Mirghani HO. Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association? World J Clin Cases 2025; 13(35): 113980 [PMID: 41479736 DOI: 10.12998/wjcc.v13.i35.113980]
Corresponding Author of This Article
Hyder Osman Mirghani, MD, Full Professor, Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia. s.hyder63@hotmail.com
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Endocrinology & Metabolism
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Editorial
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 16, 2025 (publication date) through Jan 9, 2026
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World Journal of Clinical Cases
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2307-8960
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Mirghani HO. Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association? World J Clin Cases 2025; 13(35): 113980 [PMID: 41479736 DOI: 10.12998/wjcc.v13.i35.113980]
World J Clin Cases. Dec 16, 2025; 13(35): 113980 Published online Dec 16, 2025. doi: 10.12998/wjcc.v13.i35.113980
Papillary thyroid carcinoma and primary aldosteronism: A new syndrome or a mere association?
Hyder Osman Mirghani
Hyder Osman Mirghani, Internal Medicine, University of Tabuk, Tabuk 51941, Saudi Arabia
Author contributions: Mirghani HO conceived and designed the study, conducted the literature search, drafted and made critical revisions to the manuscript, and provided final approval of the version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hyder Osman Mirghani, MD, Full Professor, Internal Medicine, University of Tabuk, Prince Fahd Bin Sulta, Tabuk 51941, Saudi Arabia. s.hyder63@hotmail.com
Received: September 9, 2025 Revised: September 20, 2025 Accepted: December 15, 2025 Published online: December 16, 2025 Processing time: 99 Days and 2 Hours
Abstract
Primary aldosteronism (PA) is a common disorder, and the condition is underdiagnosed; the prevalence could reach one-third in patients with hypertension, and thyroid carcinoma is the second most common cancer, with papillary thyroid carcinoma (PTC) accounting for 90% of cases. Lymph node metastasis is common in PTC. However, pressure symptoms, including invasion of major local veins and the vagus nerve, are extremely rare. The association between primary hyperaldosteronism and PTC is rare. The interaction between genetic and environmental factors could explain the association. Whether the coexistence of PTC and PA influences the prognosis of PTC is to be explained. The association between PTC and PA with contralateral metastasis, vagus nerve involvement, and invasion to the internal jugular vein is extremely rare. We conducted a comprehensive literature search for relevant articles addressing the possible association of PA and PTC, and we found only 17 cases reported in the literature. The majority were women (10:6 with one study not reporting the gender), the ages ranged from 48 years to 77 years, and perioperative diagnosis was possible in 8 cases. Physicians might need to screen patients with PTC and local invasion for PA.
Core Tip: Papillary thyroid carcinoma (PTC) and primary aldosteronism are common endocrine disorders. However, their coexistence in the same patient is rare. Local invasion of PTC, including invasion of major local veins and vagus nerve, is extremely rare. This manuscript reviewed the available literature regarding the possible association of PTC and primary aldosteronism and discussed the extremely rare contralateral metastasis and local invasion of PTC to the vagus nerve and internal jugular vein. Our manuscript gave a broader insight into the coexistence of two common endocrine disorders and discussed the risk factors for their association.
