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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 16, 2025; 13(35): 113980
Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.113980
Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.113980
Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association?
Hyder Osman Mirghani, Internal Medicine, University of Tabuk, Tabuk 51941, Saudi Arabia
Author contributions: Mirghani HO conceived and designed the study, conducted the literature search, drafted and made critical revisions to the manuscript, and provided final approval of the version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyder Osman Mirghani, MD, Full Professor, Internal Medicine, Univer
Received: September 9, 2025
Revised: September 20, 2025
Accepted: December 15, 2025
Published online: December 16, 2025
Processing time: 99 Days and 2 Hours
Revised: September 20, 2025
Accepted: December 15, 2025
Published online: December 16, 2025
Processing time: 99 Days and 2 Hours
Core Tip
Core Tip: Papillary thyroid carcinoma (PTC) and primary aldosteronism are common endocrine disorders. However, their coexistence in the same patient is rare. Local invasion of PTC, including invasion of major local veins and vagus nerve, is extremely rare. This manuscript reviewed the available literature regarding the possible association of PTC and primary aldosteronism and discussed the extremely rare contralateral metastasis and local invasion of PTC to the vagus nerve and internal jugular vein. Our manuscript gave a broader insight into the coexistence of two common endocrine disorders and discussed the risk factors for their association.