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"Thank you for publishing our recent case report. We are grateful for the opportunity to contribute to the journal's clinical ..."
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"Thank you for publishing our recent case report. We are grateful for the opportunity to contribute to the journal's clinical literature. Sharing such experiences is vital for advancing collective medical knowledge and enhancing patient care. We welcome any feedback or discussion from colleagues and readers of the journal. thank you very much and best regards. "
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Qin JW, Wu JC, Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, Wu W, Zhang SG, Nashan B. De novo schizophrenia after liver transplantation: A case report. World J Hepatol 2026; 18(1): 114291
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"Over all hassle free experience walking through publishing in WJH. Peer review was very objective and balanced. Expedited publication ..."
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"Over all hassle free experience walking through publishing in WJH. Peer review was very objective and balanced. Expedited publication aiming at shorter turnaround time is desirable. regarding PDF visual appeal, across BPG publishing house, the colour coding/ lay out seems to be the same; each journal lay out may be made unique at the same time retaining some basic identifiers. "
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Joseph A, Mathew S, Nair HR. Blood markers vs transient elastography for liver stiffness and steatosis in metabolic dysfunction-associated steatotic liver disease. World J Hepatol 2026; 18(1): 113475
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"The editorial process of the World Journal of Clinical Oncology is intuitive providing a easy navigation. The reviewers' comments ..."
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"The editorial process of the World Journal of Clinical Oncology is intuitive providing a easy navigation. The reviewers' comments and editorial process contributed for the final adjustments of the manuscript. We do believe the all support provided helped us to finalize the manuscript with the necessary refinements to achieve the high standards of the journal. "
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Pernomian LS, Teixeira MF, Araujo RL, Serrano Uson Junior PL. Perioperative immunotherapy in gastric cancer in the spotlight. World J Clin Oncol 2025; 16(12): 110988
20654 items Read more >>
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. ..."
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" The manuscript is written well. Its structure is appropriate for this type of article. Ethical approval form meets the requirements. Methods are appropriate and effective. Results are appropriate of methods and are authentic. Tables and biostatistics data are perfect. The references are adequate of topic. Language of article is satisfied."
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Lee H, Han YH, Chung JW, Kim KO, Kwon KA, Kim JH. Upper gastrointestinal bleeding with duodenal varix: A case report. World J Clin Cases 2026; 14(4): 116648
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"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. ..."
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"Obese people are prone to GERD and SG increases the frequency of GERD after surgery, so SG is worth considering for those with GERD. RYDG and OAB are good weight loss surgeries without the risk of GERD. For patients with GERD, the surgical procedure should be selected as suggested by authors."
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Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600
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"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and ..."
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"Obesity is associated with a high proportion of patients with gastroesophageal reflux disease (GERD). In recent years, metabolic and bariatric surgery (MBS) has been considered the most effective treatment for weight loss in obese patients. The most commonly performed surgical procedures are sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and single-anastomotic gastric bypass (OAGB). MBS has different effects on obesity-related GERD depending on the type of procedure performed.
The results suggest that RYGB consistently leads to significant improvement or remission of GERD symptoms, reduced HCl exposure, and reduced need for PPI therapy in obese patients. RYGB and OAGB are more effective than SG for weight loss and GERD control. RYGB is therefore the preferred bariatric procedure for obese patients with clinically evident GERD.
SG is associated with a higher risk of new onset or worsening of GERD, an increased incidence of erosive esophagitis, and an increased risk of Barrett's esophagus. The pathophysiology of these effects is multifactorial and involves changes in gastric anatomy and lower esophageal sphincter function.
Therefore, the choice of the type of surgical procedure that should be performed must be individualized, with RYGB being preferred in obese patients with significant GERD or Barrett's esophagus, while SG can be performed in patients without reflux symptoms but requires careful preoperative assessment of GERD risk.
The aforementioned data should be taken seriously and guide the physician and patient with obesity and GERD towards making the right surgical decisions."
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Xing Y, Yan WM, Bai RX. Effects of bariatric surgery on obesity associated gastroesophageal reflux disease: Insights from a systematic review and network meta-analysis. World J Gastroenterol 2026; 32(6): 114600
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"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's ..."
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"Fatigue is a frequent and particularly burdensome symptom with significant impact on the quality of life of patients with Crohn's disease. In daily medical practice, its treatment is often inadequate since it is usually attributed to side effects of the drugs administered to treat the underlying disease or to psychological causes. The study under review found that indeed, psychological symptoms such as depression, anxiety, stress of any cause, and insomnia are related to its occurrence. In particular, stress is likely to induce the symptom through probable immunological effects. Of interest was the frequent occurrence of fatigue with increased white blood cell count. It therefore seems that fatigue in patients with Crohn's disease has a multifactorial etiology, not exclusively attributable to disease activity or inflammatory markers. As the researchers pointed out, fatigue among IBD patients should receive greater attention in the near future. By conducting additional relevant studies, we will be able to accurately identify the factors that contribute to fatigue, enabling us to develop and implement strategies to effectively identify and support patients experiencing fatigue."
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Morais TC, Couto G, Silva BCD, Lisbôa RA, da Cruz BS, Viana MGF, de Sousa GBC, Arenas LP, Nery ES, Fortes FML, de Almeida NP, Pimentel AM, Fontes JAM, Surlo VC, Chebli JF, Rocha R, Santana GO. Psychological and hematological factors associated with fatigue in patients with Crohn’s disease receiving pharmacological treatment. World J Gastroenterol 2026; 32(5): 115673
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"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete ..."
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"The editorial article summarizes current knowledge and clinical approaches to the diagnosis and management of cancer-related incomplete intestinal obstruction (CRIO). Given the multifactorial and complex pathophysiology of CRIO, it is inherently challenging to comprehensively describe all clinical conditions. Nevertheless, the authors successfully present a well-structured and comprehensive overview by organizing the discussion into a clear and logical framework."
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Liu JL, Wang CX, Wang HL. Advances in the management of cancer-related incomplete intestinal obstruction: Therapeutic strategies and emerging interventions. World J Gastroenterol 2026; 32(5): 115030
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"This article provides an interesting topic, with valuable first-hand information.
There were also some notable limitations, as ..."
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"This article provides an interesting topic, with valuable first-hand information.
There were also some notable limitations, as addressed in the following:
Of the “Abstract”. The aim does not match well the conclusion.
Some “Keywords” are not adequate. “Metagenomic next-generation sequencing” should be moved from “Keywords”.
There was no “analysis” or associated description in the “Methods” of the “Abstract”, and this is not adequate.
The “Results” in “Abstract” were not consistent with the “Methods” of the “Abstract”.
There was no gold standard (guidelines) and criteria for the diagnosis of pulmonary nocardiosis in the “Materials and Methods”.
The imaging characteristics (Table 4) were not complete, and which should include a complex item comprising two or more imaging characteristics of the lungs .
A total of the pulmonary nocardiosis caused by different species in Table 4 was not 102.
The pulmonary nocardiosis treated by different medications in Table 5 was not clear, some patients treated using more than one medications, and the total number was not 102.
Figure 1 was not necessary, and associated information can be listed in table or presented in text.
Images of pulmonary nocardiosis were not sufficient, and more other representative images had better be added.
The English is not professionalism.
The “Conclusion” that “Nocardia pneumonia commonly coexists with bronchiectasis. Although mNGS has greatly enhanced its detection rate, N. wallacei pneumonia is distinguished on chest CT by its primary presentation of bronchopneumonia, unlike other types.” was not adequate, and it was not well matching the contents of the “Results”."
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Wang HJ, Zhang YN, An L. Clinical and radiographic feature of pulmonary nocardiosis: A study of 102 cases. World J Radiol 2026; 18(1): 114552
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"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can ..."
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"Please explain in more detail the mechanism of carcinogenesis caused by bile reflux into the esophagus. Author write Bile acids can act through specific signalling pathways, activating nuclear farnesoid X receptor and plasma-membrane-bound G protein-coupled bile acid receptors, and also likely through the interaction between these receptors. The coupling of G protein-coupled bile acid receptor to the stimulatory protein Gs leads to activation of adenylate cyclase, intracellular cAMP accumulation and protein kinase A activation, directly impacting on smooth muscle contractile activity.
Also, the author's theory of how bile reflux reduces esophageal motility is a new and interesting one. I would like to see more detailed research into esophageal motility beyond the 24-hour pH meter.
"
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Gadelha KKL, Santos AA, Correia-de-Sá P, Magalhães PJC, da Silva MTB. Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease? World J Gastroenterol 2026; 32(4): 114560
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"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an ..."
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"The article presents a coherent and well‑structured argument by explaining why indocyanine green (ICG) fluorescence has become an essential tool in hepatocellular carcinoma surgery and supporting this with evidence from systematic reviews and clinical studies. It logically organizes the diverse applications of ICG—segmental mapping, detection of superficial lesions, thermal ablation guidance, and tumor‑biology assessment—showing how each technique addresses specific surgical limitations. The discussion consistently links fluorescence patterns to pathological features and clinical decision‑making, reinforcing the article’s central claim that ICG enhances precision, safety, and oncologic outcomes in minimally invasive liver surgery."
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Piccolo G, Barabino M, Benuzzi L, Formisano G, Bianchi PP. Clinical applications of indocyanine green fluorescence for the treatment of hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(1): 114339
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"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the ..."
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"The article maintains clear logical flow by presenting a rare SMARCB1‑deficient pancreatic rhabdoid carcinoma case and linking the unusual initial presentation—spontaneous splenic rupture—to the tumor’s aggressive biology. Its diagnostic reasoning is coherent, moving from clinical findings to imaging, pathology, and molecular profiling that distinctly separate the ductal adenocarcinoma and rhabdoid components. The discussion logically integrates existing literature to highlight the rarity, poor prognosis, and potential benefit of aggressive multimodal therapy, underscoring the need for targeted approaches in this molecular subtype."
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Yao WQ, Ma XY, Wang GH. Clinicopathologic features of SMARCB1/INI1-deficient pancreatic undifferentiated rhabdoid carcinoma: A case report and review of literature. World J Gastrointest Oncol 2026; 18(1): 114021
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"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer ..."
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"The article demonstrates strong logical coherence by clearly establishing the clinical gap in evidence for treating esophageal cancer patients with liver metastases and justifying the need to compare chemotherapy alone with chemoimmunotherapy. Its methodology is rigorous and transparent, using well‑defined inclusion criteria, detailed baseline characteristics, and standardized outcome measures such as RECIST, overall survival, and progression‑free survival. The conclusions logically follow from the data, showing that adding immune checkpoint inhibitors significantly improves survival and response rates without increasing severe toxicity, and the study further strengthens its argument by identifying independent prognostic factors through multivariate Cox regression analysis."
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Dai EH, Que SH, Xu H, Zhong GQ, Zhang Z, Liang X, Zhai SW, Li YT, Wang JJ, Feng W. Efficacy and safety of immune checkpoint inhibitors plus chemotherapy in esophageal cancer patients with liver metastases. World J Gastrointest Oncol 2026; 18(1): 113440
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"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy ..."
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"The study presents a logically coherent argument by clearly identifying the clinical gap in evidence for nivolumab‑based chemotherapy in advanced gastric cancer with massive ascites and justifying the need for retrospective evaluation. Its methodology is well‑structured, using clearly defined ascites‑burden groups and standardized clinical criteria to ensure meaningful comparisons of outcomes and safety profiles. The conclusions follow naturally from the data, showing that although prognosis remains poor in the high‑ascites group, nivolumab plus chemotherapy provides measurable ascites improvement and acceptable toxicity, supporting its potential therapeutic value in this challenging population."
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Matsumoto T, Sugimoto S, Omori R, Makiyama C, Nakasya A, Nagai H, Yasui H, Higashi R, Sasamoto A, Satake H. Efficacy and safety of nivolumab plus chemotherapy in patients with advanced gastric cancer with massive ascites. World J Gastrointest Oncol 2026; 18(1): 112944
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"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the ..."
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"The document presents a clear, logical structure with well‑labeled sections and concise summaries that guide the reader through the study’s objectives and findings. The methods and results are supported by detailed experimental design and high‑quality figures and tables, which enhance reproducibility and data transparency. The discussion highlights clinical relevance and practical implications, effectively linking mechanistic insights to potential therapeutic strategies."
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Vescio F, Curcio S, Aquila I, Ammendola M, Tarallo AP. Right patient approach to experimental stromal cell therapies for gastrointestinal tumors. World J Gastrointest Oncol 2026; 18(1): 112630
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"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate ..."
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"Intraductal papillary mucinous neoplasms (IPMN) are clinically important precancerous conditions of the pancreas. Their accurate diagnosis requires a combination of imaging and endoscopic techniques. Pancreatoscopy enables direct visualization of the pancreatic duct, targeted biopsies, and the definition of disease boundaries. Existing data support the view that pancreatoscopy is a satisfactory and promising method for determining which patients with IPMN should undergo surgery, as well as the extent of resection for each patient. However, excessive enthusiasm should not prevail. The method is not widely applied; learning requires a dedicated endoscope and a sufficient number of patients per year to maintain and further increase experience, which is a very important factor. For the widespread acceptance and adoption of the method, it is necessary to conduct prospective, very well-designed multicenter studies aiming to precisely determine many parameters e.g. its diagnostic contribution and accuracy, which patients should undergo the examination, what is the impact on therapeutic decisions, what is the cost-benefit ratio and finally to determine whether it improves the survival and/or quality of life of patients. Based on the above observations, pancreatoscopy should be decided on a case-by-case basis and performed in specialized centers."
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Abusharar M, Barritt C, Mavroeidis VK, Aroori S. Role of pancreatoscopy in the management of suspected and confirmed intraductal papillary mucinous neoplasm of the pancreas. World J Gastroenterol 2026; 32(4): 112635
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"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data ..."
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"The paper is highly informative and comprehensive. The authors have gathered and synthesized the most significant and relevant data from the literature, presenting it in a clear and well-structured manner. The review provides valuable insights into the topic, highlights key mechanisms and clinical implications, and offers a solid foundation for future research and practical applications."
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Singh B, Singh H, Kaur S, Singh B. Preclinical pharmacology studies of zingerone with special reference to potential therapeutic applications. World J Immunol 2026; 16(1): 111511
15
"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s ..."
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"The editorial appropriately highlights that the target article opens a new avenue for potential therapeutic strategies in Parkinson’s disease and points out the lack of comprehensive studies to fully elucidate the underlying mechanisms. It also outlines future research directions. Overall, the editorial adds value to the target manuscript by providing complementary discussion and contextualization."
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Chen YX, Sun NQ, Mo SJ. Rhapontin activating nuclear factor erythroid 2-related factor 2 to ameliorate Parkinson’s disease-associated gastrointestinal dysfunction. World J Gastroenterol 2026; 32(4): 114468
16
"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with ..."
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"The work is a readable, visually clear review that reframes fatty liver through choline metabolism and mitochondrial stress, with solid editorial transparency. Concise upgrades—documented search/selection methods, figure/table evidence anchoring, explicit evidence‑tier labeling with effect sizes, and a short limitations/certainty note—would materially improve objectivity, credibility, and practical value for hepatology and metabolism audiences. The article is transparent on provenance, timelines, and authorship; it also includes a conflict‑of‑interest declaration. These are positives for editorial/ethical standards. For maximal clarity to non‑specialists, consider adding a one‑line ethics note that no new human/animal data were generated and that the work synthesizes published evidence only.
Methodologically, the piece reads as a narrative review. To support quality tracking and reproducibility, please add a concise 'search strategy and selection' box containing the following information: databases used, the exact date of the last search, key terms, language limits, inclusion/exclusion criteria and dual-reviewer screening/extraction. This would substantiate the statement of a comprehensive survey and help readers to assess selection bias.
The figures and tables are clear and helpful. Legends could be strengthened by stating whether panels are conceptual or data-derived, defining all abbreviations at first use, citing the primary sources that support each panel and adding n/assay details when values are quoted. Providing a single, consolidated evidence table per claim (model, dose/exposure, effect size/direction, study type and citation) would further aid readers.
The interpretation is generally cautious, but the evidence tier should be labelled consistently (in vitro vs. animal vs. human) and comparative claims (citicoline vs. α-GPC; LA/ethanol as 'mitochondrial toxins') should be anchored to primary studies with effect directions and context. It is important to explicitly note when human data are pilot/underpowered. A brief paragraph explaining why quantitative synthesis was not feasible (due to heterogeneity of models/endpoints) and a graded certainty statement for each major conclusion would prevent 'vote-counting'.
The biostatistics and data availability could be improved. Where numerical differences are cited in tables or text (e.g. '2.6-fold increase in plasma choline' or 'up to 30% reduction in triglycerides in preclinical models'), include the study design, sample size, comparator and 95% confidence intervals (CIs) where available. Consider including a small supplementary file with raw or minimally processed values from the cited studies."
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Mercola J. Fatty liver reexamined choline and mitochondrial toxin amelioration. World J Biol Chem 2025; 16(4): 111831
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"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating ..."
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"The work is transparent about its provenance, timelines and author contributions. It also discloses a conflict of interest relating to the author's role as company founder and their involvement in product development related to C15:0.
This review is a readable and visually clear synthesis of C15:0 mechanisms with good editorial transparency and a useful mechanistic overview. A few concise upgrades, such as search/methods transparency, evidence-tier labelling, quantitative anchors for key effects and explicit limitations, would materially improve objectivity, credibility and practical value for translational audiences.
As a narrative review, the article summarises the proposed mechanistic actions of pentadecanoic acid (C15:0), including partial PPAR-α/δ agonism, AMPK activation, mTOR suppression, HDAC6 inhibition and modulation of the anti-inflammatory pathway, and provides helpful pathway schematics and a BioMAP® heatmap.
Regarding theinterpretation, the figures are legible and informative, but several mechanistic statements are presented as causal when much of the evidence is preclinical or platform-based (e.g. BioMAP® panels and cell assays). Please anchor each mechanism to specific primary studies and consistently label the evidence tier (in vitro, in vivo or human observational). Where the review draws parallels between the effects of C15:0 and metformin/rapamycin, cite comparative, peer-reviewed experiments and quantify the direction of the effects to avoid 'phenotypic mirroring' based on analogy alone. If you are relying on cell-system phenotyping reports, you should specify the doses, reference compounds and cytotoxicity thresholds, and discuss the limits of generalisability.
Figures/tables: Expand figure legends to state whether values are empirical (with n, assay and statistics) or conceptual and include scale and statistical annotations where applicable.
Biostatistics and certainty: Although a formal meta-analysis is not expected, readers would benefit from the reporting of representative effect sizes (e.g. EC₅₀ ranges or fold changes with 95% confidence intervals) for key targets, alongside a short paragraph explaining why quantitative synthesis across studies is not feasible (e.g. heterogeneity of models and endpoints). Providing a graded certainty statement (e.g. 'moderate' for PPAR-α/δ binding; 'low'/'very low' for clinical efficacy) would prevent over-extrapolation.
Providing a neutral summary that acknowledges the limited number of human prospective trials of C15:0 for metabolic or longevity endpoints would align enthusiasm with the current evidence base."
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Mercola J. Molecular and cellular mechanisms of pentadecanoic acid. World J Biol Chem 2025; 16(4): 111258
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"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the ..."
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"The manuscript is fully transparent in terms of its editorial process and declares any conflicts of interest and compliance with the PRISMA 2009 guidelines. This is a timely and relevant systematic review of the gut microbiome and chemotherapy-induced cardiotoxicity, with good editorial transparency and a useful PRISMA framework. The reference list is current and thematically appropriate. These factors positively contribute to ethical and reporting standards, making provenance clear to readers. Consider adding a brief statement confirming that no new human or animal data were collected, and that only published or registry data were used, to close the ethics loop for non-specialists.
As a systematic review, the methods section would benefit from providing compact yet reproducible details. While you do include a PRISMA flow diagram, the main text should also specify the databases searched (with the exact date of the last search), the full search strings, any language restrictions, the inclusion/exclusion criteria, and the tool used for the risk-of-bias assessment (e.g. ROBINS-I, RoB2 or SYRCLE). A short table summarising study designs, sample sizes, chemotherapy classes, cardiotoxicity definitions and microbiome endpoints would help readers to understand the heterogeneity.
Regarding the results and interpretation, the narrative rightly identifies microbial metabolites and gut–heart crosstalk as candidate pathways. Anchoring these mechanisms to recent overviews of microbiome–chemotherapy interactions and core mechanistic reviews would improve the balance and timeliness of the review.
The figures and tables are adequate (PRISMA and one data table are included in the journal assets). The legends could be strengthened by declaring whether each figure is conceptual or data-derived, defining all abbreviations at first use and adding a per-study evidence table (study; cancer/chemo; cardiotoxicity endpoint; microbiome assay; key finding; risk of bias).
Readers will expect some appraisal of effect direction/size where feasible (e.g., HRs/ORs for cardiotoxicity associations or standardised mean differences for metabolite levels), even if a meta-analysis is not possible. Including a concise 'why no pooling' paragraph (explaining heterogeneity in definitions, assays and timepoints) and a GRADE-style certainty statement for each major conclusion (very low, low or moderate) would prevent 'vote-counting' impressions and increase the utility of the review's conclusions."
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Abdulaal R, Afara I, Harajli A, Al Mashtoub E, Tarchichi A, Hassan K, Afara A, Abou Fakher J, Salhab S, Fassih I, Tlais M. Gut microbiome and chemotherapy-induced cardiotoxicity: A systematic review of evidence and emerging therapies. World J Biol Chem 2025; 16(4): 112221
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"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor ..."
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"This study is clearly presented, transparent and visually clear that would be notably strengthened by fuller methodological rigor (randomization/blinding/power, assay standards), richer statistics and data sharing, and a more circumspect translational framing. These concise additions would enhance objectivity, credibility, and scientific utility for the community. The references are appropriate and full editorial metadata are provided. Funding and conflict-of-interest statements are also included, along with details of compliance with the ARRIVE guidelines, animal ethics approval, and CC BY-NC 4.0 licensing. This transparency aligns with the journal’s quality policy and is a strength of the article. It would be beneficial to add a brief ethics note to clarify humane endpoints and analgesia during tail transection for readers who are not specialists.
The methods section would benefit from a more concise description to support reproducibility. Report the sex and exact age range/ageing criterion of the mice, their housing conditions, and the full rationale for the therapeutic BoNT formulation (serotype, units/kg, injection site/volume, and timeline to assay). Given the focus on coagulation, full protocols for platelet aggregation should be added (e.g. agonist, concentration, light transmission vs microscopy) and standard plasma assays (PT/INR, aPTT, fibrinogen) should be included to triangulate the tail bleeding endpoint. These additions would make the work easier to replicate and compare with prior haemostasis literature.
The results are clear and the figures are legible, but several quality improvements would be helpful. For Figures 1–3, it would include n per group on the plots and show all data points with mean ± SD/SEM. State the exact statistical tests used (normality testing, two-sidedness and corrections for multiplicity) and report effect sizes with 95% CIs. In the legends, indicate how many independent experiments/animals the images are representative of, and add scale bars and magnifications. Where possible, provide raw or minimally processed data (e.g. bleeding times, body weights, aggregation percentages) in a supplementary file to meet current data availability expectations.
Interpretation should be cautious to avoid overreach. While a single dose in ageing mice suggests a pro-coagulant/anti-haemorrhagic effect, the systemic or off-target neuromuscular actions of BoNT could confound behaviour during the assay. Please discuss the potential mechanisms (e.g. platelet number/function, coagulation cascade, or local vasomotor effects) and outline experiments that would clarify them (e.g. complete blood count/platelet counts, thromboelastography, ROTEM, or endothelial markers). Translational claims (e.g. use in trauma/surgery) should be limited until dose–response, time-course, safety (toxicity, motor impairment) and reversibility are established, and the findings should be considered in the context of contemporary BoNT pharmacology/safety reviews."
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Ravichandran S, Joseph JHM, Sellathamby S, Kandasamy M. Intramuscular injection of therapeutic botulinum toxin facilitates blood coagulation in experimental aging mice. World J Biol Chem 2025; 16(4): 112376
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"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, ..."
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"This minireview is a useful and well-illustrated synthesis of the IFN-γ–ISG axis in glioblastoma, with good editorial transparency, alongside transparent metadata on provenance.
The piece could be elevated to a best-practice minireview while preserving its brevity and readability by adding a concise methods note for literature selection, tightening causal language, enriching legends/references to anchor mechanisms, and stating limitations explicitly.
Regarding the results and their interpretation, the mechanistic thread is accurate and accessible.
The figures are clear and didactic. However, a compact summary table cross-linking each ISG to its function, model/evidence, clinical signal (if applicable) and approximate level of evidence would help translational readers further.
The language quality is high, and minor spacing artefacts appear to be HTML rendering issues that will not affect the PDF. A short, explicit 'Limitations and outlook' paragraph acknowledging the non-systematic approach, potential selection bias and the need for stratified clinical validation of IFN-γ/ISG signatures in standard-of-care and immunotherapy contexts would round off the manuscript's critical appraisal. "
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Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC. Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. World J Biol Chem 2025; 16(4): 112768
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Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 2264
- Peer-reviewers
- 35969
- Manuscripts received today
- 0
- Manuscript reviews today
- 1
- Unhandled manuscripts today
- 167
- Active peer-reviewers today
- 260
- Reviewer acceptance today
- 2
- Reviewer refusals today
- 3
- Total accepted manuscripts
- 40057
- Total rejected manuscripts
- 44554
- Total peer-reviewers
- 4677287
- Total submissions
- 37886
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1
"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and ..."
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"This Editorial thoroughly explores the field of AI use in diagnostic radiology. It provides a complete overview of the potential and the current applications of AI in the field with great potential, strong diagnostic performance but in my opinion it does spotlight with the due consideration the potential drawbacks coming from the extensive use of AI in the clinical field. The enthusiasm generated from the high precision and performance and the consequent advantages in terms of resource and time save for operators outpaced evaluation of broader consequences. Concerns include trainee deskilling, automation bias, unclear medicolegal accountability, and inequitable access due to infrastructure demands. The authors emphasize that technical accuracy alone is insufficient and call for longitudinal studies, training models that preserve independent reasoning, and deployment strategies that address equity. Without systematic assessment of professional, clinical, and societal impacts, AI adoption risks being driven by non-evidence-based factors. "
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He ZX, Wang J, Yang JS. Expanding the applications of artificial intelligence in emergency radiology: Advancing precision medicine and resource efficiency. World J Radiol 2026; 18(1): 117814
2
"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced ..."
[Read more]
"This study demonstrates that presenilin-1 (PS-1) is significantly associated with β-catenin activation, PTEN phosphorylation, advanced tumor stage, and poor survival in gastric cancer. The combination of clinical data and functional assays strengthens the evidence for the PS-1/β-catenin/p-PTEN axis in promoting invasion and metastasis. These findings highlight a potential therapeutic target for gastric cancer treatment. "
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Lin X, Lin GF, Gu FT, Li YL. Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer. World J Gastrointest Oncol 2026; 18(2): 115689
3
"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that ..."
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"In this paper, the tumor indicators of patients with gastric cancer after operation were detected and analyzed. It was found that CEA and AFP were closely related to the recurrence of gastric cancer, which provided a good basis for judging the health level of patients with gastric cancer after operation. But it also needs the support of large-scale clinical data. At the same time, patients with gastric cancer need more tumor indicators to explore a better combination for judging the prognosis of patients with gastric cancer. "
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Duan XX, Yu X, Zhou L. Timeliness of postoperative serum carcinoembryonic antigen monitoring for predicting recurrence after gastric cancer surgery. World J Gastrointest Surg 2026; 18(1): 114309
4
"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic ..."
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"Dear Editor, I am writing in response to your invitation to comment on the prospective study by Güneş et al., entitled “Diagnostic value of interleukin-8 in colon cancer,” published in your esteemed journal. The authors provide valuable data reinforcing the role of interleukin-8 (IL-8) as an independent diagnostic biomarker in colon adenocarcinoma. Their work rightly concludes that IL-8 holds promise, particularly as part of a multi-marker panel. I would like to extend this discussion by contextualizing IL-8 within the current, rapidly evolving biomarker landscape of colorectal cancer (CRC), as recently elaborated in an editorial on this topic. The future of CRC management lies in a dynamic, multi-layered biomarker strategy that integrates three key pillars: 1) Mismatch repair (MMR) status to dictate therapeutic class (chemotherapy vs. immunotherapy); 2) Perioperative carcinoembryonic antigen (CEA) for immediate risk stratification, especially within microsatellite stable (MSS) disease; and 3) Postoperative circulating tumor DNA (ctDNA) as a dynamic tool to guide treatment intensity and de-escalation, as definitively demonstrated by the recent AGITG DYNAMIC-III trial. In this framework, the findings on IL-8 by Güneş et al. present a compelling opportunity. While its standalone diagnostic accuracy (AUC=0.68) is moderate, its independent predictive value suggests a distinct biological role, likely rooted in its pro-inflammatory and angiogenic functions. This positions IL-8 not as a replacement for the aforementioned pillars, but as a potential complementary element, particularly within the MSS cohort. Specifically, IL-8 could enhance the second pillar (risk stratification) by providing additional biological granularity. For instance, in MSS patients with normal or borderline CEA levels, an elevated IL-8 might signal a more aggressive tumor biology driven by inflammation, potentially identifying a subset that would benefit from closer surveillance or adjuvant therapy. Furthermore, given its link to angiogenesis and immune modulation, IL-8 merits investigation as a predictive biomarker for responses to anti-angiogenic therapies (e.g., bevacizumab) and possibly immunotherapy, even in MSS/pMMR tumors. Therefore, I propose that the next logical step for research, as inspired by both this study and the broader editorial perspective, is to evaluate IL-8 within integrated multi-marker panels. Combining IL-8 with CEA, ctDNA, and potentially other inflammatory markers (e.g., CRP) in algorithm-driven models could significantly improve diagnostic sensitivity, prognostic stratification, and predictive accuracy. This approach aligns perfectly with the paradigm of dynamic precision oncology, where multiple data streams are synthesized to guide personalized therapeutic navigation. I congratulate the authors on their contribution and thank you for the opportunity to share these perspectives, hoping they may stimulate further research into the integrative potential of IL-8 within the modern CRC biomarker ecosystem. Sincerely, Pr Nabil Ismaili Mohammed VI University of Sciences and Health (UM6SS), Mohammed VI Foundation of Sciences and Hrealth (FM6SS), Casablanca, Morocco, nismaili@um6ss.ma, 0000-0001-5786-5134 "
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Güneş G, Fırat Oğuz E, Kayılıoğlu I, Dinç T. Diagnostic value of interleukin-8 in colon cancer: Prospective, case-control study. World J Gastrointest Surg 2026; 18(1): 115444
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"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden ..."
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"Systemic antifungal therapy is the backbone of treatment for invasive fungal infections, but it carries an under-recognized burden of endocrine and physiological toxicity. The review by Thakkar et al. (2026) provides an important framework for understanding how these agents affect human cytochrome P450 enzymes and renal function, leading to adrenal insufficiency, mineralocorticoid excess, and electrolyte abnormalities. This review deserves recognition, and adding a global perspective to it could provide new recommendations. If possible, I would like to submit a letter addressing this perspective. "
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Thakkar S, Kantroo V, Nagendra L, Dutta D, Kamrul-Hasan ABM, Kalra S, Bhattacharya S. Endocrine consequences of antifungal therapy: A missed entity. World J Clin Cases 2026; 14(2): 117140
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"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal ..."
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"I read with interest the study comparing the ASGE lexicon and the AGREE classification for adverse events in gastrointestinal endoscopy. The authors are to be commended for their rigorous analysis of a large institutional registry and for highlighting the conceptual differences between two widely used adverse event frameworks. The high concordance observed between ASGE and AGREE confirms that both systems are robust for capturing clinically significant complications. However, the discordance noted for transient cardiorespiratory and sedation-related events raises an important interpretive issue. The ASGE lexicon intentionally captures such occurrences as “incidents,” supporting quality improvement and preventive strategies, whereas AGREE excludes many of these events by design, prioritising clinical consequence and post-procedural intervention. While this approach improves specificity, it may inadvertently narrow the safety signal. From a patient-centred perspective, events such as inadequate sedation, procedural discomfort, or transient hypoxia—although self-limiting—can significantly influence patient-reported experience, satisfaction, and trust in endoscopic services. These experiential harms may not require escalation of care yet remain meaningful to patients and may affect willingness for repeat procedures. Their exclusion from adverse event datasets risks underestimating quality concerns that are increasingly relevant in value-based care. The study also underscores that adverse event classification represents only one dimension of endoscopy quality. Domains such as procedural appropriateness, missed or delayed diagnoses, bowel preparation adequacy, photodocumentation quality, scheduling delays, and patient-initiated procedure termination are not captured by adverse event frameworks but are integral to comprehensive quality assessment. In summary, while standardised adverse event classification remains essential for benchmarking and safety governance, it should be complemented by patient-reported experience measures and broader quality indicators. A multidimensional framework integrating safety, experience, and appropriateness may better align endoscopy quality metrics with contemporary patient-centred practice. "
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Corsi O, Martinez R, Aguirre J, Friedrich I, Galeno V, Jimenez V, Briones P, Díaz LA, Espino A, Vargas JI. Application of a novel adverse event classification scale in a Latin American gastrointestinal endoscopy unit. World J Gastrointest Endosc 2026; 18(1): 111384
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"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation ..."
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"This minireview provides a timely and balanced synthesis of the evolving role of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the management of pancreatic neuroendocrine tumors (pNETs). The authors appropriately frame EUS-RFA as a promising yet still selective therapeutic option, and the “lights and shadows” construct is effective in highlighting both its clinical potential and its current limitations A major strength of the article lies in its comprehensive collation of published clinical experience across functioning and non-functioning pNETs. The tabulated summaries are particularly valuable for readers seeking an overview of technical success, clinical response, and adverse event profiles. Importantly, the authors avoid overstating efficacy and consistently acknowledge the predominance of retrospective series, limited follow-up durations, and heterogeneity in response definitions—an intellectua rigour that strengthens the manuscript. From a conceptual standpoint, the review highlights a key paradigm shift: EUS-RFA is no longer merely a salvage or palliative modality, but a potential intermediate option within the “grey zone” of small, low-grade pNETs, especially in patients unfit for surgery or those prioritizing minimally invasive approaches. This raises an important clinical question not fully resolved in current guidelines—whether EUS-RFA should eventually be positioned as a disease-modifying therapy rather than an alternative to surveillance. The discussion on radiological response assessment underscores a critical unmet need in the field. The lack of standardized imaging endpoints, timing of follow-up, and correlation with long-term oncologic outcomes limits meaningful comparison across studies. Future consensus on response metrics—possibly integrating contrast-enhanced harmonic EUS, cross-sectional imaging, and biochemical markers—would significantly enhance interpretability and clinical adoption. Finally, the article appropriately calls attention to procedural standardization and risk mitigation, particularly regarding pancreatitis prevention and proximity to the main pancreatic duct. These considerations will be central if EUS-RFA is to move beyond expert centers into broader clinical practice. Overall, this review serves as a valuable reference for gastroenterologists, endosonographers, and multidisciplinary teams managing pNETs. It also clearly delineates the research priorities required before EUS-RFA can be fully integrated into evidence-based treatment algorithms. "
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Tringali A, Caiazzo A. Role of endoscopic ultrasound in the treatment of pancreatic neuroendocrine tumors: Lights and shadows of endoscopic ultrasound-guided radiofrequency ablation. World J Gastrointest Endosc 2026; 18(1): 113617
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"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis ..."
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"Commentary: Clinical Considerations in Immunocompromised Patients With Edwardsiella tarda–Associated Spontaneous Bacterial Peritonitis The case report by Usuda et al., recently published in the World Journal of Clinical Cases, represents a notable contribution to clinical microbiology by documenting, to the best of current knowledge, the first reported case of spontaneous bacterial peritonitis (SBP) caused by Edwardsiella tarda in an immunocompromised patient undergoing dialysis [1].This report substantially expands the recognized infectious spectrum in patients with end-stage renal disease (ESRD) and underscores the need for heightened clinical awareness of atypical and opportunistic pathogens in this vulnerable population. One particularly commendable aspect of this report is the authors’ detailed discussion of the virulence mechanisms of E. tarda. The organism’s capacity to survive and replicate within macrophages plays a pivotal role in its pathogenicity, especially in hosts with compromised cellular immunity [2,3]. In the present case, the coexistence of diabetic nephropathy and long-term dialysis likely created a permissive immunological milieu that facilitated this opportunistic infection. Such intracellular persistence provides a plausible explanation for the severe and insidious clinical course observed, even in the absence of classical epidemiological exposures such as raw seafood consumption or contact with freshwater environments. Equally noteworthy is the authors’ adherence to principles of antimicrobial stewardship. The stepwise transition from empirical broad-spectrum therapy with cefmetazole to targeted, de-escalated treatment using cefalexin—guided by comprehensive antimicrobial susceptibility testing (Table 3)—offers a valuable therapeutic reference for clinicians managing similarly rare infections. Nevertheless, building on the authors’ insightful acknowledgment of the limitations surrounding “ascites culture conversion,” I would like to propose a more structured and rigorous framework for defining treatment endpoints in such high-risk cases. While clinical and symptomatic improvement remains an essential marker of response, it may be insufficient when dealing with pathogens such as E. tarda, which possess the ability to persist intracellularly [4,5]. Accordingly, I suggest an integrated “imaging-to-microbiology” strategy prior to antibiotic discontinuation. First, advanced imaging modalities—such as abdominal computed tomography or high-resolution ultrasonography—should be systematically incorporated to objectively assess the resolution of ascites. Complete radiological absorption of ascitic fluid would substantially strengthen the clinical justification for treatment cessation. Conversely, if residual ascites is detected, even in minimal or loculated forms, reliance on systemic inflammatory markers such as C-reactive protein or leukocyte counts alone may be misleading. Given the organism’s persistence potential [3], repeat diagnostic paracentesis should be strongly considered to confirm microbiological eradication. This dual confirmation—radiological and microbiological—would provide a more robust and evidence-based rationale for terminating antimicrobial therapy [6], thereby reducing the risk of relapse in immunocompromised patients. In conclusion, while this case report fills an important gap in the current literature, it also highlights the need to refine discharge and treatment-completion criteria for rare causes of SBP. Adoption of an imaging-guided microbiological confirmation strategy may enhance the precision of clinical decision-making and ultimately improve long-term outcomes in patients with complex comorbidities. 参考文献 [1]Usuda D , Furukawa D, Imaizumi R et al. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026,6; 14(1): 115102. [2][2]Qin L, Li F, Wang X, Sun Y, Bi K, Gao Y. Proteomic analysis of macrophage in response to Edwardsiella tarda-infection. Microb Pathog, 2017; 111: 86-93 [RCA] [PMID: 28826764 DOI: 10.1016/j.micpath.2017.08.028] [3]Zhang L, Ni C, Xu W, Dai T, Yang D, Wang Q, Zhang Y, Liu Q. Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda. J Bacteriol 2016; 198: 1534-1542 [RCA] [PMID: 26953340 DOI: 10.1128/JB.00978-15] [4]An L, Chan JL, Nguyen M, Yang S, Deville JG. Case Report: Disseminated Edwardsiella tarda infection in an immunocompromised patient. Front Cell Infect Microbiol 2023; 13: 1292768 [RCA] [PMID: 38053529 DOI: 10.3389/fcimb.2023.1292768] [5]Matsukawa H, Usuda D, Takami H, Nomura T, Sugita M. A Case of Edwardsiella tarda Infection With Iliopsoas Abscess Following Acute Pyelonephritis. Cureus 2024; 16: e58868 [RCA] [PMID: 38800258 DOI: 10.7759/cureus.58868] [6]A Rimola , G García-Tsao, M Navasa, L J Piddock, R Planas, B Bernard, J M Inadomi. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. J Hepatol, 2000; 32(1):142-53[RCA][PMID: 10673079 DOI: 10.1016/s0168-8278(00)80201-9] "
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Usuda D, Furukawa D, Imaizumi R, Ono R, Kaneoka Y, Nakajima E, Kato M, Sugawara Y, Shimizu R, Inami T, Kawai K, Matsubara S, Tanaka R, Suzuki M, Shimozawa S, Hotchi Y, Osugi I, Katou R, Ito S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Nomura T, Sugita M. Spontaneous bacterial peritonitis due to Edwardsiella tarda in an immuno-compromised dialysis patient: A case report and review of literature. World J Clin Cases 2026; 14(1): 115102
9
"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall ..."
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"This paper presents a systematic retrospective analysis of the incidence and clinical significance of gallstones and gallbladder wall thickening in patients with liver cirrhosis, offering valuable clinical observations for practitioners. The study clearly indicates that the prevalence of gallbladder abnormalities—including gallstones and asymptomatic wall thickening—is significantly higher in patients with cirrhosis, especially in the decompensated stage, compared to the general population. This finding aligns with previous research and further supports the pivotal role of portal hypertension and hepatic dysfunction in the development of gallbladder pathology. Notably, the authors emphasize that these imaging findings are often related to cirrhosis itself rather than being indicators of acute cholecystitis. This distinction is clinically important, as it can help prevent unnecessary interventions—such as misdiagnosis and surgery for presumed acute cholecystitis—particularly in asymptomatic individuals. Moreover, the study suggests that gallbladder abnormalities correlate more strongly with the decompensated state of cirrhosis than with its etiology, providing a fresh perspective on the mechanisms underlying gallbladder changes in these patients. However, several limitations should be acknowledged. First, the retrospective design and single-center sample may limit the generalizability of the results. Second, the study lacks in-depth analysis of subgroups based on the etiology of cirrhosis, leaving it unclear whether findings differ notably in non-alcoholic liver disease patients. Finally, potential influencing factors such as gallbladder motility and medication use were not systematically evaluated, even though they may contribute to wall thickening and stone formation. Overall, this paper offers practical clinical insights into the imaging assessment of the gallbladder in cirrhotic patients. Future prospective, multicenter studies incorporating more pathophysiological parameters—such as gallbladder motility and bile composition—could help further elucidate the complex relationship between cirrhosis and gallbladder disorders and contribute to optimized clinical decision-making. "
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Tsankof A, Protopapas AA, Kyritsi V, Gogou C, Kyziroglou M, Papathanasiou E, Chatzikosma C, Michalopoulos A, Savopoulos C, Protopapas AN. Gallstones and gallbladder wall thickening in patients with cirrhosis: Prevalence and clinical impact. World J Clin Cases 2026; 14(1): 114043
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"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Tian F, Huang ZC, Khizar H, Qiu K. Efficacy of indomethacin for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: A comprehensive meta-analysis of randomized controlled trials. World J Gastroenterol 2026; 32(1): 113232
11
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly ..."
[Read more]
"This meta-analysis systematically retrieved and synthesized evidence from 30 randomized controlled trials (RCTs) involving nearly 17,000 patients, providing the most comprehensive assessment to date on the efficacy of indomethacin for preventing post-ERCP pancreatitis (PEP). It offers valuable, up-to-date evidence-based references for clinical practice, and the authors' efforts are highly commendable. Nevertheless, while acknowledging its contributions, two critical methodological limitations must be highlighted, which may compromise the interpretation and generalizability of its findings. The present commentary aims to identify two key methodological flaws in this meta-analysis that seriously undermine the statistical validity and clinical interpretability of its results. First, the authors inappropriately disaggregated seven multi-arm randomized controlled trials into multiple independent pairwise comparisons for inclusion in the analysis. This practice directly violates the core assumption of data independence in meta-analyses: different comparison groups derived from the same trial are correlated due to the shared control arm. Treating these as independent samples artificially inflates the total sample size, misestimates the weight of each study, and leads to an inappropriate narrowing of confidence intervals, thereby increasing the risk of Type I or Type II errors. Second, the definition of the "control group" in the study encompasses interventions with extremely high clinical heterogeneity, including placebo, normal saline, other active medications (e.g., diclofenac, somatostatin), and invasive procedures (e.g., pancreatic duct stenting). Pooling these controls with vastly different mechanisms of action and therapeutic efficacies renders the reported pooled relative risk (RR = 0.85) clinically meaningless. Furthermore, the high heterogeneity observed (I² = 79%) is most likely attributable to this flawed methodological design. In summary, the aforementioned issues cast doubt on the statistical credibility of the primary conclusion—that "indomethacin does not significantly reduce the incidence of PEP"—and also make it difficult to provide a reasonable clinical interpretation for practice. Given that this review incorporates multiple interrelated interventions for comparison, network meta-analysis would represent a more appropriate methodological framework. It can rigorously integrate data from multi-arm trials and simultaneously evaluate the relative efficacy of all relevant preventive strategies. "
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Ding Y, Wang CY, Pan YT, Wang YJ, Zhao AG, Wen HZ. Scutellaria baicalensis Georgi as a potential therapeutic drug intervention in ulcerative colitis: Mechanisms of action and clinical trials. World J Gastroenterol 2026; 32(1): 114558
12
"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing ..."
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"I read the excellent paper by Rajak et al. The review is organized and precisely addresses the role of microplastics in inducing metabolic-associated steatotic liver disease and its progression. The review raises a growing emergency: the relationship between air pollution and human health. This can be a stimulus for policymakers and international organizations to take concrete action. However, it should be remembered that a proper lifestyle can mitigate the negative impact of microplastics on the liver and human health in general. While waiting for long-term measures, this is information that can yield short-term results. On this issue, it will be my concern to send a letter to the editor. Sincerely, Gianni Testino "
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Rajak S, Shahi A, Yadav A, Medhe P, Sinha RA. Microplastics in metabolic dysfunction-associated steatotic liver disease: An emerging threat to liver health. World J Hepatol 2025; 17(12): 111198
13
"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as ..."
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"1.The article does not cover the temporal and spatial dynamic changes of inflammatory cytokines during the development of NSCLC, as well as how these changes affect the occurrence and development of drug resistance. For instance, are there any differences in the expression levels of inflammatory cytokines in the early stage, progression stage, and resistance stage of the tumor? Are their distributions different in various parts of the tumor (such as the primary lesion and metastatic lesion)? It is suggested to utilize techniques such as in situ hybridization and immunohistochemistry, combined with single-cell sequencing and spatial transcriptomics, to study the temporal and spatial dynamic changes of inflammatory cytokines in different development stages and different locations of NSCLC. By analyzing longitudinal samples of patients (such as before treatment, during treatment, and after resistance), the dynamic change patterns of inflammatory cytokines during the process of drug resistance can be revealed. 2. Although IL-6R blockade shows the effect of reversing drug resistance, single-target therapy may have limitations in efficacy or the risk of drug resistance escape. It is suggested to explore IL-6/IL-8 dual-target inhibition in preclinical models, or to combine it with downstream pathway inhibitors (such as JAK/STAT, PI3K/AKT, NF-κB inhibitors) or immune checkpoint inhibitors to evaluate its synergistic anti-tumor effect and its remodeling effect on the tumor microenvironment, in order to provide theoretical basis for future clinical trials of combination therapy. "
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Calibasi-Kocal G. Inflammatory cytokine-associated cisplatin resistance in non-small cell lung cancer and re-sensitization through interleukin-6 receptor blockade. World J Clin Oncol 2025; 16(12): 114275
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ..."
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"Author: Priya Hazrah Professor, Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com, ORCID ID 0009-0008-1915-3978 Deborshi Sharma Director Professor Department of Surgey ABVIMS, New Delhi. Email: drdeborshi@gmail.com, ORCID ID 0000-0001-8251-8484 Sonali Mittal Assistant professor, Lady Hardinge Medical College, New Delhi Email: sonali.prachi@gmail.com, ORCID 0000-0002-6289-7656 Corresponding Author: Priya Hazrah Professor Department of Surgery, Lady Hardinge Medical College, New Delhi. Email: priyahazrah@gmail.com We read with tremendous interest your article entitled “Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders.” It was a very apt and concise review of commonly performed third space endoscopy (TSE) procedures, namely the C, Z, E, and G POEM (per oral endoscopic myotomy). Here, we would like to highlight other evolving procedures related to third space endoscopy and also the emerging concept of “fourth space endoscopy.” POETRE, peroral esophageal tunnelling for restoration of the esophagus, based on the principle of TSE, is an innovative technique of submucosal tunnelling proposed to be a useful therapeutic option in long-segment complete esophageal luminal obstruction in a few case series [1, 2]. PREM/PAEM (per rectal/per anal myotomy) is another novel use of TSE with limited exploration in patients with Hirschsprung’s disease [3]. STER (submucosal tunnelling endoscopic resection) and POET (peroral endoscopic excision of tumor) have been reported to be safe procedures for resection of extramucosal tumors in the upper gastrointestinal tract with acceptable complication rates vouched for in recent meta-analyses [4-7]. Further, TSE can be used to gain peritoneal access, as seen in POEM+F (POEM with fundoplication). Building upon the model of third space endoscopy is a forthcoming concept of fourth space endoscopy based on the technique of sub-serosal dissection for excision of extramucosal tumors in the upper gastrointestinal tract, like gastrointestinal stromal tumors, leiomyoma, hamartoma, etc., published in a limited case series [8]. The feasibility of using the principle of the fourth-space endoscopy procedure for vagotomy is investigational and has been reported currently in an anecdotal non-human study [9]. The fourth space is also utilized at times in POEM to enable a full-thickness myotomy [10]. References 1. Wagh MS, Draganov PV. Per-oral endoscopic tunneling for restoration of the esophagus: a novel endoscopic submucosal dissection technique for therapy of complete esophageal obstruction. Gastrointest Endosc. 2017 Apr;85(4):722-727. doi: 10.1016/j.gie.2016.08.035. Epub 2016 Sep 7. PMID: 27612924. 2. Félix C, Barreiro P, Rodrigues Azevedo J, Maia L, Küttner-Magalhães R, Pedroto I, Chagas C. Per-oral endoscopic tunneling for restoration of the esophagus (POETRE) in the management of a complete esophageal obstruction. Endosc Int Open. 2021 Jul;9(7):E1084-E1085. doi: 10.1055/a-1463-3059. Epub 2021 Jun 17. PMID: 34222634; PMCID: PMC8211479. 3. Bapaye A, Dashatwar P, Biradar V, Biradar S, Pujari R. Initial experience with per-rectal endoscopic myotomy for Hirschsprung's disease: medium and long term outcomes of the first case series of a novel third-space endoscopy procedure. Endoscopy. 2021 Dec;53(12):1256-1260. doi: 10.1055/a-1332-6902. Epub 2021 Mar 2. PMID: 33291158. 4. Onimaru M, Inoue H, Bechara R, Tanabe M, Abad MRA, Ueno A, Shimamura Y, Sumi K, Ikeda H, Ito H. Clinical outcomes of per-oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia. Dig Endosc. 2020 Mar;32(3):328-336. doi: 10.1111/den.13471. Epub 2019 Jul 22. PMID: 31234231. 5. Peng W, Tan S, Huang S, Ren Y, Li H, Peng Y, Fu X, Tang X. Efficacy and safety of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors with more than 1-year' follow-up: a systematic review and meta-analysis. Scand J Gastroenterol. 2019 Apr;54(4):397-406. doi: 10.1080/00365521.2019.1591500. Epub 2019 Mar 29. PMID: 30925071. 6. Song S, Wang X, Zhang S, Li Y, Zhang X, Chu X. Efficacy and complications of submucosal tunneling endoscopic resection for upper gastrointestinal submucosal tumors and exploration for influencing factors. Z Gastroenterol. 2018 Apr;56(4):365-373. English. doi: 10.1055/s-0043-123765. Epub 2018 Jan 18. PMID: 29346827. 7. Cao B, Lu J, Tan Y, Liu D. Efficacy and safety of submucosal tunneling endoscopic resection for gastric submucosal tumors: a systematic review and meta-analysis. Rev Esp Enferm Dig. 2021 Jan;113(1):52-59. doi: 10.17235/reed.2020.6989/2020. PMID: 33222480. 8. Liu F, Zhang S, Ren W, Yang T, Lv Y, Ling T, Zou X, Wang L. The fourth space surgery: endoscopic subserosal dissection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer. Surg Endosc. 2018 May;32(5):2575-2582. doi: 10.1007/s00464-017-5985-z. Epub 2017 Dec 20. PMID: 29264757. 9. Kadkhodayan K, Irani S. Endoscopic truncal vagotomy. Exploring the fourth space. A technical feasibility study in a porcine model. VideoGIE. 2025 Mar 4;10(7):340-344. doi: 10.1016/j.vgie.2025.02.012. PMID: 40642399; PMCID: PMC12237756. 10. Jiang T, Yang Y, Luo W. Application of the fourth space in peroral endoscopic myotomy (POEM) surgery for achalasia. Rev Esp Enferm Dig. 2025 Jun 27. doi: 10.17235/reed.2025.11331/2025. Epub ahead of print. PMID: 40575899. "
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Restrepo-Rodas G, Rodriguez J. Mastering the third space: Innovations in intramural endoscopic surgery for gastrointestinal disorders. World J Gastrointest Endosc 2025; 17(12): 111206
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using ..."
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"This article addresses an important and timely topic: differentiation-based strategies for colorectal cancer (CRC) therapy using natural products. The authors present a comprehensive in vitro study suggesting that Ferula assafoetida (FA) induces differentiation and apoptosis in Caco-2 colon cancer cells, potentially via activation of the JNK/MAPK pathway. As a reader, the work is interesting, methodologically broad, and conceptually aligned with current interests in natural compound–based cancer therapeutics, although certain conceptual and interpretative gaps limit its translational impact. As a reader, I would regard this article as a useful exploratory study that justifies further mechanistic, protein-level, and in vivo investigations, rather than a conclusive demonstration of FA as a differentiation therapy for CRC. "
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Abdelsalam HM, Abdelghany AM, Ahmed WA, Diab AA, Abdellateif MS. Ferula assafoetida induced colon cancer cells differentiation through JNK/MAPK signalling pathway activation. World J Exp Med 2025; 15(4): 110757
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"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal ..."
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"his retrospective study by Cooper et al. provides a valuable comparison of endoscopic band ligation (EBL) and endoscopic thermal therapy (ETT) as initial treatments for nodular gastric antral vascular ectasia (GAVE), a rare and challenging subtype. The analysis of 37 patients demonstrates that EBL outperforms ETT, with significantly higher clinical remission rates (90% vs. 69%, P=0.041), shorter treatment intervals (172 vs. 928 days, P=0.013), and fewer required endoscopic sessions (1.95 vs. 5.56, P=0.009), supported by improved hemoglobin levels and reduced transfusions. The findings robustly advocate for EBL as a first-line approach due to its efficiency and lower treatment burden. However, limitations include the small sample size, single-center design, and retrospective nature, which may affect generalizability. Despite this, the study fills a critical gap in nodular GAVE management and underscores the need for prospective multicenter trials to validate EBL's superiority and optimize clinical protocols. "
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Cooper JA, Statham E, Holyfield A, Shoreibah MG, Peter S. Initial treatment approaches for nodular gastric antral vascular ectasia: A comparison of endoscopic band ligation and thermal therapies. World J Gastrointest Endosc 2025; 17(12): 111872
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"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices ..."
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"The minireview by El Dada et al. offers a timely synthesis of endoscopic ultrasound (EUS)-guided coil embolization for gastric varices (GVs), highlighting its potential as a safer, precise alternative to traditional therapies like cyanoacrylate injection. Strengths include systematic comparisons with meta-analytic data (e.g., 96.7% obliteration rate for EUS-coil/cyanoacrylate vs. 70.6% for cyanoacrylate alone), practical technical details (coil selection, Doppler confirmation), real-world case illustrations, and cost-effectiveness analysis (1,831vs.11,000 hospitalization). However, limitations persist: reliance on retrospective/single-center data, absence of randomized controlled trials (RCTs) against TIPS/BRTO, and lack of long-term (>5 years) rebleeding/complication data (e.g., coil migration). The authors appropriately call for multicenter RCTs to standardize protocols, explore material combinations, and integrate predictive biomarkers. Despite gaps, the review compellingly argues for EUS-coil’s inclusion in GV guidelines, serving as a valuable reference for advancing therapeutic endoscopy with balanced analysis of efficacy, safety, and accessibility. "
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El Dada A, El Khoury M, Stephan P, Nehme F. Endoscopic ultrasound-guided coil embolization for gastric varices: A promising alternative to traditional therapies. World J Gastrointest Endosc 2025; 17(12): 110168
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation ..."
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"Name of Journal: World Journal of Gastroenterology Manuscript Type: LETTER TO THE EDITOR Dialister-Associated Succinate Dysregulation in Crohn’s Disease: Clinical and Therapeutic Implications 1Fotios S. Fousekis, 1Konstantinos H. Katsanos, 2Konstantinos Vlachos, 2Georgios D. Lianos 1Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece 2Department of Surgery, University Hospital of Ioannina, University of Ioannina, Greece Corresponding author: Fotios S. Fousekis, MD, PhD, Department of Gastroenterology, University Hospital of Ioannina, University of Ioannina Ioannina, Greece, email: fotisfous@gmail.com Abstract Growing evidence suggests that altered gut microbiota–derived succinate metabolism plays an important role in Crohn’s disease activity and postoperative recurrence. Particular emphasis is placed on Dialister, a gut bacterial genus that consumes succinate inefficiently, potentially leading to its accumulation and increased intestinal inflammation. Elevated succinate may impair immune regulation and enhance inflammatory signaling through SUCNR1 activation and hypoxia-inducible factor-1α stabilization. Recent findings identifying specific Dialister strains associated with postoperative recurrence provide new insight into disease monitoring and risk stratification. Although the study offers an integrative view linking microbial composition, metabolism, and inflammation, further validation using direct metabolomic and shotgun metagenomic approaches is needed. Overall, succinate appears to be a promising biomarker and therapeutic target, supporting future microbiota- and metabolism-based strategies for the management of inflammatory bowel disease. Key words: Crohn’s disease; Inflammatory bowel disease; Gut microbiota; Succinate; Dialister; Postoperative recurrence Core tip Accumulation of the microbial metabolite succinate is increasingly recognized as a key driver of inflammation in Crohn’s disease. Recent evidence links Dialister enrichment to impaired succinate clearance, disease activity, and postoperative recurrence, highlighting succinate as a promising biomarker and therapeutic target in inflammatory bowel disease. To the editor Dialister, an anaerobic Gram-negative genus of the human gut microbiome, has gained clinical interest due to its role in succinate metabolism. While capable of utilizing succinate as a substrate for propionate production, Dialister exhibits relatively slow consumption rates compared with efficient succinate consumers such as Phascolarctobacterium. This inefficiency may result in elevated luminal succinate levels, particularly in the context of inflammatory bowel disease (IBD) (1). Succinate accumulation may disrupt regulatory T cell (Treg) function by promoting FOXP3 degradation, thereby reducing immune tolerance and further amplifying inflammation (2). Furthermore, elevated succinate stabilizes hypoxia-inducible factor-1α (HIF-1α) by inhibiting prolyl hydroxylase activity, which prevents HIF-1α degradation and leads to enhanced inflammatory gene expression and perpetuation of tissue injury, particularly in IBD (3). We read with great interest the recently published article by Boronat-Toscano and colleagues on Dialister-driven succinate accumulation and its association with disease activity and postoperative recurrence in Crohn’s disease (4). This study offers valuable insights into a rapidly growing field of research that links gut microbiota, host metabolism, and inflammation. It positions succinate not just as a metabolic by-product but also as a functional biomarker and potential therapeutic target. One of the major strengths of this work is its integrative, multi-level approach, which combines clinical and biochemical measures of disease activity, such as the Harvey–Bradshaw Index, C-reactive protein, and fecal calprotectin, with gut microbiome profiling using 16S rRNA sequencing and host molecular markers related to succinate signaling, specifically the expression of the succinate receptor SUCNR1 (4). Notably, this study highlights specific Dialister operational taxonomic units (OTUs) in the intestinal mucosa that correlate with the risk and severity of postoperative recurrence. This goes beyond existing knowledge by identifying strain-level microbial signatures with potential predictive value, suggesting that variability within Dialister is vital for patient stratification and disease progression after surgery. The authors also propose a mechanism for succinate accumulation in Crohn's disease, involving the downregulation of NADH dehydrogenase and the upregulation of fumarate reductase and succinate transporters. This metabolic shift enhances succinate production and export by the gut microbiota (4). Despite these strengths, we would like to highlight several issues that merit further discussion. The functional analysis of the gut microbiome is based on predictive approaches (PICRUSt2) rather than on direct measurements of metabolic fluxes or shotgun metagenomic sequencing. Validation of these predictions is essential for robust conclusions. Targeted metabolomic analyses, using mass spectrometry or nuclear magnetic resonance, allow for direct quantification of metabolites as succinate and can confirm the functional activity of predicted pathways (5). In addition shotgun metagenomic sequencing may provide a more comprehensive and direct assessment of the genetic potential for metabolic pathways, including those involved in succinate production and consumption, by sequencing all microbial DNA present in a sample (6). These findings also open important avenues for future research and therapeutic development in inflammatory bowel disease. Given the central role of succinate in promoting intestinal inflammation through SUCNR1 activation and HIF-1α stabilization, strategies aimed at reducing succinate accumulation or blocking its downstream signaling pathways warrant further investigation. Microbiota-targeted interventions, including dietary fiber enrichment, prebiotics, and probiotics designed to enhance the abundance of efficient succinate-consuming bacteria such as Phascolarctobacterium, represent a particularly promising approach, as preclinical studies have demonstrated their ability to lower succinate levels, attenuate inflammatory signaling, and restore epithelial barrier integrity (7). Avoiding supplementation of the diet with refined inulin may be considered, as evidence from mouse models suggests that it can induce abnormal succinate accumulation in the intestinal lumen, thereby contributing to colonic inflammation (8). In parallel, pharmacological inhibition of SUCNR1 using small-molecule antagonists, as well as interventions targeting HIF-1α stabilization, may offer complementary strategies to suppress succinate-driven inflammation (9, 10). Huo et al. demonstrated that the SUCNR1 inhibitor NF-56-EJ40 may suppress glycolysis in intestinal epithelial cells and attenuates Th17-mediated inflammation in a dextran sodium sulfate–induced mouse model of ulcerative colitis. Treatment reduced pro-inflammatory cytokine production, improved epithelial barrier integrity, and alleviated colonic injury, supporting SUCNR1 antagonism as a therapeutic strategy targeting both metabolic and immune pathways (7). Consistently, genetic deletion of SUCNR1 in mice protected against both acute colitis and intestinal fibrosis, while in human fibroblasts derived from Crohn’s disease patients, succinate increased SUCNR1 expression and promoted inflammatory and fibrotic markers that were effectively reversed by SUCNR1 blockade (11). While these approaches are supported by growing mechanistic and translational evidence, well-designed clinical trials will be essential to determine their efficacy and safety in patients with IBD. Conclusion The study conducted by Boronat-Toscano et al. enhances the understanding of how microbiota-driven metabolic dysregulation relates to Crohn’s disease by identifing succinate and Dialister-associated microbial signatures associated as important factors that influence disease activity and the likelihood of postoperative recurrence. These findings support the use of succinate-related biomarkers in future risk assessment and postoperative monitoring strategies. Additionally, they provide a strong biological basis for therapeutic interventions that target succinate metabolism or SUCNR1-mediated signaling. Overall, this study marks a crucial step towards developing metabolically informed, microbiome-based precision medicine for IBD. Author contributions: Fousekis FS wrote the original draft; Lianos GD contributed to conceptualization, writing, reviewing and editing; Katsanos KH and Vlachos K participated in drafting the manuscript; and all authors have read and approved the final version of the manuscript. References 1. Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE. Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status. Microbiome. 2024;12(1):186. PMID: 39350289 PMCID: PMC11441152 DOI: 10.1186/s40168-024-01897-8 2. Wang H, Hu D, Cheng Y, Gao Q, Liu K, Mani NL, Tang AY, Iyer R, Gao B, Zhou Q, Yu Q, Weinberg SE, Zhang X, Cong Y, Dulai PS, Zhang Y, Liu Z, Fang D. Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch. Nat Immunol. 2025;26(6):866-80. PMID: 40457062 PMCID: PMC12399925 DOI: 10.1038/s41590-025-02166-y 3. Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LAJ. Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha. Nature. 2013;496(7444):238-42. PMID: 23535595 PMCID: PMC4031686 DOI: 10.1038/nature11986 4. Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease. World J Gastroenterol. 2025;31(45):112618. PMID: 41378335 PMCID: PMC12687013 DOI: 10.3748/wjg.v31.i45.112618 5. Han S, Van Treuren W, Fischer CR, Merrill BD, DeFelice BC, Sanchez JM, Higginbottom SK, Guthrie L, Fall LA, Dodd D, Fischbach MA, Sonnenburg JL. A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature. 2021;595(7867):415-20. PMID: 34262212 PMCID: PMC8939302 DOI: 10.1038/s41586-021-03707-9 6. Mitra S, Forster-Fromme K, Damms-Machado A, Scheurenbrand T, Biskup S, Huson DH, Bischoff SC. Analysis of the intestinal microbiota using SOLiD 16S rRNA gene sequencing and SOLiD shotgun sequencing. BMC Genomics. 2013;14 Suppl 5(Suppl 5):S16. PMID: 24564472 PMCID: PMC3852202 DOI: 10.1186/1471-2164-14-S5-S16 7. Huo L, Chen Q, Jia S, Zhang Y, Wang L, Li X, Li Z, Sun B, Shan J, Lin J, Yang L, Sui H. Gut microbiome promotes succinate-induced ulcerative colitis by enhancing glycolysis through SUCNR1/NF-kappaB signaling pathway. Am J Physiol Cell Physiol. 2025;329(2):C440-C54. PMID: 40549551 DOI: 10.1152/ajpcell.00411.2025 8. Tian S, Paudel D, Hao F, Neupane R, Castro R, Patterson AD, Tiwari AK, Prabhu KS, Singh V. Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production. Cancer Rep (Hoboken). 2023;6(11):e1863. PMID: 37489647 PMCID: PMC10644334 DOI: 10.1002/cnr2.1863 9. Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019;574(7779):581-5. PMID: 31645725 DOI: 10.1038/s41586-019-1663-8 10. Kim YI, Yi EJ, Kim YD, Lee AR, Chung J, Ha HC, Cho JM, Kim SR, Ko HJ, Cheon JH, Hong YR, Chang SY. Local Stabilization of Hypoxia-Inducible Factor-1alpha Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation. Front Immunol. 2020;11:609689. PMID: 33519819 PMCID: PMC7840603 DOI: 10.3389/fimmu.2020.609689 11. Macias-Ceja DC, Ortiz-Masia D, Salvador P, Gisbert-Ferrandiz L, Hernandez C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R; Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD. Succinate receptor mediates intestinal inflammation and fibrosis. Mucosal Immunol. 2019;12(1):178-87. PMID: 30279517 DOI: 10.1038/s41385-018-0087-3 "
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Boronat-Toscano A, Queipo-Ortuño MI, Monfort-Ferré D, Suau R, Vañó-Segarra I, Valldosera G, Cepero C, Astiarraga B, Clua-Ferré L, Plaza-Andrade I, Aranega-Martín L, Cabrinety L, Abadia de Barbarà C, Castellano-Castillo D, Moliné A, Caro A, Domènech E, Sánchez-Herrero JF, Benaiges-Fernandez R, Fernández-Veledo S, Vendrell J, Ginés I, Sumoy L, Manyé J, Menacho M, Serena C. Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn’s disease. World J Gastroenterol 2025; 31(45): 112618
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating ..."
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"This minireview systematically synthesizes the intricate interplay between depression and gastric cancer (GC), incorporating neuroendocrine, immunological, and psychosocial mechanisms. The authors effectively underscore the bidirectional causality supported by 52 referenced studies, in alignment with the biopsychosocial model. Nonetheless, there are opportunities to enhance methodological rigor and visual communication. Although Figure 1 delineates key components of the bidirectional relationship, its informational density is suboptimal. The figure lacks a hierarchical structuring of pathways (e.g., neuroendocrine versus immune mechanisms) and does not quantify effect sizes (e.g., hazard ratios from cited meta-analyses). It is recommended to incorporate a summary table for comparison. "
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Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have ..."
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"I want to congratulate the authors, Zhang et al, for conducting a study and identifying the predictors of refractory GERD. They have identified the disease duration and anxiety as significant risk factors and at least 90 minutes of moderate-intensity physical activity per week as a protective factor for refractory GERD. One of the important findings in this study is the association of significant Overlap DGBI symptoms (such as dyspepsia, constipation, and diarrhoea) in at least 50% of GERD patients. Since most patients had a duration of illness of more than 4 years, complications of GERD and their comparison between the groups were not noted in this study (a limitation). Although hydrogen impedance is used for diagnosis, the comparison of impedance parameters is not provided. H pylori infection is a protective factor for GERD/Barrett's, which is also a limitation. This study has provided a meaningful conclusion regarding the association between long-term symptoms and refractoriness. "
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Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060
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